KEGG ORTHOLOGY: K08537

ORTHOLOGY: K08537

Entry

K08537                      KO

Symbol

NR1H4, FXR

Name

farnesoid X receptor

Pathway

map04976

Bile secretion

Disease

H00624

Progressive familial intrahepatic cholestasis

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K08537  NR1H4, FXR; farnesoid X receptor
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08537  NR1H4, FXR; farnesoid X receptor
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08537  NR1H4, FXR; farnesoid X receptor
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08537  NR1H4, FXR; farnesoid X receptor
Nuclear receptors [BR:ko03310]
1. Thyroid hormone like
  1H. Liver X receptor like receptor
   K08537  NR1H4, FXR; farnesoid X receptor

Genes

HSA:	9971(NR1H4)

PTR:	452162(NR1H4)

PPS:	100992986(NR1H4)

GGO:	101143546(NR1H4)

PON:	100433941(NR1H4)

PPYG:

129010224(NR1H4)

NLE:	100587301(NR1H4)

HMH:	116479410(NR1H4)

SSYN:

129460283(NR1H4)

MCC:	695618(NR1H4)

MCF:	102143900(NR1H4)

MTHB:

126930030

MNI:	105493847(NR1H4)

CSAB:

103238936(NR1H4)

CATY:

105573330(NR1H4)

PANU:

100997959(NR1H4)

TGE:	112634556(NR1H4)

MLEU:

105529480(NR1H4)

RRO:	104678323(NR1H4)

RBB:	108538940(NR1H4)

TFN:	117089553(NR1H4)

PTEH:

111539368(NR1H4)

CANG:

105506496(NR1H4)

CJC:	100391012(NR1H4)

SBQ:	101030117(NR1H4)

CIMI:

108294564(NR1H4)

ANAN:

105728724(NR1H4)

CSYR:

103267085(NR1H4)

MMUR:

105883957(NR1H4)

LCAT:

123639395(NR1H4)

PCOQ:

105826127(NR1H4)

OGA:	100956652(NR1H4)

MMU:	20186(Nr1h4)

MCAL:

110302992(Nr1h4)

MPAH:

110326329(Nr1h4)

RNO:	60351(Nr1h4)

MCOC:

116075988(Nr1h4)

ANU:	117696374(Nr1h4)

MUN:	110553666(Nr1h4)

CGE:	100763600(Nr1h4)

MAUA:

101828436(Nr1h4)

PROB:

127237904(Nr1h4)

PLEU:

114700633(Nr1h4)

MORG:

121463800(Nr1h4)

MFOT:

126503757

AAMP:

119803396(Nr1h4)

NGI:	103733741(Nr1h4)

HGL:	101714263(Nr1h4)

CPOC:

100734377(Nr1h4)

CCAN:

109701839(Nr1h4)

DORD:

105987871(Nr1h4)

DSP:	122119168(Nr1h4)

PLOP:

125359627(Nr1h4)

NCAR:

124983880

MMMA:

107139978(Nr1h4)

OCU:	100009485(NR1H4)

OPI:	101530384(NR1H4)

TUP:	102481612(NR1H4)

GVR:	103596083(NR1H4)

CFA:	612928(NR1H4)

CLUD:

112654377(NR1H4)

VVP:	112930725(NR1H4)

VLG:	121481171(NR1H4)

NPO:	129516982(NR1H4)

AML:	100468951(NR1H4)

UMR:	103676510(NR1H4)

UAH:	113256101(NR1H4)

UAR:	123780679(NR1H4)

ELK:

111142164

LLV:

125107500

MPUF:

101671585(NR1H4)

MNP:	132020500(NR1H4)

MLK:	131839317(NR1H4)

NVS:	122891210(NR1H4)

ORO:	101377408(NR1H4)

EJU:	114222946(NR1H4)

ZCA:	113923150(NR1H4)

MLX:	117998528(NR1H4)

NSU:	110578039(NR1H4)

LWW:	102735044(NR1H4)

FCA:	101096997(NR1H4)

PYU:	121040549(NR1H4)

PCOO:

112863454(NR1H4)

PBG:	122472580(NR1H4)

PVIV:

125171310(NR1H4)

LRUF:

124502263

PTG:	102967901(NR1H4)

PPAD:

109265396(NR1H4)

PUC:

125919469

AJU:

106973755

HHV:	120240746(NR1H4)

BTA:	540528(NR1H4)

