KEGG   PATHWAY: elk05205
Entry
elk05205                    Pathway                                
Name
Proteoglycans in cancer - Enhydra lutris kenyoni (northern sea otter)
Description
Many proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis and metastasis, affecting tumor progress. The four main types of proteoglycans include hyaluronan (HA), which does not occur as a PG but in free form, heparan sulfate proteoglycans (HSPGs), chondroitin sulfate proteoglycans (CSPGs), dematan sulfate proteoglycans (DSPG) and keratan sulfate proteoglycans (KSPGs) [BR:00535]. Among these proteoglycans such as HA, acting with CD44, promotes tumor cell growth and migration, whereas other proteoglycans such as syndecans (-1~-4), glypican (-1, -3) and perlecan may interact with growth factors, cytokines, morphogens and enzymes through HS chains [BR:00536], also leading to tumor growth and invasion. In contrast, some of the small leucine-rich proteolgycans, such as decorin and lumican, can function as tumor repressors, and modulate the signaling pathways by the interaction of their core proteins and multiple receptors.
Class
Human Diseases; Cancer: overview
Pathway map
elk05205  Proteoglycans in cancer
elk05205

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111149480  LOW QUALITY PROTEIN: CD44 antigen [KO:K06256]
111141563  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
111149641  src substrate cortactin isoform X1 [KO:K06106]
111154940  hematopoietic lineage cell-specific protein [KO:K06106]
111151268  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111146429  guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
111161665  proto-oncogene vav isoform X1 [KO:K05730]
111142837  guanine nucleotide exchange factor VAV3 [KO:K05730]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111160680  ras-related protein R-Ras [KO:K07829]
111159398  ras-related protein R-Ras2 isoform X1 [KO:K07830]
111155011  ras-related protein M-Ras [KO:K07831]
111151941  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111150582  serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111145636  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
111152707  ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
111154823  cell division control protein 42 homolog isoform X1 [KO:K04393]
111150586  ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
111158708  estrogen receptor isoform X1 [KO:K08550]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111160249  actin, cytoplasmic 2 [KO:K05692]
111145734  actin, cytoplasmic 1 [KO:K05692]
111154419  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111155650  T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
111139489  rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
111144026  transforming protein RhoA isoform X1 [KO:K04513]
111142435  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111154090  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
111144640  ankyrin-1 isoform X1 [KO:K10380]
111152577  ankyrin-2 [KO:K09255]
111144687  ankyrin-3 [KO:K09259]
111154396  GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111140152  sodium/hydrogen exchanger 1 [KO:K05742]
111140243  sodium/hydrogen exchanger 1 [KO:K05742]
111156372  serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111144767  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111149674  serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111139288  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111141992  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
111151011  protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
111140038  protein phosphatase 1 regulatory subunit 12C [KO:K17457]
111153798  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
111144941  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
111144005  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111159979  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
111152507  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
111140840  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
111145432  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
111153485  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
111156985  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
111159664  homeobox protein NANOG [KO:K10164]
111158109  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
111140887  ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
111151241  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
111144886  twist-related protein 2 [KO:K09069]
111147377  twist-related protein 1 [KO:K09069]
111144954  homeobox protein Hox-D10 [KO:K09295]
111142130  decorin [KO:K04660]
111142293  insulin-like growth factor I [KO:K05459]
111142036  insulin-like growth factor I isoform X1 [KO:K05459]
111152643  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111156293  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111149588  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
111151757  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111157728  eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
111156567  40S ribosomal protein S6 [KO:K02991]
111148822  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
111157042  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111151954  caveolin-1 [KO:K06278]
111151976  caveolin-2 isoform X1 [KO:K12958]
111144224  caveolin-3 [KO:K12959]
111160150  CD63 antigen [KO:K06497]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111144607  caspase-3 [KO:K02187] [EC:3.4.22.56]
111161420  transforming growth factor beta-1 isoform X1 [KO:K13375]
111154734  toll-like receptor 2 [KO:K10159]
111146042  toll-like receptor 4 isoform X1 [KO:K10160]
111144871  programmed cell death protein 4 [KO:K16865]
111152248  tumor necrosis factor isoform X1 [KO:K03156]
111141150  interleukin-12 subunit beta [KO:K05425]
111160180  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
111138855  receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
111146783  myc proto-oncogene protein [KO:K04377]
111159001  catenin beta-1 [KO:K02105]
111159390  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
111156154  transcription factor AP-4 [KO:K09108]
111147726  vascular endothelial growth factor A [KO:K05448]
