KEGG   PATHWAY: cpea04010
Entry
cpea04010                   Pathway                                
Name
MAPK signaling pathway - Chaetura pelagica (chimney swift)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cpea04010  MAPK signaling pathway
cpea04010

Other DBs
GO: 0000165
Organism
Chaetura pelagica (chimney swift) [GN:cpea]
Gene
104385850  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
104386585  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
104384912  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104386122  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
104393195  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104394041  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
104396908  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
104390498  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104392408  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
104388143  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
104384953  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
104386598  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
104397037  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
104392820  CACNB4; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
104393312  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104395988  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
104397014  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
104393132  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
104393223  voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
104396726  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
104393313  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
104393133  PRKCB; LOW QUALITY PROTEIN: protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
104385246  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104386038  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104391470  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104388936  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
104393667  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
104385054  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
104393356  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
104398316  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
104397735  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104397297  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
104387210  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104398941  NF1; neurofibromin [KO:K08052]
104387961  ras GTPase-activating protein 1-like [KO:K04352]
104388911  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104392257  RASA2; ras GTPase-activating protein 2 [KO:K08053]
104392402  RAP1A; ras-related protein Rap-1A [KO:K04353]
104388816  RAP1B; ras-related protein Rap-1b [KO:K07836]
104394485  EGF; pro-epidermal growth factor [KO:K04357]
104386411  TGFA; protransforming growth factor alpha [KO:K08774]
104394078  EREG; proepiregulin [KO:K09784]
104394087  AREG; amphiregulin [KO:K09782]
104391881  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104398817  FGF2; fibroblast growth factor 2 [KO:K18497]
104389329  FGF9; fibroblast growth factor 9 [KO:K04358]
104385933  FGF7; fibroblast growth factor 7 [KO:K04358]
104395734  FGF18; fibroblast growth factor 18 [KO:K04358]
104390871  FGF8; fibroblast growth factor 8 [KO:K04358]
104391813  FGF10; fibroblast growth factor 10 [KO:K04358]
104397226  FGF6; fibroblast growth factor 6 [KO:K04358]
104392443  FGF22; fibroblast growth factor 22 [KO:K04358]
104397482  FGF3; LOW QUALITY PROTEIN: fibroblast growth factor 3 [KO:K04358]
104393056  FGF20; fibroblast growth factor 20 [KO:K04358]
104388382  FGF16; fibroblast growth factor 16 [KO:K04358]
104397230  FGF23; fibroblast growth factor 23 [KO:K22428]
104392598  NGF; beta-nerve growth factor [KO:K02582]
104394627  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
104395238  NTF3; neurotrophin-3 [KO:K04356]
104394306  insulin [KO:K04526]
104396024  IGF1; insulin-like growth factor I [KO:K05459]
104394325  IGF2; insulin-like growth factor II [KO:K13769]
104393744  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
104396508  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
104390276  PDGFD; platelet-derived growth factor D [KO:K05450]
104387270  PDGFC; platelet-derived growth factor C [KO:K05450]
104393427  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104398013  KITLG; kit ligand [KO:K05461]
104396395  VEGFA; vascular endothelial growth factor A [KO:K05448]
104385492  PGF; placenta growth factor [KO:K16859]
104385383  FIGF; vascular endothelial growth factor D [KO:K05449]
104387286  VEGFC; vascular endothelial growth factor C [KO:K05449]
104392409  HGF; hepatocyte growth factor [KO:K05460]
104396615  ANGPT1; angiopoietin-1 [KO:K05465]
104390085  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
104392873  ANGPT4; angiopoietin-4 [KO:K05467]
104395617  EFNA2; ephrin-A2 [KO:K05462]
104397282  EFNA5; ephrin-A5 [KO:K05462]
104387455  EFNA1; ephrin-A1 [KO:K05462]
104387466  EFNA3; ephrin-A3 [KO:K05462]
104398594  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104395839  NRTN; neurturin [KO:K25414]
104396706  ARTN; artemin [KO:K25415]
104393487  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
104385087  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
104388112  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
104384843  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
104394388  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104391064  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104392670  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
104391708  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
104386799  NTRK2; BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
104388871  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
104386703  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104393038  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104392712  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104392613  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104393068  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104395903  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104390504  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
104395904  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104386462  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104393067  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104394665  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104391702  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104387087  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
104389173  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104393177  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104394717  SOS2; son of sevenless homolog 2 [KO:K03099]
104398553  SOS1; son of sevenless homolog 1 [KO:K03099]
104387643  HRAS; GTPase HRas [KO:K02833]
104386764  KRAS; GTPase KRas isoform X1 [KO:K07827]
104392909  NRAS; GTPase NRas [KO:K07828]
104387317  MRAS; ras-related protein M-Ras [KO:K07831]
104396045  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104398706  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104386653  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104391569  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
104393669  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104388745  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
104396683  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
104388067  MKNK2; LOW QUALITY PROTEIN: MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
104394122  RPS6KA1; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
