KEGG   PATHWAY: hai04020
Entry
hai04020                    Pathway                                
Name
Calcium signaling pathway - Hipposideros armiger (great roundleaf bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
hai04020  Calcium signaling pathway
hai04020

Other DBs
GO: 0019722
Organism
Hipposideros armiger (great roundleaf bat) [GN:hai]
Gene
109371185  TACR1; substance-P receptor [KO:K04222]
109371226  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
109371439  SLN; sarcolipin [KO:K22642]
109371489  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
109371600  P2RX3; P2X purinoceptor 3 [KO:K05217]
109371751  ADRB2; beta-2 adrenergic receptor [KO:K04142]
109371801  TACR2; substance-K receptor [KO:K04223]
109372154  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
109372167  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
109372169  [KO:K04809]
109372224  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
109372230  CALM3; calmodulin [KO:K02183]
109372316  [KO:K04959]
109372359  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
109372366  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
109372375  [KO:K04360] [EC:2.7.10.1]
109372433  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
109372443  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109372505  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
109372533  TACR3; neuromedin-K receptor [KO:K04224]
109372542  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
109372639  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
109372707  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
109372784  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
109372902  MCOLN3; mucolipin-3 [KO:K04994]
109372907  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
109372936  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109373011  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
109373019  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
109373149  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109373426  RYR3; ryanodine receptor 3 [KO:K04963]
109373436  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
109373530  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
109373565  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
109373868  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
109373962  [KO:K04962]
109374086  [KO:K05863]
109374124  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
109374154  FGF2; fibroblast growth factor 2 [KO:K18497]
109374179  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
109374195  ORAI3; protein orai-3 [KO:K16058]
109374306  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
109374595  PLN; cardiac phospholamban [KO:K05852]
109374619  [KO:K04360] [EC:2.7.10.1]
109374771  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
109374806  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
109374851  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
109374899  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
109375001  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
109375002  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109375158  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
109375340  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
109375422  [KO:K23449]
109375479  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
109375563  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
109375864  AGTR1; type-1 angiotensin II receptor [KO:K04166]
109375958  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109375976  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
109376002  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
109376154  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
109376246  P2RX6; P2X purinoceptor 6 isoform X1 [KO:K05221]
109376279  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
109377479  [KO:K04962]
109377773  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
109377781  [KO:K00476] [EC:1.14.11.16]
109378011  AVPR1A; vasopressin V1a receptor [KO:K04226]
109378262  [KO:K10785]
109378365  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
109378976  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
109378977  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
109379237  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
109379381  FGF18; fibroblast growth factor 18 [KO:K04358]
109379436  EGF; pro-epidermal growth factor [KO:K04357]
109379535  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
109379623  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
109379925  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
109379974  TNNC2; troponin C, skeletal muscle [KO:K12042]
109380044  NTSR1; neurotensin receptor type 1 [KO:K04211]
109380071  [KO:K04632]
109380072  [KO:K04632]
109380134  DRD1; D(1A) dopamine receptor [KO:K04144]
109380137  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
109380210  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
109380289  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
109380340  [KO:K02183]
109380439  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
109380562  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
109380634  MRLN; myoregulin [KO:K22643]
109380706  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
109380800  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
109380898  GRM1; metabotropic glutamate receptor 1 [KO:K04603]
109380910  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
109380957  [KO:K05860] [EC:3.1.4.11]
109381812  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
109381815  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
109381836  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
109381883  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
109382076  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
109382179  ADORA2B; adenosine receptor A2b [KO:K04267]
109382238  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
109382261  TPCN1; two pore calcium channel protein 1 [KO:K16896]
109382437  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
109382502  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
109382541  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
109382625  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
109382670  CALM1; calmodulin [KO:K02183]
109382691  STIM2; stromal interaction molecule 2 [KO:K18196]
109382695  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
109382719  BDKRB2; B2 bradykinin receptor [KO:K03916]
109382720  BDKRB1; B1 bradykinin receptor [KO:K03915]
109382864  VEGFA; vascular endothelial growth factor A [KO:K05448]
109382919  TFEB; transcription factor EB [KO:K15590]
109383003  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109383050  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
109383104  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
109383120  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
109383198  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
109383261  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
109383483  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
109383627  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
109383749  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
109383794  [KO:K02183]
109383796  [KO:K02183]
109383819  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
109383962  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
109383976  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
109384108  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
109384216  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
109384329  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
