KEGG   PATHWAY: srx03040
Entry
srx03040                    Pathway                                
Name
Spliceosome - Sinocyclocheilus rhinocerous
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
srx03040  Spliceosome
srx03040

Other DBs
GO: 0005681
Organism
Sinocyclocheilus rhinocerous [GN:srx]
Gene
107705380  [KO:K12822]
107705433  [KO:K12893]
107705723  [KO:K11091]
107705733  [KO:K12858] [EC:3.6.4.13]
107705744  [KO:K12855]
107705832  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
107706130  [KO:K12857]
107706346  [KO:K12875]
107706358  [KO:K12884]
107706906  [KO:K12818] [EC:3.6.4.13]
107706979  [KO:K11099]
107707002  [KO:K12741]
107707310  [KO:K12884]
107707363  [KO:K12741]
107709666  [KO:K21123]
107709765  [KO:K12838]
107710252  [KO:K12622]
107710575  [KO:K12842]
107710715  [KO:K19604]
107710959  [KO:K11096]
107711255  xab2; pre-mRNA-splicing factor SYF1 isoform X1 [KO:K12867]
107711331  [KO:K12812] [EC:3.6.4.13]
107711694  [KO:K12878]
107711734  [KO:K12844]
107712085  ppil1; peptidyl-prolyl cis-trans isomerase-like 1 [KO:K12733] [EC:5.2.1.8]
107712108  [KO:K12892]
107712564  srsf7; serine/arginine-rich splicing factor 7 [KO:K12896]
107713137  [KO:K12890]
107713190  [KO:K12824]
107713244  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:3.6.4.13]
107713435  [KO:K03283]
107713612  [KO:K12811] [EC:3.6.4.13]
107714048  [KO:K12890]
107714268  [KO:K12893]
107714453  [KO:K11096]
107714468  [KO:K12893]
107714657  [KO:K12862]
107714859  [KO:K12842]
107714994  [KO:K12741]
107715032  [KO:K11099]
107715383  [KO:K11984]
107715422  [KO:K12848]
107715445  [KO:K12815] [EC:3.6.4.13]
107715903  [KO:K12836]
107716003  [KO:K09564] [EC:5.2.1.8]
107716468  [KO:K12624]
107716574  [KO:K12831]
107716835  [KO:K12844]
107716923  hnrnpa3; heterogeneous nuclear ribonucleoprotein A3 [KO:K12741]
107717096  [KO:K12839]
107717936  [KO:K12621]
107718021  [KO:K12838]
107719095  [KO:K12888]
107719105  [KO:K12833]
107719195  [KO:K12843]
107719416  crnkl1; LOW QUALITY PROTEIN: crooked neck-like protein 1 [KO:K12869]
107719628  [KO:K12887]
107719800  [KO:K12828]
107719842  sf3a3; splicing factor 3A subunit 3 [KO:K12827]
107719961  [KO:K12817]
107720055  [KO:K12873]
107720299  [KO:K12860]
107720345  lsm3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
107721197  [KO:K12892]
107721313  [KO:K12893]
107721406  [KO:K12872]
107721576  [KO:K12836]
107721635  [KO:K12662]
107721862  [KO:K09564] [EC:5.2.1.8]
107722005  [KO:K12893]
107722213  [KO:K12891]
107722749  [KO:K12847]
107722899  [KO:K12892]
107723127  [KO:K12855]
107723600  [KO:K12823] [EC:3.6.4.13]
107724107  [KO:K12837]
107724177  [KO:K12858] [EC:3.6.4.13]
107724340  [KO:K19604]
107724393  [KO:K12838]
107724520  snrpc; U1 small nuclear ribonucleoprotein C [KO:K11095]
107724588  [KO:K12868]
107724853  [KO:K12837]
107724880  [KO:K11088]
107724892  snrnp200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:3.6.4.13]
107724996  [KO:K12900]
107725199  [KO:K12849]
107725297  [KO:K12861]
107725443  [KO:K12832]
107725812  [KO:K12741]
107725853  hnrnpu; heterogeneous nuclear ribonucleoprotein U [KO:K12888]
107726001  [KO:K12627]
107726072  [KO:K12820] [EC:3.6.4.13]
107726326  [KO:K12826]
107726686  [KO:K12876]
107726704  rbm25; RNA-binding protein 25 [KO:K12822]
107726815  [KO:K12845]
107727065  [KO:K12896]
107727252  [KO:K12824]
107727519  [KO:K12878]
107727778  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
107727915  [KO:K12890]
107727957  [KO:K12624]
107728025  sf3b2; splicing factor 3B subunit 2 [KO:K12829]
107728108  cdc40; LOW QUALITY PROTEIN: pre-mRNA-processing factor 17 [KO:K12816]
107728199  [KO:K12886]
107728230  [KO:K13098]
107728485  [KO:K12876]
107728570  [KO:K12887]
107729248  [KO:K12842]
107729300  [KO:K12888]
107729450  [KO:K11093]
107729497  [KO:K12835] [EC:3.6.4.13]
107729526  [KO:K13098]
107729809  [KO:K12900]
107730045  [KO:K12900]
107730329  [KO:K12886]
107730443  [KO:K12850]
107730757  [KO:K11093]
107730759  [KO:K12835] [EC:3.6.4.13]
107730915  [KO:K12880]
107731090  [KO:K12852]
107731141  [KO:K12877]
107731403  [KO:K12834]
107731643  [KO:K12849]
107731751  [KO:K12828]
107731871  [KO:K11098]
107731957  [KO:K12890]
107732376  [KO:K12833]
107732397  [KO:K12888]
107732485  [KO:K12822]
