KEGG   PATHWAY: afb04144
Entry
afb04144                    Pathway                                
Name
Endocytosis - Anoplopoma fimbria (sablefish)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
afb04144  Endocytosis
afb04144

Other DBs
GO: 0006897
Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129106810  arf6a; ADP-ribosylation factor 6a [KO:K07941]
129103420  arf6b; ADP-ribosylation factor 6b [KO:K07941]
129089346  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like [KO:K00889] [EC:2.7.1.68]
129094955  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
129100901  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
129102308  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a isoform X1 [KO:K00889] [EC:2.7.1.68]
129097015  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
129109148  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
129100652  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
129102603  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 [KO:K13712] [EC:2.7.1.68]
129110467  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
129113330  pld2; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
129103324  pld1a; phospholipase D1a isoform X1 [KO:K01115] [EC:3.1.4.4]
129089257  dnm3b; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
129101448  LOW QUALITY PROTEIN: dynamin-1-like [KO:K01528] [EC:3.6.5.5]
129101992  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
129095117  dnm3a; dynamin 3a isoform X1 [KO:K01528] [EC:3.6.5.5]
129096333  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
129098858  dnm2a; LOW QUALITY PROTEIN: dynamin-3 [KO:K23484] [EC:3.6.5.5]
129095306  clta; LOW QUALITY PROTEIN: clathrin light chain A [KO:K04644]
129089857  cltb; clathrin light chain B [KO:K04645]
129100770  cltcl1; clathrin heavy chain 1 [KO:K04646]
129113997  cltca; clathrin, heavy chain a (Hc) [KO:K04646]
129104287  clathrin heavy chain 1-like [KO:K04646]
129100686  AP-2 complex subunit alpha-2-like isoform X1 [KO:K11824]
129098548  ap2a1; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
129113099  ap2b1; AP-2 complex subunit beta [KO:K11825]
129091182  ap2m1b; LOW QUALITY PROTEIN: AP-2 complex subunit mu-B [KO:K11826]
129113211  AP-2 complex subunit mu-A-like [KO:K11826]
129113458  ap2s1; AP-2 complex subunit sigma [KO:K11827]
129099871  ehd2b; EH domain-containing protein 2b [KO:K12469]
129107769  EH domain-containing protein 2-like [KO:K12469]
129111052  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
129097102  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
129104613  tgfbr2l; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
129109188  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
129094748  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
129110885  zfyve9a; zinc finger FYVE domain-containing protein 9 [KO:K04679]
129102249  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
129100693  mothers against decapentaplegic homolog 2 [KO:K04500]
129107736  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
129108459  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
129089051  transferrin receptor protein 1-like isoform X1 [KO:K06503]
129110521  tfr1b; transferrin receptor 1b [KO:K06503]
129110777  LOW QUALITY PROTEIN: melanoma receptor tyrosine-protein kinase-like [KO:K04361] [EC:2.7.10.1]
129111957  egfra; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
129094441  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
129092578  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
129103846  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
129113075  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
129107750  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
129108015  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
129105108  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
129113104  LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-like [KO:K04707] [EC:2.3.2.27]
129113321  cblb; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
129110088  cblc; E3 ubiquitin-protein ligase CBL-C isoform X1 [KO:K22518] [EC:2.3.2.27]
129110771  sh3kbp1; SH3 domain-containing kinase-binding protein 1 [KO:K12470]
129095899  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 [KO:K11247]
129116291  endophilin-A3-like isoform X1 [KO:K11247]
129116293  LOW QUALITY PROTEIN: endophilin-A3-like [KO:K11247]
129093482  endophilin-A1-like isoform X1 [KO:K11247]
129108651  sh3gl3b; endophilin-A3b [KO:K11247]
129088874  endophilin-A2-like isoform X1 [KO:K11247]
129094283  sh3gl1b; SH3-domain GRB2-like 1b [KO:K11247]
129110814  sh3glb1a; endophilin-B1a [KO:K11248]
129103715  endophilin-B1-like [KO:K11248]
129101024  endophilin-B2-like [KO:K21269]
129102031  endophilin-B2-like isoform X1 [KO:K21269]
129111520  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
129088812  amph; amphiphysin [KO:K12562]
129104658  myc box-dependent-interacting protein 1 [KO:K12562]
129096228  epn3b; epsin-3 [KO:K12471]
129098092  epn3a; epsin-3 isoform X1 [KO:K12471]
129098186  epn2; LOW QUALITY PROTEIN: epsin-2 [KO:K12471]
129109150  epn1a; epsin-1 isoform X1 [KO:K12471]
129114543  epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
129088784  LOW QUALITY PROTEIN: epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
129094230  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
129095340  spartb; spartin b isoform X1 [KO:K19366]
129114036  sparta; spartin a [KO:K19366]
129100364  nedd4a; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K10591] [EC:2.3.2.26]
129101988  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
129112433  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
129101016  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129100117  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
