KEGG   PATHWAY: dcc05168
Entry
dcc05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Dermochelys coriacea (leatherback sea turtle)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
dcc05168  Herpes simplex virus 1 infection
dcc05168

Disease
H00365  Herpes simplex virus infection
Organism
Dermochelys coriacea (leatherback sea turtle) [GN:dcc]
Gene
119841019  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119841583  BCL2L1; bcl-2-like protein 1 [KO:K04570]
119841587  IRF9; interferon regulatory factor 9 [KO:K04693]
119841751  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
119842234  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
119842453  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
119842563  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
119842575  [KO:K08058]
119842584  [KO:K06751]
119842595  [KO:K06752]
119842598  [KO:K06752]
119842603  [KO:K06752]
119842606  [KO:K06752]
119842617  [KO:K06752]
119842667  HCFC2; host cell factor 2 isoform X2 [KO:K27390]
119842670  [KO:K05468]
119842686  [KO:K06752]
119842904  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
119842911  [KO:K03173] [EC:2.3.2.27]
119842931  TNF; tumor necrosis factor [KO:K03156]
119843142  ALYREF; THO complex subunit 4 [KO:K12881]
119843556  EIF2B1; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit alpha [KO:K03239]
119843570  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
119843648  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
119843818  [KO:K14216] [EC:2.7.7.84]
119843917  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
119844052  C5; LOW QUALITY PROTEIN: complement C5 [KO:K03994]
119844105  TSC1; hamartin isoform X2 [KO:K07206]
119844349  TRAF2; TNF receptor-associated factor 2 isoform X2 [KO:K03173] [EC:2.3.2.27]
119844591  SRSF1; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1 [KO:K12890]
119844629  [KO:K12499]
119844931  [KO:K07293] [EC:3.1.3.48]
119844955  TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152]
119845038  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
119845156  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
119845209  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119845281  [KO:K17834] [EC:2.7.7.86]
119845328  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
119845671  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
119845779  [KO:K03990]
119845813  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X3 [KO:K11219] [EC:2.7.10.2]
119845818  [KO:K03990]
119845819  [KO:K03990]
119845903  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
119846023  [KO:K03990]
119846035  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
119846087  CALR; calreticulin [KO:K08057]
119846207  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119846254  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
119846296  SRPK1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
119846335  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
119846607  NECTIN1; nectin-1 [KO:K06081]
119846689  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
119847060  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
119847077  [KO:K02159]
119847078  [KO:K02159]
119847100  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119847218  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119847226  HCFC1; LOW QUALITY PROTEIN: host cell factor 1 [KO:K14966]
119847228  [KO:K04696]
119847265  [KO:K15412]
119847363  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119847619  NECTIN2; nectin-2 isoform X3 [KO:K06531]
119847734  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
119847754  [KO:K10159]
119848206  CALR3; calreticulin-3 isoform X1 [KO:K08057]
119848340  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
119848466  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
119848579  [KO:K04519]
119848666  [KO:K04519]
119848740  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3 [KO:K07209] [EC:2.7.11.10]
119848811  [KO:K07205]
119848971  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
119849273  TP53; cellular tumor antigen p53 [KO:K04451]
119849712  IFNGR2; interferon gamma receptor 2 isoform X3 [KO:K05133]
119849774  IFNG; interferon gamma [KO:K04687]
119849982  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119850024  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
119850062  APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084]
119851076  IL6; interleukin-6 [KO:K05405]
119851344  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
119851487  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
119851560  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
119851837  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
119852574  [KO:K12896]
119852706  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
119852837  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119852884  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X3 [KO:K04404]
119852920  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
119853169  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
119853202  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
119853376  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119853559  [KO:K12896]
119853577  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
119853864  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
119854273  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119854309  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
119854513  [KO:K06751]
119854558  [KO:K05414]
119854596  [KO:K28004]
119854760  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
119854956  [KO:K06751]
119855116  [KO:K05425]
119855141  [KO:K10159]
119855215  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
119855269  [KO:K10159]
119855399  [KO:K05414]
119855567  JAK2; tyrosine-protein kinase JAK2 isoform X3 [KO:K04447] [EC:2.7.10.2]
119855572  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119855929  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
119856142  [KO:K05414]
119856222  [KO:K05414]
119856313  [KO:K05414]
119856319  DDX58; LOW QUALITY PROTEIN: antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
119856331  [KO:K06751]
119856428  [KO:K06751]
119856595  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
119856834  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119856939  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119856996  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
119857166  EIF2B2; translation initiation factor eIF-2B subunit beta isoform X1 [KO:K03754]
119857192  FADD; FAS-associated death domain protein [KO:K02373]
119857354  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
119857432  IRF7; LOW QUALITY PROTEIN: interferon regulatory factor 7 [KO:K09447]
119857747  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119857971  [KO:K12893]
119858045  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119858224  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
119858230  RELA; transcription factor p65 isoform X1 [KO:K04735]
119858567  IFNAR2; interferon alpha/beta receptor 2 isoform X2 [KO:K05131]
119858630  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119859264  NXF1; LOW QUALITY PROTEIN: nuclear RNA export factor 1 [KO:K14284]
119859541  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
119859706  BID; BH3-interacting domain death agonist [KO:K04726]
119859748  [KO:K01165]
119859759  [KO:K16060]
119859766  [KO:K02649]
119859973  CD74; HLA class II histocompatibility antigen gamma chain isoform X3 [KO:K06505]
119860410  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
119860452  STING1; stimulator of interferon genes protein [KO:K12654]
119860534  TAPBPL; tapasin-related protein isoform X7 [KO:K28445]
119860555  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119860616  IL12B; interleukin-12 subunit beta [KO:K05425]
119860656  [KO:K06752]
119860825  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
119861084  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119861088  EIF2B5; translation initiation factor eIF-2B subunit epsilon isoform X1 [KO:K03240]
119861226  POU2F1; LOW QUALITY PROTEIN: POU domain, class 2, transcription factor 1 [KO:K09364]
119861295  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119861806  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
119862208  [KO:K10054] [EC:2.3.2.-]
119862209  [KO:K10054] [EC:2.3.2.-]
119862355  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119862521  TSC2; tuberin isoform X3 [KO:K07207]
119862705  B2M; beta-2-microglobulin [KO:K08055]
119863520  [KO:K04398] [EC:3.4.22.61]
119863564  [KO:K04398] [EC:3.4.22.61]
119863580  [KO:K08738]
119863698  IFIH1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
119863823  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X3 [KO:K11220]
122455357  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
122455371  [KO:K01165]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
dcc03040  Spliceosome
dcc03050  Proteasome
dcc04115  p53 signaling pathway
dcc04210  Apoptosis
dcc04620  Toll-like receptor signaling pathway
dcc04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   

DBGET integrated database retrieval system