KEGG   PATHWAY: maua04510
Entry
maua04510                   Pathway                                
Name
Focal adhesion - Mesocricetus auratus (golden hamster)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
maua04510  Focal adhesion
maua04510

Other DBs
GO: 0005925
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101822483  [KO:K06238]
101822506  Pdgfra; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101822512  Ctnnb1; catenin beta-1 [KO:K02105]
101822552  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101822629  [KO:K06274]
101822630  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101822760  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
101822781  Vav1; proto-oncogene vav [KO:K05730]
101823016  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101823025  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
101823090  Igf1; insulin-like growth factor I [KO:K05459]
101823280  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101823304  Crkl; crk-like protein [KO:K04438]
101823512  Braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101823756  Rap1b; ras-related protein Rap-1b [KO:K07836]
101823825  Itga3; integrin alpha-3 isoform X2 [KO:K06482]
101824254  Lamc2; laminin subunit gamma-2 isoform X2 [KO:K06246]
101824325  [KO:K04393]
101824434  Emp1; epithelial membrane protein 1 [KO:K26255]
101824566  Thbs2; thrombospondin-2 [KO:K04659]
101824666  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101824731  Lama1; laminin subunit alpha-1 [KO:K05637]
101824743  Prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101824803  [KO:K04725] [EC:2.3.2.27]
101824908  Emp2; epithelial membrane protein 2 [KO:K26256]
101825008  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101825118  Parvb; beta-parvin [KO:K06275]
101825282  Elk1; ETS domain-containing protein Elk-1 [KO:K04375]
101825320  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101825449  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
101825458  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
101825464  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101825509  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101825566  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
101825606  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101825767  Rasgrf1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
101825769  Cav1; caveolin-1 isoform X1 [KO:K06278]
101825943  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101826097  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
101826377  Vtn; vitronectin [KO:K06251]
101826420  Itgav; integrin alpha-V isoform X1 [KO:K06487]
101826477  Col1a2; collagen alpha-2(I) chain [KO:K06236]
101826613  Fn1; fibronectin isoform X1 [KO:K05717]
101826731  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101827006  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
101827071  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101827266  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
101827358  [KO:K12757]
101827411  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
101827540  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101827609  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
101827753  Mylk; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101828005  Itgb3; integrin beta-3 [KO:K06493]
101828136  Prkcg; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101828362  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
101828739  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4 [KO:K00922] [EC:2.7.1.153]
101828877  Vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
101829002  Ibsp; bone sialoprotein 2 precursor [KO:K06253]
101829045  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101829259  Jun; transcription factor AP-1 [KO:K04448]
101829386  Vav2; guanine nucleotide exchange factor VAV2 isoform X6 [KO:K05730]
101829520  Tnn; tenascin-N [KO:K06252]
101829539  Spp1; osteopontin precursor [KO:K06250]
101829610  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101829713  Pdgfc; platelet-derived growth factor C [KO:K05450]
101829744  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
101829758  Itga4; integrin alpha-4 [KO:K06483]
101829822  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101829918  Vcl; vinculin isoform X1 [KO:K05700]
101830043  Itga5; integrin alpha-5 [KO:K06484]
101830308  Col2a1; collagen alpha-1(II) chain [KO:K19719]
101830366  Egf; pro-epidermal growth factor [KO:K04357]
101830595  Lamc1; laminin subunit gamma-1 [KO:K05635]
101830761  Col6a1; collagen alpha-1(VI) chain precursor [KO:K06238]
101830978  Lamb1; laminin subunit beta-1 [KO:K05636]
101831072  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
101831139  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101831281  Col9a1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
101831344  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101831400  [KO:K02649]
101831438  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
101831601  Tln1; talin-1 [KO:K06271]
101831702  Zyx; zyxin [KO:K06273]
101831918  Rhoa; transforming protein RhoA [KO:K04513]
101831982  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101832049  Itga8; integrin alpha-8 [KO:K06584]
101832187  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101832390  Arhgap5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
101832419  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101832424  Shc3; SHC-transforming protein 3 [KO:K17448]
101832477  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101832813  Col4a2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
101833080  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
101833210  Pgf; placenta growth factor [KO:K16859]
101833518  [KO:K04513]
101833646  Thbs4; thrombospondin-4 [KO:K04659]
101833693  Capn2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
101833785  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
101833975  [KO:K04659]
101834032  Pxn; paxillin isoform X1 [KO:K05760]
101834069  Cav3; caveolin-3 [KO:K12959]
101834115  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101834139  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101834505  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
101834635  Fyn; tyrosine-protein kinase Fyn isoform X2 [KO:K05703] [EC:2.7.10.2]
