KEGG   PATHWAY: mmu04371
Entry
mmu04371                    Pathway                                
Name
Apelin signaling pathway - Mus musculus (house mouse)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
mmu04371  Apelin signaling pathway
mmu04371

Other DBs
GO: 0060183
Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100038489  Apela; apelin receptor early endogenous ligand [KO:K25355]
100043318  Gng5c; G protein subunit gamma 5C [KO:K04542]
100503710  Gng14; G protein subunit gamma 14 [KO:K04347]
102633809  Gm3785; predicted gene 3785 [KO:K04542]
103968  Plin1; perilipin 1 [KO:K08768]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
104709  Pik3r6; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
105787  Prkaa1; protein kinase, AMP-activated, alpha 1 catalytic subunit [KO:K07198] [EC:2.7.11.31]
105980076  Mef2bl; myocyte enhancer factor 2B like [KO:K09261]
107589  Mylk; myosin, light polypeptide kinase [KO:K00907] [EC:2.7.11.18]
108079  Prkaa2; protein kinase, AMP-activated, alpha 2 catalytic subunit [KO:K07198] [EC:2.7.11.31]
108097  Prkab2; protein kinase, AMP-activated, beta 2 non-catalytic subunit [KO:K07199]
108099  Prkag2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit [KO:K07200]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
110891  Slc8a2; solute carrier family 8 (sodium/calcium exchanger), member 2 [KO:K05849]
110893  Slc8a3; solute carrier family 8 (sodium/calcium exchanger), member 3 [KO:K05849]
11475  Acta2; actin alpha 2, smooth muscle, aorta [KO:K12313]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
11607  Agtr1a; angiotensin II receptor, type 1a [KO:K04166]
11608  Agtr1b; angiotensin II receptor, type 1b [KO:K04166]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
12313  Calm1; calmodulin 1 [KO:K02183]
12314  Calm2; calmodulin 2 [KO:K02183]
12315  Calm3; calmodulin 3 [KO:K02183]
12326  Camk4; calcium/calmodulin-dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
12443  Ccnd1; cyclin D1 [KO:K04503]
12550  Cdh1; cadherin 1 [KO:K05689]
13653  Egr1; early growth response 1 [KO:K09203]
14219  Ccn2; cellular communication network factor 2 [KO:K06827]
14674  Gna13; guanine nucleotide binding protein, alpha 13 [KO:K04639]
14677  Gnai1; G protein subunit alpha i1 [KO:K04630]
14678  Gnai2; G protein subunit alpha i2 [KO:K04630]
14679  Gnai3; G protein subunit alpha i3 [KO:K04630]
14682  Gnaq; guanine nucleotide binding protein, alpha q polypeptide [KO:K04634]
14688  Gnb1; guanine nucleotide binding protein (G protein), beta 1 [KO:K04536]
14693  Gnb2; guanine nucleotide binding protein (G protein), beta 2 [KO:K04537]
14695  Gnb3; guanine nucleotide binding protein (G protein), beta 3 [KO:K07825]
14696  Gnb4; guanine nucleotide binding protein (G protein), beta 4 [KO:K04538]
14697  Gnb5; guanine nucleotide binding protein (G protein), beta 5 [KO:K04539]
14699  Gngt1; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [KO:K04548]
14700  Gng10; guanine nucleotide binding protein (G protein), gamma 10 [KO:K04545]
14701  Gng12; guanine nucleotide binding protein (G protein), gamma 12 [KO:K04347]
14702  Gng2; guanine nucleotide binding protein (G protein), gamma 2 [KO:K07826]
14704  Gng3; guanine nucleotide binding protein (G protein), gamma 3 [KO:K04540]
14706  Gng4; guanine nucleotide binding protein (G protein), gamma 4 [KO:K04541]
14707  Gng5; G protein subunit gamma 5 [KO:K04542]
14708  Gng7; guanine nucleotide binding protein (G protein), gamma 7 [KO:K04543]
14709  Gng8; guanine nucleotide binding protein (G protein), gamma 8 [KO:K04544]
14710  Gngt2; guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 [KO:K04549]
15184  Hdac5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16438  Itpr1; inositol 1,4,5-trisphosphate receptor 1 [KO:K04958]
16439  Itpr2; inositol 1,4,5-triphosphate receptor 2 [KO:K04959]
16440  Itpr3; inositol 1,4,5-triphosphate receptor 3 [KO:K04960]
16449  Jag1; jagged 1 [KO:K06052]
16598  Klf2; Kruppel-like transcription factor 2 (lung) [KO:K17845]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
16890  Lipe; lipase, hormone sensitive [KO:K07188] [EC:3.1.1.79]
17126  Smad2; SMAD family member 2 [KO:K04500]
17127  Smad3; SMAD family member 3 [KO:K23605]
17128  Smad4; SMAD family member 4 [KO:K04501]
17258  Mef2a; myocyte enhancer factor 2A [KO:K09260]
17259  Mef2b; myocyte enhancer factor 2B [KO:K09261]
17260  Mef2c; myocyte enhancer factor 2C [KO:K04454]
17261  Mef2d; myocyte enhancer factor 2D [KO:K09262]
17532  Mras; muscle and microspikes RAS [KO:K07831]
