KEGG   PATHWAY: pale04510
Entry
pale04510                   Pathway                                
Name
Focal adhesion - Pteropus alecto (black flying fox)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pale04510  Focal adhesion
pale04510

Other DBs
GO: 0005925
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102877892  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
102877962  LAMA4; laminin subunit alpha-4 [KO:K06241]
102878023  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
102878069  COL1A2; LOW QUALITY PROTEIN: collagen alpha-2(I) chain [KO:K06236]
102878201  ITGA9; integrin alpha-9 [KO:K06585]
102878211  ITGA8; LOW QUALITY PROTEIN: integrin alpha-8 [KO:K06584]
102878393  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102878498  PARVB; beta-parvin isoform X1 [KO:K06275]
102878549  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102878573  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
102878822  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102878877  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102878956  VTN; vitronectin [KO:K06251]
102879139  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
102879163  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102879271  RAP1A; ras-related protein Rap-1A [KO:K04353]
102879337  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102879385  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
102879390  TNR; tenascin-R [KO:K06252]
102879421  VCL; vinculin isoform X1 [KO:K05700]
102879431  CAV3; caveolin-3 [KO:K12959]
102879453  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102879709  PARVA; alpha-parvin [KO:K06275]
102879733  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X2 [KO:K12329]
102879861  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
102879956  SHC3; SHC-transforming protein 3 [KO:K17448]
102880017  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
102880320  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102880323  PAK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102880440  MYL10; myosin regulatory light chain 10 [KO:K12756]
102880509  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
102880663  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102880862  THBS2; thrombospondin-2 [KO:K04659]
102880875  MYL5; myosin light chain 5 [KO:K12753]
102881112  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
102881219  PARVG; gamma-parvin [KO:K06275]
102881448  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102881476  LAMC3; laminin subunit gamma-3 [KO:K06247]
102881611  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
102881673  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
102881884  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
102881894  ITGB3; integrin beta-3 [KO:K06493]
102881949  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102882215  EMP1; epithelial membrane protein 1 [KO:K26255]
102882441  GSK3B; glycogen synthase kinase-3 beta isoform X4 [KO:K03083] [EC:2.7.11.26]
102882462  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102882490  RAPGEF1; rap guanine nucleotide exchange factor 1 [KO:K06277]
102882963  VEGFB; vascular endothelial growth factor B [KO:K16858]
102883425  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
102883443  [KO:K16858]
102883521  VAV1; proto-oncogene vav [KO:K05730]
102883628  [KO:K06238]
102883778  RAP1B; ras-related protein Rap-1b [KO:K07836]
102883890  [KO:K06238]
102883900  ITGA2B; integrin alpha-IIb [KO:K06476]
102884158  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102884236  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
102884251  VEGFC; vascular endothelial growth factor C [KO:K05449]
102884388  [KO:K16060]
102884469  ACTB; actin, cytoplasmic 1 [KO:K05692]
102884470  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102884535  PAK5; serine/threonine-protein kinase PAK 5 isoform X2 [KO:K05736] [EC:2.7.11.1]
102884651  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
102884713  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
102884766  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
102884859  [KO:K12757]
102884860  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
102884999  ITGA1; integrin alpha-1 [KO:K06480]
102885064  MAPK10; mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
102885115  [KO:K12757]
102885144  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102885280  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
102885300  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102885330  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
102885349  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
102885384  COMP; cartilage oligomeric matrix protein isoform X1 [KO:K04659]
102885413  LAMC1; laminin subunit gamma-1 [KO:K05635]
102885507  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102885553  CRK; adapter molecule crk isoform X1 [KO:K04438]
102885749  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102885958  SHC2; SHC-transforming protein 2 [KO:K17447]
102885962  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102885990  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102886090  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
102886252  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
102886463  COL1A1; collagen alpha-1(I) chain [KO:K06236]
102886570  CAV1; caveolin-1 isoform X1 [KO:K06278]
102886612  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
102886772  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
102886777  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102886785  ITGB1; integrin beta-1 [KO:K05719]
102886796  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102887078  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102887099  FLNB; filamin-B isoform X2 [KO:K27392]
102887161  CAV2; caveolin-2 [KO:K12958]
102887359  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
102887421  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102887513  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
102887643  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102887721  CHAD; chondroadherin [KO:K06248]
102887814  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
102887827  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102887929  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