BOM:	102274534(NR1H4)

BIU:	109559429(NR1H4)

BBUB:

102401640(NR1H4)

BBIS:

104982249(NR1H4)

CHX:	102169563(NR1H4)

OAS:	101105401(NR1H4)

BTAX:

128048449(NR1H4)

ODA:	120858682(NR1H4)

CCAD:

122424001(NR1H4)

MBEZ:

129536433(NR1H4)

SSC:	100153960(NR1H4)

CFR:	102508902(NR1H4)

CBAI:

105075034(NR1H4)

CDK:	105097449(NR1H4)

VPC:	102540525(NR1H4)

BACU:

103000201(NR1H4)

BMUS:

118902052(NR1H4)

LVE:	103080334(NR1H4)

OOR:	101276333(NR1H4)

DLE:	111187853(NR1H4)

PCAD:

102996515(NR1H4)

PSIU:

116760610(NR1H4)

NASI:

112403717(NR1H4)

ECB:	100052821(NR1H4)

EPZ:	103548554(NR1H4)

EAI:	106827279(NR1H4)

MYB:	102240088(NR1H4)

MYD:	102767980(NR1H4)

MMYO:

118651930(NR1H4)

MLF:	102430686(NR1H4)

MDT:	132227128(NR1H4)

PKL:	118730088(NR1H4)

EFUS:

103288970(NR1H4)

MNA:	107545114(NR1H4)

DRO:	112321790(NR1H4)

SHON:

119002180(NR1H4)

AJM:	119060606(NR1H4)

PDIC:

114513313(NR1H4)

PHAS:

123810627(NR1H4)

MMF:	118624070(NR1H4)

PPAM:

129071387(NR1H4)

HAI:	109382290(NR1H4)

RFQ:	117029097(NR1H4)

PALE:

102895593(NR1H4)

PGIG:

120614975(NR1H4)

PVP:	105310468(NR1H4)

RAY:	107497902(NR1H4)

MJV:	108402182(NR1H4)

TOD:	119247388(NR1H4) 119248198

SARA:

101550822(NR1H4)

SETR:

126021935(NR1H4)

LAV:	100667650(NR1H4)

TMU:

101358741

ETF:	101648637(NR1H4)

DNM:	101429859(NR1H4)

MDO:	100019526(NR1H4)

GAS:	123248527(NR1H4)

SHR:	100914744(NR1H4)

AFZ:

127564882

PCW:	110205627(NR1H4)

TVP:	118850769(NR1H4)

OAA:	100074851(NR1H4)

GGA:	373902(NR1H4)

PCOC:

116233243(NR1H4)

MGP:	100549912(NR1H4)

CJO:	107312042(NR1H4)

TPAI:

128073836(NR1H4)

LMUT:

125703147(NR1H4)

NMEL:

110405521(NR1H4)

APLA:

101801467(NR1H4)

ACYG:

106036902(NR1H4)

CATA:

118250472(NR1H4)

AFUL:

116501998(NR1H4)

TGU:	100219563(NR1H4)

LSR:	110483086(NR1H4)

SCAN:

103813379(NR1H4)

PMOA:

120499915(NR1H4)

OTC:	121338623(NR1H4)

PRUF:

121357242(NR1H4)

GFR:	102039812(NR1H4)

FAB:	101819281(NR1H4)

OMA:	130267080(NR1H4)

PHI:	102104022(NR1H4)

PMAJ:

107205090(NR1H4)

CCAE:

111934080(NR1H4)

CCW:	104696417(NR1H4)

CBRC:

103618169(NR1H4)

ETL:	114058427(NR1H4)

ZAB:	102070628(NR1H4)

ZLE:	135457232(NR1H4)

ACHL:

103800337(NR1H4)

SVG:	106861449(NR1H4)

MMEA:

130585540(NR1H4)

HRT:	120751956(NR1H4)

SATI:

136361435(NR1H4)

FPG:	101912243(NR1H4)

FCH:	102045991(NR1H4)

CCRI:

104164512

NNT:	104411576(NR1H4)

SHAB:

115604899(NR1H4)

ACUN:

113491160(NR1H4)

TALA:

104361095(NR1H4)

ACHC:

115336344(NR1H4)

HALD:

104321590(NR1H4)

HLE:	104828310(NR1H4)

AGEN:

126034547

GCL:

127026825

CSTI:

104563119(NR1H4)

