KEGG   PATHWAY: mpuf05202
Entry
mpuf05202                   Pathway                                
Name
Transcriptional misregulation in cancer - Mustela putorius furo (domestic ferret)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
mpuf05202  Transcriptional misregulation in cancer
mpuf05202

Organism
Mustela putorius furo (domestic ferret) [GN:mpuf]
Gene
101682300  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
101685539  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101693526  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
106004834  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101678790  interleukin-3 [KO:K04736]
101694566  RUNX1T1; protein CBFA2T1 isoform X2 [KO:K10053]
101680954  HDAC2; histone deacetylase 2 isoform X2 [KO:K06067] [EC:3.5.1.98]
101681953  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101683686  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
101677398  NCOR1; nuclear receptor corepressor 1 isoform X14 [KO:K04650]
101689073  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
101690138  PER2; period circadian protein homolog 2 isoform X3 [KO:K02633]
101690490  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
101682942  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101674995  ITGAM; integrin alpha-M [KO:K06461]
101672891  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
101677365  JUP; junction plakoglobin [KO:K10056]
101690003  PML; protein PML isoform X3 [KO:K10054] [EC:2.3.2.-]
101682641  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
101680443  CCNA1; cyclin-A1 isoform X2 [KO:K06627]
101677173  CCNA2; cyclin-A2 [KO:K06627]
101682888  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
101677701  BCL2A1; bcl-2-related protein A1 [KO:K02162]
101681228  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
101689754  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
101688256  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101691224  TCF3; transcription factor E2-alpha isoform X2 [KO:K09063]
101692430  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
101692294  WNT16; protein Wnt-16 [KO:K01558]
101686155  ETV7; transcription factor ETV7 isoform X2 [KO:K03211]
101693942  ETV6; transcription factor ETV6 [KO:K03211]
101690739  uncharacterized protein LOC101690739 [KO:K10784]
101686008  uncharacterized protein LOC101686008 [KO:K10785]
101684702  neutrophil elastase [KO:K01327] [EC:3.4.21.37]
101693455  granzyme B [KO:K01353] [EC:3.4.21.79]
101677851  KMT2A; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
101679180  AFF1; AF4/FMR2 family member 1 isoform X3 [KO:K15184]
101675216  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
101681042  CCNT2; cyclin-T2 isoform X2 [KO:K15188]
101675921  CCNT1; cyclin-T1 isoform X1 [KO:K15188]
101685167  MLLT1; protein ENL isoform X1 [KO:K15187]
101686682  MLLT3; protein AF-9 [KO:K15187]
101684140  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
101681163  LMO2; rhombotin-2 [KO:K15612]
101688483  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
101681651  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
101678475  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
101679808  KLF3; Krueppel-like factor 3 [KO:K15605]
101686957  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
101674453  HOXA9; homeobox protein Hox-A9 [KO:K21950]
101674165  HOXA10; homeobox protein Hox-A10 [KO:K17443]
101681862  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X2 [KO:K11449] [EC:1.14.11.-]
101673270  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
101675513  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
101680407  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
101692226  PROM1; prominin-1 [KO:K06532]
101685779  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101682582  BMP2K; BMP-2-inducible protein kinase [KO:K08854] [EC:2.7.11.1]
101681935  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101688289  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101674268  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
101684567  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
101676053  HOXA11; homeobox protein Hox-A11 [KO:K21951]
101689833  SIX1; homeobox protein SIX1 [KO:K15614]
101688691  SIX4; homeobox protein SIX4 [KO:K15615]
101694532  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
101673844  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
101671285  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
101674543  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101683808  FUT8; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
101673208  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
101669990  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
101679171  BCL11B; B-cell lymphoma/leukemia 11B [KO:K22046]
101684408  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
101672301  LYL1; protein lyl-1 [KO:K15604]
101675580  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
101681374  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
101689260  REL; proto-oncogene c-Rel isoform X2 [KO:K09254]
101684525  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101691821  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101692293  baculoviral IAP repeat-containing protein 3 [KO:K16060]
101682095  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
101674297  BCL2L1; bcl-2-like protein 1 [KO:K04570]
101686613  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
101674384  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101675563  BCL6; B-cell lymphoma 6 protein [KO:K15618]
101689908  MAF; transcription factor Maf isoform X1 [KO:K09035]
101685685  ITGB7; integrin beta-7 [KO:K06590]
101690532  WHSC1; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
101679762  uncharacterized protein LOC101679762 [KO:K11253]
101680718  histone H3.3-like [KO:K11253]
101686884  H3F3A; histone H3.3 [KO:K11253]
101681179  histone H3 [KO:K11253]
