KEGG   PATHWAY: mbez05168
Entry
mbez05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Moschus berezovskii (Chinese forest musk deer)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
mbez05168  Herpes simplex virus 1 infection
mbez05168

Organism
Moschus berezovskii (Chinese forest musk deer) [GN:mbez]
Gene
129543582  LTA; lymphotoxin-alpha [KO:K05468]
129559440  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
129539173  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
129551247  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
129549430  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129555451  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
129564146  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129550521  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129562101  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129548767  RELA; transcription factor p65 [KO:K04735]
129564389  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2-like [KO:K16060]
129554248  baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
129554250  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
129536764  C-C motif chemokine 2 [KO:K14624]
129554437  NECTIN1; nectin-1 [KO:K06081]
129546684  NECTIN2; nectin-2 isoform X1 [KO:K06531]
129545152  paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
129545690  PILRA; paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
129542192  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
129551400  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
129535852  ITGA5; integrin alpha-5 [KO:K06484]
129544525  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
129563285  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129557183  SYK; tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
129539247  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
129546536  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
129557110  interferon beta-2-like [KO:K05415]
129557288  interferon beta-2 [KO:K05415]
129557307  interferon beta-2-like [KO:K05415]
129557308  interferon beta-2-like [KO:K05415]
129543141  TP53; cellular tumor antigen p53 [KO:K04451]
129558674  C3; complement C3 [KO:K03990]
129557216  C5; complement C5 [KO:K03994]
129564304  CFP; properdin [KO:K15412]
129542442  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
129547610  TLR9; LOW QUALITY PROTEIN: toll-like receptor 9 [KO:K10161]
129548144  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
129548601  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
129549318  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
129558739  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
129536594  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
129564634  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
129554762  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129560795  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
129535825  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
129560692  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
129539906  IL1B; interleukin-1 beta [KO:K04519]
129536712  CCL5; C-C motif chemokine 5 [KO:K12499]
129543262  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129551055  IL12A; interleukin-12 subunit alpha [KO:K05406]
129558692  IL12B; interleukin-12 subunit beta isoform X1 [KO:K05425]
129557515  RIGI; LOW QUALITY PROTEIN: antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
129537680  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
129560195  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
129550678  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
129551739  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
129536260  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
129557109  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129557111  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
129557266  interferon alpha-1-like [KO:K05414]
129557270  interferon alpha-1-like [KO:K05414]
129557271  interferon alpha-1 [KO:K05414]
129557272  interferon alpha-1-like [KO:K05414]
129557274  interferon alpha-1-like [KO:K05414]
129557279  interferon alpha-1-like [KO:K05414]
129557285  interferon alpha-1-like [KO:K05414]
129557286  interferon alpha-H [KO:K05414]
129561080  CGAS; LOW QUALITY PROTEIN: cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
129558440  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
129542802  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129537845  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129539892  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129548700  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
129545745  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
129539119  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
129539222  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
129563220  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
129562722  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 isoform X1 [KO:K03237]
