KEGG   PATHWAY: mrv04210
Entry
mrv04210                    Pathway                                
Name
Apoptosis - Mauremys reevesii (Reeves's turtle)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
mrv04210  Apoptosis
mrv04210

Other DBs
GO: 0006915
Organism
Mauremys reevesii (Reeves's turtle) [GN:mrv]
Gene
120372443  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
120397671  tumor necrosis factor receptor superfamily member 10A-like isoform X1 [KO:K04722]
120403085  tumor necrosis factor receptor superfamily member 6-like [KO:K04722]
120370739  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120368627  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
120402879  FADD; FAS-associated death domain protein [KO:K02373]
120392459  TNF; tumor necrosis factor isoform X1 [KO:K03156]
120400408  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
120384429  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
120374824  CFLAR; LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724]
120374759  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
120374760  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
120375092  caspase-10-like [KO:K04400] [EC:3.4.22.63]
120406192  caspase-6-like isoform X1 [KO:K04396] [EC:3.4.22.59]
120406161  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
120399323  caspase-7-like [KO:K04397] [EC:3.4.22.60]
120409074  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
120408780  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
120388365  apoptosis regulator BAX-like isoform X1 [KO:K02159]
120388370  apoptosis regulator BAX-like isoform X1 [KO:K02159]
120404933  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
120386155  DIABLO; diablo homolog, mitochondrial isoform X1 [KO:K10522]
120406783  HTRA2; serine protease HTRA2, mitochondrial isoform X1 [KO:K08669] [EC:3.4.21.108]
120374627  cytochrome c, testis-specific isoform X1 [KO:K08738]
120398714  cytochrome c [KO:K08738]
120374768  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
120387756  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
120402901  perforin-1-like [KO:K07818]
120402913  perforin-1-like [KO:K07818]
120403307  perforin-1-like [KO:K07818]
120403308  perforin-1-like [KO:K07818]
120404104  perforin-1-like [KO:K07818]
120404150  perforin-1-like isoform X1 [KO:K07818]
120404151  perforin-1-like [KO:K07818]
120404541  perforin-1-like [KO:K07818]
120404542  perforin-1-like [KO:K07818]
120404569  perforin-1-like [KO:K07818]
120404753  perforin-1-like [KO:K07818]
120404850  perforin-1-like isoform X1 [KO:K07818]
120405047  perforin-1-like [KO:K07818]
120405359  perforin-1-like [KO:K07818]
120405430  perforin-1-like [KO:K07818]
120379867  cathepsin G-like [KO:K01353] [EC:3.4.21.79]
120380056  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
120380332  mast cell protease 3-like [KO:K01353] [EC:3.4.21.79]
120380333  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
120380334  cathepsin G-like isoform X1 [KO:K01353] [EC:3.4.21.79]
120380335  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
120380379  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
120380382  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
120380383  granzyme H-like isoform X1 [KO:K01353] [EC:3.4.21.79]
120380384  duodenase-1-like [KO:K01353] [EC:3.4.21.79]
120380617  cathepsin G-like isoform X1 [KO:K01353] [EC:3.4.21.79]
120380679  mast cell protease 1A-like [KO:K01353] [EC:3.4.21.79]
120381064  mast cell protease 3-like [KO:K01353] [EC:3.4.21.79]
120381065  mast cell protease 1A-like isoform X1 [KO:K01353] [EC:3.4.21.79]
120381066  mast cell protease 3-like isoform X1 [KO:K01353] [EC:3.4.21.79]
120381069  mast cell protease 3-like [KO:K01353] [EC:3.4.21.79]
120381127  granzyme B-like [KO:K01353] [EC:3.4.21.79]
120379752  granzyme B-like isoform X1 [KO:K01353] [EC:3.4.21.79]
120393414  tubulin alpha-8 chain isoform X1 [KO:K07374]
120372463  tubulin alpha-3 chain isoform X1 [KO:K07374]
120395364  tubulin alpha-3 chain-like [KO:K07374]
120395365  tubulin alpha-3 chain-like isoform X1 [KO:K07374]
120395366  tubulin alpha-3 chain-like [KO:K07374]
120395367  tubulin alpha-3 chain [KO:K07374]
120374723  tubulin alpha-1D chain [KO:K07374]
120374724  tubulin alpha-4A chain [KO:K07374]
120408631  tubulin alpha-8 chain-like isoform X1 [KO:K07374]
120408641  tubulin alpha-8 chain isoform X1 [KO:K07374]
120390845  TUBA1B; tubulin alpha-1B chain isoform X1 [KO:K07374]
120390925  TUBA1A; tubulin alpha-1A chain [KO:K07374]
120390990  tubulin alpha-1C chain [KO:K07374]
120389975  MCL1; LOW QUALITY PROTEIN: induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
120383175  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120371790  ACTRT3; actin-related protein T3 [KO:K05692]
120372849  ACTB; actin, cytoplasmic 1 [KO:K05692]
120373001  actin, cytoplasmic type 5-like [KO:K05692]
120374144  actin, cytoplasmic type 5 [KO:K05692]
120374473  actin, cytoplasmic type 5-like [KO:K05692]
120387832  ACTL8; actin-like protein 8 isoform X1 [KO:K05692]
120407736  ACTBL2; beta-actin-like protein 2 [KO:K05692]
120386771  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
120390243  LMNA; lamin isoform X1 [KO:K12641]
120390249  prelamin-A/C-like [KO:K12641]
120391820  LMNB2; lamin-B2 isoform X1 [KO:K07611]
120373802  lamin-L(III)-like isoform X1 [KO:K07611]
120408465  LMNB1; lamin-B1 [KO:K07611]
120401815  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
120379703  PARP2; poly [ADP-ribose] polymerase 2 isoform X1 [KO:K10798] [EC:2.4.2.30]
120369168  PARP3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.30]
120399119  PARP4; protein mono-ADP-ribosyltransferase PARP4 isoform X1 [KO:K10798] [EC:2.4.2.30]
120387805  DFFA; DNA fragmentation factor subunit alpha [KO:K02310]
120387726  DFFB; DNA fragmentation factor subunit beta isoform X1 [KO:K02311] [EC:3.-.-.-]
120386871  ENDOG; endonuclease G, mitochondrial [KO:K01173]
120371667  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
120383286  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120373277  ERN2; serine/threonine-protein kinase/endoribonuclease IRE2 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