111149192  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
111151956  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111153838  E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
111157510  metalloproteinase inhibitor 3 [KO:K16866]
111161597  thrombospondin-1 [KO:K16857]
111157340  72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
111141396  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
111142093  lumican [KO:K08122]
111150819  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111150909  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111144883  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111142120  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111161133  cellular tumor antigen p53 [KO:K04451]
111151068  transforming growth factor beta-2 isoform X1 [KO:K13376]
111142395  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
111149020  heparanase isoform X1 [KO:K07964] [EC:3.2.1.166]
111145067  inactive heparanase-2 isoform X1 [KO:K07965] [EC:3.2.1.-]
111154117  syndecan-1 [KO:K06257]
111144976  urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
111139531  urokinase plasminogen activator surface receptor isoform X1 [KO:K03985]
111151317  collagen alpha-1(I) chain isoform X1 [KO:K06236]
111147195  collagen alpha-2(I) chain [KO:K06236]
111141135  integrin alpha-2 [KO:K06481]
111155558  integrin beta-1 isoform X1 [KO:K05719]
111151505  vitronectin [KO:K06251]
111155043  integrin alpha-V isoform X1 [KO:K06487]
111158107  integrin beta-3 [KO:K06493]
111143733  fibronectin isoform X1 [KO:K05717]
111155029  integrin beta-5 [KO:K06588]
111155271  hepatocyte growth factor isoform X1 [KO:K05460]
111158015  proto-oncogene Wnt-1 [KO:K03209]
111141425  frizzled-7 [KO:K02432]
111147325  frizzled-1 [KO:K02432]
111158141  frizzled-2 [KO:K02235]
111156239  frizzled-3 [KO:K02329]
111154467  frizzled-4 [KO:K02354]
111155536  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
111143924  frizzled-5 [KO:K02375]
111146642  frizzled-6 [KO:K02376]
111156537  frizzled-10 [KO:K02842]
111146438  frizzled-9 [KO:K02842]
111157949  integrin alpha-5 isoform X1 [KO:K06484]
111146804  syndecan-2 [KO:K16336]
111158717  ezrin [KO:K08007]
111153884  radixin isoform X1 [KO:K05762]
111139321  moesin [KO:K05763]
111141438  syndecan-4 [KO:K16338]
111156005  LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
111144420  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
111142213  fibroblast growth factor receptor substrate 2 [KO:K12461]
111154862  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
111156454  tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111141423  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
111152978  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
111158087  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111162208  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111139613  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
111156161  tudor-interacting repair regulator protein isoform X1 [KO:K16867]
111156467  paxillin [KO:K05760]
111146744  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111141144  proheparin-binding EGF-like growth factor [KO:K08523]
111142233  glypican-1 [KO:K08107]
111150034  insulin-like growth factor II isoform X1 [KO:K13769]
111162134  glypican-3 isoform X1 [KO:K08109]
111143458  protein Wnt-2b [KO:K00182]
111152038  protein Wnt-2 [KO:K00182]
111139433  protein Wnt-3a [KO:K00312]
111158156  proto-oncogene Wnt-3 [KO:K00312]
111154909  protein Wnt-4 [KO:K00408]
111159795  protein Wnt-5b [KO:K00444]
111144172  protein Wnt-5a isoform X1 [KO:K00444]
111145739  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
111157688  protein Wnt-7b isoform X1 [KO:K00572]
111159004  protein Wnt-7a [KO:K00572]
111141267  protein Wnt-8a [KO:K00714]
111145241  protein Wnt-8b [KO:K00714]
111139428  protein Wnt-9a [KO:K01064]
111158202  LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
111157990  protein Wnt-10b [KO:K01357]
111144711  protein Wnt-10a [KO:K01357]
111159478  protein Wnt-11 [KO:K01384]
111152110  protein Wnt-16 [KO:K01558]
111154521  sonic hedgehog protein [KO:K11988]
111145286  indian hedgehog protein [KO:K11989]
111139086  LOW QUALITY PROTEIN: protein patched homolog 1 [KO:K06225]
111152017  smoothened homolog [KO:K06226]
111154824  basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
111139087  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
111139090  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
111139097  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
111153605  LOW QUALITY PROTEIN: cathepsin L1 [KO:K01365] [EC:3.4.22.15]
111162516  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111143399  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111152267  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
111157625  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
111157628  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
111152183  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
111153701  heat shock protein beta-2 [KO:K09543]
111159680  tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
Compound
C00426  Dermatan sulfate
C00573  Keratan sulfate
C00607  Chondroitin sulfate
C00925  Heparan sulfate
G10505  Hyaluronic acid
G13063  Binding domain for FGF2 in heparin/heparan sulfate
G13064  Binding domain for HGF in heparin/heparan sulfate
Reference
PMID:18450475
  Authors
Bourguignon LY
  Title
Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
  Journal
Semin Cancer Biol 18:251-9 (2008)
DOI:10.1016/j.semcancer.2008.03.007
Reference
PMID:12729888
  Authors
Briggs MW, Sacks DB
  Title
IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton.
  Journal
FEBS Lett 542:7-11 (2003)
DOI:10.1016/S0014-5793(03)00333-8
Reference
PMID:12748184
  Authors
Bourguignon LY, Singleton PA, Zhu H, Diedrich F
  Title
Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.
  Journal
J Biol Chem 278:29420-34 (2003)
DOI:10.1074/jbc.M301885200
Reference
PMID:15655247
  Authors
Bourguignon LY, Gilad E, Rothman K, Peyrollier K
  Title
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
  Journal
J Biol Chem 280:11961-72 (2005)
DOI:10.1074/jbc.M411985200
Reference
PMID:11717317
  Authors
Turley EA, Noble PW, Bourguignon LY
  Title
Signaling properties of hyaluronan receptors.
