KEGG   PATHWAY: dcc05168
Entry
dcc05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Dermochelys coriacea (leatherback sea turtle)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
dcc05168  Herpes simplex virus 1 infection
dcc05168

Organism
Dermochelys coriacea (leatherback sea turtle) [GN:dcc]
Gene
119842670  lymphotoxin-alpha-like [KO:K05468]
119846035  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
119844955  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
119842911  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
119844349  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
119852706  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
119848740  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
119858630  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119847100  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119858045  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119854760  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
119858230  RELA; transcription factor p65 isoform X1 [KO:K04735]
119859759  inhibitor of apoptosis protein-like [KO:K16060]
119846607  NECTIN1; nectin-1 [KO:K06081]
119847619  NECTIN2; nectin-2 isoform X3 [KO:K06531]
119843570  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
119844931  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
119845903  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
119848971  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
119841751  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
119855929  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
122455357  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
119847218  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119849273  TP53; cellular tumor antigen p53 [KO:K04451]
119845779  complement C3-like [KO:K03990]
119845818  LOW QUALITY PROTEIN: complement C3-like [KO:K03990]
119845819  LOW QUALITY PROTEIN: complement C3-like [KO:K03990]
119846023  venom factor-like [KO:K03990]
119844052  C5; LOW QUALITY PROTEIN: complement C5 [KO:K03994]
119847265  properdin isoform X1 [KO:K15412]
119855141  toll-like receptor 2 type-2 [KO:K10159]
119855269  toll-like receptor 2 type-2 [KO:K10159]
119847754  toll-like receptor 2 [KO:K10159]
119851837  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119857432  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
119855215  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
119848466  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
119852920  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119847060  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
119856996  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
119852837  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119859541  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
119852884  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3 [KO:K04404]
119848666  interleukin-1 beta-like [KO:K04519]
119848579  interleukin-1 beta-like [KO:K04519]
119844629  C-C motif chemokine 5-like [KO:K12499]
119851076  IL6; interleukin-6 [KO:K05405]
119842931  TNF; tumor necrosis factor [KO:K03156]
119861806  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
119860616  IL12B; interleukin-12 subunit beta [KO:K05425]
119856319  DDX58; LOW QUALITY PROTEIN: antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
119863698  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
119854309  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
119857747  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119846207  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119850024  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
119856142  interferon kappa-like [KO:K05414]
119856222  interferon beta-like [KO:K05414]
119856313  LOW QUALITY PROTEIN: interferon epsilon-like [KO:K05414]
119854558  LOW QUALITY PROTEIN: interferon tau-2-like [KO:K05414]
119855399  interferon kappa-like [KO:K05414]
119845281  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
119853169  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
119860452  STING1; stimulator of interferon genes protein [KO:K12654]
119843648  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
119857354  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
119853202  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
119862574  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
119853864  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
119854901  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
119857093  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
119856939  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119843556  EIF2B1; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit alpha [KO:K03239]
119857166  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
119860410  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
119861088  EIF2B5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240]
119843818  LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3-like [KO:K14216] [EC:2.7.7.84]
119859748  2-5A-dependent ribonuclease isoform X1 [KO:K01165]
122455371  2-5A-dependent ribonuclease-like [KO:K01165]
119847226  HCFC1; LOW QUALITY PROTEIN: host cell factor 1 [KO:K14966]