129542195  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
129562488  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
129540609  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
129538958  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
129545271  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
129551309  RNASEL; 2-5A-dependent ribonuclease [KO:K01165]
129564454  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
129535760  HCFC2; host cell factor 2 [KO:K27390]
129546765  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
129554440  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
129541401  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
129552638  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
129544661  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
129541821  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129558611  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
129537915  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
129537127  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
129562923  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
129542305  ZNF26; zinc finger protein 26 [KO:K09228]
129542459  ZNF74; zinc finger protein 74 [KO:K09228]
129543093  ZFP57; zinc finger protein 57 homolog isoform X1 [KO:K09228]
129549188  putative zinc finger protein 56 [KO:K09228]
129549190  zinc finger protein 239-like [KO:K09228]
129549191  zinc finger protein 678-like [KO:K09228]
129549282  zinc finger protein 596-like isoform X1 [KO:K09228]
129564089  ZFP92; zinc finger protein 92 homolog [KO:K09228]
129536462  BORCS5; BLOC-1-related complex subunit 5 isoform X1 [KO:K09228]
129549775  ZNF596; zinc finger protein 596 isoform X1 [KO:K09228]
129556995  ZNF484; zinc finger protein 484 isoform X1 [KO:K09228]
129557012  ZNF169; zinc finger protein 169 isoform X1 [KO:K09228]
129557156  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
129557176  ZNF782; zinc finger protein 782 [KO:K09228]
129557192  ZFP37; zinc finger protein 37 homolog [KO:K09228]
129564293  ZNF41; zinc finger protein 41 isoform X1 [KO:K09228]
129564294  ZNF157; zinc finger protein 157 [KO:K09228]
129536893  ZNF641; zinc finger protein 641 [KO:K09228]
129543689  ZNF184; zinc finger protein 184 [KO:K09228]
129543811  ZNF311; zinc finger protein 311 [KO:K09228]
129564606  ZNF674; LOW QUALITY PROTEIN: zinc finger protein 674 [KO:K09228]
129544175  ZNF286A; zinc finger protein 286A isoform X1 [KO:K09228]
129558018  ZNF333; zinc finger protein 333 isoform X1 [KO:K09228]
129558103  ZNF557; zinc finger protein 557 isoform X1 [KO:K09228]
129558208  zinc finger protein 883-like [KO:K09228]
129558298  zinc finger protein 791-like isoform X1 [KO:K09228]
129558301  ZNF317; zinc finger protein 317 [KO:K09228]
129537700  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
129558397  ZNF300; zinc finger protein 300 [KO:K09228]
129545023  ZNF713; zinc finger protein 713 [KO:K09228]
129545038  zinc finger protein 892-like [KO:K09228]
129545304  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
129558696  zinc finger protein 354A isoform X1 [KO:K09228]
129558799  zinc finger protein 709-like [KO:K09228]
129558846  LOW QUALITY PROTEIN: zinc finger protein 564-like [KO:K09228]
129558957  ZNF133; zinc finger protein 133 [KO:K09228]
129558960  zinc finger protein 154-like [KO:K09228]
129538363  ZNF624; zinc finger protein 624 [KO:K09228]
129545315  ZNF200; zinc finger protein 200 isoform X1 [KO:K09228]
129545534  ZNF688; zinc finger protein 688 isoform X1 [KO:K09228]
129545536  ZNF689; zinc finger protein 689 [KO:K09228]
129559288  zinc finger protein 266-like isoform X1 [KO:K09228]
129559289  ZNF699; zinc finger protein 699 [KO:K09228]
129559290  zinc finger protein 266-like [KO:K09228]
129539181  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K09228]
129545714  ZNF3; zinc finger protein 3 [KO:K09228]
129545751  ZNF316; zinc finger protein 316 [KO:K09228]
129545753  ZNF12; zinc finger protein 12 [KO:K09228]
129545754  ZNF853; zinc finger protein 853 isoform X1 [KO:K09228]
129545765  RBAK; RB-associated KRAB zinc finger protein isoform X1 [KO:K09228]
129545768  zinc finger protein 182-like [KO:K09228]
129545832  ZNF597; LOW QUALITY PROTEIN: zinc finger protein 597 [KO:K09228]
129545959  ZFP28; zinc finger protein 28 homolog isoform X1 [KO:K09228]
129545966  ZNF471; zinc finger protein 471 isoform X1 [KO:K09228]
129545968  zinc finger protein 264-like [KO:K09228]
129545969  ZNF805; zinc finger protein 805 [KO:K09228]
129545971  ZNF667; zinc finger protein 667 [KO:K09228]
129545986  zinc finger protein 543-like [KO:K09228]
129545991  zinc finger protein OZF-like [KO:K09228]
129545998  ZNF71; endothelial zinc finger protein induced by tumor necrosis factor alpha [KO:K09228]
129546064  ZNF585A; zinc finger protein 585A isoform X1 [KO:K09228]
129546066  zinc finger protein 420 isoform X1 [KO:K09228]
129546068  ZNF569; zinc finger protein 569 [KO:K09228]
