KEGG   PATHWAY: nasi05168
Entry
nasi05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
nasi05168  Herpes simplex virus 1 infection
nasi05168

Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112395424  LTA; lymphotoxin-alpha [KO:K05468]
112400229  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
112411269  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
112403568  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
112413114  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
112392983  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
112400454  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
112411167  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
112393728  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
112402272  RELA; transcription factor p65 [KO:K04735]
112409959  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
112409963  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
112394151  C-C motif chemokine 2 [KO:K14624]
112411055  NECTIN1; nectin-1 isoform X1 [KO:K06081]
112415650  NECTIN2; nectin-2 isoform X1 [KO:K06531]
112399873  paired immunoglobulin-like type 2 receptor beta [KO:K15411]
112399944  paired immunoglobulin-like type 2 receptor beta isoform X1 [KO:K15411]
112397307  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
112409948  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
112393994  ITGA5; integrin alpha-5 [KO:K06484]
112410352  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
112398489  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112390842  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
112411472  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
112415465  IRF3; interferon regulatory factor 3 [KO:K05411]
112407026  IFNB1; interferon beta [KO:K05415]
112401891  TP53; cellular tumor antigen p53 [KO:K04451]
112400183  C3; LOW QUALITY PROTEIN: complement C3 [KO:K03990]
112411308  C5; complement C5 [KO:K03994]
112402598  CFP; properdin [KO:K15412]
112407985  TLR2; toll-like receptor 2 [KO:K10159]
112400529  toll-like receptor 9 isoform X1 [KO:K10161]
112407416  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
112402386  IRF7; interferon regulatory factor 7 [KO:K09447]
112409663  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
112400342  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
112396652  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
112406760  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
112404544  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
112390747  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
112410769  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
112401606  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
112398981  IL1B; interleukin-1 beta [KO:K04519]
112408067  CCL5; C-C motif chemokine 5 [KO:K12499]
112395338  IL6; interleukin-6 [KO:K05405]
112395421  TNF; tumor necrosis factor [KO:K03156]
112406240  IL12A; interleukin-12 subunit alpha [KO:K05406]
112415192  IL12B; interleukin-12 subunit beta [KO:K05425]
112393613  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
112398436  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
112408757  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
112403510  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
112394248  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
112407025  interferon alpha-1-like [KO:K05414]
112395020  interferon alpha-1-like [KO:K05414]
112395023  interferon alpha-1-like [KO:K05414]
112395027  interferon alpha-1-like [KO:K05414]
112390807  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
112404461  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
112402102  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112408799  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
112390556  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112399890  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
112405182  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