LDI:	104341385(NR1H4)

MNB:

103770819

DPUB:

104298466(NR1H4)

AVIT:

104279378(NR1H4)

BRHI:

104497300(NR1H4)

EGZ:	104132313(NR1H4)

NNI:	104011665(NR1H4)

PCRI:

104038339(NR1H4)

PCAO:

104042601(NR1H4)

PADL:

103914622(NR1H4)

AFOR:

103903018(NR1H4)

FGA:	104078489(NR1H4)

GSTE:

104260295(NR1H4)

CLV:	102089663(NR1H4)

MUI:	104541222(NR1H4)

PGUU:

104469291(NR1H4)

PLET:

104624317(NR1H4)

EHS:	104503810(NR1H4)

CMAC:

104483035(NR1H4)

CUCA:

104068653(NR1H4)

TEO:	104377504(NR1H4)

BREG:

104644010(NR1H4)

OHA:	104334486(NR1H4)

ACAR:

104523975(NR1H4)

CPEA:

104389964(NR1H4)

CVF:	104284271(NR1H4)

RTD:	128901337(NR1H4)

AAM:	106488452(NR1H4)

AROW:

112975825(NR1H4)

NPD:	112959452(NR1H4)

TGT:	104578978(NR1H4)

DNE:	112988786(NR1H4)

SCAM:

104145834(NR1H4)

ASN:	102370880(NR1H4)

AMJ:	102570897(NR1H4)

CPOO:

109316793(NR1H4)

GGN:	109295882(NR1H4)

PSS:	102459078(NR1H4)

CMY:	102948292(NR1H4)

CCAY:

125630565(NR1H4)

DCC:	119841376(NR1H4)

CPIC:

101946708(NR1H4)

TST:	117878907(NR1H4)

CABI:

116829621(NR1H4)

MRV:	120395523(NR1H4)

ACS:	100555212(nr1h4)

ASAO:

132776058(NR1H4)

PVT:	110084200(NR1H4)

SUND:

121920648 121930692(NR1H4)

PBI:	103062649(NR1H4)

PMUR:

107289408(NR1H4)

CTIG:

120312835(NR1H4)

TSR:	106547521(NR1H4)

PGUT:

117655665(NR1H4)

APRI:

131202008(NR1H4)

PTEX:

113437316(NR1H4)

NSS:	113430699(NR1H4)

VKO:	123036293(NR1H4)

PMUA:

114605057(NR1H4)

PRAF:

128422276(NR1H4)

ZVI:	118090791(NR1H4)

HCG:	128325696(NR1H4)

GJA:	107121816(NR1H4)

STOW:

125435191(NR1H4)

EMC:	129335606(NR1H4)

XLA:	108711008(nr1h4.L) 108712389

XTR:	100489310(nr1h4)

NPR:	108787160(NR1H4)

RTEM:

120932148(NR1H4)

BBUF:

120978807(NR1H4)

BGAR:

122928126(NR1H4)

MUO:	115478015(NR1H4)

GSH:	117364143(NR1H4)

DRE:	436847(nr1h4)

SRX:	107740216 107749275

SANH:

107672305 107686236

SGH:	107553955(nr1h4) 107583817

CCAR:

109051788 109108723

CAUA:

113061578 113083578 113118277

CGIB:

127934714 127976929

PTET:

122323105(nr1h4)

LROH:

127181104(nr1h4)

OMC:	131524886(nr1h4)

PPRM:

120462049(nr1h4)

RKG:	130094776(nr1h4)

MAMB:

125254824(nr1h4)

CIDE:

127500088

CERY:

137023298(nr1h4)

MASI:

127417402

TROS:

130563114(nr1h4)

TDW:	130435721(nr1h4)

MANU:

129419021(nr1h4)

IPU:

108264843

IFU:	128606621(nr1h4)

PHYP:

113534257(nr1h4)

SMEO:

124396259(nr1h4)

TFD:	113652753(nr1h4)

TVC:	132851306(nr1h4)

TRN:	134322839(nr1h4)

AMEX:

103046982(nr1h4)

CMAO:

118818432(nr1h4)

EEE:	113590574(nr1h4)

CHAR:

105898037(nr1h4)

TRU:	101078607(nr1h4)

TFS:	130536493(nr1h4)

TNG:	GSTEN00005312G001 GSTEN00007008G001 GSTEN00022799G001

LCO:	104924364(nr1h4)