120392446  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120392485  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
120386646  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
120409030  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
120407194  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
120403535  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
120369426  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
120400983  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
120388744  CAPN12; calpain-12 isoform X1 [KO:K03853] [EC:3.4.22.53]
120400953  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
120405920  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
120404553  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
120377804  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120391088  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
120401038  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
120406503  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
120403710  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
120388483  LOW QUALITY PROTEIN: cathepsin D-like [KO:K01379] [EC:3.4.23.5]
120369162  cathepsin F-like [KO:K01373] [EC:3.4.22.41]
120373479  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
120390078  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
120390507  cathepsin K-like isoform X1 [KO:K01371] [EC:3.4.22.38]
120391903  procathepsin L-like isoform X1 [KO:K01365] [EC:3.4.22.15]
120408507  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
120406225  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
120390630  cathepsin S-like isoform X1 [KO:K01368] [EC:3.4.22.27]
120390631  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
120390632  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
120390633  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
120369000  cathepsin W-like isoform X1 [KO:K08569] [EC:3.4.22.-]
120369001  cathepsin W-like isoform X1 [KO:K08569] [EC:3.4.22.-]
120380404  CTSZ; cathepsin Z [KO:K08568] [EC:3.4.18.1]
120371556  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
120372466  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
120374360  baculoviral IAP repeat-containing protein 5.1-like isoform X1 [KO:K08731]
120400223  BIRC5; baculoviral IAP repeat-containing protein 5 [KO:K08731]
120400604  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
120380635  BCL2L1; bcl-2-like protein 1 [KO:K04570]
120398465  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
120394904  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
120396472  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
120386847  disabled homolog 2-interacting protein isoform X1 [KO:K19901]
120402164  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
120405833  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120368657  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120369865  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120408932  BAD; bcl2-associated agonist of cell death [KO:K02158]
120370011  JUN; transcription factor AP-1 [KO:K04448]
120405405  FOS; proto-oncogene c-Fos [KO:K04379]
120381866  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
120386334  HRK; activator of apoptosis harakiri [KO:K02512]
120385126  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
120368653  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
120397038  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120388769  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120405241  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
120405938  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120369204  RELA; transcription factor p65 isoform X1 [KO:K04735]
120405829  PTPN13; tyrosine-protein phosphatase non-receptor type 13 [KO:K02374]
120370396  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
120391837  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
120408769  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
120386584  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
120373646  BCL2A1; bcl-2-related protein A1 [KO:K02162]
120398929  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
120402898  PIDD1; p53-induced death domain-containing protein 1 [KO:K10130]
120408423  PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
120375179  CASP2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
120402881  NGF; beta-nerve growth factor [KO:K02582]
120390665  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
120396041  cytokine receptor common subunit beta-like [KO:K04738]
120379174  cytokine receptor common subunit beta-like isoform X1 [KO:K04738]
120371749  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120371816  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120387926  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120391575  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
120370714  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
120407838  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120374088  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
120405059  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120388568  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120401029  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120405072  HRAS; GTPase HRas [KO:K02833]
120388368  ras-like protein isoform X1 [KO:K07827]
120407327  KRAS; GTPase KRas isoform X1 [KO:K07827]
120404663  NRAS; GTPase NRas [KO:K07828]
120409502  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120373628  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120391732  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120386132  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120404454  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Related
pathway
mrv04010  MAPK signaling pathway
mrv04020  Calcium signaling pathway
mrv04115  p53 signaling pathway
mrv04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
LinkDB

DBGET integrated database retrieval system