KEGG   PATHWAY: amex04218
Entry
amex04218                   Pathway                                
Name
Cellular senescence - Astyanax mexicanus (Mexican tetra)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
amex04218  Cellular senescence
amex04218

Other DBs
GO: 0090398
Organism
Astyanax mexicanus (Mexican tetra) [GN:amex]
Gene
103021427  nbn; nibrin [KO:K10867]
103021516  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
103021658  [KO:K04348] [EC:3.1.3.16]
103021747  rheb; GTP-binding protein Rheb [KO:K07208]
103021914  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
103021956  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
103021967  mybl2b; v-myb avian myeloblastosis viral oncogene homolog-like 2b [KO:K21769]
103022173  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103022377  lin9; protein lin-9 homolog [KO:K21773]
103022559  e2f3; transcription factor E2F3 [KO:K06620]
103022816  e2f1; transcription factor E2F1 [KO:K17454]
103022904  foxo3b; forkhead box protein O3B [KO:K09408]
103022947  [KO:K06751]
103023085  [KO:K05863]
103023390  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103023536  zgc:55558; GTPase KRas [KO:K07827]
103023558  hipk1a; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
103023587  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
103023637  [KO:K01367] [EC:3.4.22.52]
103023802  tsc1b; TSC complex subunit 1b [KO:K07206]
103023991  rbb4l; histone-binding protein RBBP7 isoform X1 [KO:K10752]
103024081  rbl1; retinoblastoma-like protein 1 [KO:K04681]
103024199  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
103024279  capn8; calpain-8 [KO:K03853] [EC:3.4.22.53]
103024512  mapkapk2b; MAP kinase-activated protein kinase 2b [KO:K04443] [EC:2.7.11.1]
103024575  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103024607  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
103024720  capn1a; calpain 1, (mu/I) large subunit a [KO:K01367] [EC:3.4.22.52]
103024819  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
103024969  ets1; protein C-ets-1 isoform X2 [KO:K02678]
103025007  zgc:114130; mRNA decay activator protein ZFP36L1 isoform X1 [KO:K18753]
103025186  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103025436  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
103025600  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103025658  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
103025705  tsc1a; TSC complex subunit 1a isoform X1 [KO:K07206]
103025738  [KO:K02183]
103025743  traf3ip2a; E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
103025750  smad2; mothers against decapentaplegic homolog 2 isoform X2 [KO:K04500]
103026112  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
103026113  foxo3a; forkhead box protein O3a [KO:K09408]
103026146  capn2b; calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
103026459  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
103026702  hipk1b; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
103026712  cxcl8a; interleukin-8 [KO:K10030]
103026930  [KO:K04456] [EC:2.7.11.1]
103026948  eif4ebp1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103027004  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
103027084  igfbp3; insulin-like growth factor-binding protein 3 [KO:K10138]
103027226  e2f5; transcription factor E2F5 [KO:K04682]
103027354  e2f2; transcription factor E2F2 [KO:K09389]
103027563  rras2; ras-related protein R-Ras2 [KO:K07830]
103027768  mcu; calcium uniporter protein, mitochondrial [KO:K20858]
103027811  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
103027909  [KO:K21771]
103027930  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103028137  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
103028275  [KO:K06269] [EC:3.1.3.16]
103028318  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103028596  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
103028644  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103028876  [KO:K06626]
103028966  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
103029075  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103029105  zfp36l1b; mRNA decay activator protein ZFP36L1b [KO:K18753]
103029246  mrasa; ras-related protein M-Ras [KO:K07831]
103029337  fbxw11b; F-box and WD repeat domain-containing 11-B [KO:K03362]
103029589  calml4a; calmodulin-like protein 4a [KO:K02183]
103029638  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a [KO:K04402]
103029972  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
103029988  [KO:K10030]
103030168  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103030248  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
103030457  ccne2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
103030509  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103030512  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
103030972  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
103031085  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
103031239  mrasb; ras-related protein M-Ras [KO:K07831]
103031262  gata4; transcription factor GATA-4 [KO:K09183]
103031397  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
103031649  [KO:K18753]
103031674  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
103031725  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103031956  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
103032041  rela; transcription factor p65 isoform X1 [KO:K04735]
103032478  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103032706  foxo1a; forkhead box protein O1-A [KO:K07201]
103032770  calml4b; calmodulin-like protein 4 [KO:K02183]
103032909  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103032923  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
103033069  tgfb1b; transforming growth factor beta-1 proprotein [KO:K13375]
103033313  [KO:K06269] [EC:3.1.3.16]
103033357  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
103033501  mapkapk2a; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
103033522  tsc2; tuberin isoform X1 [KO:K07207]
103033643  hus1; checkpoint protein HUS1 isoform X1 [KO:K10903]
103033933  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
103033997  myca; transcriptional regulator Myc-A [KO:K04377]
103034175  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
103034254  cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103034359  rassf5; ras association domain-containing protein 5 isoform X3 [KO:K08015]
103034389  [KO:K17332]
103034409  rad9a; cell cycle checkpoint control protein RAD9A [KO:K10994] [EC:3.1.11.2]
103034489  mre11a; double-strand break repair protein MRE11 isoform X1 [KO:K10865]
103034518  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
103034594  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
103034962  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
103035263  lin52; protein lin-52 homolog [KO:K21775]
103035499  ccna2; cyclin-A2 [KO:K06627]
103035598  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
103035641  mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103035956  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
103035973  slc25a5; ADP/ATP translocase 2 [KO:K05863]
103036120  [KO:K10030]
103036194  gadd45bb; growth arrest and DNA-damage-inducible, beta b [KO:K04402]
103036204  zfp36l2; mRNA decay activator protein ZFP36L2 isoform X1 [KO:K18753]
103036359  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
103036419  [KO:K10030]
103036562  hipk3b; homeodomain-interacting protein kinase 3 [KO:K08826] [EC:2.7.11.1]
103036716  [KO:K10030]
103036851  [KO:K06751]
103037042  [KO:K06751]
103037187  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
103037384  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
103037427  [KO:K04451]
103037680  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
103037741  calm1b; calmodulin-1b [KO:K02183]
103038067  lin54; protein lin-54 homolog [KO:K21776]
103038163  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
103038167  mycb; transcriptional regulator Myc-B [KO:K04377]
103038241  kras; GTPase KRas isoform X1 [KO:K07827]
103038273  [KO:K06620]
103038503  [KO:K06751]
103038616  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
103038797  [KO:K18753]
103038869  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103039064  mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
103039224  [KO:K04402]
103039366  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
103039512  ccna1; cyclin-A1 [KO:K06627]
