KEGG   PATHWAY: cfr04010
Entry
cfr04010                    Pathway                                
Name
MAPK signaling pathway - Camelus ferus (Wild Bactrian camel)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
cfr04010  MAPK signaling pathway
cfr04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Camelus ferus (Wild Bactrian camel) [GN:cfr]
Gene
102503460  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102503497  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
102503514  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102503567  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
102503577  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102503597  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
102503604  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102503654  DAXX; death domain-associated protein 6 [KO:K02308]
102504138  [KO:K05099] [EC:2.7.10.1]
102504151  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102504272  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102504464  FGF20; fibroblast growth factor 20 [KO:K04358]
102504523  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102504702  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
102504854  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
102504877  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102505073  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
102505108  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102505114  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
102505119  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102505131  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102505323  NTF3; neurotrophin-3 isoform X4 [KO:K04356]
102505358  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
102505383  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
102505396  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
102505726  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
102505759  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102505811  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102505857  MAX; protein max isoform X1 [KO:K04453]
102505905  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102506193  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
102506204  RELA; transcription factor p65 isoform X1 [KO:K04735]
102506236  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
102506255  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102506410  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
102506413  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102506459  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102506484  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
102506513  RELB; LOW QUALITY PROTEIN: transcription factor RelB [KO:K09253]
102506564  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102506575  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102506593  FGF6; fibroblast growth factor 6 [KO:K04358]
102506629  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
102506677  KITLG; kit ligand isoform X1 [KO:K05461]
102506694  TGFA; protransforming growth factor alpha [KO:K08774]
102506716  FGF16; fibroblast growth factor 16 [KO:K04358]
102506717  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
102506774  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
102506811  FGF8; fibroblast growth factor 8 [KO:K04358]
102507142  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
102507247  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102507254  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102507309  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
102507567  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
102507710  MEF2C; myocyte-specific enhancer factor 2C isoform X2 [KO:K04454]
102507712  EREG; proepiregulin [KO:K09784]
102507805  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
102507832  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
102507837  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
102507976  AREG; amphiregulin [KO:K09782]
102507992  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X16 [KO:K04436]
102508076  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102508082  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
102508142  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102508422  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
102508482  GADD45A; LOW QUALITY PROTEIN: growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102508666  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
102508710  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
102508761  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102508766  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102508813  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102508884  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
102508911  EFNA2; ephrin-A2 [KO:K05462]
102508964  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102508974  MAPT; microtubule-associated protein tau isoform X12 [KO:K04380]
102508985  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102509143  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102509299  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
102509341  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
102509448  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102509504  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102509562  NRAS; GTPase NRas [KO:K07828]
102509624  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102509744  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102509790  SRF; serum response factor [KO:K04378]
102509815  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
102509937  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
102509959  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102510021  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
102510084  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102510135  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102510147  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
102510153  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
102510291  RASGRP4; RAS guanyl-releasing protein 4 isoform X2 [KO:K12363]
102510424  TNF; tumor necrosis factor [KO:K03156]
102510551  NTF4; neurotrophin-4 [KO:K12457]
102510802  FGF23; fibroblast growth factor 23 [KO:K22428]
102511050  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102511057  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
102511078  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102511086  MYC; myc proto-oncogene protein [KO:K04377]
102511169  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
102511209  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102511298  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102511345  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102511459  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102511476  CRK; adapter molecule crk isoform X1 [KO:K04438]
102511529  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X2 [KO:K04442] [EC:2.7.11.1]
102511604  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102511649  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102511686  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
102511705  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
102511859  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
102511888  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
102511996  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102512022  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102512204  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102512476  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
102512542  [KO:K04408] [EC:2.7.11.1]
102512589  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102512878  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
102512951  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102512968  EFNA5; ephrin-A5 isoform X3 [KO:K05462]
102513025  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
102513163  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102513202  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102513277  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102513465  FGF10; fibroblast growth factor 10 [KO:K04358]
102513473  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
102513516  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102513532  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
102513538  [KO:K04460] [EC:3.1.3.16]
102513578  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
102513589  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102513707  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102513829  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102513858  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102513924  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102513995  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102514045  STK4; serine/threonine-protein kinase 4 [KO:K04411]
102514127  VEGFC; vascular endothelial growth factor C [KO:K05449]
102514176  FGF21; fibroblast growth factor 21 [KO:K22429]
102514431  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
102514486  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102514614  NRTN; neurturin [KO:K25414]
102514634  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102514709  FLNA; filamin-A [KO:K04437]