129099809  itchb; itchy E3 ubiquitin protein ligase b [KO:K05632] [EC:2.3.2.26]
129105720  itcha; itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
129096001  E3 ubiquitin-protein ligase SMURF2-like [KO:K04678] [EC:2.3.2.26]
129098207  E3 ubiquitin-protein ligase SMURF2 isoform X1 [KO:K04678] [EC:2.3.2.26]
129098383  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
129110559  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
129095220  ldlrb; low-density lipoprotein receptor [KO:K12473]
129097931  ldlra; low density lipoprotein receptor a [KO:K12473]
129097296  ldlrap1a; low density lipoprotein receptor adapter protein 1a [KO:K12474]
129107571  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1 [KO:K12474]
129103364  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
129093599  si:dkey-19b23.8; low density lipoprotein receptor adapter protein 1 [KO:K12474]
129102888  dab2; disabled homolog 2 isoform X1 [KO:K12475]
129109124  C-C chemokine receptor type 1-like isoform X1 [KO:K04180]
129104825  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
129111868  C-X-C chemokine receptor type 2-like [KO:K05050]
129104340  C-X-C chemokine receptor type 1-like isoform X1 [KO:K05050]
129088873  C-X-C chemokine receptor type 4-like [KO:K04189]
129104510  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
129091896  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
129113572  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
129104292  rhodopsin kinase GRK1-like [KO:K00909] [EC:2.7.11.14]
129104360  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
129088977  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
129102105  grk3; LOW QUALITY PROTEIN: beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
129095613  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
129100809  grk5l; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
129113200  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
129113277  arrestin red cell isoform X1 [KO:K04439]
129093074  arrb2b; arrestin, beta 2b [KO:K04439]
129103975  arrb1; beta-arrestin-1 isoform X1 [KO:K04439]
129112411  waslb; LOW QUALITY PROTEIN: WASP like actin nucleation promoting factor b [KO:K23612]
129108310  wasla; LOW QUALITY PROTEIN: WASP like actin nucleation promoting factor a [KO:K23612]
129096287  actr2a; actin-related protein 2-A [KO:K17260]
129092117  actin-related protein 2-A [KO:K17260]
129093907  zgc:101810; actin-related protein 2 [KO:K17260]
129111696  actin-related protein 3 [KO:K18584]
129104634  actin-related protein 3-like [KO:K18584]
129095530  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
129095994  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
129098928  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
129111740  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
129102571  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
129105428  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
129106110  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
129094349  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
129116516  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
129095886  wipf2a; LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 2 [KO:K19475]
129092480  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
129097626  LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 3-like [KO:K19475]
129098621  LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 2-like [KO:K19475]
129089608  hspa8b; heat shock protein family A (Hsp70) member 8b [KO:K03283]
129110116  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
129100425  hspa1b; heat shock 70 kDa protein-like [KO:K03283]
129113380  hspa8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
129099116  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
129099117  heat shock 70 kDa protein 1-like [KO:K03283]
129094935  dnajc6; putative tyrosine-protein phosphatase auxilin [KO:K09526]
129107942  washc4; WASH complex subunit 4 [KO:K18465]
129109320  washc5; WASH complex subunit 5 [KO:K18464]
129092271  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
129108417  wash1; LOW QUALITY PROTEIN: WASH complex subunit 1 [KO:K18461]
129112642  washc3; WASH complex subunit 3 [KO:K18463]
129099733  F-actin-capping protein subunit alpha-1-like [KO:K10364]
129105653  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
129108050  F-actin-capping protein subunit alpha-2 [KO:K10364]
129105471  capzb; F-actin-capping protein subunit beta [KO:K10365]
129103839  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
129099383  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
129090100  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
129113618  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
129100259  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
129113110  snx12; sorting nexin-12 isoform X1 [KO:K17918]
129107273  snx3; sorting nexin-3 [KO:K17918]
129105015  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
129101287  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
129105393  ras-related protein rab7-like [KO:K07897]
129105747  ras-related protein rab7 [KO:K07897]
129106456  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
129097859  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
129104393  stam2; signal transducing adapter molecule 2 [KO:K04705]
129108243  tsg101a; tumor susceptibility 101a [KO:K12183]
129096168  mvb12a; LOW QUALITY PROTEIN: multivesicular body subunit 12A [KO:K12186]
129101345  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
129102210  mvb12ba; LOW QUALITY PROTEIN: multivesicular body subunit 12Ba [KO:K12186]
129097214  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
129095644  vps37a; vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
