 Polyketide synthase (PKS)
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 Modular type I PKS
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Iterative type I PKS
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Type II PKS
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C9-C14 cyclized polyketide type
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C7-C14 cyclized polyketide type
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Octaketide PKS
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 K05551 actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05552 actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05553 actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
K12420 actIII, oxyJ, snoaD, aknA; ketoreductase [EC:1.1.1.-]
K05554 actVII; aromatase [EC:4.2.1.-]
K05555 actIV; cyclase [EC:4.-.-.-]
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Nonaketide PKS
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K05551 actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05552 actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05553 actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
K12420 actIII, oxyJ, snoaD, aknA; ketoreductase [EC:1.1.1.-]
K14249 oxyK; bifunctional cyclase/aromatase [EC:4.2.1.-]
K14250 oxyN, snoaM, dpsY, aknW, mtmY; cyclase
K15926 jadI; cyclase
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Decaketide PKS
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K05551 actI1, oxyA, tcmK, snoa1, aknB, mtmP; minimal PKS ketosynthase (KS/KS alpha) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05552 actI2, oxyB, tcmL, snoa2, aknC, mtmK; minimal PKS chain-length factor (CLF/KS beta) [EC:2.3.1.- 2.3.1.260 2.3.1.235]
K05553 actI3, oxyC, tcmM, snoa3, aknD, mtmS; minimal PKS acyl carrier protein
K12420 actIII, oxyJ, snoaD, aknA; ketoreductase [EC:1.1.1.-]
K14250 oxyN, snoaM, dpsY, aknW, mtmY; cyclase
K15884 snoaE, aknE1; bifunctional aromatase (cyclase/dehydratase) [EC:4.2.1.-]
K15886 tcmN; multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235]
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Type III PKS
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PKS-NRPS hybrid
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Nonribosomal peptide synthetase (NRPS)
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Linear NRPS
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Emericellamide synthetase
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Cyanopeptolin synthetase
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ACV synthetase
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Bacitracin synthetase
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Viomycin synthetase
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Pristinamycin I synthetase
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Tyrocidine synthetase
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Surfactin family lipopeptide synthetase
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Iturin family lipopeptide synthetase
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Fengycin family lipopeptide synthetase
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Arthrofactin type cyclic lipopeptide synthetase
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Vancomycin synthetase
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Nocardicin synthetase
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Bialaphos synthetase
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L-2-amino-4-methoxy-trans-3-butenoic acid synthetase
