KEGG   PATHWAY: elk05165
Entry
elk05165                    Pathway                                
Name
Human papillomavirus infection - Enhydra lutris kenyoni (northern sea otter)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
elk05165  Human papillomavirus infection
elk05165

Organism
Enhydra lutris kenyoni (northern sea otter) [GN:elk]
Gene
111158015  proto-oncogene Wnt-1 [KO:K03209]
111143458  protein Wnt-2b [KO:K00182]
111152038  protein Wnt-2 [KO:K00182]
111139433  protein Wnt-3a [KO:K00312]
111158156  proto-oncogene Wnt-3 [KO:K00312]
111154909  protein Wnt-4 [KO:K00408]
111159795  protein Wnt-5b [KO:K00444]
111144172  protein Wnt-5a isoform X1 [KO:K00444]
111145739  LOW QUALITY PROTEIN: protein Wnt-6 [KO:K00445]
111157688  protein Wnt-7b isoform X1 [KO:K00572]
111159004  protein Wnt-7a [KO:K00572]
111141267  protein Wnt-8a [KO:K00714]
111145241  protein Wnt-8b [KO:K00714]
111139428  protein Wnt-9a [KO:K01064]
111158202  LOW QUALITY PROTEIN: protein Wnt-9b [KO:K01064]
111157990  protein Wnt-10b [KO:K01357]
111144711  protein Wnt-10a [KO:K01357]
111159478  protein Wnt-11 [KO:K01384]
111152110  protein Wnt-16 [KO:K01558]
111141425  frizzled-7 [KO:K02432]
111147325  frizzled-1 [KO:K02432]
111158141  frizzled-2 [KO:K02235]
111156239  frizzled-3 [KO:K02329]
111154467  frizzled-4 [KO:K02354]
111155536  LOW QUALITY PROTEIN: frizzled-8 [KO:K02375]
111143924  frizzled-5 [KO:K02375]
111146642  frizzled-6 [KO:K02376]
111156537  frizzled-10 [KO:K02842]
111146438  frizzled-9 [KO:K02842]
111154625  segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
111161117  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
111148907  LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
111149303  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
111149921  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111156118  axin-1 isoform X1 [KO:K02157]
111158088  axin-2 isoform X1 [KO:K04385]
111161627  adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
111148270  adenomatous polyposis coli protein isoform X1 [KO:K02085]
111159001  catenin beta-1 [KO:K02105]
111140875  casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
111153386  telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
111141244  transcription factor 7 isoform X1 [KO:K02620]
111148131  transcription factor 7-like 1 isoform X1 [KO:K04490]
111145217  transcription factor 7-like 2 isoform X1 [KO:K04491]
111161912  ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
111144566  toll-like receptor 3 [KO:K05401]
111161725  TIR domain-containing adapter molecule 1 [KO:K05842]
111148495  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
111151174  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
111142106  serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
111160645  interferon regulatory factor 3 isoform X1 [KO:K05411]
111156577  interferon beta [KO:K05415]
111157665  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
111156131  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
111144225  transcriptional adapter 3 [KO:K11315]
111161133  cellular tumor antigen p53 [KO:K04451]
111144009  membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
111144778  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111155563  partitioning defective 3 homolog isoform X1 [KO:K04237]
111141641  partitioning defective 6 homolog beta [KO:K06093]
111152962  partitioning defective 6 homolog alpha [KO:K06093]
111154316  partitioning defective 6 homolog gamma [KO:K06093]
111148089  protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
111154565  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
111154823  cell division control protein 42 homolog isoform X1 [KO:K04393]
111146525  protein scribble homolog isoform X1 [KO:K16175]
111155042  disks large homolog 1 isoform X1 [KO:K12076]
111154393  disks large homolog 2 isoform X1 [KO:K12075]
111161008  disks large homolog 3 isoform X1 [KO:K21098]
111160315  lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
111139221  lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
111161767  protein crumbs homolog 3 [KO:K06090]
111142889  inaD-like protein [KO:K06092]
111148772  MAGUK p55 subfamily member 5 [KO:K06091]
111159823  von Willebrand factor isoform X1 [KO:K03900]
111161597  thrombospondin-1 [KO:K16857]
111158682  thrombospondin-2 [KO:K04659]
111148277  LOW QUALITY PROTEIN: thrombospondin-4 [KO:K04659]
111139020  LOW QUALITY PROTEIN: thrombospondin-3 [KO:K04659]
111144008  cartilage oligomeric matrix protein [KO:K04659]
111143733  fibronectin isoform X1 [KO:K05717]
111151317  collagen alpha-1(I) chain isoform X1 [KO:K06236]
111147195  collagen alpha-2(I) chain [KO:K06236]
111157855  collagen alpha-1(II) chain isoform X1 [KO:K19719]
111142203  collagen alpha-3(IV) chain [KO:K06237]
111146901  collagen alpha-1(IV) chain [KO:K06237]
111161271  collagen alpha-5(IV) chain [KO:K06237]
111161277  collagen alpha-6(IV) chain [KO:K06237]
111147037  collagen alpha-2(IV) chain [KO:K06237]
111143029  collagen alpha-4(IV) chain [KO:K06237]
111141881  collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111154965  collagen alpha-4(VI) chain-like [KO:K06238]
