KEGG   PATHWAY: maua04151
Entry
maua04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Mesocricetus auratus (golden hamster)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
maua04151  PI3K-Akt signaling pathway
maua04151

Other DBs
GO: 0043491
Organism
Mesocricetus auratus (golden hamster) [GN:maua]
Gene
101830366  Egf; pro-epidermal growth factor [KO:K04357]
101823727  Tgfa; protransforming growth factor alpha [KO:K08774]
101834349  Ereg; proepiregulin [KO:K09784]
101837230  Areg; amphiregulin [KO:K09782]
101823630  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101834448  Fgf2; fibroblast growth factor 2 [KO:K18497]
101830284  Fgf8; fibroblast growth factor 8 isoform X3 [KO:K04358]
101838365  Fgf4; fibroblast growth factor 4 [KO:K04358]
101838622  Fgf3; fibroblast growth factor 3 [KO:K04358]
101837518  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
101841394  Fgf22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101831487  Fgf18; fibroblast growth factor 18 [KO:K04358]
101835364  Fgf6; fibroblast growth factor 6 [KO:K04358]
101828598  Fgf16; fibroblast growth factor 16 [KO:K04358]
101828286  Fgf9; fibroblast growth factor 9 [KO:K04358]
101828703  Fgf7; fibroblast growth factor 7 [KO:K04358]
101837923  Fgf20; fibroblast growth factor 20 [KO:K04358]
101838888  Fgf10; fibroblast growth factor 10 [KO:K04358]
106021596  fibroblast growth factor 8-like [KO:K04358]
101828257  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101838091  Fgf19; fibroblast growth factor 19 [KO:K22603]
101842115  Fgf21; fibroblast growth factor 21 [KO:K22429]
101835630  Fgf23; fibroblast growth factor 23 [KO:K22428]
110342135  Ngf; beta-nerve growth factor [KO:K02582]
101837384  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
101832672  Ntf3; neurotrophin-3 [KO:K04356]
101844774  Ntf4; neurotrophin-4 [KO:K12457]
101823595  Ins; insulin [KO:K04526]
101823090  Igf1; insulin-like growth factor I [KO:K05459]
101824029  Igf2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
101832477  Pdgfa; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
101835912  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
101834115  Pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
101829713  Pdgfc; platelet-derived growth factor C [KO:K05450]
101826376  Csf1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101837932  Kitlg; kit ligand isoform X1 [KO:K05461]
101827195  Flt3lg; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
101839822  Vegfa; vascular endothelial growth factor A precursor [KO:K05448]
101834505  Vegfb; vascular endothelial growth factor B isoform X1 [KO:K16858]
101833210  Pgf; placenta growth factor [KO:K16859]
101823025  Vegfd; vascular endothelial growth factor D isoform X3 [KO:K05449]
101828877  Vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
101829822  Hgf; hepatocyte growth factor isoform X1 [KO:K05460]
101829973  Angpt1; angiopoietin-1 isoform X1 [KO:K05465]
101835194  Angpt2; angiopoietin-2 [KO:K05466]
101827925  Angpt4; angiopoietin-4 isoform X2 [KO:K05467]
101834666  Efna2; ephrin-A2 [KO:K05462]
101828475  Efna5; ephrin-A5 isoform X1 [KO:K05462]
101837986  Efna3; ephrin-A3 isoform X1 [KO:K05462]
101838252  Efna4; ephrin-A4 [KO:K05462]
101837719  Efna1; ephrin-A1 isoform X1 [KO:K05462]
101835435  Gdnf; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
101828307  Nrtn; neurturin [KO:K25414]
101832755  Artn; artemin [KO:K25415]
101825771  Pspn; persephin [KO:K25416]
101838749  Egfr; epidermal growth factor receptor isoform X2 [KO:K04361] [EC:2.7.10.1]
101822760  Erbb2; receptor tyrosine-protein kinase erbB-2 precursor [KO:K05083] [EC:2.7.10.1]
101828925  Erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
101831481  Erbb4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
101842486  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
101837200  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
101826351  Fgfr3; fibroblast growth factor receptor 3 isoform X6 [KO:K05094] [EC:2.7.10.1]
101828736  Fgfr4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101825585  Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101843619  Ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
101839587  Ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
121134754  LOW QUALITY PROTEIN: insulin receptor-like [KO:K04527] [EC:2.7.10.1]
121136483  Insr; insulin receptor [KO:K04527] [EC:2.7.10.1]
101825606  Igf1r; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101822506  Pdgfra; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101840188  Pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101839736  Csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
101844689  Kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
101833265  LOW QUALITY PROTEIN: mast/stem cell growth factor receptor Kit-like [KO:K05091] [EC:2.7.10.1]
101824111  Flt3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
101840690  Flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
101835846  Flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
101844417  Kdr; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101825509  Met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
101840374  Tek; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
101831253  Epha2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
101835994  Ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
101842418  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
101842876  Sos1; son of sevenless homolog 1 [KO:K03099]
101840462  Sos2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
101838968  Hras; GTPase HRas isoform X1 [KO:K02833]
101835944  Kras; GTPase KRas isoform X1 [KO:K07827]
101841999  Nras; GTPase NRas isoform X1 [KO:K07828]
121137054  GTPase NRas-like [KO:K07828]
101843997  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101831139  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101822879  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101825943  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101841668  Mapk3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101832053  Irs1; insulin receptor substrate 1 [KO:K16172]