119842667  HCFC2; host cell factor 2 isoform X2 [KO:K27390]
119861226  POU2F1; LOW QUALITY PROTEIN: POU domain, class 2, transcription factor 1 [KO:K09364]
119847734  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
119846689  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
119851487  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
119858567  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
119847228  suppressor of cytokine signaling 3-like [KO:K04696]
119842904  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
119860825  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
119845813  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X3 [KO:K11219] [EC:2.7.10.2]
119863823  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X3 [KO:K11220]
119845671  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
119841587  IRF9; interferon regulatory factor 9 [KO:K04693]
119847249  zinc finger protein 501-like [KO:K09228]
119854819  zinc finger protein OZF-like isoform X1 [KO:K09228]
119841306  zinc finger protein 239-like [KO:K09228]
119841307  zinc finger protein 79-like [KO:K09228]
119841419  zinc finger protein 501-like isoform X1 [KO:K09228]
119849088  zinc finger protein OZF-like isoform X4 [KO:K09228]
119862694  zinc finger protein 850-like [KO:K09228]
119842475  zinc finger protein OZF-like isoform X1 [KO:K09228]
119842477  zinc finger protein 345-like [KO:K09228]
119842478  zinc finger protein 501-like isoform X3 [KO:K09228]
119842490  zinc finger protein 879-like isoform X1 [KO:K09228]
119842494  zinc finger protein 3-like [KO:K09228]
119842495  zinc finger protein 771-like [KO:K09228]
119842496  zinc finger protein 239-like isoform X1 [KO:K09228]
119842502  zinc finger protein 251-like isoform X1 [KO:K09228]
119842581  zinc finger protein 70-like [KO:K09228]
119842634  zinc finger protein 383-like isoform X1 [KO:K09228]
119842642  zinc finger protein 501-like isoform X2 [KO:K09228]
119842753  zinc finger protein 436-like isoform X1 [KO:K09228]
119842754  zinc finger protein 436-like [KO:K09228]
119842755  zinc finger protein 883-like isoform X2 [KO:K09228]
119842758  zinc finger protein 436-like isoform X1 [KO:K09228]
119842760  zinc finger protein 250-like isoform X2 [KO:K09228]
119842762  zinc finger protein 501-like isoform X3 [KO:K09228]
119842767  zinc finger protein 436-like [KO:K09228]
119849245  ZNF3; zinc finger protein 3 isoform X3 [KO:K09228]
119849344  zinc finger protein OZF-like [KO:K09228]
119849373  zinc finger protein 436-like isoform X1 [KO:K09228]
119849374  zinc finger protein 34-like isoform X1 [KO:K09228]
119849376  zinc finger protein 436-like isoform X44 [KO:K09228]
119849388  zinc finger protein OZF-like isoform X3 [KO:K09228]
119849389  zinc finger protein OZF-like isoform X1 [KO:K09228]
119849403  zinc finger protein 501-like isoform X20 [KO:K09228]
119849402  zinc finger protein 501-like isoform X2 [KO:K09228]
119849404  zinc finger protein 436-like isoform X1 [KO:K09228]
119849405  zinc finger protein 34-like isoform X1 [KO:K09228]
119849407  zinc finger protein 773-like isoform X2 [KO:K09228]
119849409  zinc finger protein 501-like isoform X2 [KO:K09228]
119849410  zinc finger protein 501-like [KO:K09228]
119849418  zinc finger protein 3-like [KO:K09228]
119842846  zinc finger protein 664-like isoform X1 [KO:K09228]
119842851  zinc finger protein OZF-like isoform X1 [KO:K09228]
119842921  zinc finger protein 239-like [KO:K09228]
119843030  zinc finger protein 436-like isoform X1 [KO:K09228]
119843034  zinc finger protein 345-like [KO:K09228]
119843283  zinc finger protein 345-like isoform X3 [KO:K09228]
119843284  zinc finger protein 420-like isoform X1 [KO:K09228]
119843285  zinc finger protein 420-like [KO:K09228]
119843286  zinc finger protein 260-like isoform X3 [KO:K09228]
119843287  zinc finger protein 420-like isoform X5 [KO:K09228]
119843295  zinc finger protein 84-like isoform X5 [KO:K09228]
119843315  zinc finger protein 260-like isoform X1 [KO:K09228]
119856500  zinc finger protein 250-like isoform X1 [KO:K09228]
119856507  zinc finger protein 436-like isoform X1 [KO:K09228]
119856508  zinc finger protein 250-like [KO:K09228]
119856525  zinc finger protein 497-like isoform X1 [KO:K09228]
119863814  zinc finger protein 436-like isoform X10 [KO:K09228]
119863252  zinc finger protein 883-like isoform X1 [KO:K09228]
119843324  zinc finger protein 501-like [KO:K09228]
119843328  zinc finger protein 436-like isoform X3 [KO:K09228]
119843335  putative zinc finger protein 66 isoform X1 [KO:K09228]
119843338  zinc finger protein 345-like isoform X2 [KO:K09228]
119843347  zinc finger protein 501-like [KO:K09228]
119843348  zinc finger protein 436-like isoform X2 [KO:K09228]
119850706  zinc finger protein 777-like isoform X4 [KO:K09228]
119850707  zinc finger protein 777-like [KO:K09228]
119850771  zinc finger protein 271-like isoform X1 [KO:K09228]
119850772  zinc finger protein 436-like isoform X1 [KO:K09228]
119850773  zinc finger protein 354C-like isoform X1 [KO:K09228]
119850776  zinc finger protein 777-like isoform X1 [KO:K09228]
119850781  zinc finger protein 436-like isoform X1 [KO:K09228]
119850783  zinc finger protein 282-like [KO:K09228]
119850784  zinc finger protein 282-like [KO:K09228]
119850788  zinc finger protein 420-like [KO:K09228]
