KEGG   PATHWAY: lww04020
Entry
lww04020                    Pathway                                
Name
Calcium signaling pathway - Leptonychotes weddellii (Weddell seal)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
lww04020  Calcium signaling pathway
lww04020

Other DBs
GO: 0019722
Organism
Leptonychotes weddellii (Weddell seal) [GN:lww]
Gene
102746288  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
102733463  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
102745509  SLC8A1; sodium/calcium exchanger 1 isoform X2 [KO:K05849]
102738408  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
102726124  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
102745101  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
102739967  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
102748632  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102732556  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102747257  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102739170  ADORA2A; adenosine receptor A2a [KO:K04266]
102744451  ADORA2B; adenosine receptor A2b [KO:K04267]
102726319  ADRB1; beta-1 adrenergic receptor [KO:K04141]
102730623  ADRB2; beta-2 adrenergic receptor [KO:K04142]
102730474  ADRB3; beta-3 adrenergic receptor [KO:K04143]
102733361  DRD1; D(1A) dopamine receptor [KO:K04144]
102739048  DRD5; D(1B) dopamine receptor [KO:K05840]
102732761  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
102727376  HTR4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
102749347  5-hydroxytryptamine receptor 5B [KO:K04161]
102729696  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
102738768  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
102729446  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
102743109  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
102742813  neuroendocrine secretory protein 55 [KO:K04632]
102738541  guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
102739347  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102741598  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102729355  adenylate cyclase type 4-like isoform X1 [KO:K08044] [EC:4.6.1.1]
102750941  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102732736  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102733005  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
102728665  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102735449  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
102729236  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102750259  PLN; cardiac phospholamban [KO:K05852]
102742528  SLN; sarcolipin [KO:K22642]
115937350  MRLN; myoregulin [KO:K22643]
102726307  CUNH4orf3; uncharacterized protein C4orf3 homolog isoform X1 [KO:K26467]
102743344  SMIM6; small integral membrane protein 6 isoform X1 [KO:K26468]
102743473  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
102746427  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
102740475  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
102730415  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
102745617  STIM2; stromal interaction molecule 2 [KO:K18196]
102747344  ORAI1; calcium release-activated calcium channel protein 1 isoform X2 [KO:K16056]
102727408  ORAI2; protein orai-2 isoform X1 [KO:K16057]
102750118  ORAI3; protein orai-3 [KO:K16058]
102731073  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102742095  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102745809  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102726559  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102741399  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
102745364  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
102750591  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102726125  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
102729649  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102749455  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
102736063  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102745823  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
102748893  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102732929  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X3 [KO:K05213]
102735794  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
102736038  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
102739226  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
102727998  P2X purinoceptor 3 [KO:K05217]
102739388  P2RX4; P2X purinoceptor 4 isoform X3 [KO:K05218]
102745196  P2RX5; P2X purinoceptor 5 [KO:K05219]
102743118  P2RX6; P2X purinoceptor 6 [KO:K05221]
102740186  P2X purinoceptor 7 isoform X1 [KO:K05220]
102738593  RYR1; ryanodine receptor 1 [KO:K04961]
102729122  RYR2; ryanodine receptor 2 [KO:K04962]
102732355  RYR3; ryanodine receptor 3 [KO:K04963]
102732587  TRDN; triadin [KO:K23449]
102750555  CASQ1; calsequestrin-1 [KO:K23468]
102746494  calsequestrin-2-like [KO:K23445]
102728276  aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
102725735  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
102734588  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
102738226  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102734067  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
102731415  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
102730984  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
102733129  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102729478  endothelin-1 receptor [KO:K04197]
102750997  EDNRB; endothelin receptor type B [KO:K04198]
102737791  F2R; proteinase-activated receptor 1 [KO:K03914]
102733766  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
102743020  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
102738484  GRPR; gastrin-releasing peptide receptor [KO:K04169]
102740283  HRH1; histamine H1 receptor [KO:K04149]
102743632  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
102734362  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
102744476  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
102748816  5-hydroxytryptamine receptor 2A-like [KO:K04157]
102738722  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
102725993  OXTR; oxytocin receptor [KO:K04229]
102735055  vasopressin V1a receptor [KO:K04226]
102746705  AVPR1B; vasopressin V1b receptor [KO:K04227]
102727221  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
102744963  PTAFR; platelet-activating factor receptor [KO:K04279]
102741125  prostaglandin E2 receptor EP3 subtype [KO:K04260]
102744301  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
102729925  BDKRB1; B1 bradykinin receptor [KO:K03915]
102729944  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
102735676  TACR1; substance-P receptor [KO:K04222]
102738039  TACR2; substance-K receptor [KO:K04223]
102734049  TACR3; neuromedin-K receptor [KO:K04224]
102743608  TBXA2R; thromboxane A2 receptor [KO:K04264]
102729351  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
102751109  LOW QUALITY PROTEIN: thyrotropin-releasing hormone receptor-like [KO:K04282]
102739104  CCKAR; cholecystokinin receptor type A [KO:K04194]
102739478  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
102747594  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102731450  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
102732710  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102728195  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
102733018  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
102742915  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102738528  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102739254  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102749801  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102745087  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102742552  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102749895  fibroblast growth factor 1-like [KO:K18496]