111155113  collagen alpha-5(VI) chain [KO:K06238]
111155151  collagen alpha-6(VI) chain [KO:K06238]
111155778  collagen alpha-2(VI) chain isoform X1 [KO:K06238]
111155800  collagen alpha-1(VI) chain [KO:K06238]
111143302  LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
111141418  collagen alpha-3(IX) chain [KO:K08131]
111152338  collagen alpha-1(IX) chain [KO:K08131]
111142456  laminin subunit alpha-1 [KO:K05637]
111147662  laminin subunit alpha-2 [KO:K05637]
111142476  laminin subunit alpha-3 isoform X1 [KO:K06240]
111141516  laminin subunit alpha-5 isoform X1 [KO:K06240]
111158255  laminin subunit alpha-4 isoform X1 [KO:K06241]
111155260  laminin subunit beta-1 isoform X1 [KO:K05636]
111144053  laminin subunit beta-2 isoform X1 [KO:K06243]
111162354  laminin subunit beta-3 [KO:K06244]
111155309  laminin subunit beta-4 [KO:K06245]
111150738  laminin subunit gamma-1 [KO:K05635]
111150870  laminin subunit gamma-2 [KO:K06246]
111145465  laminin subunit gamma-3-like [KO:K06247]
111145932  laminin subunit gamma-3 [KO:K06247]
111151500  LOW QUALITY PROTEIN: chondroadherin [KO:K06248]
111155225  reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
111155535  osteopontin isoform X1 [KO:K06250]
111151505  vitronectin [KO:K06251]
111150918  tenascin-N [KO:K06252]
111150683  tenascin-R [KO:K06252]
111146196  tenascin [KO:K06252]
111152238  tenascin-X [KO:K06252]
111157488  bone sialoprotein 2 isoform X1 [KO:K06253]
111140770  integrin alpha-1 [KO:K06480]
111141135  integrin alpha-2 [KO:K06481]
111158126  integrin alpha-IIb isoform X1 [KO:K06476]
111151764  integrin alpha-3 [KO:K06482]
111160297  integrin alpha-4 isoform X1 [KO:K06483]
111157949  integrin alpha-5 isoform X1 [KO:K06484]
111144193  integrin alpha-6 isoform X1 [KO:K06485]
111160156  integrin alpha-7 isoform X1 [KO:K06583]
111155529  integrin alpha-8 isoform X1 [KO:K06584]
111159088  integrin alpha-9 isoform X1 [KO:K06585]
111162005  integrin alpha-10 isoform X1 [KO:K06586]
111153129  integrin alpha-11 [KO:K06587]
111155043  integrin alpha-V isoform X1 [KO:K06487]
111155558  integrin beta-1 isoform X1 [KO:K05719]
111158107  integrin beta-3 [KO:K06493]
111160262  integrin beta-4 [KO:K06525]
111155029  integrin beta-5 [KO:K06588]
111142308  integrin beta-6 isoform X1 [KO:K06589]
111157851  integrin beta-7 [KO:K06590]
111147337  integrin beta-8 [KO:K06591]
111146744  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
111156467  paxillin [KO:K05760]
111152248  tumor necrosis factor isoform X1 [KO:K03156]
111159748  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
111152832  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111150819  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
111150909  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
111144883  tumor necrosis factor receptor superfamily member 6 [KO:K04390]
111149616  FAS-associated death domain protein [KO:K02373]
111141026  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
111144607  caspase-3 [KO:K02187] [EC:3.4.22.56]
111160256  Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
111141024  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111144543  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
111153735  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
111160772  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
111144887  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
111156936  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
111149174  protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
111154409  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
111159912  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
111155025  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
111157091  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
111150668  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
111149986  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
111160383  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
111147753  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
111148624  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
111145731  hamartin isoform X1 [KO:K07206]
111156259  tuberin isoform X1 [KO:K07207]
111154404  GTP-binding protein Rheb [KO:K07208]
111154883  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111144538  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
111149588  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
111151757  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111152355  bcl-2 homologous antagonist/killer [KO:K14021]
111149975  bcl2-associated agonist of cell death [KO:K02158]
111140848  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
111155003  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111147545  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111154641  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
111143470  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111155224  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111143790  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111161374  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111148765  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111150885  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111158571  LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
