KEGG   PATHWAY: salp04382
Entry
salp04382                   Pathway                                
Name
Cornified envelope formation - Salvelinus sp. IW2-2015 (Arctic char)
Class
Organismal Systems; Development and regeneration
Pathway map
salp04382  Cornified envelope formation
salp04382

Organism
Salvelinus sp. IW2-2015 (Arctic char) [GN:salp]
Gene
111949477  [KO:K01372] [EC:3.4.22.40]
111949585  [KO:K06087]
111949647  [KO:K06087]
111949729  [KO:K06087]
111950041  [KO:K04354]
111950071  [KO:K06087]
111950277  [KO:K28333]
111950724  [KO:K06087]
111950793  [KO:K06087]
111950803  [KO:K06087]
111950817  [KO:K06087]
111950895  [KO:K06087]
111951179  [KO:K06087]
111951641  [KO:K07603]
111951713  [KO:K10383]
111951769  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
111951856  [KO:K04354]
111951887  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
111952022  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
111952030  [KO:K10383]
111952177  [KO:K06087]
111952551  [KO:K01367] [EC:3.4.22.52]
111952630  [KO:K10247] [EC:2.3.1.199]
111952700  [KO:K01349] [EC:3.4.21.75]
111952767  furin; furin isoform X1 [KO:K01349] [EC:3.4.21.75]
111952983  [KO:K10249] [EC:2.3.1.199]
111953040  [KO:K28333]
111953294  [KO:K06087]
111953464  [KO:K06087]
111953645  [KO:K06087]
111953649  [KO:K06087]
111953818  [KO:K06087]
111953841  [KO:K06087]
111954381  [KO:K11584]
111954525  [KO:K10249] [EC:2.3.1.199]
111954655  [KO:K11584]
111954757  [KO:K23761]
111954958  [KO:K23767]
111955164  [KO:K28333]
111955200  [KO:K23758]
111955331  [KO:K06087]
111955374  [KO:K17274]
111955590  [KO:K10388]
111955806  [KO:K23767]
111956005  [KO:K06087]
111956147  [KO:K28333]
111956149  [KO:K23758]
111956261  [KO:K06237]
111956308  [KO:K06237]
111956324  [KO:K06087]
111956506  [KO:K10381]
111956551  [KO:K05619] [EC:2.3.2.13]
111956590  [KO:K06240]
111956593  [KO:K06240]
111956607  [KO:K04708] [EC:1.1.1.102]
111956896  [KO:K10249] [EC:2.3.1.199]
111956972  [KO:K10247] [EC:2.3.1.199]
111957078  [KO:K07597]
111957090  [KO:K06246]
111957249  [KO:K08672] [EC:3.4.21.-]
111957369  [KO:K00720] [EC:2.4.1.80]
111957521  [KO:K06087]
111957527  [KO:K06087]
111957535  [KO:K06087]
111957879  [KO:K04354]
111957969  [KO:K06087]
111958770  [KO:K10388]
111958797  [KO:K23758]
111958944  [KO:K08670] [EC:3.4.21.109]
111958965  [KO:K08670] [EC:3.4.21.109]
111959002  [KO:K06087]
111959011  [KO:K06087]
111959019  [KO:K06087]
111959026  [KO:K06087]
111959046  [KO:K23765]
111959390  [KO:K06087]
111959482  [KO:K06237]
111959484  [KO:K06237]
111959672  [KO:K06087]
111959772  [KO:K06485]
111959909  [KO:K11583]
111960129  [KO:K10386]
111960207  [KO:K06087]
111960339  [KO:K06087]
111960488  [KO:K01372] [EC:3.4.22.40]
111960566  [KO:K03456]
111960642  [KO:K06087]
111960646  [KO:K06237]
111960900  [KO:K01367] [EC:3.4.22.52]
111961263  slc27a4; long-chain fatty acid transport protein 4 [KO:K08745] [EC:6.2.1.-]
111961273  [KO:K07604]
111961541  [KO:K04354]
111961732  [KO:K06088]
111961848  [KO:K05622] [EC:2.3.2.13]
111961930  [KO:K04382] [EC:3.1.3.16]
111961971  sptlc1; serine palmitoyltransferase 1 [KO:K00654] [EC:2.3.1.50]
111962247  [KO:K07604]
111962262  [KO:K07605]
111962271  [KO:K07605]
111962447  [KO:K01349] [EC:3.4.21.75]
111962795  hal; histidine ammonia-lyase [KO:K01745] [EC:4.3.1.3]
111963000  [KO:K06244]
111963159  [KO:K06087]
111963430  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
111963686  [KO:K06087]
111963743  [KO:K06087]
111963815  [KO:K04382] [EC:3.1.3.16]
111963877  [KO:K06087]
111964087  [KO:K04354]
111964128  [KO:K06087]
111964244  [KO:K08670] [EC:3.4.21.109]
