KEGG   PATHWAY: phi04020
Entry
phi04020                    Pathway                                
Name
Calcium signaling pathway - Pseudopodoces humilis (Tibetan ground-tit)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
phi04020  Calcium signaling pathway
phi04020

Other DBs
GO: 0019722
Organism
Pseudopodoces humilis (Tibetan ground-tit) [GN:phi]
Gene
102113310  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
102104342  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
102114460  SLC8A2; sodium/calcium exchanger 2 isoform X3 [KO:K05849]
102111921  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X3 [KO:K05850] [EC:7.2.2.10]
102105769  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
102100080  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
102106911  plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
102110816  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102103122  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102111270  ADORA2A; adenosine receptor A2a [KO:K04266]
102107785  ADORA2B; adenosine receptor A2b [KO:K04267]
102113245  ADRB1; beta-1 adrenergic receptor [KO:K04141]
102102944  ADRB2; beta-2 adrenergic receptor [KO:K04142]
102111297  ADRB3; beta-3 adrenergic receptor [KO:K04143]
102111882  DRD1; D(1A) dopamine receptor [KO:K04144]
102109760  DRD5; D(1B) dopamine receptor [KO:K05840]
102112671  D(1) dopamine receptor-like [KO:K05840]
102101295  D(1) dopamine receptor-like [KO:K05840]
102100003  histamine H2 receptor-like [KO:K04150]
102099071  probable G-protein coupled receptor No9 [KO:K04150]
102099817  histamine H2 receptor-like [KO:K04150]
102104944  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
102113052  5-hydroxytryptamine receptor 5B-like [KO:K04161]
102114614  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
102102205  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
102106600  5-hydroxytryptamine receptor 7-like [KO:K04163]
102103601  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
102103803  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
102107758  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
102110269  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102113898  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102106688  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102108193  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102103610  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
102112800  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102108377  PLN; cardiac phospholamban [KO:K05852]
102114155  SLN; sarcolipin [KO:K22642]
102112747  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
102107999  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102112361  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
102102201  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
102110062  STIM2; stromal interaction molecule 2 isoform X2 [KO:K18196]
102113680  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
102109905  ORAI2; protein orai-2 [KO:K16057]
102106069  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
102103301  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102111116  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
102111358  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102099919  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102107124  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102110220  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102111160  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
102108511  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
102103258  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102109591  CHRFAM7A; CHRNA7-FAM7A fusion protein [KO:K04809]
102107326  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
102108893  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
102113741  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
102112194  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102102883  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
102106210  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102102971  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
102114144  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
102102022  P2RX1; P2X purinoceptor 1 [KO:K05215]
102113330  P2RX3; P2X purinoceptor 3 [KO:K05217]
102112929  P2RX4; P2X purinoceptor 4 isoform X2 [KO:K05218]
102105994  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
102100542  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
102114265  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
102105661  RYR2; ryanodine receptor 2 [KO:K04962]
102102931  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
102099259  TRDN; triadin [KO:K23449]
102107113  CASQ2; calsequestrin-2 [KO:K23445]
102100401  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
102101344  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
102099926  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
102103691  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
102108110  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
102105127  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
102104078  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
102112440  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102112626  EDNRA; endothelin-1 receptor [KO:K04197]
102101313  EDNRB; endothelin B receptor [KO:K04198]
102107001  endothelin B receptor-like [KO:K04198]
102108910  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
102107527  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
102104616  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
102109279  GRPR; gastrin-releasing peptide receptor [KO:K04169]
102105211  HRH1; histamine H1 receptor [KO:K04149]
102106216  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
102100868  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
102101838  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
102103132  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
102099336  NTSR1; neurotensin receptor type 1 [KO:K04211]
102106864  OXTR; oxytocin receptor [KO:K04229]
102110756  AVPR1A; vasopressin V1a receptor [KO:K04226]
102105205  AVPR1B; vasopressin V1b receptor [KO:K04227]
102108046  PTAFR; platelet-activating factor receptor [KO:K04279]
102111740  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
102113860  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
102102183  BDKRB1; B1 bradykinin receptor [KO:K03915]
102111629  BDKRB2; B2 bradykinin receptor [KO:K03916]
102104311  TACR1; substance-P receptor [KO:K04222]
102102338  TACR2; substance-K receptor [KO:K04223]
102111130  TACR3; neuromedin-K receptor [KO:K04224]
102103217  TBXA2R; thromboxane A2 receptor [KO:K04264]
102114270  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
102100543  thyrotropin-releasing hormone receptor-like [KO:K04282]
102110685  CCKAR; cholecystokinin receptor type A [KO:K04194]
102103686  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
102099500  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102103304  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
102102102  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102112980  EGF; pro-epidermal growth factor [KO:K04357]
102109017  TGFA; protransforming growth factor alpha [KO:K08774]
102099148  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
102099229  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102106969  PDGFC; platelet-derived growth factor C [KO:K05450]
102112153  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102103492  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102104728  FGF2; fibroblast growth factor 2 [KO:K18497]
