KEGG   PATHWAY: xla04530
Entry
xla04530                    Pathway                                
Name
Tight junction - Xenopus laevis (African clawed frog)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
xla04530  Tight junction
xla04530

Other DBs
GO: 0005923
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
108703499  crb3.S; protein crumbs homolog 3 isoform X1 [KO:K06090]
108711726  crb3.L; uncharacterized protein crb3.L [KO:K06090]
108709432  cldn34.S; claudin-34 [KO:K06087]
398929  cldn5.L; claudin-5 [KO:K06087]
379132  cldn1.S; claudin 1 S homeolog [KO:K06087]
379396  cldn7.L; claudin 7 L homeolog [KO:K06087]
446591  cldn6.1.L; claudin 6, gene 1 L homeolog [KO:K06087]
398928  cldn18.L; claudin 18 L homeolog [KO:K06087]
444474  cldn14.L; claudin 14 L homeolog [KO:K06087]
496231  cldn19.S; claudin 19 S homeolog [KO:K06087]
447224  cldn3.L; claudin 3 L homeolog [KO:K06087]
398209  cldn6.2.S; claudin 6, gene 2 S homeolog [KO:K06087]
398409  cldn6.2.L; claudin 6, gene 2 L homeolog [KO:K06087]
734640  cldn4.L; claudin 4 L homeolog [KO:K06087]
108708184  cldn34.L; claudin-34 [KO:K06087]
494684  cldn19.L; uncharacterized protein LOC494684 [KO:K06087]
108711792  cldn15.1.L; claudin-15 [KO:K06087]
108696093  claudin-10 [KO:K06087]
108716970  cldn1.L; claudin-1 [KO:K06087]
108717013  claudin-11 isoform X2 [KO:K06087]
108719490  claudin-23 [KO:K06087]
108717111  cldn15.2.L; claudin-19 isoform X1 [KO:K06087]
108718049  claudin-16 [KO:K06087]
108717590  claudin-15 [KO:K06087]
108717595  cldn18.S; claudin-18 isoform X1 [KO:K06087]
108696575  claudin-16 [KO:K06087]
108699518  cldn2.L; claudin-2 [KO:K06087]
398408  cldn6.1.S; claudin4L2 [KO:K06087]
444247  cldn5.S; claudin 5 (transmembrane protein deleted in velocardiofacial syndrome) S homeolog [KO:K06087]
108705377  claudin-11 isoform X2 [KO:K06087]
108703421  cldn15.1.S; claudin-15 [KO:K06087]
108703582  cldn7.S; claudin-7 [KO:K06087]
108696433  cldn22.L; putative claudin-24 [KO:K06087]
108696436  putative claudin-24 [KO:K06087]
108706022  cldn22.S; putative claudin-24 [KO:K06087]
108706030  putative claudin-24 [KO:K06087]
108707422  cldn17.1.L; claudin-8 [KO:K06087]
108707424  cldn17.3.L; claudin-8 [KO:K06087]
108707495  putative claudin-24 [KO:K06087]
108708483  cldn10.L; claudin-10 [KO:K06087]
108708865  cldn17.3.S; claudin-8 [KO:K06087]
108708866  cldn17.1.S; claudin-8 [KO:K06087]
108709076  cldn8.1.S; claudin-8 [KO:K06087]
108709240  cldn14.S; claudin-14 [KO:K06087]
108709320  cldn4.S; claudin-4 [KO:K06087]
108709321  claudin-3 [KO:K06087]
108707885  cldn8.1.L; claudin-8 [KO:K06087]
496360  cldn12.S; claudin 12 S homeolog [KO:K06087]
121396504  claudin-16-like [KO:K06087]
398133  ocln.S; occludin isoform X1 [KO:K06088]
431839  ocel1.2.S; uncharacterized protein LOC431839 [KO:K06088]
108713406  ocel1.2.L; occludin [KO:K06088]
108717687  occludin-like isoform X1 [KO:K06088]
379346  f11r.S; F11 receptor S homeolog precursor [KO:K06089]
398627  f11r.L; junctional adhesion molecule A [KO:K06089]
108709215  jam2.S; junctional adhesion molecule B isoform X1 [KO:K06735]
108707891  jam2.L; junctional adhesion molecule B isoform X1 [KO:K06735]
108696377  junctional adhesion molecule C [KO:K06785]
108697545  jam3.S; junctional adhesion molecule C [KO:K06785]
394408  bves.L; blood vessel epicardial substance-A [KO:K21108]
779321  bves.S; blood vessel epicardial substance-B [KO:K21108]
379055  cdc42.L; cell division cycle 42 L homeolog [KO:K04393]