129546070  ZNF567; zinc finger protein 567 [KO:K09228]
129546071  zinc finger protein 461-like [KO:K09228]
129546073  ZNF568; zinc finger protein 568 isoform X1 [KO:K09228]
129546076  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
129546082  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
129552747  ZNF777; zinc finger protein 777 isoform X1 [KO:K09228]
129552748  ZNF786; zinc finger protein 786 isoform X1 [KO:K09228]
129552749  ZNF282; zinc finger protein 282 [KO:K09228]
129552750  ZNF398; zinc finger protein 398 isoform X1 [KO:K09228]
129552751  ZNF783; zinc finger protein 783 [KO:K09228]
129552752  ZNF212; zinc finger protein 212 [KO:K09228]
129552754  ZNF746; zinc finger protein 746 isoform X1 [KO:K09228]
129559406  ZNF354C; zinc finger protein 354C [KO:K09228]
129559407  ZNF879; zinc finger protein 879 isoform X1 [KO:K09228]
129559408  ZNF454; zinc finger protein 454 [KO:K09228]
129559415  zinc finger protein 709-like isoform X1 [KO:K09228]
129559494  ZNF93; zinc finger protein 93 [KO:K09228]
129559616  ZNF554; zinc finger protein 554 isoform X1 [KO:K09228]
129559617  zinc finger protein 77-like isoform X1 [KO:K09228]
129559619  LOW QUALITY PROTEIN: zinc finger protein 77-like [KO:K09228]
129539462  ZNF892; zinc finger protein 892 isoform X1 [KO:K09228]
129539463  ZNF2; zinc finger protein 2 isoform X1 [KO:K09228]
129546084  ZNF792; zinc finger protein 792 [KO:K09228]
129546087  zinc finger protein 30 homolog isoform X1 [KO:K09228]
129546088  ZNF570; zinc finger protein 570 isoform X1 [KO:K09228]
129546089  ZFP14; zinc finger protein 14 homolog isoform X1 [KO:K09228]
129546091  ZFP82; zinc finger protein 82 homolog isoform X1 [KO:K09228]
129546092  ZNF565; zinc finger protein 565 isoform X1 [KO:K09228]
129546097  zinc finger protein 383 [KO:K09228]
129546098  zinc finger protein 607-like isoform X1 [KO:K09228]
129546100  zinc finger protein 664-like [KO:K09228]
129546102  zinc finger protein 566 isoform X1 [KO:K09228]
129546105  ZNF829; zinc finger protein 829 [KO:K09228]
129546107  ZNF793; zinc finger protein 793 isoform X1 [KO:K09228]
129546176  zinc finger protein 665-like [KO:K09228]
129546183  ZNF114; zinc finger protein 114 [KO:K09228]
129546285  zinc finger protein 211-like [KO:K09228]
129546293  ZNF582; zinc finger protein 582 [KO:K09228]
129546314  LOW QUALITY PROTEIN: zinc finger protein 383-like [KO:K09228]
129546315  zinc finger protein 501-like [KO:K09228]
129546316  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
129546319  zinc finger protein 665-like [KO:K09228]
129546321  zinc finger protein ZFP2-like [KO:K09228]
129546323  zinc finger protein 845-like [KO:K09228]
129546324  zinc finger protein 347-like [KO:K09228]
129546325  zinc finger protein 845-like [KO:K09228]
129546328  zinc finger protein 432-like [KO:K09228]
129546336  zinc finger protein 345-like isoform X1 [KO:K09228]
129546338  ZNF606; zinc finger protein 606 [KO:K09228]
129546341  ZNF132; zinc finger protein 132 [KO:K09228]
129546343  zinc finger protein 256-like [KO:K09228]
129546344  ZNF135; LOW QUALITY PROTEIN: zinc finger protein 135 [KO:K09228]
129546346  zinc finger protein 324A-like isoform X1 [KO:K09228]
129546352  ZNF584; zinc finger protein 584 isoform X1 [KO:K09228]
129546365  zinc finger protein 658B-like isoform X1 [KO:K09228]
129546366  zinc finger protein 256-like isoform X1 [KO:K09228]
129546367  zinc finger protein 154-like [KO:K09228]
129546368  zinc finger protein 551-like [KO:K09228]
129546369  LOW QUALITY PROTEIN: zinc finger protein 551-like [KO:K09228]
129546370  zinc finger protein 211-like [KO:K09228]
129546371  zinc finger protein 211-like isoform X1 [KO:K09228]
129546373  ZNF304; zinc finger protein 304 [KO:K09228]
129546374  zinc finger protein 211-like isoform X1 [KO:K09228]
129546376  LOW QUALITY PROTEIN: zinc finger protein 548-like [KO:K09228]
129546377  zinc finger protein 211-like [KO:K09228]
129546378  zinc finger protein OZF-like isoform X1 [KO:K09228]
129546380  LOW QUALITY PROTEIN: zinc finger protein 211-like [KO:K09228]
129546381  zinc finger protein OZF-like isoform X1 [KO:K09228]
129546384  zinc finger protein 773-like isoform X1 [KO:K09228]
129546386  zinc finger protein OZF-like [KO:K09228]
129546387  zinc finger protein OZF-like isoform X1 [KO:K09228]
129546388  ZNF772; zinc finger protein 772 [KO:K09228]
129546389  zinc finger protein 550-like isoform X1 [KO:K09228]
129546408  zinc finger protein 721-like [KO:K09228]
129546410  zinc finger protein 665-like isoform X1 [KO:K09228]
129546411  LOW QUALITY PROTEIN: zinc finger protein ZFP2-like [KO:K09228]
129546412  zinc finger protein 160-like isoform X1 [KO:K09228]
129546413  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
129546414  zinc finger protein 836-like [KO:K09228]
129546415  zinc finger protein 677-like [KO:K09228]
129546416  LOW QUALITY PROTEIN: zinc finger protein 331-like [KO:K09228]
129546424  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
129546425  zinc finger protein 665-like [KO:K09228]