112398926  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
112391176  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
112401166  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
112408760  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
112394824  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
112411678  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
112412734  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
112415673  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
112397262  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
112397263  2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
112391174  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
112406763  HCFC1; host cell factor 1 [KO:K14966]
112391043  HCFC2; host cell factor 2 isoform X1 [KO:K27390]
112411046  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
112398061  POU2F1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
112415637  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
112408548  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
112408636  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
112410494  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
112412959  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
112400181  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
112392137  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
112394097  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
112404988  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
112395516  zinc finger protein 684-like [KO:K09228]
112395517  ZNF684; zinc finger protein 684 [KO:K09228]
112409414  ZNF205; zinc finger protein 205 isoform X1 [KO:K09228]
112409419  ZNF200; zinc finger protein 200 [KO:K09228]
112409422  ZSCAN32; LOW QUALITY PROTEIN: zinc finger and SCAN domain-containing protein 32 [KO:K09228]
112395712  ZNF485; LOW QUALITY PROTEIN: zinc finger protein 485 [KO:K09228]
112395734  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
112402587  ZNF41; LOW QUALITY PROTEIN: zinc finger protein 41 [KO:K09228]
112402594  ZNF157; zinc finger protein 157 isoform X1 [KO:K09228]
112402729  ZNF300; zinc finger protein 300 isoform X1 [KO:K09228]
112409490  ZNF597; zinc finger protein 597 isoform X1 [KO:K09228]
112409708  ZNF596; zinc finger protein 596 isoform X1 [KO:K09228]
112409769  ZNF81; zinc finger protein 81 [KO:K09228]
112409770  ZNF182; zinc finger protein 182 isoform X1 [KO:K09228]
112396236  ZNF10; zinc finger protein 10 isoform X1 [KO:K09228]
112396238  zinc finger protein 84 isoform X1 [KO:K09228]
112396240  ZNF605; zinc finger protein 605 isoform X1 [KO:K09228]
112396241  ZNF891; zinc finger protein 891 [KO:K09228]
112396362  ZNF77; LOW QUALITY PROTEIN: zinc finger protein 77 [KO:K09228]
112402778  zinc finger protein 300-like isoform X1 [KO:K09228]
112396911  ZNF606; zinc finger protein 606 isoform X1 [KO:K09228]
112396913  zinc finger protein 132-like [KO:K09228]
112396915  ZNF135; zinc finger protein 135 [KO:K09228]
112396917  LOW QUALITY PROTEIN: zinc finger protein 132-like [KO:K09228]
112396918  zinc finger protein 324A-like [KO:K09228]
112396921  ZNF584; zinc finger protein 584 isoform X1 [KO:K09228]
112410706  ZNF510; zinc finger protein 510 [KO:K09228]
112410707  ZNF782; zinc finger protein 782 [KO:K09228]
112410726  zinc finger protein 33B [KO:K09228]
112410728  ZNF37A; zinc finger protein 37A [KO:K09228]
112397038  ZNF7; zinc finger protein 7 isoform X1 [KO:K09228]
112397040  ZNF250; zinc finger protein 250 isoform X1 [KO:K09228]
112397050  ZNF34; zinc finger protein 34 isoform X1 [KO:K09228]
112397056  ZNF623; zinc finger protein 623 [KO:K09228]
112397104  zinc finger protein 252-like isoform X1 [KO:K09228]
112397248  ZNF169; zinc finger protein 169 isoform X1 [KO:K09228]
112403780  ZNF589; LOW QUALITY PROTEIN: zinc finger protein 589 [KO:K09228]
112397957  zinc finger protein 211-like isoform X1 [KO:K09228]
112397958  zinc finger protein 211-like [KO:K09228]