101838156  Tlr2; toll-like receptor 2 isoform X1 [KO:K10159]
101824088  Tlr4; toll-like receptor 4 [KO:K10160]
101841113  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X2 [KO:K04392]
101830753  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
121143240  Cd19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
101826215  Pik3ap1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
101843583  Gh1; somatotropin precursor [KO:K05438]
101843376  prolactin precursor [KO:K05439]
101823615  prolactin-6A1-like [KO:K05439]
101824659  prolactin-6A1-like [KO:K05439]
101841774  prolactin-5A1-like [KO:K05439]
101837777  Osm; oncostatin-M [KO:K05418]
101835410  Il2; interleukin-2 precursor [KO:K05429]
101839443  Il6; interleukin-6 [KO:K05405]
101843742  Il4; interleukin-4 [KO:K05430]
110340351  Il7; interleukin-7 isoform X1 [KO:K05431]
101824534  interferon alpha-12-like [KO:K05414]
101836898  interferon alpha-12-like [KO:K05414]
101836618  interferon alpha-12-like [KO:K05414]
101824794  interferon alpha-9-like [KO:K05414]
121144094  interferon alpha-12-like [KO:K05414]
121144095  interferon alpha-12-like [KO:K05414]
121144097  interferon alpha-12-like [KO:K05414]
121144098  interferon alpha-12-like [KO:K05414]
121144100  interferon alpha-9-like [KO:K05414]
121144101  interferon alpha-12-like [KO:K05414]
121144102  interferon alpha-12-like [KO:K05414]
121144103  interferon alpha-12-like [KO:K05414]
121144104  interferon alpha-12-like [KO:K05414]
121144105  interferon alpha-12-like [KO:K05414]
121144026  Ifnb1; interferon beta [KO:K05415]
106021967  Epo; erythropoietin isoform X1 [KO:K05437]
101823561  Csf3; granulocyte colony-stimulating factor [KO:K05423]
101829135  Ghr; growth hormone receptor isoform X1 [KO:K05080]
101838338  Prlr; prolactin receptor isoform X1 [KO:K05081]
101824546  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
101838934  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
101831461  Il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
101824015  Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
101825858  Il6r; interleukin-6 receptor subunit alpha [KO:K05055]
101844429  Il4r; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
101826635  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
101828375  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
106021446  Ifnar2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101825850  Epor; erythropoietin receptor isoform X1 [KO:K05079]
106022359  Csf3r; granulocyte colony-stimulating factor receptor [KO:K05061]
101843653  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101831977  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101842209  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101826477  Col1a2; collagen alpha-2(I) chain [KO:K06236]
101844568  Col1a1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101830308  Col2a1; collagen alpha-1(II) chain [KO:K19719]
101832813  Col4a2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
101833080  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
101840042  Col4a6; collagen alpha-6(IV) chain [KO:K06237]
101840309  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
101837630  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
101837899  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
101830761  Col6a1; collagen alpha-1(VI) chain precursor [KO:K06238]
101838398  Col6a2; collagen alpha-2(VI) chain precursor [KO:K06238]
101842797  Col6a6; collagen alpha-6(VI) chain isoform X4 [KO:K06238]
101844826  Col6a5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
101822483  LOW QUALITY PROTEIN: collagen alpha-4(VI) chain-like [KO:K06238]
101827266  Col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
101838799  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
101831281  Col9a1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
101844031  Col9a3; collagen alpha-3(IX) chain isoform X2 [KO:K08131]
101822630  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101824731  Lama1; laminin subunit alpha-1 [KO:K05637]
101837968  Lama5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
101839171  Lama3; laminin subunit alpha-3 isoform X1 [KO:K06240]
101834813  Lama4; laminin subunit alpha-4 [KO:K06241]
101830978  Lamb1; laminin subunit beta-1 [KO:K05636]
101842429  Lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
101834766  Lamb3; laminin subunit beta-3 [KO:K06244]
101830595  Lamc1; laminin subunit gamma-1 [KO:K05635]
101824254  Lamc2; laminin subunit gamma-2 isoform X2 [KO:K06246]
121136460  laminin subunit gamma-3-like [KO:K06247]
121137946  LOW QUALITY PROTEIN: laminin subunit gamma-3-like [KO:K06247]
121138416  LOW QUALITY PROTEIN: laminin subunit gamma-3-like [KO:K06247]
101842965  Chad; chondroadherin [KO:K06248]
101831344  Reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101827006  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
101824566  Thbs2; thrombospondin-2 [KO:K04659]
101833646  Thbs4; thrombospondin-4 [KO:K04659]
101833975  cartilage oligomeric matrix protein [KO:K04659]
101835090  Thbs3; thrombospondin-3 [KO:K04659]
101826613  Fn1; fibronectin isoform X1 [KO:K05717]
101829539  Spp1; osteopontin precursor [KO:K06250]
101826377  Vtn; vitronectin [KO:K06251]
101841047  Tnxb; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
101841265  Tnr; tenascin-R isoform X1 [KO:K06252]
101838767  Tnc; tenascin isoform X1 [KO:K06252]
101829520  Tnn; tenascin-N [KO:K06252]
101841493  Vwf; von Willebrand factor [KO:K03900]
101829002  Ibsp; bone sialoprotein 2 precursor [KO:K06253]
101841837  Itga1; integrin alpha-1 [KO:K06480]
101836141  Itga2; integrin alpha-2 [KO:K06481]
101843208  Itga2b; integrin alpha-IIb isoform X1 [KO:K06476]
101823825  Itga3; integrin alpha-3 isoform X2 [KO:K06482]
101829758  Itga4; integrin alpha-4 [KO:K06483]
101830043  Itga5; integrin alpha-5 [KO:K06484]
101839961  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
101827609  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
101832049  Itga8; integrin alpha-8 [KO:K06584]
