KEGG   PATHWAY: cfr05208
Entry
cfr05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Camelus ferus (Wild Bactrian camel)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
cfr05208  Chemical carcinogenesis - reactive oxygen species
cfr05208

Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102503460  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102503497  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102503577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102503581  NCF1; neutrophil cytosol factor 1 [KO:K08011]
102503644  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102503878  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
102504138  [KO:K05099] [EC:2.7.10.1]
102504272  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102504304  [KO:K00799] [EC:2.5.1.18]
102504305  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
102504523  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102504562  [KO:K00799] [EC:2.5.1.18]
102504600  [KO:K04565] [EC:1.15.1.1]
102504617  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102504715  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
102504726  [KO:K00416]
102504739  [KO:K02263]
102505023  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
102505040  PLD1; phospholipase D1 isoform X3 [KO:K01115] [EC:3.1.4.4]
102505103  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
102505386  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
102505428  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
102505652  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
102505690  [KO:K02649]
102505780  GSTM4; LOW QUALITY PROTEIN: glutathione S-transferase Mu 4 [KO:K00799] [EC:2.5.1.18]
102505905  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102505913  [KO:K00420]
102505930  [KO:K07293] [EC:3.1.3.48]
102506036  [KO:K00799] [EC:2.5.1.18]
102506051  [KO:K02267]
102506135  [KO:K02263]
102506175  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
102506204  RELA; transcription factor p65 isoform X1 [KO:K04735]
102506336  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
102506366  SLC26A1; sulfate anion transporter 1 [KO:K14700]
102506447  [KO:K02271]
102506459  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102506489  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
102506544  [KO:K02264]
102506605  MGST2; LOW QUALITY PROTEIN: microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
102506774  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102507060  [KO:K02270]
102507191  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X2 [KO:K05638]
102507247  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102507559  [KO:K02137]
102507621  ACP1; low molecular weight phosphotyrosine protein phosphatase isoform X2 [KO:K14394] [EC:3.1.3.2 3.1.3.48]
102507693  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
102507723  [KO:K07416] [EC:1.14.14.1]
102508142  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102508336  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
102508476  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
102508617  AS3MT; arsenite methyltransferase isoform X1 [KO:K07755] [EC:2.1.1.137]
102508758  [KO:K00799] [EC:2.5.1.18]
102508840  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
102508877  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
102508921  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
102509027  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102509221  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
102509421  [KO:K02271]
102509448  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102509562  NRAS; GTPase NRas [KO:K07828]
102509578  LPO; lactoperoxidase isoform X2 [KO:K12550] [EC:1.11.1.7]
102509827  [KO:K02270]
102509853  [KO:K08009]
102509936  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
102510124  [KO:K07415] [EC:1.14.14.-]
102510141  [KO:K03944]
102510326  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
102510567  SLC26A2; sulfate transporter isoform X1 [KO:K14701]
102510682  [KO:K07410] [EC:1.14.14.1]
102510949  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
102510956  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
102511004  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
102511078  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102511089  [KO:K02270]
102511134  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102511190  [KO:K00417]
102511209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102511255  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
102511298  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102511501  [KO:K02266]
102511573  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
102511678  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
102511856  NCF2; neutrophil cytosol factor 2 [KO:K08010]
102511954  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
102512003  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
102512235  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
102512378  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102512576  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
102512681  [KO:K02266]
102512695  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
102512974  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
102513074  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
102513205  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102513318  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102513578  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102513603  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
102513911  [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
102514016  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
102514077  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
102514229  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
102514377  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
102514464  [KO:K00799] [EC:2.5.1.18]
102514495  [KO:K00414]
102514673  [KO:K00418]
102514716  [KO:K00799] [EC:2.5.1.18]
102514843  VEGFA; vascular endothelial growth factor A [KO:K05448]
102514861  NOX1; NADPH oxidase 1 isoform X2 [KO:K08008]
102514870  [KO:K02268]
102514933  [KO:K02263]
102515029  PRKD2; LOW QUALITY PROTEIN: serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
102515104  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102515110  [KO:K02265]
102515165  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
102515191  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
102515306  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102515350  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102515424  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
102515646  [KO:K00415]
