Entry
Name
Cytokine-cytokine receptor interaction - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ajm04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:
ajm ]
Gene
119037675 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
119041838 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
119054540 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
119063817 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
119065454 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
119044903 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
119043451 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
119042868 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
119053545 tumor necrosis factor ligand superfamily member 12-like isoform X1 [KO:K05474 ]
119044901 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
119063769 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
119065392 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
119065442 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
119053546 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
119042870 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
119045813 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
119048017 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
119035395 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
119036993 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
119048019 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
119045748 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
119045499 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
119045760 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
119052448 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
119049182 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
119053829 GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056 ]
119063512 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
119049688 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
119049190 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
119053846 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
119050769 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
119051856 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
119047917 IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172 ]
119060225 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
119064091 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
119060191 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
119050575 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
119055301 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
119057762 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
119055941 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
119041884 tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K04722 ]
119054722 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
119047179 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
119044128 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
119042072 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
119052652 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
119051827 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
119057577 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
119056250 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
119064137 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
119063314 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
119055927 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
119050564 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
119050595 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
119053572 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
119062284 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
119060518 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
119037150 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
119051734 RELT; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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