111964347  [KO:K01367] [EC:3.4.22.52]
111964428  [KO:K06087]
111964429  [KO:K06087]
111964431  [KO:K06087]
111964432  [KO:K06087]
111964433  [KO:K06087]
111964434  [KO:K06087]
111964435  [KO:K06087]
111964436  [KO:K06087]
111964805  cldn12; claudin-12 [KO:K06087]
111965030  [KO:K28333]
111965104  [KO:K23758]
111965926  [KO:K06485]
111965999  [KO:K04382] [EC:3.1.3.16]
111966387  [KO:K28344]
111966853  [KO:K07605]
111966854  [KO:K07605]
111966855  [KO:K07604]
111966856  [KO:K07604]
111967189  [KO:K07603]
111967407  cldn19; claudin-19 [KO:K06087]
111967974  [KO:K01481] [EC:3.5.3.15]
111968238  [KO:K06525]
111968269  [KO:K10382]
111968412  sptlc2; serine palmitoyltransferase 2 [KO:K00654] [EC:2.3.1.50]
111968652  ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
111968837  [KO:K06087]
111968941  [KO:K11584]
111969103  [KO:K05701]
111969435  [KO:K01349] [EC:3.4.21.75]
111969729  [KO:K10387]
111969805  [KO:K28344]
111969963  [KO:K01481] [EC:3.5.3.15]
111970040  [KO:K06087]
111970371  [KO:K06244]
111970452  [KO:K07605]
111970453  [KO:K07605]
111970454  [KO:K07604]
111970468  [KO:K10387]
111970538  [KO:K07605]
111970554  [KO:K10387]
111970676  [KO:K16628]
111970785  [KO:K06087]
111970932  [KO:K06087]
111970982  [KO:K07604]
111971189  [KO:K06240]
111971218  [KO:K10381]
111971672  [KO:K06237]
111972208  [KO:K06087]
111972247  [KO:K05619] [EC:2.3.2.13]
111972603  [KO:K06087]
111972729  [KO:K11584]
111972790  [KO:K00654] [EC:2.3.1.50]
111972916  [KO:K18684] [EC:4.2.1.152 5.4.4.7]
111972973  [KO:K05646]
111973191  [KO:K18684] [EC:4.2.1.152 5.4.4.7]
111973296  [KO:K06087]
111973471  [KO:K10249] [EC:2.3.1.199]
111974070  [KO:K01349] [EC:3.4.21.75]
111974262  [KO:K04354]
111974279  [KO:K04382] [EC:3.1.3.16]
111974518  [KO:K05701]
111974623  [KO:K16628]
111974765  [KO:K06087]
111974872  [KO:K07604]
111974907  [KO:K06087]
111975116  [KO:K06485]
111975287  [KO:K05619] [EC:2.3.2.13]
111975461  [KO:K07597]
111975462  [KO:K07597]
111975539  [KO:K10381]
111975908  [KO:K06087]
111975923  [KO:K01349] [EC:3.4.21.75]
111976123  [KO:K10247] [EC:2.3.1.199]
111976645  [KO:K07604]
111976671  [KO:K07605]
111976922  [KO:K05622] [EC:2.3.2.13]
111977284  [KO:K07605]
111977567  [KO:K10382]
111978157  [KO:K04354]
111978250  [KO:K06087]
111978953  [KO:K06237]
111978963  [KO:K06087]
111979095  [KO:K06237]
111979160  [KO:K07597]
111979340  [KO:K04708] [EC:1.1.1.102]
111979477  [KO:K06246]
111979561  [KO:K06485]
111979615  [KO:K06240]
111979698  [KO:K06088]
111979761  [KO:K10381]
111979783  [KO:K10247] [EC:2.3.1.199]
111979818  [KO:K06087]
111979931  [KO:K07604]
111980048  [KO:K07604]
111980080  [KO:K07604]
111980309  [KO:K07604]
111980461  evpl; envoplakin [KO:K10383]
111980762  [KO:K06087]
111981006  [KO:K07604]
111981188  [KO:K04382] [EC:3.1.3.16]
111981473  [KO:K07604]
111981509  [KO:K07604]
111981758  [KO:K12642]
111982072  [KO:K08745] [EC:6.2.1.-]
111982316  [KO:K07604]
111982360  [KO:K10056]
111982367  [KO:K07604]
111982368  [KO:K07604]
111982372  [KO:K07604]
111982393  [KO:K07604]
111982437  [KO:K07604]
111982454  [KO:K07604]
111982514  [KO:K06087]
111982613  [KO:K07604]
111982763  [KO:K03456]
111982781  [KO:K06087]
111982784  [KO:K06087]
111982785  [KO:K06087]
111982786  [KO:K06087]
112067742  [KO:K07605]
112067864  [KO:K06087]
112068018  [KO:K10056]
112068336  [KO:K06237]
112068511  [KO:K17274]
112068512  [KO:K17274]
112068791  cldn18; claudin-18 [KO:K06087]
112068935  ocln; occludin [KO:K06088]
112069012  ugcg; LOW QUALITY PROTEIN: ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
112069053  [KO:K04354]