102741264  fibroblast growth factor 2 [KO:K18497]
102730111  FGF8; fibroblast growth factor 8 [KO:K04358]
102730845  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
102749300  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102749151  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102738127  FGF4; fibroblast growth factor 4 [KO:K04358]
102749402  fibroblast growth factor 18 [KO:K04358]
102733219  fibroblast growth factor 5-like [KO:K04358]
102748200  FGF16; fibroblast growth factor 16 [KO:K04358]
102729385  FGF20; fibroblast growth factor 20 [KO:K04358]
102746981  FGF5; fibroblast growth factor 5 [KO:K04358]
102749207  FGF9; fibroblast growth factor 9 [KO:K04358]
102750047  FGF18; fibroblast growth factor 18 [KO:K04358]
102726457  FGF10; fibroblast growth factor 10 [KO:K04358]
102747841  FGF6; fibroblast growth factor 6 [KO:K04358]
102747801  FGF19; fibroblast growth factor 19 [KO:K22603]
102727569  FGF21; fibroblast growth factor 21 [KO:K22429]
102747259  FGF23; fibroblast growth factor 23 [KO:K22428]
102740057  vascular endothelial growth factor A isoform X1 [KO:K05448]
102749006  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
102746991  VEGFD; vascular endothelial growth factor D [KO:K05449]
102745986  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
102746197  NGF; beta-nerve growth factor [KO:K02582]
102740930  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102749689  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
102737253  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
102735234  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
102747863  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102746830  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
102740115  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102734086  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
102734583  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
102747964  FGFR3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
102745341  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
102737429  vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102735323  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102726334  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102727057  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102741802  BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
102738387  NTRK3; NT-3 growth factor receptor [KO:K05101] [EC:2.7.10.1]
102735430  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102746788  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
102727050  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102750588  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
102733379  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
102738258  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
102739019  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102736489  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102750198  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102751213  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
102727444  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
102739383  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
102737552  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
102739407  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102735685  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
102745629  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102748690  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102732387  TPCN1; two pore calcium channel protein 1 [KO:K16896]
102730791  TPCN2; two pore calcium channel protein 2 [KO:K14077]
102729325  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
102739211  mucolipin-2 [KO:K04993]
102737900  mucolipin-3 isoform X2 [KO:K04994]
102750390  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
102742615  SPHK2; sphingosine kinase 2 isoform X4 [KO:K04718] [EC:2.7.1.91]
102742377  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102751218  voltage-dependent anion-selective channel protein 1-like [KO:K05862]
102734457  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102747348  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102725835  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102734685  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102750278  ADP/ATP translocase 3 [KO:K05863]
102737381  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102745503  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102744216  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102725889  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102730540  TNNC2; troponin C, skeletal muscle [KO:K12042]
102730620  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102738071  calmodulin-like [KO:K02183]
102736921  calmodulin-like [KO:K02183]
102731712  CALM3; calmodulin-3 [KO:K02183]
102738351  calmodulin-like [KO:K02183]
102736922  calmodulin-like [KO:K02183]
102738889  CALM2; calmodulin-2 [KO:K02183]
102732458  CALML6; calmodulin-like protein 6 [KO:K02183]
102735924  CALM1; calmodulin-1 [KO:K02183]
102726280  CALML5; calmodulin-like protein 5 [KO:K02183]
102750042  calmodulin-like protein 3 [KO:K02183]
102726108  calmodulin-like [KO:K02183]
102739272  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
102733439  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
102746800  phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
102751245  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform [KO:K07190]
102746541  PHKB; phosphorylase b kinase regulatory subunit beta [KO:K07190]
102744951  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102750760  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102745310  myosin light chain kinase 3-like [KO:K00907] [EC:2.7.11.18]
102737434  myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102736475  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X2 [KO:K08794] [EC:2.7.11.17]
102734245  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102726493  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
102743812  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
102732377  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
102749725  calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
102739246  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
102743467  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
102747867  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102732630  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102749914  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102740449  transcription factor EB [KO:K15590]
102730825  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102748078  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
102726309  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
102740880  nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
102741156  nitric oxide synthase, endothelial-like [KO:K13242] [EC:1.14.13.39]
102745391  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
102747638  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
102746138  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
102736119  protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
102744118  inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
102745805  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102749862  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102732903  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102741890  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
lww04010  MAPK signaling pathway
lww04070  Phosphatidylinositol signaling system
lww04210  Apoptosis
lww04720  Long-term potentiation
lww04730  Long-term depression
KO pathway
ko04020   
LinkDB

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