129095865  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
129113619  vps37d; vacuolar protein sorting-associated protein 37D isoform X1 [KO:K12185]
129097400  vacuolar protein sorting-associated protein 37D-like [KO:K12185]
129093135  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
129091001  snf8; vacuolar-sorting protein SNF8 [KO:K12188]
129113584  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
129091417  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
129091207  chmp6b; charged multivesicular body protein 6 [KO:K12195]
129098847  charged multivesicular body protein 6-like [KO:K12195]
129105699  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
129100343  LOW QUALITY PROTEIN: charged multivesicular body protein 4b-like [KO:K12194]
129107992  charged multivesicular body protein 4b-like [KO:K12194]
129110931  chmp4c; charged multivesicular body protein 4c [KO:K24782]
129103495  chmp3; charged multivesicular body protein 3 [KO:K12193]
129091368  chmp2a; charged multivesicular body protein 2a [KO:K12191]
129104575  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
129101372  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
129094356  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
129113000  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
129107772  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
129107166  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
129089815  charged multivesicular body protein 1b-like [KO:K12197]
129113137  chmp1b; charged multivesicular body protein 1b [KO:K12197]
129107991  chmp1a; charged multivesicular body protein 1a [KO:K12197]
129110470  chmp5b; charged multivesicular body protein 5 [KO:K12198]
129115419  chmp5a; charged multivesicular body protein 5 [KO:K12198]
129101360  ist1; IST1 homolog [KO:K19476]
129097578  pdcd6ip; programmed cell death 6-interacting protein isoform X1 [KO:K12200]
129103405  spg21; maspardin [KO:K19367]
129106802  igf2r; cation-independent mannose-6-phosphate receptor [KO:K06564]
129100831  snx2; sorting nexin-2 [KO:K17917]
129101989  sorting nexin-1-like [KO:K17917]
129107853  snx1a; sorting nexin-1a [KO:K17917]
129106025  si:dkey-28n18.9; uncharacterized protein si:dkey-28n18.9 [KO:K17920]
129092106  snx5; sorting nexin-5 [KO:K17920]
129103127  snx6; sorting nexin-6 isoform X1 [KO:K17920]
129099351  src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129105318  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
129108847  GTPase HRas [KO:K02833]
129095377  uncharacterized protein LOC129095377 [KO:K05069]
129098187  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
129113109  cytokine receptor common subunit gamma-like [KO:K05070]
129099318  LOW QUALITY PROTEIN: rho-related GTP-binding protein RhoA-D-like [KO:K04513]
129099319  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
129105477  rho-related GTP-binding protein RhoA-B [KO:K04513]
129100387  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
129100403  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
129106029  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
129096886  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
129096897  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129096898  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
129096899  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
129096901  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129096902  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129096977  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129097327  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
129097328  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129116783  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129116835  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like [KO:K06751]
129094776  folr; folate receptor [KO:K13649]
129098832  rtbdn; retbindin [KO:K13649]
129108276  cav1; caveolin-1 [KO:K06278]
129100389  cav4b; caveolin-2 [KO:K12958]
129106355  LOW QUALITY PROTEIN: caveolin-2-like [KO:K12958]
129106412  cav4a; caveolin-2 [KO:K12958]
129108668  cav2; caveolin-2 [KO:K12958]
129106292  cav3; caveolin-3 isoform X1 [KO:K12959]
129106904  ehd3; EH domain-containing protein 3 [KO:K12476]
129103644  ehd4; EH domain-containing protein 4 [KO:K12477]
129107791  eea1; early endosome antigen 1 [KO:K12478]
129096752  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
129109400  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
129104194  rab5b; ras-related protein Rab-5B [KO:K07888]
129091180  ras-related protein Rab-5C-like [KO:K07889]
129098424  rab5c; ras-related protein Rab-5C [KO:K07889]
129113624  rabep1; LOW QUALITY PROTEIN: rab GTPase-binding effector protein 1 [KO:K12480]
129100120  rabenosyn-5 [KO:K12481]
129103325  rab4a; LOW QUALITY PROTEIN: ras-related protein Rab-4A [KO:K07879]
129089854  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
129104076  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
129090115  ehd1a; EH domain-containing protein 1a [KO:K12483]
129096875  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
129112390  sorting nexin-4-like [KO:K17919]
129104489  snx4; sorting nexin-4 [KO:K17919]
129105315  rab22a; ras-related protein Rab-22A [KO:K07891]
129088789  rab31; ras-related protein Rab-31 [KO:K07891]
129106895  rab10; ras-related protein Rab-10 [KO:K07903]
129095070  ras-related protein Rab-8A [KO:K07901]
129113101  ras-related protein Rab-8A [KO:K07901]
129100808  rab35b; ras-related protein Rab-35b [KO:K07876]
129097970  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
129099232  rab11a; ras-related protein Rab-11A [KO:K07904]
129109053  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
129094951  ras-related protein Rab-11B-like [KO:K07905]
129094952  ras-related protein Rab-11B [KO:K07905]
