KEGG   PATHWAY: dle04510
Entry
dle04510                    Pathway                                
Name
Focal adhesion - Delphinapterus leucas (beluga whale)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
dle04510  Focal adhesion
dle04510

Other DBs
GO: 0005925
Organism
Delphinapterus leucas (beluga whale) [GN:dle]
Gene
111162912  [KO:K12757]
111162913  CRKL; crk-like protein [KO:K04438]
111162972  MYL12B; myosin regulatory light chain 12B [KO:K12757]
111163022  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
111163079  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
111163214  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
111163498  EMP2; epithelial membrane protein 2 [KO:K26256]
111164118  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
111164302  ITGA9; integrin alpha-9 [KO:K06585]
111164467  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
111164604  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
111164624  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
111164732  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
111164744  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
111164771  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
111164877  MYL5; myosin light chain 5 [KO:K12753]
111165019  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
111165046  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111165224  PARVA; alpha-parvin isoform X1 [KO:K06275]
111165564  ELK1; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-1 [KO:K04375]
111165611  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
111165706  TNN; tenascin-N isoform X2 [KO:K06252]
111165733  TNR; tenascin-R isoform X1 [KO:K06252]
111165746  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
111165780  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
111165781  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
111165911  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
111165957  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
111166300  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111166388  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
111166407  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
111166462  CHAD; chondroadherin [KO:K06248]
111166652  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111166713  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
111166972  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
111167062  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
111167253  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
111167562  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
111167641  SHC3; SHC-transforming protein 3 [KO:K17448]
111167894  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
111168040  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111168108  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111168165  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
111168189  [KO:K06238]
111168228  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
111168261  LAMA2; laminin subunit alpha-2 [KO:K05637]
111168304  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
111168369  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
111168370  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
111168922  VEGFD; vascular endothelial growth factor D [KO:K05449]
111168973  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111169176  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
111169265  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111169371  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
111169438  CTNNB1; catenin beta-1 [KO:K02105]
111169643  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111169692  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
111169717  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
111169895  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111169961  CAV3; caveolin-3 [KO:K12959]
111170236  ITGA2B; integrin alpha-IIb [KO:K06476]
111170340  HRAS; GTPase HRas isoform X1 [KO:K02833]
111170344  ACTB; actin, cytoplasmic 1 [KO:K05692]
111170483  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
111170584  FLNA; filamin-A isoform X1 [KO:K04437]
111170701  TNXB; tenascin-X [KO:K06252]
111170902  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
111171109  [KO:K00907] [EC:2.7.11.18]
111171309  [KO:K16858]
111171621  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
111171639  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
111171669  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
111171786  ITGB5; integrin beta-5 [KO:K06588]
111171803  FN1; fibronectin isoform X1 [KO:K05717]
111171889  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
111171891  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
111171971  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111172195  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
111172258  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
111172530  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111172869  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
111172949  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
111173031  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
111173177  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
111173342  VEGFC; vascular endothelial growth factor C [KO:K05449]
111173766  RAP1B; ras-related protein Rap-1b [KO:K07836]
111173839  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111173908  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
111173917  ITGA5; integrin alpha-5 [KO:K06484]
111173950  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
111174067  COL2A1; collagen alpha-1(II) chain [KO:K19719]
111174250  FLNB; filamin-B isoform X1 [KO:K27392]
111174398  RHOA; transforming protein RhoA [KO:K04513]
111174406  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
111174620  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
111174855  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
111174925  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111175094  [KO:K04393]
111175188  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
111175648  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
111175760  [KO:K02649]
111175871  JUN; transcription factor AP-1 [KO:K04448]
111176008  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111176246  PGF; placenta growth factor isoform X1 [KO:K16859]
111176383  COL4A2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
111176384  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
111176521  EMP1; epithelial membrane protein 1 [KO:K26255]
111176638  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
111176651  VWF; von Willebrand factor [KO:K03900]
111177032  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
111177101  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
111177115  LAMC3; laminin subunit gamma-3 [KO:K06247]
111177281  TNC; tenascin isoform X1 [KO:K06252]
111177302  ZYX; zyxin [KO:K06273]
111177507  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
111177559  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111177653  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111177685  TLN2; talin-2 isoform X1 [KO:K06271]
111177745  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111177762  ITGA11; integrin alpha-11 [KO:K06587]
111178037  ITGB1; integrin beta-1 [KO:K05719]
111178094  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
111178811  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111178866  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
111179012  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
111179049  IBSP; bone sialoprotein 2 [KO:K06253]
111179051  SPP1; osteopontin [KO:K06250]
111179235  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111179292  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
111179315  CAV1; caveolin-1 isoform X1 [KO:K06278]
111179321  CAV2; caveolin-2 [KO:K12958]
111179506  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111179935  ITGA10; integrin alpha-10 [KO:K06586]
111180034  RAP1A; ras-related protein Rap-1A [KO:K04353]
111180098  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
111180199  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
111180700  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
111180731  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
111180855  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111180877  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
111180889  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
111180975  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
111180981  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
111181088  COL1A2; collagen alpha-2(I) chain [KO:K06236]
111181452  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
111181472  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
111181617  SHC4; SHC-transforming protein 4 [KO:K17449]
111181755  [KO:K05735] [EC:2.7.11.1]
111181763  THBS1; thrombospondin-1 [KO:K16857]
111181867  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
111181886  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111181944  ITGB8; integrin beta-8 [KO:K06591]
111182181  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111182232  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
111182314  MYL10; myosin regulatory light chain 10 [KO:K12756]
111182589  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
111182681  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
111182710  ACTG1; actin, cytoplasmic 2 [KO:K05692]
111182817  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
111182833  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
111182917  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111183020  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
111183086  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111183266  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
111183536  VCL; vinculin isoform X1 [KO:K05700]
111183632  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
111183676  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
111183810  BAD; bcl2-associated agonist of cell death [KO:K02158]
111183816  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
111184199  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111184217  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
111184432  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
111184472  LAMB1; laminin subunit beta-1 [KO:K05636]
111184514  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
111184548  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111184566  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
111184636  LAMC1; laminin subunit gamma-1 [KO:K05635]
111184637  LAMC2; laminin subunit gamma-2 [KO:K06246]
111184724  LAMB3; laminin subunit beta-3 [KO:K06244]
111184890  THBS4; thrombospondin-4 [KO:K04659]
111184900  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111185202  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
111185668  VTN; vitronectin isoform X1 [KO:K06251]
111185687  CRK; adapter molecule crk isoform X1 [KO:K04438]
111185984  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111186135  EGF; pro-epidermal growth factor [KO:K04357]
111186210  PARVB; beta-parvin isoform X1 [KO:K06275]
111186216  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
111186304  PARVG; gamma-parvin isoform X1 [KO:K06275]
111186344  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
111186354  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111186385  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
111186728  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
111186789  ITGA2; integrin alpha-2 [KO:K06481]
111186810  ITGA1; integrin alpha-1 [KO:K06480]
111186816  LAMA5; laminin subunit alpha-5 [KO:K06240]
111186906  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
111187002  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
111187262  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111187347  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111187819  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
111188003  TLN1; talin-1 [KO:K06271]
111188135  PXN; paxillin isoform X5 [KO:K05760]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
dle04010  MAPK signaling pathway
dle04060  Cytokine-cytokine receptor interaction
dle04070  Phosphatidylinositol signaling system
dle04110  Cell cycle
dle04151  PI3K-Akt signaling pathway
dle04310  Wnt signaling pathway
dle04512  ECM-receptor interaction
dle04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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