103039674  [KO:K01367] [EC:3.4.22.52]
103039704  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103039809  rbbp4; histone-binding protein RBBP4 [KO:K10752]
103039814  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
103039914  nras; GTPase NRas [KO:K07828]
103040103  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
103040186  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103040333  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103040439  hipk2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
103040512  [KO:K15040]
103040648  rb1; retinoblastoma-associated protein [KO:K06618]
103040659  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103040877  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
103040979  slc25a4; ADP/ATP translocase 1 [KO:K05863]
103041235  tesmin; spexin prohormone 2 [KO:K21776]
103041254  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
103041389  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103041606  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103041608  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
103041774  cdkn1d; cyclin-dependent kinase inhibitor 1D [KO:K06625]
103042001  ccne1; G1/S-specific cyclin-E1 [KO:K06626]
103042062  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
103042110  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
103042262  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
103042377  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103042400  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
103042476  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
103042551  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
103042559  tgfbr2a; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103042634  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
103042847  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
103043112  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103043213  ccnb3; G2/mitotic-specific cyclin-B3 isoform X1 [KO:K21771]
103043313  slc25a6; ADP/ATP translocase 3 [KO:K05863]
103043733  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
103043949  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
103043956  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X2 [KO:K04851]
103044256  trpv4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
103044956  zfp36l1a; mRNA decay activator protein ZFP36L1a [KO:K18753]
103045036  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103045062  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103045210  [KO:K04446]
103045792  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
103045836  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
103046107  ccnb1; G2/mitotic-specific cyclin-B1 isoform X1 [KO:K05868]
103046193  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
103046274  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
103046520  foxo1b; forkhead box protein O1-B [KO:K07201]
103046618  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103046742  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103046962  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103046977  hipk3a; homeodomain-interacting protein kinase 3a isoform X1 [KO:K08826] [EC:2.7.11.1]
103046996  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
103047038  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
103047046  lin37; protein lin-37 homolog isoform X1 [KO:K21774]
103047217  cdkn1a; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
103047285  rras; ras-related protein R-Ras [KO:K07830]
103047431  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
103047585  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103047757  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103047840  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
107197131  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
111188412  calm1a; calmodulin-1a [KO:K02183]
111189396  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B isoform X1 [KO:K04685]
111190038  [KO:K06751]
111190039  [KO:K06751]
111190274  [KO:K06751]
111190275  [KO:K06751]
111190556  [KO:K06751]
111190847  [KO:K06751]
111190848  [KO:K06751]
111191499  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
111191914  il6; interleukin-6 [KO:K05405]
111193515  [KO:K06751]
111194341  [KO:K10138]
111196138  zgc:162184; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
111196646  [KO:K06751]
111197025  [KO:K06751]
111197124  [KO:K06751]
111197571  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
125782187  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125782414  [KO:K04402]
125786766  [KO:K06751]
125788844  [KO:K06751]
125788846  [KO:K06751]
125788850  [KO:K06751]
125788853  [KO:K06751]
125788874  [KO:K06751]
125788938  [KO:K04388] [EC:2.7.11.30]
125790028  [KO:K06751]
125790048  [KO:K06751]
125790050  [KO:K06751]
125790053  [KO:K06751]
125790054  [KO:K06751]
125799128  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
125806068  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
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Cell 155:1104-18 (2013)
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Cell Cycle 14:3771-2 (2015)
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Martin N, Bernard D
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Calcium signaling and cellular senescence.
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Cell Calcium S0143-4160(17)30049-0 (2017)
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PMID:25764980
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Calcium homeostasis in cancer: A focus on senescence.
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Biochim Biophys Acta 1853:1974-9 (2015)
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PMID:24062309
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McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
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Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
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J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
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PMID:27288568
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Ras signaling through RASSF proteins.
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Semin Cell Dev Biol 58:86-95 (2016)
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PMID:28455242
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Barnoud T, Schmidt ML, Donninger H, Clark GJ
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The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
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Cancer Lett 400:30-36 (2017)
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PMID:26404840
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Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
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Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
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Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
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Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
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  Title
Senescence from G2 arrest, revisited.
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Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
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PMID:24981831
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Mowla SN, Lam EW, Jat PS
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Cellular senescence and aging: the role of B-MYB.
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Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
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PMID:22546858
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Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
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SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
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J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
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Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
amex04020  Calcium signaling pathway
amex04068  FoxO signaling pathway
amex04110  Cell cycle
amex04115  p53 signaling pathway
amex04150  mTOR signaling pathway
KO pathway
ko04218   

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