112397960  LOW QUALITY PROTEIN: zinc finger protein 304-like [KO:K09228]
112397964  zinc finger protein 543-like isoform X1 [KO:K09228]
112404489  LOW QUALITY PROTEIN: zinc finger protein 549-like [KO:K09228]
112411315  LOW QUALITY PROTEIN: zinc finger protein 25-like [KO:K09228]
112411340  ZFP37; LOW QUALITY PROTEIN: zinc finger protein 37 homolog [KO:K09228]
112411514  ZNF79; zinc finger protein 79 [KO:K09228]
112397965  zinc finger protein 264-like [KO:K09228]
112397968  zinc finger protein 345-like [KO:K09228]
112397971  LOW QUALITY PROTEIN: zinc finger protein 256-like [KO:K09228]
112397972  zinc finger protein 304-like [KO:K09228]
112397973  LOW QUALITY PROTEIN: zinc finger protein 416-like [KO:K09228]
112397974  LOW QUALITY PROTEIN: zinc finger protein 773-like [KO:K09228]
112397975  LOW QUALITY PROTEIN: zinc finger protein 548-like [KO:K09228]
112397976  zinc finger protein OZF-like [KO:K09228]
112397977  zinc finger protein OZF-like [KO:K09228]
112397978  zinc finger protein 501-like [KO:K09228]
112397979  zinc finger protein 549-like isoform X1 [KO:K09228]
112397980  zinc finger protein 773-like [KO:K09228]
112397981  zinc finger protein 772-like [KO:K09228]
112397982  ZNF550; zinc finger protein 550 isoform X1 [KO:K09228]
112397989  zinc finger protein 256-like [KO:K09228]
112397990  zinc finger protein 256-like [KO:K09228]
112397992  ZNF671; zinc finger protein 671 [KO:K09228]
112397993  zinc finger protein OZF-like isoform X1 [KO:K09228]
112397994  zinc finger protein 211-like [KO:K09228]
112397999  LOW QUALITY PROTEIN: zinc finger protein 551-like [KO:K09228]
112398001  zinc finger protein 304-like [KO:K09228]
112398002  LOW QUALITY PROTEIN: zinc finger protein 548-like [KO:K09228]
112398003  zinc finger protein 501-like [KO:K09228]
112398016  putative uncharacterized zinc finger protein 814 isoform X1 [KO:K09228]
112398017  LOW QUALITY PROTEIN: zinc finger protein 211-like [KO:K09228]
112398347  ZNF783; protein ZNF783 [KO:K09228]
112398348  ZNF212; zinc finger protein 212 isoform X1 [KO:K09228]
112398352  ZNF398; zinc finger protein 398 isoform X1 [KO:K09228]
112398353  ZNF425; LOW QUALITY PROTEIN: zinc finger protein 425 [KO:K09228]
112398356  ZNF777; LOW QUALITY PROTEIN: zinc finger protein 777 [KO:K09228]
112398357  ZNF786; zinc finger protein 786 [KO:K09228]
112398384  ZNF343; LOW QUALITY PROTEIN: zinc finger protein 343 [KO:K09228]
112404743  LOW QUALITY PROTEIN: zinc finger protein 300-like [KO:K09228]
112404744  zinc finger protein OZF-like [KO:K09228]
112398641  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112398804  ZNF674; LOW QUALITY PROTEIN: zinc finger protein 674 [KO:K09228]
112405349  ZNF624; LOW QUALITY PROTEIN: zinc finger protein 624 [KO:K09228]
112405363  ZNF286A; zinc finger protein 286A [KO:K09228]
112405368  ZNF133; zinc finger protein 133 isoform X1 [KO:K09228]
112412238  ZNF74; LOW QUALITY PROTEIN: zinc finger protein 74 [KO:K09228]
112412356  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
112412358  LOW QUALITY PROTEIN: zinc finger protein 33B-like [KO:K09228]
112412359  ZNF248; zinc finger protein 248 isoform X1 [KO:K09228]
112412361  ZNF25; zinc finger protein 25 [KO:K09228]
112398932  zinc finger protein 501-like isoform X1 [KO:K09228]
112398933  ZNF2; zinc finger protein 2 [KO:K09228]
112399065  ZNF514; zinc finger protein 514 isoform X1 [KO:K09228]
112399163  ZNF768; zinc finger protein 768 [KO:K09228]
112399164  ZNF764; zinc finger protein 764 isoform X1 [KO:K09228]
112405699  ZNF658; zinc finger protein 658 isoform X1 [KO:K09228]
112412553  ZFP57; zinc finger protein 57 homolog [KO:K09228]
112412564  zinc finger protein 184 [KO:K09228]
112412600  zinc finger protein 311-like [KO:K09228]
112412609  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
112412815  zinc finger protein 354B isoform X1 [KO:K09228]
112412852  ZNF879; LOW QUALITY PROTEIN: zinc finger protein 879 [KO:K09228]
112399263  ZNF689; zinc finger protein 689 [KO:K09228]
112399462  ZNF713; zinc finger protein 713 isoform X1 [KO:K09228]
