KEGG   PATHWAY: amex04218
Entry
amex04218                   Pathway                                
Name
Cellular senescence - Astyanax mexicanus (Mexican tetra)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
amex04218  Cellular senescence
amex04218

Other DBs
GO: 0090398
Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103033069  tgfb1; transforming growth factor beta-1 [KO:K13375]
103024607  transforming growth factor beta-1-like [KO:K13375]
103042476  transforming growth factor beta-2-like [KO:K13376]
103026112  tgfb2; transforming growth factor beta-2 [KO:K13376]
103032923  tgfb3; transforming growth factor beta-3 [KO:K13377]
103034175  TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
103047038  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103042559  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
103031725  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103025750  smad2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
103027004  mothers against decapentaplegic homolog 3 [KO:K23605]
103027811  mothers against decapentaplegic homolog 3 [KO:K23605]
111189396  cyclin-dependent kinase 4 inhibitor B-like isoform X1 [KO:K04685]
103034254  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103047757  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103031956  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
103031397  ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
111193357  G1/S-specific cyclin-D1-like [KO:K10151]
103045792  ccnd3; LOW QUALITY PROTEIN: G1/S-specific cyclin-D3 [KO:K10152]
103040648  rb1; retinoblastoma-associated protein [KO:K06618]
103024081  rbl1; retinoblastoma-like protein 1 [KO:K04681]
103033933  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103022816  e2f1; transcription factor E2F1 [KO:K17454]
103027354  transcription factor E2F2 isoform X1 [KO:K09389]
103022559  transcription factor E2F3-like [KO:K06620]
103038273  e2f3; transcription factor E2F3 isoform X1 [KO:K06620]
103027226  e2f5; transcription factor E2F5 [KO:K04682]
103038757  transcription factor E2F4-like [KO:K04682]
103032909  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103045036  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103041606  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103022173  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111190801  LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
103035767  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
103029972  pik3r3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103046618  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103046520  forkhead box protein O1-B-like [KO:K07201]
103032706  foxo1; forkhead box protein O1 [KO:K07201]
103026113  forkhead box protein O3-like [KO:K09408]
103022904  foxo3; forkhead box protein O3 [KO:K09408]
103047217  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103041774  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
103028318  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103030457  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
103028876  G1/S-specific cyclin-E2-like [KO:K06626]
103042001  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
111189994  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
111189995  zinc-alpha-2-glycoprotein-like [KO:K06751]
103046651  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
103023887  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
107197241  H-2 class I histocompatibility antigen, D-P alpha chain-like [KO:K06751]
111190038  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111190039  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
107197243  LOW QUALITY PROTEIN: class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
111189894  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
111189002  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
103022132  HLA class I histocompatibility antigen, B-14 alpha chain-like [KO:K06751]
103041738  zinc-alpha-2-glycoprotein-like [KO:K06751]
103040725  zinc-alpha-2-glycoprotein-like [KO:K06751]
103037042  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
111190736  uncharacterized protein LOC111190736 [KO:K06751]
103040406  H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
111190556  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
111190557  LOW QUALITY PROTEIN: BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
111190560  patr class I histocompatibility antigen, alpha chain G-like [KO:K06751]
111189477  zinc-alpha-2-glycoprotein-like [KO:K06751]
111189485  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
103041896  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
111193516  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
103042726  patr class I histocompatibility antigen, CH28 alpha chain-like [KO:K06751]
103036851  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like isoform X1 [KO:K06751]
111189383  zinc-alpha-2-glycoprotein-like [KO:K06751]
111190273  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
111190274  zinc-alpha-2-glycoprotein-like [KO:K06751]
111190275  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111190276  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
111190847  LOW QUALITY PROTEIN: RLA class I histocompatibility antigen, alpha chain 11/11-like [KO:K06751]
111190848  zinc-alpha-2-glycoprotein-like [KO:K06751]
103032096  HLA class I histocompatibility antigen, alpha chain E-like [KO:K06751]
103022225  LOW QUALITY PROTEIN: H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
111197025  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103022947  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103043382  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
111190737  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103038503  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111188435  zinc-alpha-2-glycoprotein-like [KO:K06751]
111193514  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
103044490  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
111193610  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
103038241  GTPase KRas isoform X1 [KO:K07827]
103023536  GTPase HRas-like [KO:K07827]
103039914  nras; GTPase NRas [KO:K07828]
103047285  rras; ras-related protein R-Ras [KO:K07830]
103027563  rras2; ras-related protein R-Ras2 [KO:K07830]
111196825  ras-related protein M-Ras-like [KO:K07831]
103031239  ras-related protein M-Ras isoform X1 [KO:K07831]
103029246  ras-related protein M-Ras-like [KO:K07831]
103021516  hras; GTPase HRas [KO:K02833]
103040103  GTPase HRas [KO:K02833]
103040659  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103026930  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103023390  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103040186  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103024575  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103023802  hamartin [KO:K07206]
103025705  tsc1; hamartin isoform X1 [KO:K07206]
103033522  tsc2; tuberin isoform X1 [KO:K07207]
111196194  GTP-binding protein Rheb-like isoform X1 [KO:K07208]
103021747  LOW QUALITY PROTEIN: GTP-binding protein Rheb [KO:K07208]
103035598  GTP-binding protein Rheb-like [KO:K07208]
103042377  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103046962  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103025186  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103031674  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
103039512  ccna1; cyclin-A1 [KO:K06627]
103035499  ccna2; cyclin-A2 [KO:K06627]
103021967  mybl2; LOW QUALITY PROTEIN: myb-related protein B [KO:K21769]
103022377  lin9; protein lin-9 homolog [KO:K21773]
103047046  lin37; protein lin-37 homolog isoform X1 [KO:K21774]
103035263  lin52; protein lin-52 homolog [KO:K21775]
103038067  lin54; protein lin-54 homolog [KO:K21776]
103041235  protein lin-54 homolog [KO:K21776]
103023991  histone-binding protein RBBP7 isoform X1 [KO:K10752]
103039809  rbbp4; histone-binding protein RBBP4 [KO:K10752]
103038167  transcriptional regulator Myc-B-like [KO:K04377]
103033997  transcriptional regulator Myc [KO:K04377]
103039064  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