102888244  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102888738  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102888926  SHC4; SHC-transforming protein 4 [KO:K17449]
102888961  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102889033  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
102889111  ITGA5; integrin alpha-5 [KO:K06484]
102889114  CDC42; cell division control protein 42 homolog [KO:K04393]
102889143  VEGFD; vascular endothelial growth factor D [KO:K05449]
102889149  DOCK1; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 1 [KO:K13708]
102889210  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
102889227  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102889348  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
102889367  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102889392  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
102889561  IBSP; bone sialoprotein 2 [KO:K06253]
102889576  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102889597  SOS2; son of sevenless homolog 2 [KO:K03099]
102889771  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102889783  PGF; placenta growth factor isoform X1 [KO:K16859]
102889996  FLNA; filamin-A isoform X1 [KO:K04437]
102890230  SPP1; osteopontin [KO:K06250]
102890264  ITGA11; integrin alpha-11 [KO:K06587]
102890277  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
102890305  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
102890331  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
102890394  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
102890398  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
102890668  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102890689  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102890778  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
102890845  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
102891095  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
102891249  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
102891509  FN1; fibronectin isoform X1 [KO:K05717]
102891515  RHOA; transforming protein RhoA [KO:K04513]
102891539  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
102891552  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102891637  [KO:K02649]
102891781  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
102891799  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102891920  PXN; paxillin isoform X2 [KO:K05760]
102892062  ITGB5; integrin beta-5 [KO:K06588]
102892078  LAMC2; laminin subunit gamma-2 [KO:K06246]
102892254  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102892412  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
102892640  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
102892706  LAMA5; laminin subunit alpha-5 [KO:K06240]
102892777  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102892921  VASP; vasodilator-stimulated phosphoprotein isoform X6 [KO:K06274]
102893439  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102893495  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102893670  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102893900  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
102893935  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
102894123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102894333  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
102894361  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102894443  SHC1; LOW QUALITY PROTEIN: SHC-transforming protein 1 [KO:K06279]
102894689  TLN2; talin-2 [KO:K06271]
102894718  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
102894733  ZYX; zyxin [KO:K06273]
102895248  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
102895362  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
102895390  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102895440  ITGAV; integrin alpha-V [KO:K06487]
102896121  JUN; transcription factor AP-1 [KO:K04448]
102896150  LAMB4; laminin subunit beta-4 [KO:K06245]
102896270  HRAS; GTPase HRas isoform X3 [KO:K02833]
102896303  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
102896443  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102896485  ITGB7; integrin beta-7 [KO:K06590]
102896504  LAMB3; laminin subunit beta-3 [KO:K06244]
102896564  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
102896638  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102896849  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
102896887  ITGA4; integrin alpha-4 [KO:K06483]
102896950  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102896988  COL6A1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
102897097  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
102897122  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102897185  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
102897225  LAMA3; laminin subunit alpha-3 isoform X6 [KO:K06240]
102897424  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102897644  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102897695  CAPN2; calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
102897699  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102898080  CRKL; crk-like protein [KO:K04438]
102898083  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
102898254  ITGB4; integrin beta-4 [KO:K06525]
102898305  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102898331  COL4A1; LOW QUALITY PROTEIN: collagen alpha-1(IV) chain [KO:K06237]
102898345  THBS4; thrombospondin-4 [KO:K04659]
102898395  RELN; reelin isoform X2 [KO:K06249] [EC:3.4.21.-]
102898474  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
102898508  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
102898698  TNC; tenascin isoform X4 [KO:K06252]
102898784  THBS1; thrombospondin-1 [KO:K16857]
102898835  EMP2; epithelial membrane protein 2 [KO:K26256]
102898992  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
102898998  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
112469042  [KO:K05096] [EC:2.7.10.1]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pale04010  MAPK signaling pathway
pale04060  Cytokine-cytokine receptor interaction
pale04070  Phosphatidylinositol signaling system
pale04110  Cell cycle
pale04151  PI3K-Akt signaling pathway
pale04310  Wnt signaling pathway
pale04512  ECM-receptor interaction
pale04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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