129546427  zinc finger protein 665-like [KO:K09228]
129546432  zinc finger protein 845-like isoform X1 [KO:K09228]
129546435  zinc finger protein 665-like isoform X1 [KO:K09228]
129546437  ZNF175; zinc finger protein 175 isoform X1 [KO:K09228]
129546438  zinc finger protein 160-like [KO:K09228]
129546440  ZNF613; zinc finger protein 613 isoform X1 [KO:K09228]
129559956  ZNF250; zinc finger protein 250 [KO:K09228]
129560200  ZNF7; zinc finger protein 7 isoform X1 [KO:K09228]
129560213  ZNF34; zinc finger protein 34 [KO:K09228]
129560222  ZNF623; zinc finger protein 623 [KO:K09228]
129539902  ZNF79; zinc finger protein 79 isoform X1 [KO:K09228]
129546441  zinc finger protein 160-like isoform X1 [KO:K09228]
129546446  ZNF614; zinc finger protein 614 [KO:K09228]
129546449  LOW QUALITY PROTEIN: zinc finger protein OZF-like [KO:K09228]
129546452  zinc finger protein 84-like isoform X1 [KO:K09228]
129546453  zinc finger protein 665-like [KO:K09228]
129546454  ZNF350; zinc finger protein 350 isoform X1 [KO:K09228]
129546456  LOW QUALITY PROTEIN: zinc finger protein 501-like [KO:K09228]
129546457  zinc finger protein 350 [KO:K09228]
129546473  ZNF577; LOW QUALITY PROTEIN: zinc finger protein 577 [KO:K09228]
129546496  zinc finger protein 382-like [KO:K09228]
129546508  ZNF473; zinc finger protein 473 [KO:K09228]
129546712  ZNF112; zinc finger protein 112 isoform X1 [KO:K09228]
129546713  ZNF227; zinc finger protein 227 isoform X1 [KO:K09228]
129546715  ZNF235; zinc finger protein 235 isoform X1 [KO:K09228]
129546716  zinc finger protein 234-like isoform X1 [KO:K09228]
129546721  ZNF283; zinc finger protein 283 [KO:K09228]
129546724  ZNF45; zinc finger protein 45 [KO:K09228]
129546725  ZNF404; zinc finger protein 404 isoform X1 [KO:K09228]
129540308  ZNF684; zinc finger protein 684 [KO:K09228]
129546878  ZNF599; zinc finger protein 599 isoform X1 [KO:K09228]
129546879  zinc finger protein 181 isoform X1 [KO:K09228]
129546929  ZNF23; zinc finger protein 23 isoform X1 [KO:K09228]
129546965  ZFP90; zinc finger protein 90 homolog [KO:K09228]
129547262  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
129547300  ZNF180; LOW QUALITY PROTEIN: zinc finger protein 180 [KO:K09228]
129547322  ZNF529; zinc finger protein 529 [KO:K09228]
129554562  ZNF214; zinc finger protein 214 isoform X1 [KO:K09228]
129541101  ZFP69; zinc finger protein 69 homolog isoform X1 [KO:K09228]
129541103  ZFP69B; LOW QUALITY PROTEIN: zinc finger protein 69 homolog B [KO:K09228]
129547977  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K09228]
129555202  zinc finger protein 510-like [KO:K09228]
129547996  SLC25A26; S-adenosylmethionine mitochondrial carrier protein isoform X1 [KO:K09228]
129548109  zinc finger protein 621-like isoform X1 [KO:K09228]
129548110  ZNF619; LOW QUALITY PROTEIN: zinc finger protein 619 [KO:K09228]
129548112  zinc finger protein 621-like isoform X1 [KO:K09228]
129534875  ZNF275; zinc finger protein 275 [KO:K09228]
129535159  ZNF81; zinc finger protein 81 [KO:K09228]
129535160  ZNF182; zinc finger protein 182 isoform X1 [KO:K09228]
129542277  ZNF268; zinc finger protein 268 isoform X1 [KO:K09228]
129542278  ZNF84; zinc finger protein 84 isoform X1 [KO:K09228]
129542279  ZNF605; zinc finger protein 605 [KO:K09228]
129542281  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
129542282  ZNF891; zinc finger protein 891 [KO:K09228]
129542283  ZNF140; zinc finger protein 140 isoform X1 [KO:K09228]
129555836  ZNF248; zinc finger protein 248 isoform X1 [KO:K09228]
129555837  ZNF25; zinc finger protein 25 [KO:K09228]
129555839  zinc finger protein 33B isoform X1 [KO:K09228]
129555840  zinc finger protein 37A-like isoform X1 [KO:K09228]
129549623  ZNF397; zinc finger protein 397 [KO:K09228]
129559336  BST2; bone marrow stromal antigen 2 isoform X1 [KO:K06731]
129536468  IFNG; interferon gamma [KO:K04687]
129560886  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
129552631  IFNGR2; interferon gamma receptor 2 [KO:K05133]
129557601  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
129543652  DAXX; death domain-associated protein 6 [KO:K02308]
129537593  SP100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
129550473  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
129543429  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
129543658  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
129543193  TAPBP; tapasin [KO:K08058]
129550572  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
129559609  CALR; calreticulin [KO:K08057]
129543112  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543113  BOLA class I histocompatibility antigen, alpha chain BL3-7 isoform X1 [KO:K06751]
129543114  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543175  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
129543498  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
129558890  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
129562382  B2M; beta-2-microglobulin [KO:K08055]
129562383  beta-2-microglobulin [KO:K08055]
