KEGG   PATHWAY: cpea04810
Entry
cpea04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Chaetura pelagica (chimney swift)
Class
Cellular Processes; Cell motility
Pathway map
cpea04810  Regulation of actin cytoskeleton
cpea04810

Other DBs
GO: 0030036
Organism
Chaetura pelagica (chimney swift) [GN:cpea]
Gene
104393410  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
104385203  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
104387795  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
104389952  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
104391132  CXCL12; stromal cell-derived factor 1 [KO:K10031]
104391156  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
104390414  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
104395810  F2R; proteinase-activated receptor 1 [KO:K03914]
104394306  insulin [KO:K04526]
104394485  EGF; pro-epidermal growth factor [KO:K04357]
104391881  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104398817  FGF2; fibroblast growth factor 2 [KO:K18497]
104389329  FGF9; fibroblast growth factor 9 [KO:K04358]
104385933  FGF7; fibroblast growth factor 7 [KO:K04358]
104395734  FGF18; fibroblast growth factor 18 [KO:K04358]
104390871  FGF8; fibroblast growth factor 8 [KO:K04358]
104391813  FGF10; fibroblast growth factor 10 [KO:K04358]
104397226  FGF6; fibroblast growth factor 6 [KO:K04358]
104392443  FGF22; fibroblast growth factor 22 [KO:K04358]
104397482  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
104393056  FGF20; fibroblast growth factor 20 [KO:K04358]
104388382  FGF16; fibroblast growth factor 16 [KO:K04358]
104397230  FGF23; fibroblast growth factor 23 [KO:K22428]
104393744  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
104396508  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104390276  PDGFD; platelet-derived growth factor D [KO:K05450]
104387270  PDGFC; platelet-derived growth factor C [KO:K05450]
104393487  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104384843  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
104394388  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104391064  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104392670  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104393038  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104392712  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104388156  FN1; fibronectin [KO:K05717]
104398501  ITGA1; integrin alpha-1 [KO:K06480]
104398500  ITGA2; integrin alpha-2 [KO:K06481]
104387553  ITGA4; integrin alpha-4 [KO:K06483]
104387390  ITGA6; integrin alpha-6 [KO:K06485]
104394072  ITGA8; integrin alpha-8 [KO:K06584]
104389994  ITGA9; integrin alpha-9 [KO:K06585]
104386524  ITGA11; integrin alpha-11 [KO:K06587]
104386619  ITGAV; LOW QUALITY PROTEIN: integrin alpha-V [KO:K06487]
104397060  ITGB1; integrin beta-1 [KO:K05719]
104391752  ITGB2; integrin beta-2 [KO:K06464]
104390236  ITGB3; integrin beta-3 [KO:K06493]
104393245  ITGB4; integrin beta-4 [KO:K06525]
104387304  ITGB5; integrin beta-5 [KO:K06588]
104387350  ITGB6; integrin beta-6 [KO:K06589]
104386360  ITGB8; integrin beta-8 [KO:K06591]
104390868  KNG1; LOW QUALITY PROTEIN: kininogen-1 [KO:K03898]
104389084  BDKRB1; B1 bradykinin receptor [KO:K03915]
104389085  B2 bradykinin receptor-like [KO:K03916]
104394209  B2 bradykinin receptor-like [KO:K03916]
104398151  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
104388685  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
104390419  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
104397691  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
104389883  C5; complement C5 [KO:K03994]
104398613  C6; complement component C6 [KO:K03995]
104398587  C7; complement component C7 [KO:K03996]
104385157  C8A; complement component C8 alpha chain [KO:K03997]
104385190  C8B; complement component C8 beta chain [KO:K03998]
104398616  C9; complement component C9 [KO:K04000]
104385246  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104393316  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
104386038  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104395036  FYVE, RhoGEF and PH domain-containing protein 3-like [KO:K05722]
104387818  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
104386318  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
104384916  CRK; adapter molecule crk [KO:K04438]
104395117  CRKL; crk-like protein [KO:K04438]
104392476  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
104389754  SRC; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
104394717  SOS2; son of sevenless homolog 2 [KO:K03099]
104398553  SOS1; son of sevenless homolog 1 [KO:K03099]
104387643  HRAS; GTPase HRas [KO:K02833]
104386764  KRAS; GTPase KRas isoform X1 [KO:K07827]
104392909  NRAS; GTPase NRas [KO:K07828]
104387317  MRAS; ras-related protein M-Ras [KO:K07831]
104388301  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
104390114  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
104395385  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
104395456  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
104395652  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
104396688  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
104388868  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
104389904  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
104396884  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
104392425  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
104396045  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104398706  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104395709  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