102515749  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102515937  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102515952  ATP5PO; LOW QUALITY PROTEIN: ATP synthase subunit O, mitochondrial [KO:K02137]
102516214  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
102516285  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102516372  KRAS; GTPase KRas isoform X1 [KO:K07827]
102516397  PTPN1; tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
102516822  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
102516847  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102516893  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102516943  JUN; transcription factor AP-1 [KO:K04448]
102517014  SOS2; son of sevenless homolog 2 [KO:K03099]
102517088  [KO:K02266]
102517156  AHR; LOW QUALITY PROTEIN: aryl hydrocarbon receptor [KO:K09093]
102517204  ABL2; tyrosine-protein kinase ABL2 isoform X5 [KO:K08887] [EC:2.7.10.2]
102517243  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
102517269  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
102517399  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
102517471  [KO:K00411] [EC:7.1.1.8]
102517521  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102517586  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102517878  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
102518111  [KO:K07408] [EC:1.14.14.1]
102518323  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
102518362  [KO:K07409] [EC:1.14.14.1]
102518561  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102518585  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
102518643  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102518805  [KO:K00799] [EC:2.5.1.18]
102518825  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102518907  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
102519101  [KO:K04456] [EC:2.7.11.1]
102519140  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
102519310  ABL1; tyrosine-protein kinase ABL1 isoform X2 [KO:K06619] [EC:2.7.10.2]
102519397  FOS; proto-oncogene c-Fos [KO:K04379]
102519409  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102519415  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
102519500  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
102519717  [KO:K00799] [EC:2.5.1.18]
102519781  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102519782  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102519947  [KO:K00799] [EC:2.5.1.18]
102519984  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
102519994  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102520048  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102520409  [KO:K11352]
102520419  [KO:K05863]
102520541  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102520672  [KO:K00418]
102520779  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [KO:K03941] [EC:7.1.1.2]
102520901  PLD2; phospholipase D2 isoform X2 [KO:K01115] [EC:3.1.4.4]
102520923  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
102521001  SLC26A9; solute carrier family 26 member 9 isoform X2 [KO:K14706]
102521082  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
102521191  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
102521513  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
102521591  EPHX3; epoxide hydrolase 3 isoform X1 [KO:K22368] [EC:3.3.2.10]
102521659  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102521935  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
102522078  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
102522243  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102522368  SOD2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
102522433  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
102522489  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
102522632  [KO:K00418]
102522662  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
102522956  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
102523245  [KO:K00799] [EC:2.5.1.18]
102523295  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
102523341  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
102523502  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102523663  [KO:K00799] [EC:2.5.1.18]
102523689  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
102523769  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102523839  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
102523856  SDHA; LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
102523866  [KO:K00413]
102523889  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
102523993  [KO:K00419]
102524100  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102524104  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
102524165  CAT; catalase [KO:K03781] [EC:1.11.1.6]
102524231  [KO:K02265]
102524292  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
102524334  HRAS; GTPase HRas isoform X1 [KO:K02833]
102524547  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
106729149  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106730896  [KO:K15040]
116656624  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
116657863  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
116661570  [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
116662114  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
116662174  [KO:K02272]
116664480  [KO:K03957]
116666021  [KO:K02267]
116666513  [KO:K02273]
116666587  [KO:K03957]
116669325  [KO:K05862]
5326218  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
5326219  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
5326220  COX3; cytochrome c oxidase subunit III [KO:K02262]
5326221  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
5326222  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
5326223  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
5326224  COX2; cytochrome c oxidase subunit II [KO:K02261]
5326225  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
5326226  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
5326227  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
5326228  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
5326229  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
5326230  CYTB; cytochrome b [KO:K00412]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
cfr00190  Oxidative phosphorylation
cfr00980  Metabolism of xenobiotics by cytochrome P450
cfr04010  MAPK signaling pathway
cfr04064  NF-kappa B signaling pathway
cfr04066  HIF-1 signaling pathway
cfr04151  PI3K-Akt signaling pathway
cfr04370  VEGF signaling pathway
cfr05207  Chemical carcinogenesis - receptor activation
cfr05211  Renal cell carcinoma
cfr05215  Prostate cancer
cfr05219  Bladder cancer
cfr05221  Acute myeloid leukemia
cfr05222  Small cell lung cancer
cfr05223  Non-small cell lung cancer
cfr05224  Breast cancer
cfr05225  Hepatocellular carcinoma
KO pathway
ko05208   

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