111142072  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111142115  cyclin-dependent kinase inhibitor 1B [KO:K06624]
111147618  cyclin-dependent kinase inhibitor 1 [KO:K06625]
111149458  G1/S-specific cyclin-D1 [KO:K04503]
111159766  G1/S-specific cyclin-D2 [KO:K10151]
111147855  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
111160230  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
111147246  cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
111161443  G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
111146791  G1/S-specific cyclin-E2 [KO:K06626]
111160135  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
111146911  retinoblastoma-associated protein [KO:K06618]
111141610  retinoblastoma-like protein 1 isoform X1 [KO:K04681]
111157436  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
111148465  26S proteasome regulatory subunit 4 [KO:K03062]
111141556  transcription factor E2F1 [KO:K17454]
111154269  cyclin-A2 [KO:K06627]
111158563  cyclin-A1 [KO:K06627]
111153730  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
111147364  serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
111147726  vascular endothelial growth factor A [KO:K05448]
111144921  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
111144397  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
111139191  NF-kappa-B essential modulator [KO:K07210]
111153611  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
111149956  transcription factor p65 [KO:K04735]
111142120  E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
111145710  transcriptional repressor NF-X1 isoform X1 [KO:K12236]
111142974  histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
111158262  histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
111159668  chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
111140921  interferon regulatory factor 1 [KO:K09444]
111147566  TATA box-binding protein-like protein 1 [KO:K03120]
111158703  TATA-box-binding protein [KO:K03120]
111140634  TATA box-binding protein-like protein 2 [KO:K03120]
111152501  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
111139664  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q8 alpha chain-like [KO:K06751]
111152201  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152203  DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
111152204  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
111152405  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, A-36 alpha chain [KO:K06751]
111139175  B-cell receptor-associated protein 31 [KO:K14009]
111151188  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
111148052  V-type proton ATPase subunit B, kidney isoform [KO:K02147]
111155049  V-type proton ATPase subunit B, brain isoform [KO:K02147]
111146645  V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
111154195  V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
111148774  V-type proton ATPase subunit D isoform X1 [KO:K02149]
111159822  V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
111155954  V-type proton ATPase subunit E 2 [KO:K02150]
111152026  V-type proton ATPase subunit F [KO:K02151]
111142544  V-type proton ATPase subunit G 1-like isoform X1 [KO:K02152]
111151163  V-type proton ATPase subunit G 3 [KO:K02152]
111152277  V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
111146191  V-type proton ATPase subunit G 1 isoform X1 [KO:K02152]
111155413  V-type proton ATPase subunit H isoform X1 [KO:K02144]
111151299  V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
111151992  V-type proton ATPase 116 kDa subunit a [KO:K02154]
111156406  V-type proton ATPase 116 kDa subunit a [KO:K02154]
111150062  V-type proton ATPase 116 kDa subunit a [KO:K02154]
111146695  V-type proton ATPase subunit d 2 [KO:K02146]
111152837  V-type proton ATPase subunit d 1 [KO:K02146]
111141215  V-type proton ATPase subunit e 1 [KO:K02153]
111154444  V-type proton ATPase subunit e 2 [KO:K02153]
111156039  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
111143472  V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
111139189  V-type proton ATPase subunit S1 [KO:K03662]
111156359  pro-epidermal growth factor isoform X1 [KO:K04357]
111157042  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
111160411  growth factor receptor-bound protein 2 [KO:K04364]
111158354  son of sevenless homolog 1 isoform X1 [KO:K03099]
111160889  son of sevenless homolog 2 isoform X1 [KO:K03099]
111140316  GTPase HRas isoform X1 [KO:K02833]
111159984  GTPase KRas isoform X1 [KO:K07827]
111143238  GTPase NRas [KO:K07828]
111144322  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111153158  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111161815  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111162236  LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111142759  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111150791  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
111140991  prostaglandin E2 receptor EP4 subtype [KO:K04261]