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Anabaenopeptin synthetase
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K28594 aptA; anabaenopeptin synthetase AptA
K28595 aptB; anabaenopeptin synthetase AptB
K28596 aptC; anabaenopeptin synthetase AptC
K28597 aptD; anabaenopeptin synthetase AptD
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Linear gramicidin synthetase
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Iterative NRPS
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Nonlinear NRPS
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Yersiniabactin synthetase
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Pyochelin synthetase
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Mycobactin synthetase
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K04787 mbtA; mycobactin salicyl-AMP ligase [EC:6.3.2.-]
K04788 mbtB; mycobactin phenyloxazoline synthetase
K04790 mbtC; mycobactin polyketide synthetase MbtC
K04791 mbtD; mycobactin polyketide synthetase MbtD
K04789 mbtE; mycobactin peptide synthetase MbtE
K04792 mbtF; mycobactin peptide synthetase MbtF
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Vibriobactin synthetase
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Myxochelin synthetase
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Petrobacin synthetase
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Syringomycin synthetase
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Vanchrobactin synthetase
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Isonitrile lipopeptide synthase
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Polyketide tailoring proteins
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Hydrolase
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Ketoreductase
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Oxygenase
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K14366 eryF, CYP107A; 6-deoxyerythronolide B hydroxylase [EC:1.14.15.35]
K14370 eryK, CYP113A; erythromycin 12 hydroxylase [EC:1.14.13.154]
K16008 oleP, CYP107D; cytochrome P450 monooxygenase OleP
K16006 pikC, CYP107L; pikromycin synthase [EC:1.14.15.33]
K14372 aveE, CYP171A; cytochrome P450 hydroxylase [EC:1.14.-.-]
K15992 tylI, CYP113B; cytochrome P450 TylI
K15991 tylHI, CYP105L1; 20-oxo-5-O-mycaminosyltylactone 23-monooxygenase [EC:1.14.15.34]
K16022 rif19; flavoprotein hydroxylase
K20789 CYP140A7; cytochrome P450 hydroxylase [EC:1.14.-.-]
K24292 mycCI, CYP105L2; mycinamicin VIII C21 methyl hydroxylase [EC:1.14.-.-]
K24390 mycG, CYP107E1; mycinamicin IV hydroxylase/epoxidase [EC:1.14.-.-]
K16379 fkbD, rapJ; cytochrome P450 C-9 hydroxylase
K16380 rapN; cytochrome P450 RapN
K16389 amphN, nysN, fscP, pimG; cytochrome P450 monooxygenase
K16390 amphL, nysL, pimD; cytochrome P450 monooxygenase
K16400 epoK; cytochrome P450 enzyme
K14630 actVA5; two-component flavin-dependent monooxygenase [EC:1.14.14.-]
K14632 actVA6; C-6 monooxygenase
K20420 ncsB3; 2-hydroxy-5-methyl-1-naphthoate 7-hydroxylase [EC:1.14.15.31]
K21184 sgcC, mdpC; two-component FAD-dependent monooxygenase [EC:1.14.14.15 1.14.14.-]
K21159 sgcF, ncsF2, kedF; epoxide hydrolase
K21222 kedN3; cytochrome P450 monooxygenase [EC:1.14.-.-]
K21257 calO2; orsellenic acid P450 oxidase [EC:1.14.-.-]
K14253 oxyE; 6-methylpretetramide 4-monooxygenase [EC:1.14.13.232]
K14252 oxyL; 6-methylpretetramide 4-monooxygenase / 4-hydroxy-6-methylpretetramide 12a-monooxygenase [EC:1.14.13.232 1.14.13.233]
K14256 oxyS, cts8; anhydrotetracycline 6-monooxygenase / 5a,11a-dehydrotetracycline 5-monooxygenase [EC:1.14.13.38 1.14.13.234]