104386653  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104391569  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
104388745  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104394936  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104387153  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104393947  regulator of cell cycle RGCC-like [KO:K26108]
104386074  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
104394979  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
104384869  RHOA; transforming protein RhoA [KO:K04513]
104393800  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104395979  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104398523  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104390636  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104391727  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104387912  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104388293  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
104397200  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
104385133  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
104388976  ARHGEF7; rho guanine nucleotide exchange factor 7 [KO:K13710]
104388866  ARF GTPase-activating protein GIT1-like [KO:K05737]
104396934  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
104395815  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
104385529  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
104391638  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
104387305  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
104388580  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
104389431  PPP1CC; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
104395247  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
104392017  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
104397964  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
104389432  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
104390665  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
104396213  MYL10; myosin regulatory light chain 10 [KO:K12756]
104396941  myosin regulatory light chain 2, smooth muscle minor isoform-like isoform X1 [KO:K12757]
104396942  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
104395990  MYH9; myosin-9 isoform X1 [KO:K10352]
104398183  MYH10; myosin-10 isoform X1 [KO:K10352]
104393708  MYH11; myosin-11 isoform X1 [KO:K10352]
104388399  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
104394130  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
104393319  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
104398384  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
104393896  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
104397041  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
104388433  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
104387427  PIKFYVE; LOW QUALITY PROTEIN: 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
104395142  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
104391560  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
104398508  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
104386205  ENAH; protein enabled homolog isoform X1 [KO:K05746]
104394681  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
104391441  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2-like [KO:K05748]
104386256  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
104392584  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
104397432  NCKAP1; nck-associated protein 1 [KO:K05750]
104387429  ABI2; abl interactor 2 [KO:K05751]
104394721  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
104385066  ACTR2; actin-related protein 2 [KO:K17260]
104391165  ACTR3; actin-related protein 3 [KO:K18584]
104396204  ACTR3B; actin-related protein 3B [KO:K18584]
104385259  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
104385260  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
104387474  ARPC2; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 2 [KO:K05758]
104389411  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
104386140  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104385255  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
104391979  ACTL9; actin-like protein 9 isoform X1 [KO:K05692]
104393236  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104395079  profilin-2-like [KO:K05759]
104386231  profilin-3-like [KO:K05759]
104392941  PFN4; profilin-4 [KO:K05759]
104395153  PXN; paxillin [KO:K05760]
104389549  EZR; ezrin [KO:K08007]
104390289  RDX; radixin [KO:K05762]
104387806  MSN; moesin isoform X1 [KO:K05763]
104386626  thymosin beta-12-like [KO:K05764]
104385408  CFL2; cofilin-2 [KO:K05765]
104384833  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104388011  SSH1; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104391498  VCL; vinculin [KO:K05700]
104385784  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
104395800  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
104398222  ras GTPase-activating-like protein IQGAP3 [KO:K05767]
104389795  GSN; gelsolin [KO:K05768]
104386379  SCIN; adseverin [KO:K05768]
104395873  LOW QUALITY PROTEIN: alpha-actinin-4-like [KO:K05699]
104397677  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
104384772  adenomatous polyposis coli protein-like [KO:K02085]
104392491  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
104387935  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
cpea04010  MAPK signaling pathway
cpea04510  Focal adhesion
cpea04520  Adherens junction
KO pathway
ko04810   
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