103037427  cellular tumor antigen p53-like [KO:K04451]
103046742  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103034359  rassf5; ras association domain-containing protein 5 isoform X3 [KO:K08015]
103028966  F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
103029337  F-box/WD repeat-containing protein 11-like [KO:K03362]
103046977  homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
103026702  LOW QUALITY PROTEIN: homeodomain-interacting protein kinase 1 [KO:K08826] [EC:2.7.11.1]
103040439  hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
103023558  homeodomain-interacting protein kinase 1-like isoform X1 [KO:K08826] [EC:2.7.11.1]
103036562  homeodomain-interacting protein kinase 3-like [KO:K08826] [EC:2.7.11.1]
103037187  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103028275  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
103034594  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
103033313  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103030509  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
103034518  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
103027930  RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103025658  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
103028644  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103030512  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103041389  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103047585  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103024969  protein C-ets-1 isoform X2 [KO:K02678]
111191499  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like [KO:K04433] [EC:2.7.12.2]
103035641  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103035956  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
103046996  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
103028137  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
103042110  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
103043112  LOW QUALITY PROTEIN: mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103040333  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103029638  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
103042551  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103038163  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
103036194  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
103039224  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
103036359  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103047431  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
103046107  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
103043733  G2/mitotic-specific cyclin-B2 [KO:K21770]
103043213  G2/mitotic-specific cyclin-B3-like isoform X1 [KO:K21771]
103027909  G2/mitotic-specific cyclin-B3-like [KO:K21771]
103034489  mre11; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
103041254  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
103021427  nbn; nibrin [KO:K10867]
103045062  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103034962  chek2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
103034409  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
103030972  cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10995]
103042262  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
103033643  hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
103025436  atr; LOW QUALITY PROTEIN: serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
103021956  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
103026459  sqstm1; LOW QUALITY PROTEIN: sequestosome-1 [KO:K14381]
103031262  gata4; transcription factor GATA-4 isoform X1 [KO:K09183]
103025743  traf3ip2; adapter protein CIKS [KO:K21124]
103038869  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103032041  putative transcription factor p65 homolog [KO:K04735]
111191914  interleukin-6-like [KO:K05405]
103036120  interleukin-8-like [KO:K10030]
103026712  interleukin-8-like [KO:K10030]
103036419  interleukin-8-like [KO:K10030]
103036716  interleukin-8-like [KO:K10030]
103029988  cxcl13; C-X-C motif chemokine 13 [KO:K10030]
111194341  insulin-like growth factor-binding protein 3 [KO:K10138]
103027084  insulin-like growth factor-binding protein 3 [KO:K10138]
103042062  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
103026948  eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
103033501  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
103024512  MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
103036204  mRNA decay activator protein ZFP36L2-A-like isoform X1 [KO:K18753]
103025007  mRNA decay activator protein ZFP36L1-like isoform X1 [KO:K18753]
103038797  mRNA decay activator protein ZFP36L1-like [KO:K18753]
103044956  zfp36l1; mRNA decay activator protein ZFP36L1 [KO:K18753]
103031649  zfp36l2; mRNA decay activator protein ZFP36L2 [KO:K18753]
103029105  mRNA decay activator protein ZFP36L1-like [KO:K18753]
103033357  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103043956  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
103044256  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
111197571  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
103021914  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
103042634  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103023637  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103024720  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
111196138  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103026146  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
107197131  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
103024279  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111188412  calmodulin-like [KO:K02183]
103023587  calmodulin [KO:K02183]
103029589  calmodulin-like protein 4 [KO:K02183]
103024819  calmodulin [KO:K02183]
103032770  calmodulin-like protein 4 [KO:K02183]
103037741  calmodulin [KO:K02183]
103028596  calmodulin [KO:K02183]
103042400  calm2; calmodulin-2 [KO:K02183]
103025738  calml6; calmodulin-like protein 6 [KO:K02183]
103021658  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103043949  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
103032478  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
103046193  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
103039366  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform-like isoform X1 [KO:K04348] [EC:3.1.3.16]
103037384  calcineurin subunit B type 1 [KO:K06268]
103042847  calcineurin subunit B type 1 isoform X1 [KO:K06268]
103031085  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103045210  nuclear factor of activated T-cells, cytoplasmic 1-like [KO:K04446]
103038616  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103034389  nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
103030248  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103029075  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103041608  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
103030168  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
103040877  itpr1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103025600  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103035973  ADP/ATP translocase 2 [KO:K05863]
103040979  ADP/ATP translocase 1 [KO:K05863]
103047840  ADP/ATP translocase 2 [KO:K05863]
103043313  ADP/ATP translocase 1 [KO:K05863]
103023085  ADP/ATP translocase 2-like [KO:K05863]
103046274  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
103024199  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103037680  voltage-dependent anion-selective channel protein 2 [KO:K15040]
103040512  voltage-dependent anion-selective channel protein 2 [KO:K15040]
103039704  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103027768  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
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Related
pathway
amex04020  Calcium signaling pathway
amex04068  FoxO signaling pathway
amex04110  Cell cycle
amex04115  p53 signaling pathway
amex04150  mTOR signaling pathway
KO pathway
ko04218   
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