KEGG   PATHWAY: aang04020
Entry
aang04020                   Pathway                                
Name
Calcium signaling pathway - Anguilla anguilla (European eel)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
aang04020  Calcium signaling pathway
aang04020

Other DBs
GO: 0019722
Organism
Anguilla anguilla (European eel) [GN:aang]
Gene
118206234  adrb3a; adrenoceptor beta 3a isoform X1 [KO:K04143]
118206244  [KO:K04634]
118206245  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
118206299  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
118206305  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
118206365  [KO:K04515] [EC:2.7.11.17]
118206434  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
118206631  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
118206696  [KO:K16896]
118206728  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
118206745  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a isoform X1 [KO:K04360] [EC:2.7.10.1]
118206754  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
118206829  fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
118206845  [KO:K05452]
118206902  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
118206946  p2rx2; P2X purinoceptor 2 [KO:K05216]
118206982  p2rx7; P2X purinoceptor 7 [KO:K05220]
118206984  p2rx4b; P2X purinoceptor 4b isoform X1 [KO:K05218]
118207001  [KO:K16056]
118207050  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
118207090  f2r; proteinase-activated receptor 1 [KO:K03914]
118207103  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
118207125  adora2aa; adenosine A2a receptor a [KO:K04266]
118207210  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
118207322  ntsr1; neurotensin receptor type 1 [KO:K04211]
118207385  [KO:K05084] [EC:2.7.10.1]
118207405  [KO:K04958]
118207429  camk1gb; calcium/calmodulin-dependent protein kinase IGb isoform X1 [KO:K08794] [EC:2.7.11.17]
118207455  [KO:K12042]
118207456  [KO:K12042]
118207471  [KO:K04282]
118207724  [KO:K05850] [EC:7.2.2.10]
118207859  [KO:K08794] [EC:2.7.11.17]
118208107  oxtrl; oxytocin receptor like [KO:K04229]
118208113  [KO:K04851]
118208164  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
118208223  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
118208340  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
118208388  mst1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
118208405  mst1ra; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
118208555  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
118208580  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
118208607  ngfa; neurotrophin-7 [KO:K02582]
118208634  [KO:K04857]
118208677  [KO:K04632]
118208728  [KO:K15590]
118208818  grm5b; metabotropic glutamate receptor 5b [KO:K04604]
118208821  [KO:K22642]
118208997  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
118209433  ryr1b; ryanodine receptor 1b isoform X1 [KO:K04961]
118209739  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
118209920  pdgfd; platelet-derived growth factor D [KO:K05450]
118209991  stim1a; stromal interaction molecule 1a isoform X1 [KO:K16059]
118210165  itpkcb; inositol-trisphosphate 3-kinase Cb isoform X1 [KO:K00911] [EC:2.7.1.127]
118210237  [KO:K04267]
118210338  [KO:K05219]
118210509  mst1rb; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
118210591  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
118210606  [KO:K04853]
118210625  oxtr; oxytocin receptor isoform X1 [KO:K04229]
118210698  [KO:K08794] [EC:2.7.11.17]
118210822  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118210826  tnnc1b; troponin C type 1b (slow) [KO:K05865]
118210832  [KO:K12042]
118210865  [KO:K12042]
118210907  hrh1; histamine H1 receptor [KO:K04149]
118210969  bdkrb1; B1 bradykinin receptor [KO:K03916]
118211042  [KO:K17332]
118211054  atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
118211174  [KO:K02183]
118211202  [KO:K05865]
118211203  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
118211232  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
118211250  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
118211261  tfeb; LOW QUALITY PROTEIN: transcription factor EB [KO:K15590]
118211309  [KO:K04851]
118211513  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
118211653  [KO:K02582]
118211802  [KO:K05084] [EC:2.7.10.1]
118211910  [KO:K04211]
118211950  [KO:K13755] [EC:3.1.4.17]
118211975  [KO:K04282]
118212214  [KO:K04360] [EC:2.7.10.1]
118212286  [KO:K04143]
118212348  [KO:K04222]
118212370  grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
118212376  fgf10a; fibroblast growth factor 10a [KO:K04358]
118212395  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
118212486  [KO:K16896]
118212497  [KO:K04515] [EC:2.7.11.17]
118212526  ptafr; platelet-activating factor receptor [KO:K04279]