101687717  histone H3.1 [KO:K11253]
101675486  H3F3B; histone H3.3 [KO:K11253]
101682026  histone H3.3-like type 2 [KO:K11253]
106004309  histone H3.1-like [KO:K11253]
106004310  histone H3.1-like [KO:K11253]
106004311  histone H3.1-like [KO:K11253]
101683478  LOW QUALITY PROTEIN: uncharacterized protein LOC101683478 [KO:K11253]
101671045  histone H3.1-like [KO:K11253]
101670700  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
101675555  PAX8; paired box protein Pax-8 isoform X2 [KO:K09293]
101688974  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
101685997  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
101679943  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
101693923  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
101684809  PRCC; proline-rich protein PRCC [KO:K13105]
101683773  TFE3; transcription factor E3 isoform X1 [KO:K09105]
101671066  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101671765  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
101687550  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
101680648  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
101693754  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
101688701  stromelysin-1 [KO:K01394] [EC:3.4.24.17]
101677351  MMP9; matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
101670230  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
101694390  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
101681232  SPINT1; kunitz-type protease inhibitor 1 [KO:K15619]
101688902  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
101692998  ETV4; ETS translocation variant 4 isoform X5 [KO:K15592]
101691281  ETV5; ETS translocation variant 5 [KO:K15593]
101682788  SLC45A3; LOW QUALITY PROTEIN: solute carrier family 45 member 3 [KO:K15379]
101682116  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
101681735  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
106004729  probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
101690589  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
101682448  MYCN; N-myc proto-oncogene protein [KO:K09109]
101682511  MAX; protein max isoform X1 [KO:K04453]
101689782  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101681759  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101677794  TP53; cellular tumor antigen p53 [KO:K04451]
101679276  BMI1; polycomb complex protein BMI-1 [KO:K11459]
101686835  SP1; transcription factor Sp1 [KO:K04684]
101684746  ZBTB17; zinc finger and BTB domain-containing protein 17 [KO:K10500]
101684239  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101680416  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101676080  MEN1; menin isoform X1 [KO:K14970]
101685938  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
101679209  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
101680922  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
101673045  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
101679858  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101679105  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
101692849  FEV; protein FEV [KO:K09437]
101690281  ATF1; cyclic AMP-dependent transcription factor ATF-1 [KO:K09053]
101678509  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 isoform X4 [KO:K15589]
101673428  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101682042  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
101670628  WT1; Wilms tumor protein isoform X1 [KO:K09234]
101684232  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101674646  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
101670115  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
101688858  TSPAN7; tetraspanin-7 [KO:K06571]
101684808  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
106003400  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
101673053  TAF15; TATA-binding protein-associated factor 2N [KO:K14651]
101673938  FUS; RNA-binding protein FUS isoform X3 [KO:K13098]
101684783  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101679238  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
101671465  IL6; interleukin-6 [KO:K05405]
101675384  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
101680542  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101680239  RELA; transcription factor p65 [KO:K04735]
101676365  CXCL8; interleukin-8 [KO:K10030]
101693051  PAX3; paired box protein Pax-3 isoform X4 [KO:K09381]
101687740  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
101690363  FOXO1; forkhead box protein O1 [KO:K07201]
101689297  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101678390  SS18L1; calcium-responsive transactivator isoform X2 [KO:K15623]
101685450  SS18; protein SSXT isoform X1 [KO:K15623]
101692248  putative protein SSX6 [KO:K15624]
101688532  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
101675655  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
101674139  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101693694  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
101678248  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101686802  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
101688916  BAK1; bcl-2 homologous antagonist/killer isoform X3 [KO:K14021]
101691261  DDB2; DNA damage-binding protein 2 [KO:K10140]
101693891  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Curr Opin Genet Dev 19:82-91 (2009)
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Exp Cell Res 315:2399-409 (2009)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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MYCN oncoprotein targets and their therapeutic potential.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
mpuf04115  p53 signaling pathway
mpuf05211  Renal cell carcinoma
mpuf05215  Prostate cancer
mpuf05216  Thyroid cancer
mpuf05221  Acute myeloid leukemia
KO pathway
ko05202   
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