KEGG   PATHWAY: phi04010
Entry
phi04010                    Pathway                                
Name
MAPK signaling pathway - Pseudopodoces humilis (Tibetan ground-tit)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
phi04010  MAPK signaling pathway
phi04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Pseudopodoces humilis (Tibetan ground-tit) [GN:phi]
Gene
102099121  [KO:K19663] [EC:2.7.11.13]
102099148  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
102099159  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
102099204  [KO:K04388] [EC:2.7.11.30]
102099229  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102099294  FGF4; fibroblast growth factor 4 [KO:K04358]
102099438  RAP1B; ras-related protein Rap-1b [KO:K07836]
102099537  FGF22; fibroblast growth factor 22 [KO:K04358]
102099568  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102099590  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
102099617  PGF; placenta growth factor isoform X1 [KO:K16859]
102099870  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102099919  CACNA1A; LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102099952  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102100012  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102100025  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X3 [KO:K04348] [EC:3.1.3.16]
102100267  FGF23; fibroblast growth factor 23 [KO:K22428]
102100311  PRKCA; protein kinase C alpha type isoform X2 [KO:K02677] [EC:2.7.11.13]
102100491  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
102100533  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102100550  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102100562  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102100592  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X3 [KO:K04733] [EC:2.7.11.1]
102100681  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102100701  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102100801  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102100827  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102100835  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102100883  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102100899  FGF8; fibroblast growth factor 8 [KO:K04358]
102100980  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102100999  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
102101107  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X4 [KO:K04428] [EC:2.7.11.25]
102101199  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102101219  HRAS; GTPase HRas [KO:K02833]
102101421  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102101445  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102101491  TP53; cellular tumor antigen p53 [KO:K04451]
102101539  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102101573  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
102101771  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
102101839  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X6 [KO:K04406] [EC:2.7.11.1]
102101993  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102102138  SOS1; son of sevenless homolog 1 [KO:K03099]
102102139  CRK; adapter molecule crk isoform X1 [KO:K04438]
102102208  MAX; protein max isoform X4 [KO:K04453]
102102245  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
102102248  TGFB3; transforming growth factor beta-3 [KO:K13377]
102102285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102102293  [KO:K04437]
102102399  FGF3; fibroblast growth factor 3 [KO:K04358]
102102426  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102102492  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102102554  [KO:K04424] [EC:2.7.11.25]
102102557  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
102102585  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
102102589  FGF19; fibroblast growth factor 19 [KO:K22603]
102102631  CRKL; crk-like protein [KO:K04438]
102102657  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102102678  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102102693  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102102818  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102102877  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
102102932  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102103084  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
102103099  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
102103169  ANGPT1; angiopoietin-1 [KO:K05465]
102103181  FOS; proto-oncogene c-Fos [KO:K04379]
102103258  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102103301  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102103364  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102103462  FGF18; fibroblast growth factor 18 [KO:K04358]
102103492  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102103513  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102103559  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
102103577  NRTN; neurturin [KO:K25414]
102103637  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102103712  FGF9; fibroblast growth factor 9 [KO:K04358]
102103717  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102103747  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
102103765  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102103825  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102103941  JUND; transcription factor jun-D [KO:K04449]
102104037  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102104081  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
102104127  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102104207  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
102104322  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102104366  [KO:K04864]
102104483  BDNF; brain-derived neurotrophic factor [KO:K04355]
102104707  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
102104728  FGF2; fibroblast growth factor 2 [KO:K18497]
102104762  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102104798  RELB; transcription factor RelB [KO:K09253]
102104813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102104824  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102104959  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102105113  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102105117  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102105125  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102105183  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102105200  FGF16; fibroblast growth factor 16 [KO:K04358]
102105250  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102105264  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102105268  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102105313  ANGPT4; angiopoietin-4 [KO:K05467]
102105390  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102105408  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102105425  ARTN; artemin [KO:K25415]
102105460  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102105524  SRF; serum response factor [KO:K04378]
102105530  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
102105828  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102105891  RELA; transcription factor p65 [KO:K04735]
102106058  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102106065  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102106069  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
102106096  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X2 [KO:K04863]
102106150  [KO:K05866] [EC:3.1.3.48]
102106217  IL1R1; interleukin-1 receptor type 1 isoform X2 [KO:K04386]
102106236  [KO:K16342] [EC:3.1.1.4]
102106254  CDC42; cell division control protein 42 homolog [KO:K04393]
102106364  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102106384  TRAF2; TNF receptor-associated factor 2 isoform X4 [KO:K03173] [EC:2.3.2.27]
102106389  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102106412  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
102106417  [KO:K17534] [EC:2.7.11.25]
102106432  [KO:K16342] [EC:3.1.1.4]
102106559  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
102106610  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
102106617  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102106744  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102106810  STK4; serine/threonine-protein kinase 4 [KO:K04411]
102106833  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102106942  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102106969  PDGFC; platelet-derived growth factor C [KO:K05450]