101834766  Lamb3; laminin subunit beta-3 [KO:K06244]
101834813  Lama4; laminin subunit alpha-4 [KO:K06241]
101834992  Itga11; integrin alpha-11 [KO:K06587]
101835018  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
101835039  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101835090  Thbs3; thrombospondin-3 [KO:K04659]
101835360  Itgb1; integrin beta-1 [KO:K05719]
101835694  Birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
101835727  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101835751  Pak5; serine/threonine-protein kinase PAK 5 isoform X2 [KO:K05736] [EC:2.7.11.1]
101835840  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101835846  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101835885  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
101835912  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101836141  Itga2; integrin alpha-2 [KO:K06481]
101836144  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
101836153  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
101836282  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101836494  Rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
101836507  Mylk4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
101836539  Parva; alpha-parvin isoform X1 [KO:K06275]
101836988  Tln2; talin-2 isoform X2 [KO:K06271]
101837493  [KO:K12757]
101837515  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101837553  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
101837554  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101837630  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
101837899  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
101837968  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
101838062  Vav3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
101838398  Col6a2; collagen alpha-2(VI) chain precursor [KO:K06238]
101838520  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
101838535  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
101838749  Egfr; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101838767  Tnc; tenascin isoform X1 [KO:K06252]
101838799  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
101838968  Hras; GTPase HRas isoform X1 [KO:K02833]
101839171  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101839264  Crk; adapter molecule crk isoform X1 [KO:K04438]
101839375  Actg1; actin, cytoplasmic 2 [KO:K05692]
101839822  Vegfa; vascular endothelial growth factor A precursor [KO:K05448]
101839961  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
101840042  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
101840069  Itgb7; integrin beta-7 [KO:K06590]
101840188  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101840296  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101840309  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
101840462  Sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
101840690  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101841047  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
101841113  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101841127  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
101841237  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
101841265  Tnr; tenascin-R isoform X1 [KO:K06252]
101841290  Shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
101841364  Rap1a; ras-related protein Rap-1A isoform X1 [KO:K04353]
101841399  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
101841493  Vwf; von Willebrand factor [KO:K03900]
101841602  Shc4; SHC-transforming protein 4 [KO:K17449]
101841615  Itgb5; integrin beta-5 [KO:K06588]
101841668  Mapk3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101841730  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101841837  Itga1; integrin alpha-1 [KO:K06480]
101842052  Flna; filamin-A isoform X1 [KO:K04437]
101842312  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101842418  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
101842429  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
101842444  Flnb; LOW QUALITY PROTEIN: filamin-B [KO:K27392]
101842568  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101842797  Col6a6; collagen alpha-6(VI) chain isoform X4 [KO:K06238]
101842876  Sos1; son of sevenless homolog 1 [KO:K03099]
101842965  Chad; chondroadherin [KO:K06248]
101843056  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101843083  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101843167  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101843208  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
101843392  Itgb6; integrin beta-6 [KO:K06589]
101843435  Shc2; SHC-transforming protein 2 [KO:K17447]
101843459  Mylk3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
101843471  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101843920  Parvg; gamma-parvin isoform X1 [KO:K06275]
101843989  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101843997  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101844031  Col9a3; collagen alpha-3(IX) chain isoform X2 [KO:K08131]
101844224  [KO:K12757]
101844354  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
101844417  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101844490  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101844568  Col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101844587  Actb; actin, cytoplasmic 1 [KO:K05692]
101844826  Col6a5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
106020726  Cav2; caveolin-2 isoform X1 [KO:K12958]
106020891  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
106022343  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
110339912  [KO:K16060]
121133988  Myl10; myosin regulatory light chain 10 [KO:K12756]
121136460  [KO:K06247]
121137946  [KO:K06247]
121138416  [KO:K06247]
121140759  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
maua04010  MAPK signaling pathway
maua04060  Cytokine-cytokine receptor interaction
maua04070  Phosphatidylinositol signaling system
maua04110  Cell cycle
maua04151  PI3K-Akt signaling pathway
maua04310  Wnt signaling pathway
maua04512  ECM-receptor interaction
maua04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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