KEGG   PATHWAY: pale04010
Entry
pale04010                   Pathway                                
Name
MAPK signaling pathway - Pteropus alecto (black flying fox)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pale04010  MAPK signaling pathway
pale04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102877720  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102877847  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102877853  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102877877  ARAF; serine/threonine-protein kinase A-Raf isoform X2 [KO:K08845] [EC:2.7.11.1]
102877921  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
102877927  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
102878133  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X4 [KO:K05126] [EC:2.7.10.1]
102878191  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
102878341  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102878342  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102878393  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
102878395  RELA; transcription factor p65 [KO:K04735]
102878481  MECOM; MDS1 and EVI1 complex locus protein isoform X1 [KO:K04462] [EC:2.1.1.367]
102878618  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
102878662  ANGPT2; angiopoietin-2 [KO:K05466]
102878822  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
102878877  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
102878894  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
102878980  MAPT; microtubule-associated protein tau isoform X4 [KO:K04380]
102879034  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102879271  RAP1A; ras-related protein Rap-1A [KO:K04353]
102879288  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
102879337  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102879346  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102879408  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102879469  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102879500  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
102879561  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
102879764  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
102879891  MRAS; ras-related protein M-Ras [KO:K07831]
102880029  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102880048  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
102880166  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
102880203  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102880315  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
102880323  PAK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
102880382  PSPN; persephin [KO:K25416]
102880410  IGF2; insulin-like growth factor II [KO:K13769]
102880422  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
102880632  [KO:K03283]
102880663  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102880692  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102880725  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
102880759  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
102880857  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102880867  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102881080  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
102881117  [KO:K04526]
102881119  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102881295  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
102881410  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
102881450  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
102881508  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102881523  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X3 [KO:K04863]
102881794  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
102881941  RRAS; ras-related protein R-Ras [KO:K07829]
102881979  MAX; protein max isoform X2 [KO:K04453]
102882076  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102882088  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102882134  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
102882452  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102882462  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102882572  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
102882632  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
102882682  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X2 [KO:K04850]
102882855  MAP3K6; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
102882899  FGFR2; fibroblast growth factor receptor 2 isoform X8 [KO:K05093] [EC:2.7.10.1]
102882910  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102882941  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102882958  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102882963  VEGFB; vascular endothelial growth factor B [KO:K16858]
102883069  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
102883094  NRTN; neurturin [KO:K25414]
102883156  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102883167  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102883204  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102883307  RASA1; ras GTPase-activating protein 1 [KO:K04352]
102883346  FGF23; fibroblast growth factor 23 [KO:K22428]
102883421  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
102883443  [KO:K16858]
102883519  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
102883593  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X9 [KO:K04407] [EC:2.7.11.1]
102883684  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
102883778  RAP1B; ras-related protein Rap-1b [KO:K07836]
102883825  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
102884034  KITLG; kit ligand isoform X1 [KO:K05461]
102884120  NTF4; neurotrophin-4 [KO:K12457]
102884154  TGFB1; transforming growth factor beta-1 [KO:K13375]
102884251  VEGFC; vascular endothelial growth factor C [KO:K05449]
102884312  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102884439  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
102884454  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
102884470  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102884477  AREG; amphiregulin [KO:K09782]
102884629  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
102884726  EREG; proepiregulin [KO:K09784]
102884740  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X5 [KO:K04408] [EC:2.7.11.1]
102885041  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102885064  MAPK10; mitogen-activated protein kinase 10 isoform X5 [KO:K04440] [EC:2.7.11.24]
102885081  FGF19; fibroblast growth factor 19 [KO:K22603]
102885138  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
102885144  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102885152  DAXX; death domain-associated protein 6 [KO:K02308]
102885173  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
102885300  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102885454  NGF; beta-nerve growth factor [KO:K02582]
102885507  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
102885530  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
102885553  CRK; adapter molecule crk isoform X1 [KO:K04438]
102885554  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
102885749  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102885752  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102885790  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
102885821  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
102885883  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
102885950  NRAS; GTPase NRas isoform X2 [KO:K07828]
102885962  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102885990  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102886161  RELB; transcription factor RelB [KO:K09253]
102886310  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
102886389  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
102886440  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
102886476  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102886540  FGF21; fibroblast growth factor 21 [KO:K22429]
102886671  ANGPT1; angiopoietin-1 isoform X2 [KO:K05465]
102886679  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102886682  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
102886741  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102886796  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
102886964  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102887004  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X3 [KO:K04436]
102887078  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102887101  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
102887331  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
102887421  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
102887540  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X4 [KO:K04443] [EC:2.7.11.1]
102887581  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102887632  TNF; tumor necrosis factor [KO:K03156]
102887643  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102887662  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102887777  FGF7; fibroblast growth factor 7 [KO:K04358]
102887778  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
102887882  FGF9; fibroblast growth factor 9 [KO:K04358]
102888058  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
102888098  FGF20; fibroblast growth factor 20 [KO:K04358]
102888144  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
102888274  [KO:K16342] [EC:3.1.1.4]
