KEGG   PATHWAY: sbq04621
Entry
sbq04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
sbq04621  NOD-like receptor signaling pathway
sbq04621

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101032974  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
101030587  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
101043425  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101044006  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101052971  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104650103  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
101048714  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101035787  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101035406  RELA; transcription factor p65 [KO:K04735]
101033664  IL1B; interleukin-1 beta [KO:K04519]
101027404  IL18; interleukin-18 [KO:K05482]
101034757  IL6; interleukin-6 [KO:K05405]
101031357  TNF; tumor necrosis factor isoform X2 [KO:K03156]
101049298  CXCL8; interleukin-8 [KO:K10030]
101048540  C-X-C motif chemokine 2 [KO:K05505]
101052050  CCL2; C-C motif chemokine 2 [KO:K14624]
101053219  CCL5; C-C motif chemokine 5 [KO:K12499]
101039558  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
101046624  neutrophil defensin 1-like isoform X2 [KO:K05230]
101047148  defensin-5 [KO:K05230]
101049999  neutrophil defensin 4 [KO:K05230]
104650356  theta defensin subunit A-like [KO:K05230]
104650357  defensin-5-like [KO:K05230]
101050964  theta defensin subunit A-like [KO:K05230]
101047470  beta-defensin 4A-like [KO:K21100]
101047788  beta-defensin 103 [KO:K23126]
101034571  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
101045636  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101041553  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X3 [KO:K04403]
101040230  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101029958  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
101038546  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101043202  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101039160  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101027742  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101048066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101037444  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101044137  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101040899  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101052690  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101043809  JUN; transcription factor AP-1 [KO:K04448]
101052514  ATG16L1; autophagy-related protein 16-1 isoform X2 [KO:K17890]
101033513  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
101042519  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
101031788  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
101045502  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
101049912  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101047075  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101028665  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101032297  SUGT1; suppressor of G2 allele of SKP1 homolog [KO:K12795]
101027416  sharpin [KO:K20894]
101038299  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
101048716  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
101031174  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101031146  CARD6; caspase recruitment domain-containing protein 6 [KO:K12797]
101048551  TRIP6; thyroid receptor-interacting protein 6 [KO:K12792]
101035027  ERBB2IP; protein LAP2 isoform X2 [KO:K12796]
101043827  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
101027816  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
101035434  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101031994  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
101033308  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
101039669  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
101052980  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
101035231  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101043245  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
101053608  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101027871  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101044125  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
101033122  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101034616  IRF7; interferon regulatory factor 7 [KO:K09447]
101032308  interferon alpha-8-like [KO:K05414]
101032622  interferon alpha-2-like [KO:K05414]
101032943  IFNA13; interferon alpha-1/13 [KO:K05414]
104649849  interferon alpha-5-like [KO:K05414]
101034105  interferon alpha-8-like [KO:K05414]
101034416  interferon alpha-5-like [KO:K05414]
101034728  IFNA21; interferon alpha-21 [KO:K05414]
101035681  IFNB1; interferon beta [KO:K05415]
101046794  NLRX1; NLR family member X1 [KO:K12653]
101031122  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
101053386  ANTXR1; anthrax toxin receptor 1 isoform X1 [KO:K20909]
101052367  NLRP1; NACHT, LRR and PYD domains-containing protein 1 isoform X1 [KO:K12798]
101037266  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
101048062  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
101051366  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
101039294  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101047879  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
101032875  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
101037782  PANX1; pannexin-1 [KO:K03443]
101046955  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
101030727  TRPM2; transient receptor potential cation channel subfamily M member 2 [KO:K04977] [EC:3.6.1.13]
101052786  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
101042064  TRPV2; transient receptor potential cation channel subfamily V member 2 [KO:K04971]
101044482  CASR; extracellular calcium-sensing receptor [KO:K04612]
101031009  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
101046851  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
101047168  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
101052271  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
101029401  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
101029556  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101049881  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101048916  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101031406  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104649961  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
101038914  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
101045138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101031167  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
101043239  OAS2; 2'-5'-oligoadenylate synthase 2 isoform X1 [KO:K14216] [EC:2.7.7.84]
101043563  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101043879  OAS1; 2'-5'-oligoadenylate synthase 1 isoform X1 [KO:K14216] [EC:2.7.7.84]
101039040  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
101054190  DHX33; LOW QUALITY PROTEIN: putative ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
101033894  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
101041459  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
101047042  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
101046389  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
101039686  DNM1L; dynamin-1-like protein isoform X3 [KO:K17065] [EC:3.6.5.5]
101047935  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
101052306  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101045425  cytochrome b-245 light chain [KO:K08009]
101039571  TXNIP; thioredoxin-interacting protein [KO:K20910]
101036752  TXN2; thioredoxin, mitochondrial [KO:K03671]
101037557  TXN; thioredoxin [KO:K03671]
101034197  thioredoxin-like [KO:K03671]
101035094  NEK7; serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
101051789  lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
101053947  BRCC3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
101033641  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101035124  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101039180  heat shock protein HSP 90-beta [KO:K04079]
101051018  heat shock protein 90 homolog [KO:K04079]
101028609  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
101036489  CARD8; caspase recruitment domain-containing protein 8 [KO:K12801]
101044931  GPSM3; G-protein-signaling modulator 3 isoform X1 [KO:K15838]
101036319  PYDC1; pyrin domain-containing protein 1 [KO:K12802]
101045359  MEFV; pyrin [KO:K12803]
101052332  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X2 [KO:K12804]
101053601  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101046905  FADD; FAS-associated death domain protein [KO:K02373]
101049025  CARD18; caspase recruitment domain-containing protein 18 [KO:K12806]
101038433  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
101051594  NLRP7; NACHT, LRR and PYD domains-containing protein 7 isoform X1 [KO:K20864]
101040773  NLRP12; NACHT, LRR and PYD domains-containing protein 12 [KO:K20865]
101044546  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
101048415  GBP2; interferon-induced guanylate-binding protein 2 [KO:K20897]
101048730  GBP5; guanylate-binding protein 5 [KO:K20898]
101049716  LOW QUALITY PROTEIN: interferon-inducible protein AIM2 [KO:K12966]
101044662  uncharacterized protein LOC101044662 [KO:K20914]
101054387  TP53BP1; tumor suppressor p53-binding protein 1 isoform X2 [KO:K20915]
101052068  RHOA; transforming protein RhoA [KO:K04513]
104650592  ras-like GTP-binding protein O-RHO [KO:K04513]
104652261  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
101035022  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
101049988  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
101040886  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101030406  GBP4; guanylate-binding protein 4 [KO:K20899]
101048089  GBP1; interferon-induced guanylate-binding protein 1 [KO:K20899]
101049043  LOW QUALITY PROTEIN: guanylate-binding protein 3 [KO:K20899]
101030717  GBP7; guanylate-binding protein 7 [KO:K20899]
101048389  caspase-4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
101047124  GSDMD; gasdermin-D isoform X2 [KO:K20917]
101035044  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101031615  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101028662  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101030811  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101029836  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
101051991  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
101043935  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101041287  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101052794  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101029005  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
101032869  TMEM173; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
sbq04010  MAPK signaling pathway
sbq04064  NF-kappa B signaling pathway
sbq04140  Autophagy - animal
sbq04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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