102107124  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102107194  STMN1; stathmin [KO:K04381]
102107277  ZNF653; zinc finger protein 653 [KO:K04405]
102107299  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102107321  EREG; proepiregulin [KO:K09784]
102107403  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102107441  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102107459  FGF10; fibroblast growth factor 10 [KO:K04358]
102107463  DAXX; death domain-associated protein 6 [KO:K02308]
102107711  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
102107801  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102107854  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102108061  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
102108122  FIGF; vascular endothelial growth factor D [KO:K05449]
102108158  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102108298  MEF2C; myocyte-specific enhancer factor 2C isoform X3 [KO:K04454]
102108455  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
102108458  [KO:K05096] [EC:2.7.10.1]
102108460  [KO:K04421] [EC:2.7.11.25]
102108461  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102108508  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
102108511  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
102108567  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102108615  STK3; serine/threonine-protein kinase 3 [KO:K04412]
102108626  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
102108627  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102108659  IL1B; interleukin-1 beta [KO:K04519]
102108835  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102108851  MYC; myc proto-oncogene protein [KO:K04377]
102108887  HSPB1; heat shock protein beta-1 [KO:K04455]
102108932  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102109017  TGFA; protransforming growth factor alpha [KO:K08774]
102109055  [KO:K16342] [EC:3.1.1.4]
102109120  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102109164  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102109199  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102109241  [KO:K16342] [EC:3.1.1.4]
102109398  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102109420  [KO:K16342] [EC:3.1.1.4]
102109433  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
102109473  PPM1B; protein phosphatase 1B [KO:K04461] [EC:3.1.3.16]
102109500  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102109535  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
102109553  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102109599  [KO:K16342] [EC:3.1.1.4]
102109636  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102109663  NF1; neurofibromin isoform X2 [KO:K08052]
102109689  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
102109777  [KO:K16342] [EC:3.1.1.4]
102109818  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102109820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102109925  NTF3; neurotrophin-3 [KO:K04356]
102109958  [KO:K16342] [EC:3.1.1.4]
102110009  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
102110049  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102110075  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102110174  [KO:K04873]
102110220  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102110285  NRAS; GTPase NRas [KO:K07828]
102110749  FGF20; fibroblast growth factor 20 [KO:K04358]
102110772  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102110807  [KO:K04441] [EC:2.7.11.24]
102110832  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
102110989  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102111004  [KO:K04441] [EC:2.7.11.24]
102111016  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04865]
102111111  AREG; LOW QUALITY PROTEIN: amphiregulin [KO:K09782]
102111116  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
102111137  KITLG; kit ligand isoform X1 [KO:K05461]
102111139  MRAS; ras-related protein M-Ras [KO:K07831]
102111160  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
102111203  INS; insulin [KO:K04526]
102111242  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102111338  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102111343  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102111358  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102111387  IGF2; insulin-like growth factor II [KO:K13769]
102111404  NGF; beta-nerve growth factor [KO:K02582]
102111436  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102111524  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102111634  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102111644  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102111930  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102111999  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102112025  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
102112031  FGF5; fibroblast growth factor 5 [KO:K04358]
102112033  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102112153  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102112187  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
102112236  JUN; transcription factor AP-1 [KO:K04448]
102112281  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
102112465  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102112513  EFNA1; ephrin-A1 [KO:K05462]
102112636  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
102112685  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102112698  EFNA5; ephrin-A5 [KO:K05462]
102112703  EFNA4; ephrin-A4 [KO:K05462]
102112765  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
102112781  TGFB1; transforming growth factor beta-1 [KO:K13375]
102112800  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102112828  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102112832  EFNA2; ephrin-A2 [KO:K05462]
102112867  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102112893  KRAS; GTPase KRas [KO:K07827]
102112946  IGF1; insulin-like growth factor I [KO:K05459]
102112975  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
102112980  EGF; pro-epidermal growth factor [KO:K04357]
102113050  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
102113190  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102113267  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
102113293  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
102113307  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
102113324  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
102113348  PPP5D1; protein PPP5D1 [KO:K04460] [EC:3.1.3.16]
102113463  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X2 [KO:K04466] [EC:2.7.11.25]
102113468  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102113476  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102113493  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102113512  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102113646  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102113668  PPM1A; protein phosphatase 1A isoform X4 [KO:K04457] [EC:3.1.3.16]
102113891  FGF17; fibroblast growth factor 17 [KO:K04358]
102113899  [KO:K07210]
102114034  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102114105  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
102114147  FGF6; fibroblast growth factor 6 [KO:K04358]
102114163  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
102114178  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102114296  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102114309  SOS2; son of sevenless homolog 2 [KO:K03099]
102114381  VEGFA; vascular endothelial growth factor A isoform X3 [KO:K05448]
102114546  DUSP1; dual specificity protein phosphatase 1 isoform X2 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102114558  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102114598  TGFB2; transforming growth factor beta-2 [KO:K13376]
102114724  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102114753  EFNA3; ephrin-A3 [KO:K05462]
106628736  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
106628809  PSPN; persephin [KO:K25416]
106628898  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
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Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
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Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
phi04070  Phosphatidylinositol signaling system
phi04110  Cell cycle
phi04115  p53 signaling pathway
phi04210  Apoptosis
phi04310  Wnt signaling pathway
KO pathway
ko04010   

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