112069371  [KO:K04382] [EC:3.1.3.16]
112069495  [KO:K01367] [EC:3.4.22.52]
112069675  [KO:K04382] [EC:3.1.3.16]
112069729  [KO:K04354]
112070452  [KO:K11584]
112070645  [KO:K23761]
112070779  [KO:K07603]
112070783  [KO:K23768]
112070789  [KO:K23758]
112070790  [KO:K23765]
112071106  [KO:K06087]
112071207  [KO:K07605]
112071588  [KO:K06087]
112071651  ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
112071942  [KO:K01201] [EC:3.2.1.45]
112072304  [KO:K06087]
112072511  [KO:K06088]
112072581  [KO:K11584]
112072736  [KO:K06237]
112072827  [KO:K06087]
112073114  [KO:K06087]
112073195  gba2; non-lysosomal glucosylceramidase [KO:K17108] [EC:3.2.1.45]
112073331  [KO:K00654] [EC:2.3.1.50]
112073472  [KO:K04354]
112074125  [KO:K00654] [EC:2.3.1.50]
112074730  [KO:K06087]
112074734  [KO:K06087]
112074822  [KO:K01745] [EC:4.3.1.3]
112075142  [KO:K23761]
112075267  [KO:K08745] [EC:6.2.1.-]
112075388  [KO:K11583]
112076182  [KO:K23765]
112077603  [KO:K06087]
112077887  [KO:K23761]
112079099  [KO:K23758]
112079311  [KO:K12642]
112079443  [KO:K06087]
112080163  [KO:K01201] [EC:3.2.1.45]
112080442  [KO:K06087]
112080649  [KO:K06525]
112080903  [KO:K06087]
Compound
C00064  L-Glutamine
C00076  Calcium cation
C00135  L-Histidine
C00154  Palmitoyl-CoA
C00162  Fatty acid
C00187  Cholesterol
C00785  Urocanate
C00836  Sphinganine
C01879  5-Oxoproline
C02934  3-Dehydrosphinganine
C22352  Ultra-long-chain fatty acid
C22353  Ultra-long-chain omega-hydroxy fatty acid
C23027  Ultra-long-chain omega-hydroxy fatty acyl-CoA
C23028  Ultra-long-chain omega-hydroxyceramide
C23029  linoleate-esterified acylceramide
C23030  Acylglucosylceramide
Reference
PMID:15803139
  Authors
Candi E, Schmidt R, Melino G
  Title
The cornified envelope: a model of cell death in the skin.
  Journal
Nat Rev Mol Cell Biol 6:328-40 (2005)
DOI:10.1038/nrm1619
Reference
PMID:29153780
  Authors
Egawa G, Kabashima K
  Title
Barrier dysfunction in the skin allergy.
  Journal
Allergol Int 67:3-11 (2018)
DOI:10.1016/j.alit.2017.10.002
Reference
PMID:32218335
  Authors
Ishitsuka Y, Roop DR
  Title
Loricrin: Past, Present, and Future.
  Journal
Int J Mol Sci 21:ijms21072271 (2020)
DOI:10.3390/ijms21072271
Reference
PMID:34639001
  Authors
Gallegos-Alcala P, Jimenez M, Cervantes-Garcia D, Salinas E
  Title
The Keratinocyte as a Crucial Cell in the Predisposition, Onset, Progression, Therapy and Study of the Atopic Dermatitis.
  Journal
Int J Mol Sci 22:ijms221910661 (2021)
DOI:10.3390/ijms221910661
Reference
PMID:30776025
  Authors
Goleva E, Berdyshev E, Leung DY
  Title
Epithelial barrier repair and prevention of allergy.
  Journal
J Clin Invest 129:1463-1474 (2019)
DOI:10.1172/JCI124608
Reference
PMID:23954553
  Authors
Breiden B, Sandhoff K
  Title
The role of sphingolipid metabolism in cutaneous permeability barrier formation.
  Journal
Biochim Biophys Acta 1841:441-52 (2014)
DOI:10.1016/j.bbalip.2013.08.010
Reference
PMID:31974308
  Authors
Yamamoto H, Hattori M, Chamulitrat W, Ohno Y, Kihara A
  Title
Skin permeability barrier formation by the ichthyosis-causative gene FATP4 through formation of the barrier lipid omega-O-acylceramide.
  Journal
Proc Natl Acad Sci U S A 117:2914-2922 (2020)
DOI:10.1073/pnas.1917525117
Reference
PMID:36902463
  Authors
Ge F, Sun K, Hu Z, Dong X
  Title
Role of Omega-Hydroxy Ceramides in Epidermis: Biosynthesis, Barrier Integrity and Analyzing Method.
  Journal
Int J Mol Sci 24:ijms24055035 (2023)
DOI:10.3390/ijms24055035
Related
pathway
salp00600  Sphingolipid metabolism
KO pathway
ko04382   

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