KEGG   PATHWAY: pale04060
Entry
pale04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Pteropus alecto (black flying fox)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
pale04060  Cytokine-cytokine receptor interaction
pale04060

Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102877703  [KO:K05511]
102877709  CCR9; C-C chemokine receptor type 9 [KO:K04184]
102877755  TNFSF8; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 8 [KO:K05471]
102877930  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102878005  TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478]
102878027  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
102878124  [KO:K21092]
102878242  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
102878371  CCL5; C-C motif chemokine 5 [KO:K12499]
102878494  [KO:K05066]
102878621  THPO; thrombopoietin [KO:K06854]
102878749  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
102878836  IL33; interleukin-33 [KO:K12967]
102878927  CCL26; C-C motif chemokine 26 [KO:K21096]
102878946  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
102878958  [KO:K04192]
102878960  INHBA; inhibin beta A chain [KO:K04667]
102879129  CCR7; C-C chemokine receptor type 7 [KO:K04182]
102879186  CCL24; C-C motif chemokine 24 [KO:K21097]
102879198  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
102879394  IL23A; interleukin-23 subunit alpha [KO:K05426]
102879561  FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390]
102879662  GDF3; growth/differentiation factor 3 [KO:K22672]
102879670  GDF6; growth/differentiation factor 6 [KO:K20012]
102879707  IFNLR1; interferon lambda receptor 1 precursor [KO:K05140]
102879789  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
102879791  EBI3; interleukin-27 subunit beta [KO:K24476]
102879883  CCR10; C-C chemokine receptor type 10 [KO:K04185]
102879899  [KO:K05486]
102879965  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
102880079  GDF7; growth/differentiation factor 7 [KO:K20013]
102880090  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
102880153  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
102880170  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
102880288  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
102880336  MPL; thrombopoietin receptor [KO:K05082]
102880346  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
102880398  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
102880415  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
102880427  CCR6; LOW QUALITY PROTEIN: C-C chemokine receptor type 6 [KO:K04181]
102880610  [KO:K05440]
102880650  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
102880756  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
102880759  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
102880880  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
102880884  GDF5; growth/differentiation factor 5 [KO:K04664]
102880916  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
102881155  BMP7; bone morphogenetic protein 7 isoform X1 [KO:K16621]
102881163  GDF15; growth/differentiation factor 15 [KO:K05504]
102881265  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
102881295  TGFB2; transforming growth factor beta-2 isoform X2 [KO:K13376]
102881363  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
102881676  CD70; CD70 antigen [KO:K05470]
102881920  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
102881936  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
102882003  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
102882020  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
102882035  IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137]
102882071  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
102882436  IFNG; interferon gamma precursor [KO:K04687]
102882571  [KO:K05440]
102882664  LEPR; leptin receptor [KO:K05062]
102882681  IL26; interleukin-26 [KO:K05446]
102882703  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
102882815  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
102882933  IL22; interleukin-22 [KO:K05445]
102882941  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102882955  TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
102883062  IL21R; interleukin-21 receptor [KO:K05075]
102883166  EPO; erythropoietin [KO:K05437]
102883204  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102883273  CCL13; C-C motif chemokine 13 [KO:K16595]
102883396  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
102883479  [KO:K05073]
102883529  CCL8; C-C motif chemokine 8 [KO:K16596]
102883786  [KO:K14624]
102884053  TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X2 [KO:K05157]
102884154  TGFB1; transforming growth factor beta-1 [KO:K13375]
102884188  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
102884214  IL12B; interleukin-12 subunit beta [KO:K05425]
102884262  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
102884307  EDA; ectodysplasin-A isoform X8 [KO:K05480]
102884439  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