107732607  [KO:K12863]
107733416  [KO:K12879]
107733427  prpf19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
107733509  [KO:K12848]
107733950  cdc5l; cell division cycle 5-like protein [KO:K12860]
107733969  [KO:K09567] [EC:5.2.1.8]
107734195  [KO:K12834]
107734269  [KO:K12868]
107734484  prpf40a; pre-mRNA-processing factor 40 homolog A [KO:K12821]
107734517  [KO:K12861]
107734584  lsm6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
107736331  [KO:K12870]
107736490  [KO:K12893]
107736553  [KO:K11088]
107736561  [KO:K12733] [EC:5.2.1.8]
107736927  [KO:K11088]
107736959  [KO:K12893]
107737342  [KO:K12900]
107737741  [KO:K12873]
107737761  [KO:K13098]
107738052  [KO:K11098]
107738206  [KO:K12875]
107738208  [KO:K12884]
107738342  [KO:K12815] [EC:3.6.4.13]
107738735  sf3b3; splicing factor 3B subunit 3 isoform X1 [KO:K12830]
107738889  [KO:K12816]
107739189  [KO:K12816]
107739404  [KO:K03283]
107739522  [KO:K12837]
107739570  [KO:K12897]
107739996  [KO:K12847]
107740072  [KO:K13025] [EC:3.6.4.13]
107740291  snrpb; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086]
107741110  [KO:K12880]
107741361  [KO:K12819]
107741598  [KO:K12879]
107742128  [KO:K12838]
107742278  [KO:K12875]
107742305  [KO:K11092]
107742793  [KO:K12841]
107742865  snrnp40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
107743018  [KO:K12881]
107743087  [KO:K12825]
107743233  [KO:K12871]
107743282  [KO:K11097]
107743616  [KO:K12832]
107743637  [KO:K12856]
107743661  [KO:K12627]
107743787  [KO:K12818] [EC:3.6.4.13]
107743802  [KO:K12662]
107743931  [KO:K12827]
107744300  [KO:K12837]
107744347  [KO:K11086]
107744373  [KO:K11095]
107744510  rbmx; RNA-binding motif protein, X chromosome [KO:K12885]
107745199  [KO:K03283]
107745271  [KO:K12821]
107745681  [KO:K12845]
107745791  [KO:K12877]
107745910  [KO:K12869]
107746364  [KO:K12896]
107746377  [KO:K12842]
107746969  prpf3; U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
107747002  [KO:K03283]
107747083  [KO:K12623]
107747200  sf3a1; splicing factor 3A subunit 1 [KO:K12825]
107747222  [KO:K12865]
107747436  [KO:K11094]
107747811  [KO:K12863]
107747960  [KO:K06063]
107748065  [KO:K12829]
107748105  [KO:K12872]
107748229  [KO:K11091]
107748463  [KO:K12840]
107748584  [KO:K03283]
107748675  [KO:K12897]
107748689  txnl4a; thioredoxin-like protein 4A [KO:K12859]
107748799  [KO:K12823] [EC:3.6.4.13]
107748861  [KO:K12881]
107748959  ppih; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
107749180  [KO:K12850]
107749677  pqbp1; polyglutamine-binding protein 1 [KO:K12865]
107749892  [KO:K12897]
107750226  [KO:K12826]
107750321  ncbp1; nuclear cap-binding protein subunit 1 [KO:K12882]
107750324  [KO:K12824]
107750678  [KO:K12892]
107750863  [KO:K12839]
107751242  [KO:K11097]
107751323  [KO:K12824]
107751343  [KO:K12882]
107751398  [KO:K03283]
107751522  [KO:K12884]
107751605  [KO:K12866]
107751697  [KO:K11087]
107751822  [KO:K11087]
107752053  [KO:K12885]
107752098  dhx16; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 isoform X1 [KO:K12813] [EC:3.6.4.13]
107752202  ctnnbl1; beta-catenin-like protein 1 [KO:K12864]
107752553  [KO:K12886]
107752634  [KO:K12621]
107752723  aqr; intron-binding protein aquarius [KO:K12874]
107752847  [KO:K12871]
107752881  [KO:K12897]
107753298  [KO:K12845]
107753477  [KO:K12831]
107753736  [KO:K12841]
107753747  [KO:K12841]
107753932  [KO:K12875]
107754559  [KO:K12741]
107754831  [KO:K12812] [EC:3.6.4.13]
107754925  [KO:K12893]
107754997  [KO:K12852]
107755150  [KO:K12840]
107755521  [KO:K12891]
107755641  [KO:K11092]
107755814  snrnp27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
107756021  lsm7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
107756174  [KO:K11984]
107756424  [KO:K12883]
107756482  [KO:K12819]
107756601  [KO:K12893]
107756948  [KO:K12856]
107757042  snrpb2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
107757092  [KO:K12822]
107757340  [KO:K12867]
107757432  [KO:K12886]
107757551  [KO:K12896]
107757621  [KO:K12862]
107757870  [KO:K12811] [EC:3.6.4.13]
107757920  [KO:K12623]
107758467  [KO:K12872]
107758775  [KO:K12837]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   

DBGET integrated database retrieval system