118212554  fgfr1b; fibroblast growth factor receptor 1b [KO:K04362] [EC:2.7.10.1]
118212571  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
118212690  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
118212760  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
118212771  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
118212785  p2rx4a; P2X purinoceptor 4a isoform X1 [KO:K05218]
118212810  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
118212898  [KO:K04135]
118212982  cacna1bb; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
118212990  [KO:K03914]
118212991  [KO:K03914]
118212992  [KO:K03914]
118212997  [KO:K03914]
118213111  [KO:K04636]
118213173  camk4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
118213253  [KO:K04358]
118213425  [KO:K15041]
118213583  itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
118213710  [KO:K04189]
118213777  [KO:K23445]
118213827  [KO:K04157]
118213870  [KO:K04169]
118213965  slc25a6; ADP/ATP translocase 3 [KO:K05863]
118213982  [KO:K04161]
118214056  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
118214168  mylka; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
118214183  [KO:K05857] [EC:3.1.4.11]
118214313  [KO:K04198]
118214341  [KO:K04194]
118214486  [KO:K05449]
118214654  [KO:K05085] [EC:2.7.10.1]
118214688  fgf19; fibroblast growth factor 19 [KO:K22603]
118214690  [KO:K04358]
118214774  [KO:K04809]
118214811  [KO:K00907] [EC:2.7.11.18]
118214964  [KO:K07190]
118215074  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
118215159  calml4b; calmodulin-like protein 4 [KO:K02183]
118215226  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
118215285  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
118215463  [KO:K04358]
118215714  [KO:K05101] [EC:2.7.10.1]
118215825  [KO:K04282]
118215928  [KO:K22429]
118215964  [KO:K05857] [EC:3.1.4.11]
118216105  ptger1b; LOW QUALITY PROTEIN: prostaglandin E receptor 1b (subtype EP1) [KO:K04258]
118216119  [KO:K05853] [EC:7.2.2.10]
118216144  [KO:K04345] [EC:2.7.11.11]
118216561  [KO:K04344]
118216698  [KO:K04855]
118216704  [KO:K19662] [EC:2.7.11.13]
118216956  [KO:K05210]
118216977  [KO:K04856]
118217014  [KO:K08049] [EC:4.6.1.1]
118217041  [KO:K04856]
118217186  [KO:K05211]
118217225  mcoln1b; mucolipin-1 isoform X1 [KO:K04992]
118217304  grin2aa; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
118217341  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
118217697  fgf8a; fibroblast growth factor 8 isoform X1 [KO:K04358]
118217727  chrm3a; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
118217748  lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
118217801  [KO:K04515] [EC:2.7.11.17]
118217836  tacr2; substance-K receptor isoform X1 [KO:K04223]
118217945  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
118217978  ptger1a; prostaglandin E receptor 1a (subtype EP1) isoform X1 [KO:K04258]
118217986  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
118218037  [KO:K05849]
118218148  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
118218186  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
118218207  [KO:K04855]
118218285  [KO:K09565] [EC:5.2.1.8]
118218425  [KO:K05860] [EC:3.1.4.11]
118218827  [KO:K04130]
118218828  [KO:K04130]
118219045  [KO:K04358]
118219149  [KO:K05850] [EC:7.2.2.10]
118219163  [KO:K05099] [EC:2.7.10.1]
118219247  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
118219269  [KO:K05460]
118219290  [KO:K04226]
118219395  [KO:K22428]
118219598  [KO:K02677] [EC:2.7.11.13]
118219610  [KO:K04718] [EC:2.7.1.91]
118219625  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
118219694  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
118219838  adrb1; beta-1 adrenergic receptor [KO:K04141]
118219851  [KO:K08049] [EC:4.6.1.1]
118219868  [KO:K04359]
118220057  [KO:K04163]
118220097  [KO:K05840]
118220213  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
118220309  [KO:K19662] [EC:2.7.11.13]
118220322  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
118220452  [KO:K06856]
118220570  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
118220641  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
118220728  [KO:K04223]
118220746  [KO:K09565] [EC:5.2.1.8]
118220805  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
118220813  [KO:K05849]
118220819  [KO:K04515] [EC:2.7.11.17]
118220834  [KO:K02183]
118220943  [KO:K03916]
118220950  [KO:K03916]
118220996  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
118221076  cacna1ab; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b isoform X1 [KO:K04344]
118221120  [KO:K05209]
118221262  [KO:K04131]
118221335  [KO:K04345] [EC:2.7.11.11]
118221354  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b [KO:K05210]
118221400  mcoln1a; mucolipin-1a [KO:K04992]