NCC:	104954412(nr1h4)

TBEN:

117491458(nr1h4)

CGOB:

115009990(nr1h4)

PGEO:

117448626(nr1h4)

GACU:

117545717(nr1h4)

EMAC:

134859349(nr1h4)

ELY:	117262637(nr1h4)

EFO:	125887695(nr1h4)

PLEP:

121949970(nr1h4)

SLUC:

116062395(nr1h4)

ECRA:

117949294(nr1h4)

ESP:	116693696(nr1h4)

PFLV:

114560249(nr1h4)

GAT:	120809864(nr1h4) 120812766

PPUG:

119196474(nr1h4)

AFB:	129108207(nr1h4)

CLUM:

117732504(nr1h4)

PSWI:

130195808(nr1h4)

MSAM:

119893451(nr1h4)

SCHU:

122874230(nr1h4)

CUD:	121515692(nr1h4)

ALAT:

119024091(nr1h4)

MZE:	101469323(nr1h4)

ONL:	100710296(nr1h4)

OAU:	116335616(nr1h4)

OLA:	101166124(nr1h4)

OML:	112152720(nr1h4)

CSAI:

133444376(nr1h4)

XMA:	102235217(nr1h4)

XCO:	114135939(nr1h4)

XHE:	116711641(nr1h4)

PRET:

103466092(nr1h4)

PFOR:

103133687(nr1h4)

PLAI:

106950920(nr1h4)

PMEI:

106916053(nr1h4)

GAF:	122835481(nr1h4)

PPRL:

129364956(nr1h4)

CVG:	107103876(nr1h4)

CTUL:

119792991(nr1h4)

GMU:	124878367(nr1h4)

NFU:	107388952(nr1h4)

KMR:	108239910(nr1h4)

ALIM:

106515605(nr1h4)

NWH:	119415637(nr1h4)

AOCE:

111568343(nr1h4)

MCEP:

125014331(nr1h4)

CSEM:

103380155(nr1h4)

POV:	109624226(nr1h4)

SSEN:

122775898(nr1h4)

HHIP:

117763347(nr1h4)

HSP:	118109825(nr1h4)

PPLT:

128444086(nr1h4)

SMAU:

118315928(nr1h4)

LCF:

108875375

SDU:	111228414(nr1h4)

SLAL:

111655324(nr1h4)

XGL:	120793503(nr1h4)

HCQ:	109530502(nr1h4)

SSCV:

125970529

SBIA:

133502191(nr1h4)

PEE:	133402692(nr1h4)

PTAO:

133478103(nr1h4)

BPEC:

110167719(nr1h4)

MALB:

109970763(nr1h4)

BSPL:

114857782(nr1h4)

SJO:	128358539(nr1h4)

SASA:

106561422 106573302

STRU:

115152176 115197371

OTW:	112218727 112232092

OMY:	110497735 110522782

OGO:	124002556(nr1h4)

ONE:	115109554 115134108

OKI:	109867617 109889523

OKE:	118396032 118401096

SALP:

111952691 111962494

SNH:	120054065 120066407

CCLU:

121532254 121576996

ELS:	105022148(nr1h4)

SFM:	108935972(nr1h4)

PKI:	111860953(nr1h4)

AANG:

118218681(nr1h4)

LOC:	102695148(nr1h4)

PSPA:

121318419 121319676

ARUT:

117419660

PSEX:

120534247(nr1h4)

LCM:	102356902(NR1H4)

CMK:	103179886(nr1h4)

RTP:	109923913(nr1h4)

CPLA:

122559330(nr1h4)

HOC:	132825034(nr1h4)

LERI:

129706307(nr1h4)

PMRN:

116945589 116957662

LRJ:

133351470

BFO:

118406651

BBEL:

109463396 109478497 109478498 109478499

CIN:	780709(fxr)

SCLV:

CANU:

OED:

Reference

PMID:18825165

Authors

Wang YD, Chen WD, Moore DD, Huang W

Title

FXR: a metabolic regulator and cell protector.

Journal

Cell Res 18:1087-95 (2008)
DOI:10.1038/cr.2008.289

Reference

PMID:10334993

Authors

Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM

Title

Bile acids: natural ligands for an orphan nuclear receptor.

Journal

Science 284:1365-8 (1999)
DOI:10.1126/science.284.5418.1365

Sequence

[hsa:9971]

LinkDB

DBGET integrated database retrieval system