17896  Myl4; myosin, light polypeptide 4 [KO:K12750]
17897  Myl3; myosin, light polypeptide 3 [KO:K12749]
17906  Myl2; myosin, light polypeptide 2, regulatory, cardiac, slow [KO:K10351]
18125  Nos1; nitric oxide synthase 1, neuronal [KO:K13240] [EC:1.14.13.39]
18126  Nos2; nitric oxide synthase 2, inducible [KO:K13241] [EC:1.14.13.39]
18127  Nos3; nitric oxide synthase 3, endothelial cell [KO:K13242] [EC:1.14.13.39]
18131  Notch3; notch 3 [KO:K20995]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18181  Nrf1; nuclear respiratory factor 1 [KO:K11831]
18576  Pde3b; phosphodiesterase 3B, cGMP-inhibited [KO:K13296] [EC:3.1.4.17]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18754  Prkce; protein kinase C, epsilon [KO:K18050] [EC:2.7.11.13]
18787  Serpine1; serine (or cysteine) peptidase inhibitor, clade E, member 1 [KO:K03982]
18791  Plat; plasminogen activator, tissue [KO:K01343] [EC:3.4.21.68]
18795  Plcb1; phospholipase C, beta 1 [KO:K05858] [EC:3.1.4.11]
18796  Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
18797  Plcb3; phospholipase C, beta 3 [KO:K05858] [EC:3.1.4.11]
18798  Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
19017  Ppargc1a; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [KO:K07202]
19079  Prkab1; protein kinase, AMP-activated, beta 1 non-catalytic subunit [KO:K07199]
19082  Prkag1; protein kinase, AMP-activated, gamma 1 non-catalytic subunit [KO:K07200]
20104  Rps6; ribosomal protein S6 [KO:K02991]
20130  Rras; related RAS viral (r-ras) oncogene [KO:K07829]
20190  Ryr1; ryanodine receptor 1, skeletal muscle [KO:K04961]
20191  Ryr2; ryanodine receptor 2, cardiac [KO:K04962]
20192  Ryr3; ryanodine receptor 3 [KO:K04963]
20541  Slc8a1; solute carrier family 8 (sodium/calcium exchanger), member 1 [KO:K05849]
20544  Slc9a1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 [KO:K05742]
20698  Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
20750  Spp1; secreted phosphoprotein 1 [KO:K06250]
208727  Hdac4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
213435  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
216036  Gm4796; predicted gene 4796 [KO:K02991]
21780  Tfam; transcription factor A, mitochondrial [KO:K11830]
21812  Tgfbr1; transforming growth factor, beta receptor I [KO:K04674] [EC:2.7.11.30]
22227  Ucp1; uncoupling protein 1 (mitochondrial, proton carrier) [KO:K08769]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
225326  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
228785  Mylk2; myosin, light polypeptide kinase 2, skeletal muscle [KO:K00907] [EC:2.7.11.18]
23796  Aplnr; apelin receptor [KO:K04174]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
238564  Mylk4; myosin light chain kinase family, member 4 [KO:K00907] [EC:2.7.11.18]
241113  Prkag3; protein kinase, AMP-activated, gamma 3 non-catalytic subunit [KO:K07200]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
271639  Adcy10; adenylate cyclase 10 [KO:K11265] [EC:4.6.1.1]
30878  Apln; apelin [KO:K05225]
30955  Pik3cg; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
320207  Pik3r5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
494124  Calm5; calmodulin 5 [KO:K02183]
56208  Becn1; beclin 1, autophagy related [KO:K08334]
56632  Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
56717  Mtor; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
58988  Rps6kb2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04688] [EC:2.7.11.1]
64337  Gng13; guanine nucleotide binding protein (G protein), gamma 13 [KO:K04547]
66066  Gng11; guanine nucleotide binding protein (G protein), gamma 11 [KO:K04546]
66734  Map1lc3a; microtubule-associated protein 1 light chain 3 alpha [KO:K10435]
66922  Rras2; related RAS viral (r-ras) oncogene 2 [KO:K07830]
67443  Map1lc3b; microtubule-associated protein 1 light chain 3 beta [KO:K10435]
70405  Calml3; calmodulin-like 3 [KO:K02183]
72508  Rps6kb1; ribosomal protein S6 kinase, polypeptide 1 [KO:K04688] [EC:2.7.11.1]
75600  Calml4; calmodulin-like 4 [KO:K02183]
75669  Pik3r4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
80796  Calm4; calmodulin 4 [KO:K02183]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
Related
pathway
mmu04010  MAPK signaling pathway
mmu04020  Calcium signaling pathway
mmu04140  Autophagy - animal
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04152  AMPK signaling pathway
mmu04270  Vascular smooth muscle contraction
mmu04530  Tight junction
mmu04923  Regulation of lipolysis in adipocytes
KO pathway
ko04371   

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