118221559  [KO:K22429]
118221586  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
118221665  fgf8b; fibroblast growth factor 8b [KO:K04358]
118221774  [KO:K05857] [EC:3.1.4.11]
118221825  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
118221864  grin2cb; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
118221921  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
118222170  [KO:K04322]
118222174  [KO:K04150]
118222208  [KO:K05095] [EC:2.7.10.1]
118222330  [KO:K04136]
118222344  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
118222375  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
118222472  [KO:K04129]
118222480  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
118222514  [KO:K04144]
118222593  [KO:K23445]
118222607  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
118222633  [KO:K04198]
118222643  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
118222684  [KO:K04322]
118222700  [KO:K04157]
118222765  fgf16; fibroblast growth factor 16 [KO:K04358]
118222857  grpr; gastrin-releasing peptide receptor [KO:K04169]
118223048  [KO:K05862]
118223071  [KO:K05449]
118223115  vegfd; vascular endothelial growth factor D [KO:K05449]
118223170  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
118223172  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118223183  [KO:K05849]
118223252  [KO:K05085] [EC:2.7.10.1]
118223264  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
118223362  slc25a5; ADP/ATP translocase 2 [KO:K05863]
118223372  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
118223579  [KO:K05857] [EC:3.1.4.11]
118223713  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
118223900  [KO:K04198]
118223998  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
118224076  [KO:K04142]
118224113  [KO:K04515] [EC:2.7.11.17]
118224264  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
118224312  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
118224341  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
118224389  [KO:K04348] [EC:3.1.3.16]
118224561  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
118224631  [KO:K04637]
118224717  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
118224887  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
118224931  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
118224946  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
118224959  [KO:K04809]
118225105  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
118225122  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
118225251  [KO:K04361] [EC:2.7.10.1]
118225407  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118225427  unm_hu7910; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
118225437  [KO:K04635]
118225468  pde1ca; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
118225550  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
118225560  grin3bb; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
118225723  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
118225803  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
118225853  mcoln2; mucolipin-2 isoform X1 [KO:K04993]
118225935  [KO:K01116] [EC:3.1.4.11]
118226024  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118226025  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
118226064  [KO:K04852]
118226258  gnal; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
118226284  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
118226327  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
118226503  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
118226623  [KO:K04262]
118226629  agtr1b; type-1 angiotensin II receptor [KO:K04166]
118226718  [KO:K18497]
118226720  [KO:K05450]
118226952  [KO:K04358]
118227016  tacr3a; tachykinin receptor 3a [KO:K04224]
118227071  p2rx3b; P2X purinoceptor 3b [KO:K05217]
118227131  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
118227167  slc25a4; ADP/ATP translocase 1 [KO:K05863]
118227181  tpcn2; two pore calcium channel protein 2 [KO:K14077]
118227202  [KO:K04358]
118227219  [KO:K04150]
118227229  fgf7; fibroblast growth factor 7 [KO:K04358]
118227285  [KO:K04348] [EC:3.1.3.16]
118227399  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
118227410  [KO:K04163]
118227419  [KO:K00907] [EC:2.7.11.18]
118227441  [KO:K08047] [EC:4.6.1.1]
118227480  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
118227535  fgf3; fibroblast growth factor 3 [KO:K04358]
118227536  [KO:K04358]
118227870  [KO:K17333]
118227970  [KO:K04197]
118227992  [KO:K05101] [EC:2.7.10.1]
118228062  [KO:K04963]
118228327  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
118228424  plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
118228434  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
118228455  adra1d; alpha-1D adrenergic receptor [KO:K04137]