108697660  cdc42.S; cell division control protein 42 homolog isoform X1 [KO:K04393]
444140  pard6g.S; par-6 family cell polarity regulator gamma S homeolog [KO:K06093]
398165  pard6b.S; partitioning defective 6 homolog beta [KO:K06093]
108700892  pard6b.L; partitioning defective 6 homolog beta [KO:K06093]
108719162  pard6g.L; partitioning defective 6 homolog gamma isoform X1 [KO:K06093]
443569  pals1.L; protein associated with LIN7 1, MAGUK family member L homeolog [KO:K06091]
108700324  MAGUK p55 subfamily member 5 [KO:K06091]
108701860  mpp4.L; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
379249  tjp3.S; tight junction protein 3 S homeolog [KO:K06097]
734528  tjp3.L; uncharacterized protein LOC734528 [KO:K06097]
108714235  patj.L; inaD-like protein isoform X1 [KO:K06092]
108714010  mpdz.L; multiple PDZ domain protein isoform X1 [KO:K06095]
108697633  prkcz.S; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
373768  prkcz.L; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
399287  prkci.L; protein kinase C iota L homeolog [KO:K06069] [EC:2.7.11.13]
108705375  prkci.S; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
108698408  amot.L; angiomotin isoform X1 [KO:K16819]
108700109  amot.S; angiomotin [KO:K16819]
100158429  amotl1.L; angiomotin like 1 L homeolog [KO:K06104]
108710012  amotl1.S; angiomotin-like protein 1 isoform X1 [KO:K06104]
108718202  amotl2.S; angiomotin-like protein 2 [KO:K06104]
108717145  amotl2.L; angiomotin-like protein 2 [KO:K06104]
108703201  arhgap17.S; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
108701645  arhgap17.L; rho GTPase-activating protein 17 isoform X1 [KO:K20638]
734382  rac1.L; Rac family small GTPase 1 L homeolog [KO:K04392]
399379  rac3.S; Rac family small GTPase 3 S homeolog [KO:K04392]
446792  nf2.S; neurofibromin 2 (merlin) S homeolog [KO:K16684]
108715396  nf2.L; merlin isoform X1 [KO:K16684]
108708338  merlin isoform X2 [KO:K16684]
431949  llgl1.S; LLGL1, scribble cell polarity complex component S homeolog [KO:K06094]
447703  llgl2.L; LLGL2, scribble cell polarity complex component L homeolog [KO:K06094]
733426  lethal giant larvae [KO:K06094]
443982  llgl2.S; LLGL2, scribble cell polarity complex component S homeolog [KO:K06094]
108716985  disks large homolog 1 isoform X6 [KO:K12076]
108718075  disks large homolog 1 isoform X3 [KO:K12076]
100127343  scrib.S; protein scribble homolog isoform X1 [KO:K16175]
108719495  scrib.L; protein scribble homolog isoform X1 [KO:K16175]
399343  ppp2cb.L; protein phosphatase 2, catalytic subunit, beta isozyme L homeolog [KO:K04382] [EC:3.1.3.16]
380045  ppp2cal.S; protein phosphatase 2 catalytic subunit alpha-like S homeolog [KO:K04382] [EC:3.1.3.16]
108706827  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
108712618  ppp2ca.S; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
398563  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
379827  ppp2r1a.L; protein phosphatase 2 regulatory subunit A, alpha L homeolog [KO:K03456]
380100  ppp2r1b.S; protein phosphatase 2 regulatory subunit A, beta S homeolog [KO:K03456]
394339  ppp2r1a.S; protein phosphatase 2 regulatory subunit A, alpha S homeolog [KO:K03456]
379305  ppp2r2d.S; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
399328  ppp2r2a.S; protein phosphatase 2 regulatory subunit B, alpha S homeolog [KO:K04354]
394301  ppp2r2b.L; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
108713256  ppp2r2b.S; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