104386969  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
104387789  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
104388312  RPS6KA3; ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
104395227  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104388620  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
104392843  MYC; myc proto-oncogene protein [KO:K04377]
104398443  SRF; serum response factor [KO:K04378]
104397946  MAPT; microtubule-associated protein tau [KO:K04380]
104394114  STMN1; stathmin [KO:K04381]
104390438  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104390440  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104390477  LOW QUALITY PROTEIN: cytosolic phospholipase A2 beta-like [KO:K16342] [EC:3.1.1.4]
104390480  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104390481  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104390482  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104390483  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104390485  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
104390486  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104388912  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104391224  interleukin-1 beta-like isoform X1 [KO:K04519]
104386187  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
104385439  TGFB3; transforming growth factor beta-3 [KO:K13377]
104387720  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
104389002  interleukin-1 receptor type 1-like [KO:K04386]
104390724  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104394158  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
104387443  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
104397620  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
104390683  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104390892  FAS; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104393800  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
104395979  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104398523  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104390636  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104394797  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104393005  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104397857  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104396189  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104396455  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104388407  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104394925  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
104390776  TAB2; LOW QUALITY PROTEIN: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104385242  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
104398425  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
104388265  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
104388947  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104391727  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104387912  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
104389748  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104396661  STK3; serine/threonine-protein kinase 3 [KO:K04412]
104397055  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104395629  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104387320  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104396174  mitogen-activated protein kinase kinase kinase 3-like [KO:K04421] [EC:2.7.11.25]
104398030  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104397667  MAP3K9; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104394894  mitogen-activated protein kinase kinase kinase MLK4 [KO:K17534] [EC:2.7.11.25]
104385090  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104387395  mitogen-activated protein kinase kinase kinase MLT [KO:K04424] [EC:2.7.11.25]
104395821  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104391251  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104390820  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104395157  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
104388862  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104398220  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104385265  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104393228  MAP2K6; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104390460  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104395360  C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
104384916  CRK; adapter molecule crk [KO:K04438]
104395117  CRKL; crk-like protein [KO:K04438]
104386551  beta-arrestin-1 [KO:K04439]
104385199  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104391113  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104386555  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104387234  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104387330  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
104393872  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
104393877  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
104389436  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104388631  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104388105  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104394190  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104398582  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104394800  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104385160  JUN; transcription factor AP-1 [KO:K04448]
104387402  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104388898  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
104396208  HSPB1; heat shock protein beta-1 [KO:K04455]
104394936  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
104387153  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
104391411  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104388836  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
104389098  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104390490  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104392648  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104394328  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104395103  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104387145  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104387253  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104397911  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104398014  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104386192  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104385640  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104397785  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
104395256  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
104386412  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104396836  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104386650  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
104387011  MAP3K14; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104397776  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104384891  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104396205  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104393663  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104391506  NFKB2; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p100 subunit [KO:K04469]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cpea04070  Phosphatidylinositol signaling system
cpea04110  Cell cycle
cpea04115  p53 signaling pathway
cpea04210  Apoptosis
cpea04310  Wnt signaling pathway
KO pathway
ko04010   
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