109384471  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
109385064  ORAI2; protein orai-2 [KO:K16057]
109385084  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
109385184  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
109385186  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
109385340  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
109385384  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
109385440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
109385540  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
109385655  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
109385680  FGF16; fibroblast growth factor 16 [KO:K04358]
109385746  [KO:K04634]
109385757  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
109385859  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
109385981  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
109386041  P2RX7; P2X purinoceptor 7 [KO:K05220]
109386055  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
109386080  P2RX4; P2X purinoceptor 4 [KO:K05218]
109386109  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
109386288  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
109386473  AVPR1B; vasopressin V1b receptor [KO:K04227]
109386480  CASQ1; calsequestrin-1 [KO:K23468]
109386487  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
109386578  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
109386687  PTAFR; platelet-activating factor receptor [KO:K04279]
109387040  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
109387120  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
109387184  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
109387257  HRH1; histamine H1 receptor [KO:K04149]
109387270  OXTR; oxytocin receptor [KO:K04229]
109387285  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
109387299  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
109387670  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
109388085  [KO:K00907] [EC:2.7.11.18]
109388365  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
109388507  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
109388540  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
109388620  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
109388624  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
109388646  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
109388950  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
109389071  EDNRB; endothelin B receptor [KO:K04198]
109389152  [KO:K04282]
109389288  FGF19; fibroblast growth factor 19 [KO:K22603]
109389289  FGF3; fibroblast growth factor 3 [KO:K04358]
109389290  FGF4; fibroblast growth factor 4 [KO:K04358]
109389312  TPCN2; two pore calcium channel protein 2 [KO:K14077]
109389346  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109389408  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
109389680  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
109389796  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109389900  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
109389917  CALM2; calmodulin [KO:K02183]
109390085  [KO:K05096] [EC:2.7.10.1]
109390284  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
109390432  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
109390487  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
109390582  FGF22; fibroblast growth factor 22 [KO:K04358]
109390640  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
109390884  [KO:K05863]
109390958  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109390975  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
109391024  FGF21; fibroblast growth factor 21 [KO:K22429]
109391059  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
109391086  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
109391149  CALML6; calmodulin-like protein 6 [KO:K02183]
109391452  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
109391502  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
109391534  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
109391742  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
109391854  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
109391881  P2RX5; P2X purinoceptor 5 [KO:K05219]
109391888  P2RX1; P2X purinoceptor 1 [KO:K05215]
109391912  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
109392029  ADRB1; beta-1 adrenergic receptor [KO:K04141]
109392133  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
109392231  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
109392273  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
109392334  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
109392355  [KO:K15040]
109392365  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
109392407  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
109392469  FGF23; fibroblast growth factor 23 [KO:K22428]
109392478  FGF6; fibroblast growth factor 6 [KO:K04358]
109392584  [KO:K05840]
109392585  [KO:K05840]
109392611  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
109392711  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
109392738  EDNRA; endothelin-1 receptor [KO:K04197]
109392740  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109392787  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
109392802  CASQ2; calsequestrin-2 [KO:K23445]
109392809  NGF; beta-nerve growth factor [KO:K02582]
109392844  FGF10; fibroblast growth factor 10 [KO:K04358]
109393379  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109393585  ADRB3; beta-3 adrenergic receptor [KO:K04143]
109393593  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
109393596  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
109393629  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
109393705  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109394203  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
109394225  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
109394251  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
109394278  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
109394331  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
109394542  FGF7; fibroblast growth factor 7 [KO:K04358]
109394578  FGF20; fibroblast growth factor 20 [KO:K04358]
109394772  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
109394916  ADORA2A; adenosine receptor A2a [KO:K04266]
109394938  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109394950  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
109394976  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
109395037  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
109395227  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
109395309  GRPR; gastrin-releasing peptide receptor [KO:K04169]
109395341  [KO:K04961]
109395552  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
109395568  HTR6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
109395578  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
109395800  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
109395862  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
109395927  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109395944  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
109396081  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
109396120  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
109396479  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
109396911  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
hai04010  MAPK signaling pathway
hai04070  Phosphatidylinositol signaling system
hai04210  Apoptosis
hai04720  Long-term potentiation
hai04730  Long-term depression
KO pathway
ko04020   

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