101838520  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
101841127  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
101834992  Itga11; integrin alpha-11 [KO:K06587]
101826420  Itgav; integrin alpha-V isoform X1 [KO:K06487]
101835360  Itgb1; integrin beta-1 [KO:K05719]
101828005  Itgb3; integrin beta-3 [KO:K06493]
101825566  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
101841615  Itgb5; integrin beta-5 [KO:K06588]
101843392  Itgb6; integrin beta-6 [KO:K06589]
101840069  Itgb7; integrin beta-7 [KO:K06590]
101841399  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
101843989  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101823280  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101828739  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X4 [KO:K00922] [EC:2.7.1.153]
101843471  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101829045  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101835039  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101831400  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101844170  F2r; proteinase-activated receptor 1 [KO:K03914]
101828505  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
101844151  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
101842657  Lpar1; lysophosphatidic acid receptor 1 [KO:K04289]
101839251  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
121142297  Lpar3; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 3 [KO:K04294]
101825707  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
121136968  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
101834976  Lpar6; lysophosphatidic acid receptor 6 [KO:K04273]
101843384  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101832216  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101842314  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
101842944  Gnb4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101839471  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101837281  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
101825356  Gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101830234  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
106022105  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101824998  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101837670  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
121133917  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101844067  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121135971  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121143991  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101825958  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101837924  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101844364  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101841484  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101825697  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101827062  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101833768  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
101844631  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
101844531  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
101835018  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X3 [KO:K06276] [EC:2.7.11.1]
101835880  Stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
101841715  Prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
101830211  Prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101823189  Ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
101834514  Tsc1; hamartin isoform X3 [KO:K07206]
101837089  Tsc2; tuberin isoform X1 [KO:K07207]
110339728  Rheb; GTP-binding protein Rheb isoform X1 [KO:K07208]
101831693  Mlst8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
101835701  Mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101840453  Rptor; regulatory-associated protein of mTOR [KO:K07204]
101825293  Eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101843796  Eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
101828207  Eif4e1b; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
101836188  Eif4e; eukaryotic translation initiation factor 4E [KO:K03259]
121136848  eukaryotic translation initiation factor 4E [KO:K03259]
101828677  Rps6kb2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
101839046  Rps6kb1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101841154  Eif4b; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
121136834  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4B-like [KO:K03258]
121135486  40S ribosomal protein S6-like [KO:K02991]
101824912  40S ribosomal protein S6 [KO:K02991]
101833684  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
101836115  Rps6; 40S ribosomal protein S6 [KO:K02991]
121140382  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
101837515  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101837310  Pkn1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
101830898  Pkn2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
101826578  Pkn3; serine/threonine-protein kinase N3 isoform X4 [KO:K23692] [EC:2.7.11.13]
101829943  Sgk1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
106023184  Sgk2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
101832863  serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
101842312  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101825464  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101840296  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101841071  Magi1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X6 [KO:K05631]
101833444  Magi2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
101825008  Pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106022699  Them4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
121138567  acyl-coenzyme A thioesterase THEM4-like [KO:K16339] [EC:3.1.2.2]
101842848  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101823886  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101837844  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101829513  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X7 [KO:K03456]