  Journal
J Biol Chem 277:4589-92 (2002)
DOI:10.1074/jbc.R100038200
Reference
PMID:9346940
  Authors
Bourguignon LY, Zhu H, Chu A, Iida N, Zhang L, Hung MC
  Title
Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation.
  Journal
J Biol Chem 272:27913-8 (1997)
DOI:10.1074/jbc.272.44.27913
Reference
PMID:22735579
  Authors
Neill T, Schaefer L, Iozzo RV
  Title
Decorin: a guardian from the matrix.
  Journal
Am J Pathol 181:380-7 (2012)
DOI:10.1016/j.ajpath.2012.04.029
Reference
PMID:22194599
  Authors
Neill T, Painter H, Buraschi S, Owens RT, Lisanti MP, Schaefer L, Iozzo RV
  Title
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1alpha, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3.
  Journal
J Biol Chem 287:5492-506 (2012)
DOI:10.1074/jbc.M111.283499
Reference
PMID:19433454
  Authors
Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
  Title
Decorin is a novel antagonistic ligand of the Met receptor.
  Journal
J Cell Biol 185:743-54 (2009)
DOI:10.1083/jcb.200901129
Reference
PMID:15994311
  Authors
Zhu JX, Goldoni S, Bix G, Owens RT, McQuillan DJ, Reed CC, Iozzo RV
  Title
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis.
  Journal
J Biol Chem 280:32468-79 (2005)
DOI:10.1074/jbc.M503833200
Reference
PMID:20974860
  Authors
Buraschi S, Pal N, Tyler-Rubinstein N, Owens RT, Neill T, Iozzo RV
  Title
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels.
  Journal
J Biol Chem 285:42075-85 (2010)
DOI:10.1074/jbc.M110.172841
Reference
PMID:18798267
  Authors
Goldoni S, Iozzo RV
  Title
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.
  Journal
Int J Cancer 123:2473-9 (2008)
DOI:10.1002/ijc.23930
Reference
PMID:23058688
  Authors
Sofeu Feugaing DD, Gotte M, Viola M
  Title
More than matrix: the multifaceted role of decorin in cancer.
  Journal
Eur J Cell Biol 92:1-11 (2013)
DOI:10.1016/j.ejcb.2012.08.004
Reference
PMID:22087031
  Authors
Merline R, Moreth K, Beckmann J, Nastase MV, Zeng-Brouwers J, Tralhao JG, Lemarchand P, Pfeilschifter J, Schaefer RM, Iozzo RV, Schaefer L
  Title
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21.
  Journal
Sci Signal 4:ra75 (2011)
DOI:10.1126/scisignal.2001868
Reference
PMID:22033227
  Authors
Teng YH, Aquino RS, Park PW
  Title
Molecular functions of syndecan-1 in disease.
  Journal
Matrix Biol 31:3-16 (2012)
DOI:10.1016/j.matbio.2011.10.001
Reference
PMID:11830493
  Authors
Derksen PW, Keehnen RM, Evers LM, van Oers MH, Spaargaren M, Pals ST
  Title
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma.
  Journal
Blood 99:1405-10 (2002)
DOI:10.1182/blood.V99.4.1405
Reference
PMID:19733083
  Authors
Fux L, Ilan N, Sanderson RD, Vlodavsky I
  Title
Heparanase: busy at the cell surface.
  Journal
Trends Biochem Sci 34:511-9 (2009)
DOI:10.1016/j.tibs.2009.06.005
Reference
PMID:18812315
  Authors
Purushothaman A, Chen L, Yang Y, Sanderson RD
  Title
Heparanase stimulation of protease expression implicates it as a master regulator of the aggressive tumor phenotype in myeloma.
  Journal
J Biol Chem 283:32628-36 (2008)
DOI:10.1074/jbc.M806266200
Reference
PMID:19255147
  Authors
Beauvais DM, Ell BJ, McWhorter AR, Rapraeger AC
  Title
Syndecan-1 regulates alphavbeta3 and alphavbeta5 integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor.
  Journal
J Exp Med 206:691-705 (2009)
DOI:10.1084/jem.20081278
Reference
PMID:20655987
  Authors
Mahtouk K, Tjin EP, Spaargaren M, Pals ST
  Title
The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.
  Journal
Biochim Biophys Acta 1806:208-19 (2010)
DOI:10.1016/j.bbcan.2010.07.006
Reference
PMID:11931647
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J Cell Sci 113 Pt 2:315-24 (2000)
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Related
pathway
elk04010  MAPK signaling pathway
elk04020  Calcium signaling pathway
elk04066  HIF-1 signaling pathway
elk04150  mTOR signaling pathway
elk04151  PI3K-Akt signaling pathway
elk04210  Apoptosis
elk04310  Wnt signaling pathway
elk04340  Hedgehog signaling pathway
elk04350  TGF-beta signaling pathway
elk04370  VEGF signaling pathway
elk04510  Focal adhesion
elk04520  Adherens junction
elk04810  Regulation of actin cytoskeleton
KO pathway
ko05205   
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