108706535  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1 [KO:K04354]
108696111  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
108698023  ppp2r2c.L; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1 [KO:K04354]
108711598  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
444443  pard3.S; par-3 family cell polarity regulator S homeolog [KO:K04237]
108718759  pard3.L; partitioning defective 3 homolog isoform X1 [KO:K04237]
735176  tiam1.S; T cell lymphoma invasion and metastasis S homeolog [KO:K05731]
108707884  tiam1.L; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
108712948  tight junction protein ZO-1 isoform X4 [KO:K05701]
496307  tjp1.S; tight junction protein ZO-1 isoform X1 [KO:K05701]
735235  tjap1.L; uncharacterized protein LOC735235 [KO:K06105]
108717653  tjap1.S; tight junction-associated protein 1 isoform X2 [KO:K06105]
108707614  disks large homolog 2 isoform X1 [KO:K12075]
108710034  disks large homolog 2 isoform X7 [KO:K12075]
108700062  dlg3.S; disks large homolog 3 isoform X6 [KO:K21098]
108698334  disks large homolog 3 isoform X3 [KO:K21098]
108712929  nedd4.S; E3 ubiquitin-protein ligase NEDD4 isoform X3 [KO:K10591] [EC:2.3.2.26]
108711373  nedd4.L; E3 ubiquitin-protein ligase NEDD4 isoform X4 [KO:K10591] [EC:2.3.2.26]
399396  nedd4l.S; NEDD4 like E3 ubiquitin protein ligase S homeolog [KO:K13305] [EC:2.3.2.26]
108718432  nedd4l.L; E3 ubiquitin-protein ligase NEDD4-like isoform X4 [KO:K13305] [EC:2.3.2.26]
398149  cgn.L; cingulin [KO:K06102]
108700437  cgn.S; cingulin-like isoform X1 [KO:K06102]
100037171  cgnl1.S; cingulin-like protein 1 isoform X1 [KO:K21110]
431812  cgnl1.L; cingulin-like 1 L homeolog [KO:K21110]
398353  arhgef2.S; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
108699605  arhgef2.L; rho guanine nucleotide exchange factor 2 isoform X4 [KO:K12791]
379326  rhoc.L; ras homolog family member C L homeolog [KO:K04513]
379416  rhoa.L; ras homolog family member A L homeolog [KO:K04513]
380133  rhoa.2.S; ras homolog gene family, member A, gene 2 S homeolog [KO:K04513]
108715815  rhoa.S; transforming protein RhoA [KO:K04513]
108709436  rhoc.S; rho-related GTP-binding protein RhoA-D [KO:K04513]
443781  gata4.L; GATA binding protein 4 L homeolog [KO:K09183]
399302  gata4.S; transcription factor GATA-4 [KO:K09183]
414611  marveld3.L; MARVEL domain-containing protein 3 isoform X1 [KO:K21099]
100137637  XB5872520.L; uncharacterized protein LOC100137637 [KO:K21099]
108704427  map3k1.S; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
108718321  map3k1.L; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
379050  jun.S; jun proto-oncogene S homeolog [KO:K04448]
399400  jun.L; jun proto-oncogene L homeolog [KO:K04448]
108700666  transcription factor AP-1-like [KO:K04448]
108712361  cftr.S; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
373725  cftr.L; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
379406  cdk4.S; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
496334  cdk6.L; cyclin-dependent kinase 6 L homeolog [KO:K02089] [EC:2.7.11.22]
734464  ybx3.S; Y-box-binding protein 3 isoform X1 [KO:K06099]
108696089  ybx3.L; Y-box-binding protein 3 [KO:K06099]
379378  sympk.S; symplekin [KO:K06100]
398425  pcna.L; proliferating cell nuclear antigen L homeolog [KO:K04802]
394328  pcna.S; proliferating cell nuclear antigen [KO:K04802]
379161  ccnd1.S; G1/S-specific cyclin-D1 b [KO:K04503]
379937  ccnd1.L; G1/S-specific cyclin-D1 [KO:K04503]