112405909  ZNF746; zinc finger protein 746 isoform X1 [KO:K09228]
112399672  zinc finger protein 596-like [KO:K09228]
112399889  ZNF12; zinc finger protein 12 isoform X1 [KO:K09228]
112393521  ZFP1; zinc finger protein 1 homolog isoform X1 [KO:K09228]
112393617  LOW QUALITY PROTEIN: zinc finger protein 786-like [KO:K09228]
112400044  LOW QUALITY PROTEIN: zinc finger protein 549-like [KO:K09228]
112400077  ZNF354A; zinc finger protein 354A [KO:K09228]
112400157  zinc finger protein 177-like isoform X1 [KO:K09228]
112400190  zinc finger protein 77-like isoform X1 [KO:K09228]
112400270  LOW QUALITY PROTEIN: zinc finger protein 555-like [KO:K09228]
112400281  zinc finger protein 77-like [KO:K09228]
112400303  ZNF557; LOW QUALITY PROTEIN: zinc finger protein 557 [KO:K09228]
112400314  LOW QUALITY PROTEIN: zinc finger protein 791-like [KO:K09228]
112406827  ZFP92; zinc finger protein 92 homolog isoform X1 [KO:K09228]
112406834  ZNF275; zinc finger protein 275 [KO:K09228]
112407043  ZNF662; LOW QUALITY PROTEIN: zinc finger protein 662 [KO:K09228]
112414364  ZNF436; zinc finger protein 436 isoform X1 [KO:K09228]
112414687  zinc finger protein 317-like isoform X1 [KO:K09228]
112394194  ZNF641; zinc finger protein 641 [KO:K09228]
112400903  ZNF334; LOW QUALITY PROTEIN: zinc finger protein 334 [KO:K09228]
112407713  ZNF214; zinc finger protein 214 [KO:K09228]
112407801  zinc finger protein 471 isoform X1 [KO:K09228]
112407803  zinc finger protein 470 isoform X1 [KO:K09228]
112407804  ZNF667; zinc finger protein 667 isoform X1 [KO:K09228]
112407805  ZNF583; zinc finger protein 583 isoform X1 [KO:K09228]
112407806  zinc finger protein 436-like [KO:K09228]
112414743  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112414777  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112414778  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112414779  zinc finger protein 709-like isoform X1 [KO:K09228]
112414781  zinc finger protein 709-like [KO:K09228]
112414786  zinc finger protein 791-like isoform X1 [KO:K09228]
112414824  zinc finger protein 260-like [KO:K09228]
112414830  LOW QUALITY PROTEIN: zinc finger protein 709-like [KO:K09228]
112414848  ZNF333; zinc finger protein 333 isoform X1 [KO:K09228]
112415202  zinc finger protein 829-like [KO:K09228]
112415203  zinc finger protein 705A-like [KO:K09228]
112415211  zinc finger protein 705A-like [KO:K09228]
112415272  LOW QUALITY PROTEIN: zinc finger protein 180-like [KO:K09228]
112415388  ZNF546; zinc finger protein 546 isoform X1 [KO:K09228]
112415421  zinc finger protein 677-like [KO:K09228]
112415422  zinc finger protein 615-like isoform X1 [KO:K09228]
112415423  zinc finger protein 615-like [KO:K09228]
112415424  ZNF613; zinc finger protein 613 isoform X1 [KO:K09228]
112415425  zinc finger protein 84-like [KO:K09228]
112415427  zinc finger protein 160-like [KO:K09228]
112415428  zinc finger protein 350-like isoform X1 [KO:K09228]
112415429  zinc finger protein 577-like isoform X1 [KO:K09228]
112415430  zinc finger protein 350-like [KO:K09228]
112415431  zinc finger protein 160-like [KO:K09228]
112415432  zinc finger protein 160-like [KO:K09228]
112415434  zinc finger protein 84-like [KO:K09228]
112415437  LOW QUALITY PROTEIN: zinc finger protein 432-like [KO:K09228]
112415442  zinc finger protein 836-like [KO:K09228]
112415474  ZNF175; zinc finger protein 175 [KO:K09228]
112415476  zinc finger protein 883-like [KO:K09228]
112415477  zinc finger protein 268-like [KO:K09228]
112415528  zinc finger protein 235 isoform X1 [KO:K09228]
112415529  LOW QUALITY PROTEIN: zinc finger protein 233-like [KO:K09228]
112415531  ZNF283; LOW QUALITY PROTEIN: zinc finger protein 283 [KO:K09228]
112415532  ZNF404; zinc finger protein 404 [KO:K09228]
112415578  zinc finger protein 347-like [KO:K09228]
112415606  ZNF473; zinc finger protein 473 isoform X1 [KO:K09228]
112415620  zinc finger protein 160-like [KO:K09228]
112415621  zinc finger protein 347-like isoform X1 [KO:K09228]
112415622  zinc finger protein 160-like isoform X1 [KO:K09228]