111141614  LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas [KO:K04632]
111141312  neuroendocrine secretory protein 55 [KO:K04632]
111162516  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111143399  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
111160657  apoptosis regulator BAX isoform X1 [KO:K02159]
111147575  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
111151973  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
111146280  cyclic AMP-responsive element-binding protein 3 [KO:K09048]
111150050  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
111138943  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
111161856  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
111147321  cyclic AMP-responsive element-binding protein 5 [KO:K09047]
111154687  E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
111151366  LOW QUALITY PROTEIN: tubulin gamma-2 chain-like [KO:K10389]
111151709  tubulin gamma-1 chain isoform X1 [KO:K10389]
111153359  pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
111140482  interferon alpha-1/2-like [KO:K05414]
111159856  interferon alpha-1/2-like [KO:K05414]
111159858  interferon alpha-1/2-like [KO:K05414]
111159859  interferon alpha-1/2-like [KO:K05414]
111159861  interferon alpha-1/2-like [KO:K05414]
111159862  interferon alpha-1/2-like [KO:K05414]
111156578  interferon alpha-2-like [KO:K05414]
111156593  interferon alpha-1/2-like [KO:K05414]
111156594  interferon alpha-1/2-like [KO:K05414]
111156604  interferon alpha-like [KO:K05414]
111140592  interferon alpha-1/2-like [KO:K05414]
111156606  interferon alpha-1/2-like [KO:K05414]
111156609  interferon alpha-1/2-like [KO:K05414]
111140329  interferon alpha-1/2-like [KO:K05414]
111140335  interferon alpha-1/2-like [KO:K05414]
111140336  interferon alpha-1/2-like [KO:K05414]
111155707  interferon alpha/beta receptor 1 [KO:K05130]
111155645  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
111142881  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
111162402  non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
111144592  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
111160141  signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
111140721  interferon regulatory factor 9 isoform X1 [KO:K04693]
111158436  interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
111156444  2'-5'-oligoadenylate synthase-like protein isoform X1 [KO:K14608]
111156445  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
111155708  interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
111155686  interferon-induced GTP-binding protein Mx2 [KO:K14754]
111154860  ubiquitin-like protein ISG15 [KO:K12159]
111141735  LOW QUALITY PROTEIN: protein jagged-1 [KO:K06052]
111145671  neurogenic locus notch homolog protein 1 [KO:K02599]
111142867  neurogenic locus notch homolog protein 2 [KO:K20994]
111143932  neurogenic locus notch homolog protein 3 [KO:K20995]
111152233  neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
111148789  presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
111160292  beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
111146201  beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
111157518  beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
111149077  mastermind-like protein 3 [KO:K06061]
111158886  mastermind-like protein 1 [KO:K06061]
111154352  mastermind-like protein 2 [KO:K06061]
111141790  recombining binding protein suppressor of hairless-like protein [KO:K06053]
111148915  recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
111155108  transcription factor HES-1 [KO:K06054]
111161239  transcription factor HES-7 isoform X1 [KO:K09087]
111143951  transcription cofactor HES-6 isoform X1 [KO:K09087]
111154571  transcription factor HES-2 [KO:K09087]
111154846  LOW QUALITY PROTEIN: transcription factor HES-3 [KO:K09088]
111154753  transcription factor HES-4 [KO:K09089]
111154575  transcription factor HES-5 [KO:K06055]
111156810  hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1 [KO:K09091]
111143160  hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
111147815  hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Sci Rep 5:13446 (2015)
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Pathogens 5:E8 (2016)
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The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
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Viruses 7:3530-51 (2015)
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PDZ domains: the building blocks regulating tumorigenesis.
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Related
pathway
elk04064  NF-kappa B signaling pathway
elk04110  Cell cycle
elk04115  p53 signaling pathway
elk04150  mTOR signaling pathway
elk04151  PI3K-Akt signaling pathway
elk04210  Apoptosis
elk04310  Wnt signaling pathway
elk04330  Notch signaling pathway
elk04510  Focal adhesion
elk04520  Adherens junction
elk04530  Tight junction
elk04612  Antigen processing and presentation
elk04620  Toll-like receptor signaling pathway
elk04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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