447748  ccndx.L; G1/S-specific cyclin-D1 [KO:K04503]
447541  MGC83948 protein [KO:K04503]
108702492  receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108700774  erbb2.L; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
379657  runx1.L; runt-related transcription factor 1 [KO:K08367]
108709238  runt-related transcription factor 1-like isoform X1 [KO:K08367]
398863  hspa4.S; heat shock protein family A (Hsp70) member 4 S homeolog [KO:K09489]
399222  hspa4.L; heat shock 70 kDa protein 4 [KO:K09489]
495828  slc9a3r1.L; uncharacterized protein LOC495828 [KO:K13365]
733155  slc9a3r1.S; SLC9A3 regulator 1 S homeolog [KO:K13365]
447216  ezr.L; ezrin L homeolog [KO:K08007]
108707573  rdx.L; radixin [KO:K05762]
733147  rdx.S; radixin [KO:K05762]
735107  msn.L; moesin isoform X2 [KO:K05763]
108700051  msn.S; moesin isoform X1 [KO:K05763]
108717735  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
108716426  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
100337595  actg1.S; actin, cytoplasmic type 5 [KO:K05692]
734918  actg1.L; actin, cytoplasmic type 8 [KO:K05692]
108703086  actb.S; actin, cytoplasmic 1 [KO:K05692]
398459  actb.L; actin, cytoplasmic 1 [KO:K05692]
100462912  cacna1d.L; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108704388  voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
108717885  mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
394391  map2k7.L; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
108712658  map2k7.S; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
380430  src.L; tyrosine-protein kinase Src-2 [KO:K05704] [EC:2.7.10.2]
373647  src.S; tyrosine-protein kinase Src-1 [KO:K05704] [EC:2.7.10.2]
444298  cttn.L; cortactin L homeolog [KO:K06106]
399111  cttn.S; cortactin S homeolog [KO:K06106]
108713011  src substrate cortactin [KO:K06106]
398923  hcls1.S; uncharacterized protein LOC398923 [KO:K06106]
443741  actr2.L; actin-related protein 2-B [KO:K17260]
734239  actr2.S; actin-related protein 2-A [KO:K17260]
380084  actr3.S; actin-related protein 3-A [KO:K18584]
108701232  actr3.L; actin-related protein 3-B [KO:K18584]
444264  arpc1b.S; actin-related protein 2/3 complex subunit 1B-B [KO:K05757]
379845  arpc1a.S; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
380108  arpc1b.L; actin-related protein 2/3 complex subunit 1B-A [KO:K05757]
108701201  actin-related protein 2/3 complex subunit 1A-B-like [KO:K05757]
108701505  arpc1a.L; actin-related protein 2/3 complex subunit 1A-B [KO:K05757]
432109  arpc2.S; actin-related protein 2/3 complex subunit 2-B [KO:K05758]
779406  arpc2.L; actin-related protein 2/3 complex subunit 2-A [KO:K05758]
379746  arpc3.L; actin-related protein 2/3 complex subunit 3-B [KO:K05756]
100036831  arpc3-a; actin-related protein 2/3 complex subunit 3-A [KO:K05756]
494639  arpc4.S; actin-related protein 2/3 complex subunit 4 [KO:K05755]
108714705  actin-related protein 2/3 complex subunit 4 [KO:K05755]
446537  arpc5l.L; actin-related protein 2/3 complex subunit 5-B [KO:K05754]
447274  arpc5.L; actin-related protein 2/3 complex subunit 5-A [KO:K05754]
447745  MGC83272 protein [KO:K05754]
444594  arpc5l.S; actin related protein 2/3 complex subunit 5-like S homeolog [KO:K05754]
108711418  whamm.L; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
100036872  was.S; uncharacterized protein LOC100036872 [KO:K05747]
733265  wasll.S; neural Wiskott-Aldrich syndrome protein [KO:K05747]
100037214  was.L; WASP actin nucleation promoting factor L homeolog [KO:K05747]