112415647  LOW QUALITY PROTEIN: zinc finger protein 112-like [KO:K09228]
112392147  zinc finger protein OZF-like [KO:K09228]
112392149  RBAK; RB-associated KRAB zinc finger protein [KO:K09228]
112392209  zinc finger protein 607-like [KO:K09228]
112392230  ZNF585A; zinc finger protein 585A isoform X1 [KO:K09228]
112392232  zinc finger protein 569 [KO:K09228]
112392233  ZNF420; zinc finger protein 420 isoform X1 [KO:K09228]
112392234  ZNF571; zinc finger protein 571 isoform X1 [KO:K09228]
112392235  zinc finger protein 345-like isoform X1 [KO:K09228]
112392237  ZNF567; zinc finger protein 567 isoform X1 [KO:K09228]
112392239  ZNF461; zinc finger protein 461 isoform X1 [KO:K09228]
112392240  HKR1; LOW QUALITY PROTEIN: Krueppel-related zinc finger protein 1 [KO:K09228]
112392242  ZNF790; zinc finger protein 790 isoform X1 [KO:K09228]
112392244  ZNF792; zinc finger protein 792 isoform X1 [KO:K09228]
112392247  ZNF527; zinc finger protein 527 isoform X1 [KO:K09228]
112392248  LOW QUALITY PROTEIN: zinc finger protein 568-like [KO:K09228]
112392249  ZNF382; zinc finger protein 382 isoform X1 [KO:K09228]
112392251  ZFP30; zinc finger protein 30 homolog isoform X1 [KO:K09228]
112392255  ZNF529; zinc finger protein 529 [KO:K09228]
112392257  zinc finger protein 570 [KO:K09228]
112392258  zinc finger protein 82 homolog isoform X1 [KO:K09228]
112392260  ZNF565; zinc finger protein 565 [KO:K09228]
112392263  ZNF383; zinc finger protein 383 [KO:K09228]
112392265  zinc finger protein 566 isoform X1 [KO:K09228]
112392268  LOW QUALITY PROTEIN: zinc finger protein 850-like [KO:K09228]
112392270  ZNF829; zinc finger protein 829 [KO:K09228]
112392271  ZNF793; zinc finger protein 793 [KO:K09228]
112392272  zinc finger protein 420-like isoform X1 [KO:K09228]
112392365  ZNF599; zinc finger protein 599 isoform X1 [KO:K09228]
112392366  LOW QUALITY PROTEIN: zinc finger protein 181-like [KO:K09228]
112392368  LOW QUALITY PROTEIN: zinc finger protein 256-like [KO:K09228]
112392394  ZFP90; zinc finger protein 90 homolog isoform X1 [KO:K09228]
112392615  ZNF189; zinc finger protein 189 isoform X1 [KO:K09228]
112393310  ZNF23; zinc finger protein 23 [KO:K09228]
112393312  ZNF19; zinc finger protein 19 [KO:K09228]
112390537  zinc finger protein 160-like isoform X1 [KO:K09228]
112390539  LOW QUALITY PROTEIN: zinc finger protein 677-like [KO:K09228]
112390541  ZNF331; zinc finger protein 331 isoform X1 [KO:K09228]
112391594  ZNF484; zinc finger protein 484 isoform X1 [KO:K09228]
112392252  zinc finger protein 14 homolog isoform X1 [KO:K09228]
112397991  zinc finger protein 256-like isoform X1 [KO:K09228]
112399864  ZNF316; zinc finger protein 316 [KO:K09228]
112414742  zinc finger protein 564-like [KO:K09228]
112414770  BST2; bone marrow stromal antigen 2 [KO:K06731]
112394138  IFNG; interferon gamma [KO:K04687]
112409086  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
112408543  IFNGR2; interferon gamma receptor 2 isoform X1 [KO:K05133]
112392497  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
112413870  DAXX; death domain-associated protein 6 [KO:K02308]
112396763  nuclear body protein SP140-like protein isoform X1 [KO:K15413]
112410980  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
112413857  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
112413821  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
112413922  TAPBP; tapasin isoform X1 [KO:K08058]
112391248  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112395837  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
112414910  CALR; calreticulin [KO:K08057]
112395459  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112395464  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
112412724  HLA class I histocompatibility antigen, B-41 alpha chain-like [KO:K06751]
112414713  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
112402512  B2M; beta-2-microglobulin [KO:K08055]
112398547  beta-2-microglobulin [KO:K08055]
112413822  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