102884525  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
102884570  CX3CL1; fractalkine [KO:K05508]
102884691  IL1RL2; interleukin-1 receptor-like 2 [KO:K05172]
102884693  MSTN; growth/differentiation factor 8 [KO:K05497]
102884720  IL17B; interleukin-17B [KO:K05490]
102884945  IL18R1; interleukin-18 receptor 1 [KO:K05173]
102884978  [KO:K04175]
102885001  IL18; interleukin-18 [KO:K05482]
102885131  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
102885204  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
102885363  IL23R; interleukin-23 receptor [KO:K05065]
102885382  TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472]
102885386  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
102885454  NGF; beta-nerve growth factor [KO:K02582]
102885468  CD40LG; CD40 ligand [KO:K03161]
102885605  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
102885624  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
102885628  IL17RA; interleukin-17 receptor A [KO:K05164]
102885663  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
102885752  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102886116  [KO:K16622]
102886142  [KO:K05505]
102886170  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
102886257  IL17RE; interleukin-17 receptor E [KO:K05168]
102886275  [KO:K05474]
102886385  [KO:K05505]
102886421  LTBR; tumor necrosis factor receptor superfamily member 3 isoform X3 [KO:K03159]
102886515  IL17RC; interleukin-17 receptor C isoform X9 [KO:K05166]
102886528  TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475]
102886533  IL24; interleukin-24 [KO:K22668]
102886625  EPOR; erythropoietin receptor [KO:K05079]
102886783  IL20; interleukin-20 [KO:K22667]
102886829  CD27; CD27 antigen [KO:K05144]
102886865  LTB; lymphotoxin-beta isoform X1 [KO:K03157]
102886916  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
102886920  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
102886941  BMP2; bone morphogenetic protein 2 [KO:K21283]
102886964  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102887033  IL19; interleukin-19 [KO:K05444]
102887064  PRL; prolactin isoform X1 [KO:K05439]
102887289  IL10; interleukin-10 [KO:K05443]
102887342  IL11; interleukin-11 isoform X2 [KO:K05417]
102887459  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
102887558  IL15; interleukin-15 isoform X2 [KO:K05433]
102887571  IL12A; interleukin-12 subunit alpha [KO:K05406]
102887575  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
102887576  IL34; interleukin-34 isoform X2 [KO:K22633]
102887632  TNF; tumor necrosis factor [KO:K03156]
102887880  LTA; lymphotoxin-alpha isoform X1 [KO:K05468]
102887958  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
102888010  IFNGR1; interferon gamma receptor 1 [KO:K05132]
102888070  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
102888258  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
102888277  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102888482  [KO:K05507]
102888823  [KO:K05438]
102888839  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
102888906  IL27; interleukin-27 subunit alpha [KO:K22629]
102888969  INHBC; inhibin beta C chain [KO:K22688]
102888985  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
102889027  GDF9; LOW QUALITY PROTEIN: growth/differentiation factor 9 [KO:K22673]
102889092  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
102889102  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
102889191  LIF; leukemia inhibitory factor isoform X1 [KO:K05419]
102889220  INHBE; inhibin beta E chain [KO:K22689]
102889242  CTF1; cardiotrophin-1 [KO:K05422]
102889450  OSM; oncostatin-M [KO:K05418]
102889489  [KO:K24382]
102889565  [KO:K22669]
102889606  CXCL17; C-X-C motif chemokine 17 [KO:K22627]
102889618  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
102889711  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
102889724  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
102889807  [KO:K22669]
102889861  AMHR2; LOW QUALITY PROTEIN: anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
102889892  CCL22; C-C motif chemokine 22 [KO:K21095]
102889915  CXCR6; LOW QUALITY PROTEIN: C-X-C chemokine receptor type 6 [KO:K04191]
102889993  IFNK; interferon kappa [KO:K05441]
102890009  [KO:K05414]
102890025  IL4; interleukin-4 [KO:K05430]
102890093  PRLR; prolactin receptor [KO:K05081]
102890148  CCL17; C-C motif chemokine 17 [KO:K21083]
102890172  CCL19; C-C motif chemokine 19 [KO:K05512]
102890275  IL13; interleukin-13 [KO:K05435]
102890421  XCR1; chemokine XC receptor 1 [KO:K04193]
102890426  CCL27; C-C motif chemokine 27 [KO:K16598]
102890443  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
102890512  IFNB1; interferon beta [KO:K05415]
102890771  IL5; interleukin-5 [KO:K05428]
102890810  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
102890837  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
102890894  [KO:K04176]
102890973  BMP15; bone morphogenetic protein 15 [KO:K05498]
102891142  CCR3; C-C chemokine receptor type 3 [KO:K04178]