443914  vasp.L; vasodilator stimulated phosphoprotein L homeolog [KO:K06274]
108700560  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
380388  prkacb.S; protein kinase cAMP-activated catalytic subunit beta S homeolog [KO:K04345] [EC:2.7.11.11]
100101276  prkaca.S; protein kinase, cAMP-dependent, alpha catalytic subunit S homeolog [KO:K04345] [EC:2.7.11.11]
108714187  prkacb.L; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108711677  prkaca.L; protein kinase, cAMP-dependent, alpha catalytic subunit L homeolog [KO:K04345] [EC:2.7.11.11]
100158399  rab13.L; uncharacterized protein LOC100158399 [KO:K06109]
108706877  arhgef18.S; rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
108719999  arhgef18.L; rho guanine nucleotide exchange factor 18-like isoform X1 [KO:K21066]
108719215  rock1.L; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
108695261  rock1.S; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100301953  rock2.S; uncharacterized protein LOC100301953 [KO:K17388] [EC:2.7.11.1]
394289  rock2.L; Rho-associated, coiled-coil containing protein kinase 2 L homeolog [KO:K17388] [EC:2.7.11.1]
447131  myl2.S; myosin light chain 2 S homeolog [KO:K10351]
108697104  myl2.L; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108720029  epb41l4b.S; band 4.1-like protein 4B [KO:K21111]
399100  stk11.L; serine/threonine-protein kinase stk11 [KO:K07298] [EC:2.7.11.1]
108706844  stk11.S; serine/threonine-protein kinase stk11-like [KO:K07298] [EC:2.7.11.1]
495290  prkaa1.L; protein kinase, AMP-activated, alpha 1 catalytic subunit L homeolog [KO:K07198] [EC:2.7.11.31]
399172  prkaa2.S; protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog [KO:K07198] [EC:2.7.11.31]
108715541  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
108714249  5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
443998  prkab1.S; protein kinase, AMP-activated, beta 1 non-catalytic subunit S homeolog [KO:K07199]
380372  prkab2.L; protein kinase, AMP-activated, beta 2 non-catalytic subunit L homeolog [KO:K07199]
108715739  prkab2.S; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
108715919  prkab1.L; 5'-AMP-activated protein kinase subunit beta-1 isoform X1 [KO:K07199]
444397  prkag1.L; protein kinase, AMP-activated, gamma 1 non-catalytic subunit L homeolog [KO:K07200]
380124  prkag3.L; protein kinase, AMP-activated, gamma 3 non-catatlytic subunit [KO:K07200]
398958  prkag2.S; protein kinase, AMP-activated, gamma 2 non-catalytic subunit S homeolog [KO:K07200]
100127310  prkag3.S; protein kinase, AMP-activated, gamma 3 non-catalytic subunit S homeolog [KO:K07200]
108718729  prkag2.L; protein kinase, AMP-activated, gamma 2 non-catalytic subunit L homeolog [KO:K07200]
108709817  prkag1.S; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
398083  myh9.L; myosin-9 [KO:K10352]
399266  myh10.S; myosin, heavy chain 10, non-muscle S homeolog [KO:K10352]
398719  myh9.S; myosin-9 [KO:K10352]
108701185  myosin-10-like [KO:K10352]
495286  myh11.L; myosin-11 isoform X2 [KO:K10352]
443585  myosin-10 isoform X6 [KO:K10352]
100216329  myh11.S; myosin-11 isoform X2 [KO:K10352]
108696665  myosin-10 isoform X6 [KO:K10352]
414678  myl6.S; uncharacterized protein LOC414678 [KO:K12751]
446851  myl9.L; myosin light chain 9 L homeolog [KO:K12755]
447704  myl9.S; myosin light chain 9 S homeolog [KO:K12755]
380472  myl12b.L; myosin light chain 12B L homeolog [KO:K12757]
108695600  myl12b.S; myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