112406844  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112406848  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
112406849  boLa class II histocompatibility antigen, DQB*0101 beta chain isoform X1 [KO:K06752]
112406850  HLA class II histocompatibility antigen, DQ alpha 2 chain [KO:K06752]
112413938  HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752]
112414040  HLA class II histocompatibility antigen, DO alpha chain-like [KO:K06752]
112414069  HLA class II histocompatibility antigen, DM beta chain isoform X1 [KO:K06752]
112391100  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
112402798  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
112403325  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112406349  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112404930  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112400438  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112414874  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
112405757  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112408453  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112415459  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112411342  TSC1; hamartin isoform X1 [KO:K07206]
112409519  TSC2; tuberin isoform X1 [KO:K07207]
112405904  RHEB; GTP-binding protein Rheb [KO:K07208]
112402675  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112413144  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112413863  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
112408049  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
112410208  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
112413909  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
112396107  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
112414252  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
112400873  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
112405207  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
112397272  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
112402107  NXF1; nuclear RNA export factor 1 [KO:K14284]
112404600  nuclear RNA export factor 2-like [KO:K14284]
112411694  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112400918  NXF3; nuclear RNA export factor 3 [KO:K14284]
112410196  ALYREF; THO complex subunit 4 [KO:K12881]
112391613  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
112399577  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
112391694  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
112392222  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
112402377  FADD; FAS-associated death domain protein [KO:K02373]
112407903  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
112415661  BAX; apoptosis regulator BAX [KO:K02159]
112414038  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112402326  BAD; bcl2-associated agonist of cell death [KO:K02158]
112406137  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
112398447  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
112409526  cytochrome c-like [KO:K08738]
112396438  cytochrome c-like [KO:K08738]
112403640  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112406320  cytochrome c [KO:K08738]
112414113  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
112394162  cytochrome c-like [KO:K08738]
112391536  cytochrome c 2 [KO:K08738]
112409026  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
112402819  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
112409662  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
nasi03040  Spliceosome
nasi03050  Proteasome
nasi04115  p53 signaling pathway
nasi04151  PI3K-Akt signaling pathway
nasi04210  Apoptosis
nasi04610  Complement and coagulation cascades
nasi04612  Antigen processing and presentation
nasi04620  Toll-like receptor signaling pathway
nasi04622  RIG-I-like receptor signaling pathway
nasi04630  JAK-STAT signaling pathway
KO pathway
ko05168   
LinkDB

DBGET integrated database retrieval system