102891153  CCL25; C-C motif chemokine 25 [KO:K13072]
102891275  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
102891380  [KO:K04177]
102891383  NODAL; nodal homolog [KO:K04666]
102891485  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102891500  CCR4; C-C chemokine receptor type 4 [KO:K04179]
102891511  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
102891559  ACVR2A; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
102891616  [KO:K04180]
102891638  GHR; growth hormone receptor [KO:K05080]
102891700  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
102891708  CCL21; C-C motif chemokine 21 [KO:K16062]
102891713  IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165]
102892027  GDF2; growth/differentiation factor 2 [KO:K05503]
102892040  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
102892156  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
102892170  BMP10; bone morphogenetic protein 10 [KO:K22670]
102892278  GDF10; growth/differentiation factor 10 [KO:K22674]
102892445  IL11RA; interleukin-11 receptor subunit alpha isoform X4 [KO:K05056]
102892534  CXCL8; interleukin-8 [KO:K10030]
102892580  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
102892597  IL25; interleukin-25 [KO:K05493]
102892753  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
102892780  [KO:K05506]
102892819  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
102892998  IL1A; interleukin-1 alpha [KO:K04383]
102893024  [KO:K05407]
102893026  IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598]
102893042  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
102893230  BMP5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
102893232  IL17C; interleukin-17C [KO:K05491]
102893238  IL1B; interleukin-1 beta [KO:K04519]
102893266  [KO:K05505]
102893304  TGFB3; transforming growth factor beta-3 [KO:K13377]
102893418  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
102893482  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
102893486  IL36RN; LOW QUALITY PROTEIN: interleukin-36 receptor antagonist protein [KO:K05483]
102893643  IFNE; interferon epsilon [KO:K05442]
102893648  BMP6; bone morphogenetic protein 6 [KO:K16620]
102893727  IL1F10; interleukin-1 family member 10 [KO:K05488]
102893860  AMH; muellerian-inhibiting factor [KO:K04665]
102893886  [KO:K05414]
102893974  [KO:K05481]
102894001  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
102894035  IFNL1; interferon lambda-1 precursor [KO:K05447]
102894060  ACKR3; atypical chemokine receptor 3 [KO:K04304]
102894127  [KO:K05440]
102894278  IL9; interleukin-9 [KO:K05432]
102894292  [KO:K05408]
102894339  CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453]
102894360  IL16; pro-interleukin-16 [KO:K22628]
102894735  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
102894803  CCL16; C-C motif chemokine 16 [KO:K21093]
102894976  BMP3; bone morphogenetic protein 3 [KO:K05496]
102895516  IL2; interleukin-2 [KO:K05429]
102895667  EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X4 [KO:K05162]
102895740  CX3CR1; LOW QUALITY PROTEIN: CX3C chemokine receptor 1 [KO:K04192]
102895746  IL6; interleukin-6 [KO:K05405]
102895772  IL21; interleukin-21 [KO:K05434]
102895952  CNTF; ciliary neurotrophic factor [KO:K05420]
102895968  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
102896000  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
102896177  BMPR1B; bone morphogenetic protein receptor type-1B isoform X2 [KO:K13578] [EC:2.7.11.30]
102896284  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
102896464  RELL1; RELT-like protein 1 [KO:K26541]
102896496  INHA; inhibin alpha chain [KO:K05500]
102896552  [KO:K10029]
102896574  [KO:K04736]
102896930  [KO:K05440]
102896937  LEP; leptin [KO:K05424]
102896947  TSLP; thymic stromal lymphopoietin [KO:K05436]
102897194  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
102897327  CCL1; C-C motif chemokine 1 [KO:K05514]
102897558  RELL2; RELT-like protein 2 isoform X1 [KO:K26541]
102897570  CCL11; LOW QUALITY PROTEIN: eotaxin [KO:K16597]
102897874  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
102897878  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
102898082  GDF11; growth/differentiation factor 11 [KO:K22679]
102898348  CCR8; C-C chemokine receptor type 8 [KO:K04183]
102898551  [KO:K12964]
102898656  IL17F; interleukin-17F [KO:K05494]
102898660  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
102898787  INHBB; inhibin beta B chain [KO:K22687]
102898804  [KO:K05408]
102898906  IL17A; interleukin-17A [KO:K05489]
102899031  IL10RB; interleukin-10 receptor subunit beta precursor [KO:K05135]
107195345  ACKR4; atypical chemokine receptor 4 [KO:K04186]
112472586  IL7; interleukin-7 [KO:K05431]
112478358  IL31; interleukin-31 [KO:K22631]
112483106  [KO:K16598]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
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Nat Rev Cancer 13:328-41 (2013)
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KO pathway
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