101828589  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101830872  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101837512  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
101830321  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101836805  Ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
101834038  Ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
101828903  Ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101844773  Ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101824258  Ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X2 [KO:K11584]
121135938  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform-like [KO:K11584]
101823849  Ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101830588  Ppp2r5c; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101831755  Ppp2r5e; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
101837956  Hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
110342745  heat shock protein HSP 90-alpha-like [KO:K04079]
101833905  LOW QUALITY PROTEIN: heat shock protein HSP 90-beta-like [KO:K04079]
101829781  Hsp90aa1; heat shock protein HSP 90-alpha [KO:K04079]
101844365  Hsp90b1; endoplasmin [KO:K09487]
101832910  Cdc37; hsp90 co-chaperone Cdc37 [KO:K09554]
101836788  Crtc2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
101843865  Phlpp2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
101835968  Phlpp1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
101835051  Tcl1a; T-cell leukemia/lymphoma protein 1A [KO:K10167]
101828158  Mtcp1; protein p13 MTCP-1 [KO:K16837]
101838293  Nos3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
101840909  Brca1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
101836282  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101843807  Gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
101832797  Gys2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
101831496  Pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
101834675  Pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
101844339  G6pc2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
101837945  G6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
101841444  G6pc1; glucose-6-phosphatase catalytic subunit 1 [KO:K01084] [EC:3.1.3.9]
101826382  Myc; myc proto-oncogene protein [KO:K04377]
101837554  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
101826412  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101844027  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101844411  Cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
101839492  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101823943  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121136139  cyclin-dependent kinase 12-like [KO:K02091] [EC:2.7.11.22]
101835885  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
101829610  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
101843918  Ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
101826826  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
101826007  Foxo3; forkhead box protein O3 [KO:K09408]
101835700  Rbl2; retinoblastoma-like protein 2 isoform X2 [KO:K16332]
101843397  Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
101835926  Bcl2l11; bcl-2-like protein 11 isoform X2 [KO:K16341]
101838010  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
101832892  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
101828221  Ywhaq; 14-3-3 protein theta [KO:K16197]
101836626  14-3-3 protein zeta-like [KO:K16197]
101838994  Ywhae; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101822872  Ywhag; 14-3-3 protein gamma [KO:K16198]
101836874  Ywhah; 14-3-3 protein eta [KO:K16198]
101836153  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
101834682  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
101833785  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
101844218  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
101838929  Creb1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
101836768  Atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
101834246  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101823321  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101837749  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101844692  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
101834652  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
101826865  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101844837  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
101831726  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
101842733  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
101830118  Rxra; retinoic acid receptor RXR-alpha [KO:K08524]
101832083  Nr4a1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
101824046  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101837015  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101834429  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101831177  Rela; transcription factor p65 isoform X1 [KO:K04735]
101839499  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101831817  Myb; transcriptional activator Myb isoform X1 [KO:K09420]
121134106  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2-like [KO:K06643] [EC:2.3.2.27]
101833011  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
101833915  Tp53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
maua00010  Glycolysis / Gluconeogenesis
maua04010  MAPK signaling pathway
maua04012  ErbB signaling pathway
maua04062  Chemokine signaling pathway
maua04064  NF-kappa B signaling pathway
maua04068  FoxO signaling pathway
maua04110  Cell cycle
maua04115  p53 signaling pathway
maua04150  mTOR signaling pathway
maua04210  Apoptosis
maua04370  VEGF signaling pathway
maua04510  Focal adhesion
maua04620  Toll-like receptor signaling pathway
maua04630  JAK-STAT signaling pathway
maua04662  B cell receptor signaling pathway
maua04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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