118228456  [KO:K04160]
118228498  chrna8; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
118228541  grm1b; metabotropic glutamate receptor 1b isoform X1 [KO:K04603]
118228793  [KO:K08043] [EC:4.6.1.1]
118228858  [KO:K05214]
118228868  [KO:K04994]
118228903  [KO:K04345] [EC:2.7.11.11]
118229128  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
118229366  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
118229531  pln; cardiac phospholamban [KO:K05852]
118229538  [KO:K04852]
118229574  [KO:K05858] [EC:3.1.4.11]
118229591  [KO:K04637]
118229594  [KO:K04637]
118229598  [KO:K04635]
118229604  [KO:K05858] [EC:3.1.4.11]
118229639  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
118229740  [KO:K04157]
118229820  [KO:K04963]
118229821  [KO:K04133]
118229938  [KO:K04267]
118229986  calm1b; calmodulin-1b [KO:K02183]
118230068  itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
118230135  [KO:K05212]
118230406  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
118230502  [KO:K04262]
118230603  [KO:K05858] [EC:3.1.4.11]
118230605  [KO:K05858] [EC:3.1.4.11]
118230804  [KO:K04264]
118230825  [KO:K04166]
118230988  [KO:K05460]
118231124  [KO:K04358]
118231132  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
118231142  [KO:K05861] [EC:3.1.4.11]
118231146  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
118231172  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
118231217  [KO:K04226]
118231260  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
118231373  [KO:K04297]
118231375  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
118231414  [KO:K04809]
118231420  [KO:K04358]
118231427  [KO:K04224]
118231429  drd5a; D(1B) dopamine receptor [KO:K05840]
118231435  fgf23; fibroblast growth factor 23 [KO:K22428]
118231483  fgf2; fibroblast growth factor 2 [KO:K18497]
118231561  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
118231624  [KO:K04348] [EC:3.1.3.16]
118231692  p2rx3a; P2X purinoceptor 3a isoform X1 [KO:K05217]
118231977  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
118232075  [KO:K04137]
118232104  casq1b; calsequestrin-1b isoform X1 [KO:K23468]
118232257  [KO:K04130]
118232301  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
118232589  [KO:K04197]
118232612  cckar; cholecystokinin receptor type A isoform X1 [KO:K04194]
118232830  pde1cb; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
118232916  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
118233055  [KO:K08041] [EC:4.6.1.1]
118233106  [KO:K23468]
118233699  chrna11; cholinergic receptor, nicotinic, alpha 11 isoform X1 [KO:K04809]
118233743  [KO:K04633]
118234126  [KO:K05857] [EC:3.1.4.11]
118234166  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118234313  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
118234492  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
118234506  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
118234624  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
118234647  [KO:K05212]
118234708  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
118234934  [KO:K05089] [EC:2.7.10.1]
118234937  [KO:K05449]
118235005  [KO:K05863]
118235076  orai2; protein orai-2 [KO:K16057]
118235092  [KO:K05849]
118235298  drd1b; dopamine receptor D1b [KO:K04144]
118235382  [KO:K04358]
118235483  calm1a; calmodulin-1a [KO:K02183]
118235572  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
118235589  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
118235615  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
118235731  [KO:K04515] [EC:2.7.11.17]
118235837  [KO:K04129]
118235900  [KO:K04157]
118235967  [KO:K00871] [EC:2.7.11.19]
118236071  stim1b; stromal interaction molecule 1b isoform X1 [KO:K16059]
118236159  [KO:K04322]
118236266  adora2b; adenosine receptor A2b [KO:K04267]
118236337  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
118236340  [KO:K04142]
118236343  [KO:K04160]
118236357  [KO:K18496]
118236393  [KO:K04961]
118236410  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
118236558  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
118236661  p2rx5; P2X purinoceptor 5 isoform X1 [KO:K05219]
118236719  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
118236744  [KO:K04348] [EC:3.1.3.16]
118237108  htr7c; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
118237163  fgf10b; fibroblast growth factor 10b [KO:K04358]
118237282  [KO:K04348] [EC:3.1.3.16]
118237369  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
118237432  tacr1a; LOW QUALITY PROTEIN: tachykinin receptor 1a [KO:K04222]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
aang04010  MAPK signaling pathway
aang04070  Phosphatidylinositol signaling system
aang04210  Apoptosis
KO pathway
ko04020   

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