102104207  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102103712  FGF9; fibroblast growth factor 9 [KO:K04358]
102110749  FGF20; fibroblast growth factor 20 [KO:K04358]
102113891  FGF17; fibroblast growth factor 17 [KO:K04358]
102114147  FGF6; fibroblast growth factor 6 [KO:K04358]
102103462  FGF18; fibroblast growth factor 18 [KO:K04358]
102107459  FGF10; fibroblast growth factor 10 [KO:K04358]
102112031  FGF5; fibroblast growth factor 5 [KO:K04358]
102099294  FGF4; fibroblast growth factor 4 [KO:K04358]
102102399  FGF3; fibroblast growth factor 3 [KO:K04358]
102105200  FGF16; fibroblast growth factor 16 [KO:K04358]
102099537  FGF22; fibroblast growth factor 22 [KO:K04358]
102100899  FGF8; fibroblast growth factor 8 [KO:K04358]
102102589  FGF19; fibroblast growth factor 19 [KO:K22603]
102100267  FGF23; fibroblast growth factor 23 [KO:K22428]
102114381  VEGFA; vascular endothelial growth factor A isoform X3 [KO:K05448]
102108122  FIGF; vascular endothelial growth factor D [KO:K05449]
102101573  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
102111404  NGF; beta-nerve growth factor [KO:K02582]
102106058  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102100351  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
102113267  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
102101445  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102108835  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102101993  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102113512  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102113476  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102111524  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102103637  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102105117  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102114034  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102109120  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102108061  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102108458  vascular endothelial growth factor receptor kdr-like isoform X2 [KO:K05096] [EC:2.7.10.1]
102110772  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102113293  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
102113646  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102100533  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102100349  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
102099870  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102102187  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
102107711  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102109901  LOW QUALITY PROTEIN: uncharacterized protein LOC102109901 [KO:K10785]
102099978  uncharacterized protein LOC102099978 [KO:K06856]
102107391  Ig mu heavy chain disease protein-like [KO:K06856]
102099602  uncharacterized protein LOC102099602 [KO:K06856]
102100115  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
102100695  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
102108822  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
102105081  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102113003  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
102100609  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
102100949  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
102114427  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
102103443  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102113055  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3 [KO:K05860] [EC:3.1.4.11]
102108407  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
102107950  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102112318  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102109497  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
102100836  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102106808  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
102099845  TPCN2; two pore calcium channel protein 2 [KO:K14077]
102113469  MCOLN1; mucolipin-1 [KO:K04992]
102110962  MCOLN2; mucolipin-2 isoform X3 [KO:K04993]
102110762  MCOLN3; mucolipin-3 [KO:K04994]
102106754  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
102100271  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102099691  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102102486  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102100744  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102105225  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102112843  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102110337  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102114225  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102109533  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102114184  TNNC2; troponin C, skeletal muscle [KO:K12042]
102108986  CALM1; calmodulin [KO:K02183]
102106395  calmodulin, striated muscle [KO:K02183]
102114456  CALM2; calmodulin [KO:K02183]
102106737  CALML4; calmodulin-like protein 4 [KO:K02183]
102104524  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
102111090  PHKB; phosphorylase b kinase regulatory subunit beta isoform X2 [KO:K07190]
102111187  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
102112125  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
102101059  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
102104582  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102106790  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
102111091  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102112254  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102114311  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
102100547  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
102106043  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
102112061  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102104633  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6 [KO:K04515] [EC:2.7.11.17]
102108054  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8 [KO:K04515] [EC:2.7.11.17]
102104310  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3 [KO:K04515] [EC:2.7.11.17]
102114009  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
102112643  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
102109818  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102100025  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
102106610  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
102111343  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102107737  TFEB; transcription factor EB [KO:K15590]
102114296  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102111394  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102105250  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102106809  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
102108817  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
102112141  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
102112344  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
102105148  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
102111231  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
102099730  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
102104761  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102113312  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102100311  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102104824  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102099121  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
phi04010  MAPK signaling pathway
phi04070  Phosphatidylinositol signaling system
phi04210  Apoptosis
KO pathway
ko04020   
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