102888351  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102888396  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
102888491  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
102888506  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
102888539  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
102888602  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102888718  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
102888822  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
102888845  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102888856  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
102888950  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
102888961  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102888973  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X4 [KO:K04442] [EC:2.7.11.1]
102888994  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
102889014  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
102889039  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X6 [KO:K04854]
102889114  CDC42; cell division control protein 42 homolog [KO:K04393]
102889143  VEGFD; vascular endothelial growth factor D [KO:K05449]
102889343  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102889367  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
102889457  NF1; neurofibromin isoform X2 [KO:K08052]
102889570  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
102889597  SOS2; son of sevenless homolog 2 [KO:K03099]
102889604  TP53; cellular tumor antigen p53 [KO:K04451]
102889618  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102889742  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102889771  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102889783  PGF; placenta growth factor isoform X1 [KO:K16859]
102889996  FLNA; filamin-A isoform X1 [KO:K04437]
102890153  FGF16; fibroblast growth factor 16 [KO:K04358]
102890331  IGF1; insulin-like growth factor I isoform X3 [KO:K05459]
102890340  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
102890394  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
102890488  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102890557  DDIT3; DNA damage-inducible transcript 3 protein isoform X2 [KO:K04452]
102890668  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102890689  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102890775  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
102890787  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
102890816  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
102890853  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
102890987  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
102891095  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
102891298  NTF3; neurotrophin-3 [KO:K04356]
102891428  FOS; proto-oncogene c-Fos [KO:K04379]
102891516  CACNA2D2; LOW QUALITY PROTEIN: voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
102891552  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102891572  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
102891706  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
102891789  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102892139  EFNA1; ephrin-A1 [KO:K05462]
102892141  FGF6; fibroblast growth factor 6 [KO:K04358]
102892345  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
102892391  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
102892533  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
102892592  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
102892637  EFNA4; ephrin-A4 [KO:K05462]
102892777  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102892819  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102892959  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
102892998  IL1A; interleukin-1 alpha [KO:K04383]
102893112  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
102893121  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
102893170  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
102893226  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
102893238  IL1B; interleukin-1 beta [KO:K04519]
102893244  FGF4; fibroblast growth factor 4 [KO:K04358]
102893261  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102893304  TGFB3; transforming growth factor beta-3 [KO:K13377]
102893401  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102893439  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102893495  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102893611  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102893618  [KO:K18019] [EC:3.1.3.48]
102893670  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102893746  TAOK2; serine/threonine-protein kinase TAO2 isoform X2 [KO:K04429] [EC:2.7.11.1]
102893956  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
102893973  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102894115  FGF18; fibroblast growth factor 18 [KO:K04358]
102894123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102894152  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102894177  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102894192  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102894279  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102894339  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
102894471  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102894546  DUSP1; LOW QUALITY PROTEIN: dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
102894573  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
102894756  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
102894780  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
102894818  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102894883  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
102894945  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X3 [KO:K04430] [EC:2.7.12.2]
102895072  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
102895169  HSPB1; heat shock protein beta-1 [KO:K04455]
102895362  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
102895390  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102895392  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102895490  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102895524  MYC; myc proto-oncogene protein [KO:K04377]
102895574  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102895590  KRAS; GTPase KRas isoform X1 [KO:K07827]
102895625  STMN1; stathmin [KO:K04381]
102895642  FGF5; fibroblast growth factor 5 [KO:K04358]
102895694  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
102895900  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102895922  FGF10; fibroblast growth factor 10 [KO:K04358]
102895969  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
102896087  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
102896121  JUN; transcription factor AP-1 [KO:K04448]
102896136  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102896224  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
102896270  HRAS; GTPase HRas isoform X3 [KO:K02833]
102896478  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
102896553  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102896608  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
102896638  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102896654  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X2 [KO:K04415] [EC:2.7.11.25]
102896690  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
102896895  FGF22; fibroblast growth factor 22 [KO:K04358]
102897014  MAPK7; mitogen-activated protein kinase 7 isoform X2 [KO:K04464] [EC:2.7.11.24]
102897122  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102897164  ARRB1; beta-arrestin-1 [KO:K04439]
102897289  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102897363  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
102897644  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102897699  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102897741  RASA2; ras GTPase-activating protein 2 isoform X2 [KO:K08053]
102897751  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
102897813  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
102897819  SRF; serum response factor isoform X1 [KO:K04378]
102897828  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
102898080  CRKL; crk-like protein [KO:K04438]
102898188  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
102898243  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102898305  AKT2; LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102898437  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
102898473  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102898528  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
102898576  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
102898592  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102898679  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
102898943  FGFR1; fibroblast growth factor receptor 1 isoform X9 [KO:K04362] [EC:2.7.10.1]
107196088  FGF2; fibroblast growth factor 2 [KO:K18497]
112469030  [KO:K03283]
112469042  [KO:K05096] [EC:2.7.10.1]
112472150  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pale04070  Phosphatidylinositol signaling system
pale04110  Cell cycle
pale04115  p53 signaling pathway
pale04210  Apoptosis
pale04310  Wnt signaling pathway
pale04668  TNF signaling pathway
KO pathway
ko04010   

DBGET integrated database retrieval system