119850789  zinc finger protein 282-like isoform X2 [KO:K09228]
119856537  zinc finger protein 436-like isoform X4 [KO:K09228]
119856554  zinc finger protein 316-like isoform X1 [KO:K09228]
119856570  zinc finger protein 883-like isoform X2 [KO:K09228]
119856790  zinc finger protein 345-like [KO:K09228]
119856794  zinc finger protein 154-like isoform X4 [KO:K09228]
119856881  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
119843872  zinc finger protein 883-like isoform X2 [KO:K09228]
119840976  zinc finger protein 271-like isoform X1 [KO:K09228]
119841420  zinc finger protein 383-like [KO:K09228]
119844222  zinc finger protein 436-like isoform X1 [KO:K09228]
119844228  zinc finger protein 436-like isoform X1 [KO:K09228]
119844247  zinc finger protein 436-like isoform X1 [KO:K09228]
119844263  zinc finger protein 182-like isoform X1 [KO:K09228]
119843275  zinc finger protein 850-like isoform X1 [KO:K09228]
119843278  zinc finger protein 585A-like isoform X1 [KO:K09228]
119842944  zinc finger protein 154-like isoform X1 [KO:K09228]
119842761  zinc finger protein 436-like [KO:K09228]
119842468  LOW QUALITY PROTEIN: zinc finger protein 260-like [KO:K09228]
119843276  zinc finger protein 585B-like isoform X1 [KO:K09228]
119843290  zinc finger protein 585A-like isoform X1 [KO:K09228]
119843288  zinc finger protein 850-like [KO:K09228]
119843296  zinc finger protein 184-like isoform X1 [KO:K09228]
119843303  zinc finger protein 436-like isoform X1 [KO:K09228]
119843366  zinc finger protein 154-like isoform X1 [KO:K09228]
119842632  zinc finger protein 501-like isoform X1 [KO:K09228]
119842631  zinc finger protein OZF-like isoform X1 [KO:K09228]
122456599  zinc finger protein 501-like isoform X1 [KO:K09228]
119843321  zinc finger protein 34-like isoform X1 [KO:K09228]
119843017  zinc finger protein 501-like isoform X1 [KO:K09228]
122456601  zinc finger protein 197-like [KO:K09228]
122456602  zinc finger protein 239-like isoform X1 [KO:K09228]
122455409  zinc finger protein 239-like isoform X1 [KO:K09228]
119843311  zinc finger protein 135-like [KO:K09228]
122456717  zinc finger protein 420-like [KO:K09228]
119842772  zinc finger protein 135-like [KO:K09228]
119843023  zinc finger protein 271-like [KO:K09228]
119843035  zinc finger protein 271-like [KO:K09228]
119843816  zinc finger protein 391-like [KO:K09228]
119843815  zinc finger protein 420-like [KO:K09228]
119846953  zinc finger protein 501-like [KO:K09228]
119851652  zinc finger protein 169-like isoform X1 [KO:K09228]
119851656  gastrula zinc finger protein XlCGF49.1-like [KO:K09228]
119847415  gastrula zinc finger protein XlCGF7.1-like [KO:K09228]
122457588  zinc finger protein 569-like isoform X1 [KO:K09228]
119849391  zinc finger protein OZF-like [KO:K09228]
119849425  zinc finger protein 260-like isoform X1 [KO:K09228]
119849381  zinc finger protein 883-like isoform X1 [KO:K09228]
119849375  zinc finger protein 883-like [KO:K09228]
119849401  zinc finger protein 883-like [KO:K09228]
119849383  zinc finger protein 883-like [KO:K09228]
122455397  zinc finger protein 3-like isoform X1 [KO:K09228]
122457738  zinc finger protein 239-like [KO:K09228]
122457740  zinc finger protein 436-like isoform X1 [KO:K09228]
122457742  gastrula zinc finger protein XlCGF7.1-like [KO:K09228]
119849259  zinc finger protein 251-like isoform X1 [KO:K09228]
119852190  zinc finger protein 271-like [KO:K09228]
119858575  zinc finger protein 501-like [KO:K09228]
119863660  zinc finger protein 271-like [KO:K09228]
119863253  zinc finger protein 271-like [KO:K09228]
119845615  zinc finger protein OZF-like isoform X1 [KO:K09228]
119846051  zinc finger protein 501-like [KO:K09228]
122458449  zinc finger protein 398-like isoform X1 [KO:K09228]
122458450  zinc finger protein 629-like [KO:K09228]
119852218  zinc finger protein 707-like isoform X1 [KO:K09228]
122458484  zinc finger protein 22-like [KO:K09228]
119850695  zinc finger protein 585A-like [KO:K09228]
119854845  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
119856569  zinc finger protein 271-like [KO:K09228]
119856875  zinc finger protein 850-like [KO:K09228]
119856510  zinc finger protein 879-like [KO:K09228]
119856879  zinc finger protein 883-like [KO:K09228]
119856519  zinc finger protein 501-like [KO:K09228]
119856538  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
119856571  zinc finger protein 2 homolog [KO:K09228]
119842474  zinc finger protein CKR1-like [KO:K09228]
119842476  zinc finger protein 566-like isoform X1 [KO:K09228]
119850774  uncharacterized protein LOC119850774 [KO:K09228]
119853837  zinc finger protein 107-like isoform X1 [KO:K09228]
119842489  zinc finger protein 436-like isoform X1 [KO:K09228]
119849774  IFNG; interferon gamma [KO:K04687]
119853577  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
119849712  IFNGR2; interferon gamma receptor 2 isoform X3 [KO:K05133]
119855567  JAK2; tyrosine-protein kinase JAK2 isoform X3 [KO:K04447] [EC:2.7.10.2]
119842563  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
119862208  protein PML-like isoform X2 [KO:K10054] [EC:2.3.2.-]
119862209  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
119842575  tapasin isoform X1 [KO:K08058]
119862355  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119848206  CALR3; calreticulin-3 isoform X1 [KO:K08057]