K15941 snoaB, dnrG, aknX; deoxynogalonate / 12-deoxyaklanonic acid monooxygenase [EC:1.13.12.22 1.13.12.-]
K15966 mtmOIV; monooxygenase [EC:1.14.13.-]
K15969 tcmH; tetracenomycin F1 monooxygenase [EC:1.13.12.21]
K15972 tcmG, elmG; tetracenomycin A2 monooxygenase-dioxygenase [EC:1.14.13.200]
K16427 dpgC; (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase [EC:1.13.11.80]
K14673 whiEII; putative monooxygenase
K14672 whiEVIII; putative polyketide hydroxylase
K15468 pksS, CYP107K1; cytochrome P450 family 107 subfamily K polypeptide 1
K15470 rhiH; cytochrome P450 monooxygenase
K16415 stiL; cytochrome P450 dependent monooxygenase
K15319 APTC; monooxygenase
K15386 APDB, CYP685A1; cytochrome P450 monooxygenase
K15387 APDD; FAD-dependent monooxygenase
K15388 APDE, CYP655; cytochrome P450 monooxygenase
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Methylase
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K14369 eryG; erythromycin 3''-O-methyltransferase [EC:2.1.1.254]
K14374 aveD; avermectin B 5-O-methyltransferase [EC:2.1.1.-]
K16381 fkbM; 31-O-methyltransferase
K15995 tylE; demethylmacrocin O-methyltransferase [EC:2.1.1.102]
K15996 tylF; macrocin O-methyltransferase [EC:2.1.1.101]
K21540 mycE; mycinamicin VI 2''-O-methyltransferase [EC:2.1.1.238]
K21539 mycF; mycinamicin III 3''-O-methyltransferase [EC:2.1.1.237]
K13320 oleY; L-olivosyl-oleandolide 3-O-methyltransferase [EC:2.1.1.239]
K16034 asm7; 20-O-methyltransferase
K16038 asm10; N-methyltransferase [EC:2.1.1.-]
K16028 asm17; O-methyltransferase
K15467 rif14; 27-O-demethylrifamycin SV methyltransferase [EC:2.1.1.315]
K15471 rhiI; O-methyltransferase [EC:2.1.1.-]
K21192 mdpB1; methyltransferase [EC:2.1.1.-]
K21189 mdpC6; O-methyltransferase [EC:2.1.1.-]
K20421 ncsB1; 2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase [EC:2.1.1.303]
K21215 ncsC5; N-methyltransferase [EC:2.1.1.-]
K21178 sgcD4; O-methyltransferase [EC:2.1.1.-]
K21255 calO6; orsellinic acid C2-O-methyltransferase [EC:2.1.1.-]
K21258 calO1; orsellinic acid C3-O-methyltransferase [EC:2.1.1.-]
K21223 kedN1; O-methyltransferase [EC:2.1.1.-]
K21224 kedN5; radical SAM C-methyltransferase
K14251 oxyF; C-methyltransferase [EC:2.1.1.-]
K14255 oxyT, ctcO, cts6; 4-amino-anhydrotetracycline N4-methyltransferase [EC:2.1.1.335]
K15942 snoaC, dnrC, dauC, aknG; O-methyltransferase / aklanonic acid methyltransferase [EC:2.1.1.- 2.1.1.288]
K15959 mtmMI; O-methyltransferase [EC:2.1.1.-]
K15963 mtmMII; C-methyltransferase [EC:2.1.1.-]
K15962 mtmC; D-mycarose 3-C-methyltransferase
K15886 tcmN; multifunctional cyclase / dehydratase / O-methyltransferase [EC:2.3.1.235]
K15970 tcmO; 8-O-methyltransferase
K15971 tcmP, elmP; O-methyltransferase [EC:2.1.1.-]
K19567 elmMI; 8-demethyl-8-alpha-L-rhamnosyltetracenomycin-C 2'-O-methyltransferase [EC:2.1.1.305]
K19568 elmMII; 8-demethyl-8-(2-methoxy-alpha-L-rhamnosyl)tetracenomycin-C 3'-O-methyltransferase [EC:2.1.1.306]
K19569 elmMIII; 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase [EC:2.1.1.307]
K19570 elmD; 8-demethyl-8-(2,3,4-trimethoxy-alpha-L-rhamnosyl)tetracenomycin-C O-methyltransferase [EC:2.1.1.-]
K16168 bpsB, srsB; methyltransferase
K16403 sorM; O-methyltransferase
K16414 stiK; methyltransferase
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Glycosyltransferase
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Halogenase
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K16033 asm12; FADH2-dependent halogenase
K21256 calO3; flavin-dependent halogenase