102514843  VEGFA; vascular endothelial growth factor A [KO:K05448]
102514942  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102515096  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
102515264  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
102515306  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102515350  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102515439  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102515455  [KO:K05465]
102515540  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
102515600  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
102515660  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102515749  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
102515857  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102515859  MAP4K2; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102515933  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102515937  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102516031  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
102516073  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
102516207  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102516248  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
102516372  KRAS; GTPase KRas isoform X1 [KO:K07827]
102516450  RAP1A; ras-related protein Rap-1A [KO:K04353]
102516458  NF1; neurofibromin isoform X1 [KO:K08052]
102516474  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102516558  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
102516584  CRKL; crk-like protein [KO:K04438]
102516599  [KO:K16342] [EC:3.1.1.4]
102516820  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102516847  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102516893  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102516943  JUN; transcription factor AP-1 [KO:K04448]
102516972  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102517010  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102517014  SOS2; son of sevenless homolog 2 [KO:K03099]
102517096  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
102517128  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
102517293  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102517334  CACNA2D4; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102517351  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
102517398  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102517431  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
102517440  HSPA1L; heat shock 70 kDa protein 1-like isoform X2 [KO:K03283]
102517521  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102517586  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102517612  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
102517621  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
102517655  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
102517682  [KO:K03283]
102517735  RRAS; ras-related protein R-Ras [KO:K07829]
102517811  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102517948  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
102518308  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
102518335  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
102518397  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
102518433  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
102518463  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
102518467  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102518538  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
102518561  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102518652  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
102518736  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
102518807  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
102518953  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
102519101  [KO:K04456] [EC:2.7.11.1]
102519112  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102519120  FGF7; fibroblast growth factor 7 [KO:K04358]
102519162  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
102519252  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
102519397  FOS; proto-oncogene c-Fos [KO:K04379]
102519497  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
102519538  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102519593  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102519604  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102519781  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102519782  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102519784  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102519996  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X3 [KO:K04864]
102520052  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
102520066  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
102520107  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102520133  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102520181  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102520352  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102520414  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102520465  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
102520881  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
102520919  PGF; placenta growth factor isoform X5 [KO:K16859]
102521127  KIT; LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102521435  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X7 [KO:K04863]
102521503  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
102521559  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102521659  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102521732  HSPB1; heat shock protein beta-1 [KO:K04455]
102521743  IL1A; interleukin-1 alpha [KO:K04383]
102521766  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
102521828  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
102521979  IL1B; interleukin-1 beta [KO:K04519]
102522017  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
102522137  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102522243  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102522287  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102522326  STMN1; stathmin [KO:K04381]
102522399  RPS6KA2; LOW QUALITY PROTEIN: ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
102522438  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102522485  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
102522525  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102522536  VEGFD; vascular endothelial growth factor D [KO:K05449]
102522544  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102522654  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
102522785  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102522951  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X3 [KO:K04862]
102523201  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
102523391  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
102523572  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102523589  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102523739  ARRB2; beta-arrestin-2 [KO:K04439]
102523767  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102523769  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102523780  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
102523849  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102523878  FGF9; fibroblast growth factor 9 isoform X5 [KO:K04358]
102523898  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
102524036  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102524037  RAP1B; ras-related protein Rap-1b [KO:K07836]
102524081  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
102524100  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102524149  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
102524334  HRAS; GTPase HRas isoform X1 [KO:K02833]
102524338  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
102524428  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
102524476  TP53; cellular tumor antigen p53 [KO:K04451]
102524525  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
106728541  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
106728753  CD14; monocyte differentiation antigen CD14 [KO:K04391]
106729149  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106729205  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X3 [KO:K04347]
106729683  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
106730424  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
106731124  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
116658237  [KO:K03283]
116658259  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
116659012  JUND; transcription factor jun-D [KO:K04449]
116659048  PSPN; persephin [KO:K25416]
116660720  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116666290  [KO:K04346]
116666555  INS; insulin [KO:K04526]
116666646  FGF4; fibroblast growth factor 4 [KO:K04358]
116666647  FGF3; fibroblast growth factor 3 [KO:K04358]
116667966  ARTN; artemin [KO:K25415]
116669020  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
cfr04070  Phosphatidylinositol signaling system
cfr04110  Cell cycle
cfr04115  p53 signaling pathway
cfr04210  Apoptosis
cfr04310  Wnt signaling pathway
cfr04668  TNF signaling pathway
KO pathway
ko04010   

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