119846087  CALR; calreticulin [KO:K08057]
119854513  class I histocompatibility antigen, F10 alpha chain-like isoform X2 [KO:K06751]
119856428  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
119854956  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119856331  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
119842584  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
119862705  B2M; beta-2-microglobulin [KO:K08055]
119860656  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
119842595  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119842598  HLA class II histocompatibility antigen, DR alpha chain-like isoform X3 [KO:K06752]
119842603  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X3 [KO:K06752]
119842606  class II histocompatibility antigen, M alpha chain [KO:K06752]
119842686  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
119842617  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
119859973  CD74; HLA class II histocompatibility antigen gamma chain isoform X3 [KO:K06505]
119861084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119861295  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119845209  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119848340  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
119855572  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119859766  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
119847363  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119856834  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119853376  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119844105  TSC1; hamartin isoform X2 [KO:K07206]
119862521  TSC2; tuberin isoform X3 [KO:K07207]
119851344  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
119845156  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
119848811  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
119846296  SRPK1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
119844591  SRSF1; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1 [KO:K12890]
119842453  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
119846254  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
119842234  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
119856595  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
119857971  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
119845328  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
119852574  serine/arginine-rich splicing factor 7 isoform X2 [KO:K12896]
119853559  serine/arginine-rich splicing factor 7 [KO:K12896]
119843917  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
119859264  NXF1; LOW QUALITY PROTEIN: nuclear RNA export factor 1 [KO:K14284]
119843142  ALYREF; THO complex subunit 4 [KO:K12881]
119860555  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119858224  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
119849982  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119841019  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119857192  FADD; FAS-associated death domain protein [KO:K02373]
119863520  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
119863564  caspase-8-like isoform X2 [KO:K04398] [EC:3.4.22.61]
119859706  BID; BH3-interacting domain death agonist [KO:K04726]
119847077  apoptosis regulator BAX-like isoform X1 [KO:K02159]
119847078  apoptosis regulator BAX-like [KO:K02159]
119846335  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
119851560  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
119841583  BCL2L1; bcl-2-like protein 1 [KO:K04570]
119863580  cytochrome c iso-1/iso-2 [KO:K08738]
119850062  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
119845038  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
119854273  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
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Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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Reference
PMID:24262390
  Authors
Ma Y, He B
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Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
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Reference
PMID:26952111
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
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Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
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Reference
PMID:12826401
  Authors
Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
PMID:27367734
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
PMID:23864622
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Gu H, Zheng Y, Roizman B
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
PMID:25798530
  Authors
Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
PMID:18508584
  Authors
Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
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Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
dcc03040  Spliceosome
dcc03050  Proteasome
dcc04115  p53 signaling pathway
dcc04210  Apoptosis
dcc04620  Toll-like receptor signaling pathway
dcc04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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