495454  uncharacterized protein LOC495454 [KO:K06786]
108713591  magi1.L; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
100158449  magi1.S; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
108712637  synaptopodin [KO:K21112]
108710822  synaptopodin isoform X1 [KO:K21112]
446865  actn4.S; actinin alpha 4 S homeolog [KO:K05699]
399422  actn1.L; actinin alpha 1 L homeolog [KO:K05699]
431885  actn1.S; uncharacterized protein LOC431885 [KO:K05699]
734930  actn4.L; uncharacterized protein LOC734930 [KO:K05699]
108703131  micall2.S; MICAL-like protein 2 [KO:K21068]
444258  micall2.L; MICAL-like 2 L homeolog [KO:K21068]
108713072  rab8a.L; ras-related protein Rab-8A [KO:K07901]
100037230  rab8a.S; ras-related protein Rab-8A [KO:K07901]
447070  rab8b.S; RAB8B, member RAS oncogene family S homeolog [KO:K07902]
447094  rab8b.L; RAB8B, member RAS oncogene family L homeolog [KO:K07902]
108712621  rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
414290  rap1a.S; RAP1A, member of RAS oncogene family S homeolog [KO:K04353]
779127  rap1a.L; RAP1A, member of RAS oncogene family L homeolog [KO:K04353]
397755  itgb1.L; integrin beta-1-A precursor [KO:K05719]
399443  itgb1.S; integrin beta-1-B precursor [KO:K05719]
496308  afdn.L; afadin [KO:K05702]
496335  afdn.S; afadin isoform X1 [KO:K05702]
108706964  tight junction protein ZO-2 isoform X1 [KO:K06098]
108714442  tight junction protein ZO-2 isoform X2 [KO:K06098]
447229  rapgef2.L; Rap guanine nucleotide exchange factor 2 L homeolog [KO:K08018]
108706643  rap guanine nucleotide exchange factor 2 isoform X4 [KO:K08018]
380172  rap2c.S; RAP2C, member of RAS oncogene family S homeolog [KO:K07839]
734719  rap2c.L; RAP2C, member of RAS oncogene family L homeolog [KO:K07839]
108717679  marveld2.L; MARVEL domain-containing protein 2 [KO:K17291]
108695299  ocel1.L; MARVEL domain-containing protein 2 isoform X1 [KO:K17291]
379210  tuba5.S; tubulin alpha 5 S homeolog [KO:K07374]
493577  tuba4b.L; tubulin alpha 4b L homeolog [KO:K07374]
397931  tubal3.1.L; tubulin alpha like 3, gene 1 L homeolog [KO:K07374]
431994  tubal3.1.S; tubulin alpha like 3, gene 1 S homeolog [KO:K07374]
496021  tuba1l.S; tubulin alpha 1 like S homeolog [KO:K07374]
379748  tuba1cl.3.L; tubulin alpha chain 1c like, L homeolog [KO:K07374]
380482  tuba1c.S; tubulin alpha 1c S homeolog [KO:K07374]
779368  tuba8.L; tubulin alpha 8 L homeolog [KO:K07374]
108711234  tubal3.2.L; tubulin alpha-3 chain [KO:K07374]
733413  tuba1al.L; tubulin alpha-1A chain [KO:K07374]
108701830  tuba1cl.2.L; tubulin alpha-1A chain isoform X2 [KO:K07374]
108702924  tuba4b.S; tubulin alpha chain isoform X1 [KO:K07374]
108702925  tuba1cl.2.S; tubulin alpha-1A chain [KO:K07374]
108702929  tubulin alpha-1A chain [KO:K07374]
108702930  tuba1cl.3.S; tubulin alpha-1A chain isoform X2 [KO:K07374]
100337592  tuba1c.L; tubulin alpha 1c L homeolog [KO:K07374]
100036943  tuba8.S; tubulin alpha 8 S homeolog [KO:K07374]
108708550  tuba1b.L; tubulin alpha chain [KO:K07374]
108708551  tuba1a.L; tubulin alpha-1A chain [KO:K07374]
108709821  tuba1b.S; tubulin alpha chain [KO:K07374]
108709822  tuba1a.S; tubulin alpha-1A chain [KO:K07374]
108708119  tuba5.L; tubulin alpha-1 chain [KO:K07374]
121397893  tubulin alpha-1D chain-like [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
xla04520  Adherens junction
xla04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
LinkDB

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