KEGG   PATHWAY: ccae04810
Entry
ccae04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Cyanistes caeruleus (blue tit)
Class
Cellular Processes; Cell motility
Pathway map
ccae04810  Regulation of actin cytoskeleton
ccae04810

Other DBs
GO: 0030036
Organism
Cyanistes caeruleus (blue tit) [GN:ccae]
Gene
111941320  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
111937972  lysophosphatidic acid receptor 1-like [KO:K04289]
111945421  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
111928583  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
111938362  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
111931155  CXCL12; stromal cell-derived factor 1 [KO:K10031]
111931764  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
111930178  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
111940635  F2R; proteinase-activated receptor 1 [KO:K03914]
111930707  INS; insulin [KO:K04526]
111927782  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
111935800  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
111931248  FGF8; fibroblast growth factor 8 [KO:K04358]
111934105  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
111929223  FGF16; fibroblast growth factor 16 [KO:K04358]
111928437  FGF20; fibroblast growth factor 20 [KO:K04358]
111929453  FGF5; LOW QUALITY PROTEIN: fibroblast growth factor 5 [KO:K04358]
111946013  fibroblast growth factor 17-like [KO:K04358]
111929899  FGF6; fibroblast growth factor 6 [KO:K04358]
111935684  FGF18; fibroblast growth factor 18 [KO:K04358]
111930412  FGF3; fibroblast growth factor 3 [KO:K04358]
111930413  FGF4; fibroblast growth factor 4 [KO:K04358]
111923652  FGF9; fibroblast growth factor 9 [KO:K04358]
111944138  FGF10; fibroblast growth factor 10 [KO:K04358]
111930414  FGF19; fibroblast growth factor 19 [KO:K22603]
111930076  FGF23; fibroblast growth factor 23 [KO:K22428]
111936274  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111934907  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
111927858  PDGFC; platelet-derived growth factor C [KO:K05450]
111923382  PDGFD; platelet-derived growth factor D [KO:K05450]
111939540  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
111923657  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111938850  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111931374  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111927721  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
111943286  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111928019  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111935543  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111931693  FN1; fibronectin [KO:K05717]
111941525  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
111941464  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
111932032  ITGA4; integrin alpha-4 [KO:K06483]
111932082  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
111924384  ITGA8; integrin alpha-8 [KO:K06584]
111923914  ITGA9; integrin alpha-9 [KO:K06585]
111942418  integrin alpha-10-like [KO:K06586]
111941993  integrin alpha-11-like [KO:K06587]
111931704  ITGAV; integrin alpha-V [KO:K06487]
111924368  ITGB1; integrin beta-1 [KO:K05719]
111931900  ITGB2; integrin beta-2 [KO:K06464]
111940101  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111937302  ITGB4; integrin beta-4 [KO:K06525]
111932261  ITGB5; integrin beta-5 [KO:K06588]
111932160  ITGB6; integrin beta-6 [KO:K06589]
111924297  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
111933378  KNG1; kininogen-1 isoform X1 [KO:K03898]
111929837  BDKRB1; B1 bradykinin receptor [KO:K03915]
111929838  BDKRB2; B2 bradykinin receptor [KO:K03916]
111936668  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
111926838  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
111930184  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
111930319  muscarinic acetylcholine receptor M5-like [KO:K04133]
111930320  muscarinic acetylcholine receptor M5-like [KO:K04133]
111937084  C5; complement C5 [KO:K03994]
111941369  C6; complement component C6 [KO:K03995]
111941385  C7; complement component C7 isoform X1 [KO:K03996]
111933009  C8A; complement component C8 alpha chain [KO:K03997]
111933008  C8B; complement component C8 beta chain [KO:K03998]
111936899  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
111941412  C9; complement component C9 [KO:K04000]
111936095  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
111937573  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
111932951  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111935264  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
111925177  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111934540  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
111936642  CRKL; crk-like protein [KO:K04438]
111937736  CRK; adapter molecule crk isoform X1 [KO:K04438]
111930975  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
111938254  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111929515  SOS2; son of sevenless homolog 2 [KO:K03099]
111926571  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111930717  HRAS; GTPase HRas [KO:K02833]
111945773  KRAS; GTPase KRas isoform X1 [KO:K07827]
111939625  NRAS; GTPase NRas [KO:K07828]
111930555  RRAS2; ras-related protein R-Ras2 [KO:K07830]
111932216  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
111928530  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
111933356  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111933753  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111938683  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111933104  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
111941370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111940405  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111937047  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
111932616  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
111942402  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
111936843  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
111935240  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111924717  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
111933966  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111940193  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111936534  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111929760  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111922589  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
111927570  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111941962  RGCC; regulator of cell cycle RGCC [KO:K26108]
111939314  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
111935135  RHOA; transforming protein RhoA [KO:K04513]
111936023  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111944780  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111937502  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111938571  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
111925537  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111933722  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111928712  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
111945870  serine/threonine-protein kinase CST20-like [KO:K05733] [EC:2.7.11.1]
111945306  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111929207  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
111942145  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111942867  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111922426  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111945986  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
111941729  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
111926462  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
111930494  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
111922724  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
111937952  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
111924950  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111925960  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
111940063  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111923845  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
111932252  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
111934649  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
111938138  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
111927633  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111936713  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111933170  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
111939610  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
111936417  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
111938346  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
111937685  MYL10; myosin regulatory light chain 10 [KO:K12756]
111923992  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
111935545  MYH9; myosin-9 [KO:K10352]
111935975  MYH11; myosin-11 isoform X1 [KO:K10352]
111937190  MYH10; myosin-10 isoform X1 [KO:K10352]
111928722  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
111938953  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
111945579  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
111940280  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
111940733  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
111924144  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
111944100  phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like [KO:K00920] [EC:2.7.1.149]
111940105  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
111932425  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
111942480  LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
111936608  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
111933154  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
111943793  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
111926265  ENAH; protein enabled homolog isoform X1 [KO:K05746]
111922966  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
111939071  WASF2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
111935493  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
111945961  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
111931890  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
111932421  ABI2; abl interactor 2 [KO:K05751]
111927262  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
111926525  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
111932300  ACTR3; actin-related protein 3 [KO:K18584]
111925497  ACTR3B; actin-related protein 3B [KO:K18584]
111936119  actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
111932194  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
111936381  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
111935039  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
111932550  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
111946142  actin, cytoplasmic 2-like [KO:K05692]
111936114  ACTB; actin, cytoplasmic 1 [KO:K05692]
111933244  PFN2; profilin-2 [KO:K05759]
111936752  PXN; paxillin [KO:K05760]
111926753  EZR; ezrin isoform X1 [KO:K08007]
111924017  RDX; radixin isoform X1 [KO:K05762]
111928621  MSN; moesin isoform X1 [KO:K05763]
111922816  TMSB4X; thymosin beta-4 [KO:K05764]
111935573  thymosin beta-4-like isoform X1 [KO:K05764]
111930025  CFL2; cofilin-2 [KO:K05765]
111936440  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
111937777  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
111931065  VCL; vinculin isoform X1 [KO:K05700]
111933926  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
111939451  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
111940722  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
111924265  SCIN; adseverin isoform X1 [KO:K05768]
111937088  GSN; gelsolin isoform X1 [KO:K05768]
111930279  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
111942417  uncharacterized protein LOC111942417 [KO:K05699]
111940694  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
111933768  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
111923528  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ccae04010  MAPK signaling pathway
ccae04510  Focal adhesion
ccae04520  Adherens junction
KO pathway
ko04810   
LinkDB

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