129543058  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
129543060  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
129543211  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
129543214  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
129543215  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
129543218  HLA class II histocompatibility antigen, DQ alpha 2 chain-like isoform X1 [KO:K06752]
129543236  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
129543392  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
129543470  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
129543574  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
129543605  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
129543630  boLa class II histocompatibility antigen, DQB*0101 beta chain [KO:K06752]
129543645  DLA class II histocompatibility antigen, DR-1 beta chain-like isoform X1 [KO:K06752]
129543651  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
129543663  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
129557775  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
129547512  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
129547513  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
129547514  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
129558475  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
129551508  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129547146  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129559156  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129553207  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
129540801  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
129550706  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129551602  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129546814  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129539141  TSC1; hamartin isoform X1 [KO:K07206]
129545260  TSC2; tuberin isoform X1 [KO:K07207]
129550533  GTP-binding protein Rheb-like [KO:K07208]
129552798  RHEB; GTP-binding protein Rheb [KO:K07208]
129551531  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
129549398  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
129543179  SRPK1; LOW QUALITY PROTEIN: SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
129539094  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
129544680  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
129535134  serine/arginine-rich splicing factor 2-like [KO:K12891]
129543413  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
129563831  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
129537754  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
129562531  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
129564458  serine/arginine-rich splicing factor 7-like [KO:K12896]
129539054  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
129542286  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
129548844  NXF1; nuclear RNA export factor 1 [KO:K14284]
129563963  nuclear RNA export factor 2-like [KO:K14284]
129563974  nuclear RNA export factor 3-like [KO:K14284]
129563977  LOW QUALITY PROTEIN: nuclear RNA export factor 3-like [KO:K14284]
129534941  nuclear RNA export factor 3-like [KO:K14284]
129535139  nuclear RNA export factor 3-like [KO:K14284]
129535176  nuclear RNA export factor 3-like [KO:K14284]
129544603  ALYREF; THO complex subunit 4 [KO:K12881]
129551094  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129555563  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129535684  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129547027  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129548659  FADD; FAS-associated death domain protein [KO:K02373]
129538041  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129537261  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
129546572  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
129543626  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
129548816  BAD; bcl2-associated agonist of cell death [KO:K02158]
129549902  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
129538419  bcl-2-like protein 1 [KO:K04570]
129562040  BCL2L1; bcl-2-like protein 1 [KO:K04570]
129536239  cytochrome c-like [KO:K08738]
129538389  cytochrome c 2 [KO:K08738]
129552526  cytochrome c [KO:K08738]
129535887  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129551377  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129549305  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
mbez03040  Spliceosome
mbez03050  Proteasome
mbez04115  p53 signaling pathway
mbez04151  PI3K-Akt signaling pathway
mbez04210  Apoptosis
mbez04610  Complement and coagulation cascades
mbez04612  Antigen processing and presentation
mbez04620  Toll-like receptor signaling pathway
mbez04622  RIG-I-like receptor signaling pathway
mbez04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

DBGET integrated database retrieval system