K16431 cepH, sgcC3, mdpC3, kedY3; FAD-dependent halogenase [EC:1.14.19.-]
K14257 ctcP, cts4, prnC; tetracycline 7-halogenase / FADH2 O2-dependent halogenase [EC:1.14.19.49 1.14.19.-]
K15650 cmaB; non-haem Fe2+, alpha-ketoglutarate-dependent halogenase
K28679 syrB2; L-threonyl-[L-threonyl-carrier protein] 4-chlorinase [EC:1.14.20.15]
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beta-Branched incorporating proteins
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Others
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K16037 asm11; 4,5-epoxidase
K16024 asm13; methoxymalonate biosynthesis protein
K16025 asm14; methoxymalonate biosynthesis acyl carrier protein
K16026 asm15; methoxymalonate biosynthesis protein
K16027 asm16; methoxymalonate biosynthesis protein
K16036 asm19; 3-O-acyltransferase
K16035 asm21; 7-O-carbamoyltransferase [EC:2.1.3.-]
K15466 rifF, asm9; amide synthase
K16023 rif20; acetyltransferase
K14626 actVIA; actinorhodin biosynthesis protein ActVIA
K14627 actVI3; dehydratase [EC:4.2.1.-]
K14628 actVI2; enoyl reductase
K14629 actVI4; enoyl reductase
K14631 actVB; flavin reductase ActVB [EC:1.5.1.-]
K16378 rapP, fkbP; pipecolate-incorporating enzyme
K15389 APDG; acyl-CoA dehydrogenase
K21160 sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2
K21161 sgcE3, ncsE3, kedE3; enediyne biosynthesis protein E3
K21162 sgcE4, ncsE4, kedE4; enediyne biosynthesis protein E4
K21163 sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5
K21164 sgcE7, ncsE7, kedE7; enediyne biosynthesis protein E7
K21165 sgcE8, ncsE8, kedE8; enediyne biosynthesis protein E8
K21166 sgcE9, ncsE9, kedE9; enediyne biosynthesis protein E9
K21167 sgcE11, ncsE11, kedE11; enediyne biosynthesis protein E11
K21168 calE1; enediyne biosynthesis protein CalE1
K21169 calE2; enediyne biosynthesis protein CalE2
K21170 calE3; enediyne biosynthesis protein CalE3
K21171 calE4; enediyne biosynthesis protein CalE4
K21172 calE5; enediyne biosynthesis protein CalE5
K21173 calE6; methionine gamma-lyase
K21174 calE9; enediyne biosynthesis protein CalE9
K21186 sgcC5, mdpC5, kedY5; condensation enzyme
K21180 sgcD6; 3-O-acyltransferase
K21185 sgcE6, mdpE6, kedE6; flavin reductase
K21191 mdpB2; CoA ligase [EC:6.2.1.-]
K21193 mdpB3; acetyltransferase/esterase
K21190 mdpC8; dehydrogenase
K20423 ncsB2; 2-hydroxy-7-methoxy-5-methyl-1-naphthoate---CoA ligase [EC:6.2.1.43]
K21209 ncsB4; acyltransferase
K21225 kedN2; acyl-CoA synthetase
K21226 kedN4; acyl-CoA N-acyltransferase
K21261 calO4; acyltransferase
K14254 oxyQ; aminotransferase
K21301 oxyR, ctcR; 5a,11a-dehydrotetracycline reductase [EC:1.3.98.4]
K21297 ctcQ; flavin reductase (NADH) [EC:1.5.1.36]
K15943 snoaL, dnrD, dauD, aknH; nogalonic acid methyl ester cyclase / aklanonic acid methyl ester cyclase [EC:5.5.1.26 5.5.1.23]
K15944 snoaF, dnrE, dauE, aknU; nogalaviketone/aklaviketone reductase [EC:1.1.1.- 1.1.1.362]
K15967 mtmW; ketoreductase
K15968 tcmI; tetracenomycin F2 cyclase [EC:4.2.1.154]
K14244 oxyD; amidotransferase [EC:6.3.5.-]
K15392 CPAD; cyclo-acetoacetyl-L-tryptophan dimethylallyltransferase [EC:2.5.1.-]
K15393 CPAO; beta-cyclopiazonate dehydrogenase [EC:1.21.99.1]
K15651 cmaC; aminocarboxycyclopropane-forming enzyme
K16404 sorR; reductase
K26570 clbQ; colibactin biosynthesis thioesterase
K26571 clbL; colibactin biosynthesis amidase
K26579 clbP; colibactin biosynthesis peptidase
K23875 tmlU; marinolic acid---CoA ligase [EC:6.2.1.60]
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Nonribosomal peptide tailoring proteins
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Polyketide Biosynthesis Proteins