129110939  ras-related protein Rab-11B-like [KO:K07905]
129090327  LOW QUALITY PROTEIN: rab11 family-interacting protein 1 [KO:K12484]
129100744  rab11fip1a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
129102328  rab11fip1b; calponin homology domain-containing protein DDB_G0272472 [KO:K12484]
129092622  rab11 family-interacting protein 2 isoform X1 [KO:K12484]
129103594  rab11fip5a; rab11 family-interacting protein 1 isoform X1 [KO:K12484]
129095482  zfyve27; protrudin isoform X1 [KO:K19368]
129099682  kif5aa; kinesin family member 5Aa [KO:K10396]
129105736  kif5ab; kinesin heavy chain isoform X1 [KO:K10396]
129110696  kinesin-1 heavy chain-like [KO:K10396]
129111885  kinesin heavy chain-like [KO:K10396]
129113245  kinesin-1 heavy chain [KO:K10396]
129104235  kinesin heavy chain-like [KO:K10396]
129091165  rab11fip3; rab11 family-interacting protein 3 [KO:K12485]
129096026  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
129099132  rab11fip4a; rab11 family-interacting protein 4A isoform X1 [KO:K12485]
129110418  partitioning defective 3 homolog isoform X1 [KO:K04237]
129088942  partitioning defective 3 homolog isoform X1 [KO:K04237]
129099640  pard6b; partitioning defective 6 homolog beta [KO:K06093]
129097345  pard6gb; par-6 family cell polarity regulator gamma b isoform X1 [KO:K06093]
129108754  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
129100061  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
129110970  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
129109580  cdc42l; cell division cycle 42, like [KO:K04393]
129105173  cdc42; cell division control protein 42 homolog [KO:K04393]
129100362  cell division control protein 42 homolog isoform X1 [KO:K04393]
129096930  cell division control protein 42 homolog [KO:K04393]
129095866  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
129092236  smap1; stromal membrane-associated protein 1 isoform X1 [KO:K12486]
129097186  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
129100122  git1; ARF GTPase-activating protein GIT1 [KO:K05737]
129101553  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
129102093  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
129105276  LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
129110487  asap1b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 [KO:K12488]
129107476  asap2b; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
129103259  asap2a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2a [KO:K12488]
129103546  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 [KO:K12488]
129116556  asap1a; LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a [KO:K12488]
129099636  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 [KO:K12489]
129105377  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
129092141  zgc:162872; LOW QUALITY PROTEIN: BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
129093368  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
129094244  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like [KO:K12489]
129105584  LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1-like [KO:K18439]
129113796  LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [KO:K18440]
129093519  arap2; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
129089823  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
129111615  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
129115560  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 [KO:K12491]
129099566  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
129105887  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
129105593  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
129112326  arfgap3; LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
129098682  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
129089689  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
129091120  PH and SEC7 domain-containing protein 1-like [KO:K12494]
129102134  PH and SEC7 domain-containing protein 3 [KO:K12494]
129092178  psda; PH and SEC7 domain-containing protein 1 [KO:K12494]
129099484  iqsec2b; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
129099557  IQ motif and SEC7 domain-containing protein 1-like isoform X1 [KO:K12495]
129105340  iqsec1b; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 1 [KO:K12495]
129100009  IQ motif and SEC7 domain-containing protein 2-like [KO:K12495]
129112447  LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3-like [KO:K12495]
129108750  iqsec3b; IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
129095416  cyth4b; cytohesin 4b [KO:K18441]
129090933  cytohesin-1-like isoform X1 [KO:K18441]
129091245  cytohesin-3-like [KO:K18441]
129097856  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
129097981  cytohesin-4-like isoform X1 [KO:K18441]
129098087  cytohesin-3 isoform X1 [KO:K18441]
129109292  cyth2; cytohesin-2 [KO:K18441]
129110608  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
129100372  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
129091933  gbf1; LOW QUALITY PROTEIN: Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
129091012  arf2b; ADP-ribosylation factor 2b [KO:K07937]
129113440  arf1; ADP-ribosylation factor 1 [KO:K07937]
129097985  arf2a; ADP-ribosylation factor 2a [KO:K07937]
129099553  arf3a; ADP-ribosylation factor 3a isoform X1 [KO:K07938]
129105206  ADP-ribosylation factor 3-like [KO:K07938]
129112238  ADP-ribosylation factor 4 [KO:K07939]
129108141  ADP-ribosylation factor 4-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
afb04060  Cytokine-cytokine receptor interaction
afb04070  Phosphatidylinositol signaling system
afb04130  SNARE interactions in vesicular transport
afb04142  Lysosome
afb04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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