Entry Name T cell receptor signaling pathway - Balaenoptera acutorostrata scammoni (minke whale)
Description Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Balaenoptera acutorostrata scammoni (minke whale) [GN:
bacu ]
Gene 103009602 PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268 ]
102999196 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099 ]
103019365 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099 ]
102997242 FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379 ]
103008077 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649 ]
103009307 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649 ]
103007464 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649 ]
103019457 PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456 ]
103017366 serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456 ]
103003377 PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354 ]
103020854 PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354 ]
103015446 PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354 ]
103001451 PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354 ]
103001016 PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583 ]
102998572 PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583 ]
103010924 PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584 ]
103006105 PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584 ]
102998528 PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584 ]
103018733 PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584 ]
103018422 PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Chen L.
Title Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
Journal Reference Authors Macian F.
Title NFAT proteins: key regulators of T-cell development and function.
Journal Reference Authors Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
Title Tec family kinases in T lymphocyte development and function.
Journal Reference Authors Huang Y, Wange RL.
Title T cell receptor signaling: beyond complex complexes.
Journal Reference Authors Schmitz ML, Bacher S, Dienz O.
Title NF-kappaB activation pathways induced by T cell costimulation.
Journal Reference Authors Alegre ML, Frauwirth KA, Thompson CB.
Title T-cell regulation by CD28 and CTLA-4.
Journal Reference Authors Horejsi V, Zhang W, Schraven B.
Title Transmembrane adaptor proteins: organizers of immunoreceptor signalling.
Journal Reference Authors Baniyash M.
Title TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response.
Journal Reference Authors Sechi AS, Wehland J.
Title Interplay between TCR signalling and actin cytoskeleton dynamics.
Journal Reference Authors Okkenhaug K, Vanhaesebroeck B.
Title PI3K in lymphocyte development, differentiation and activation.
Journal Reference Authors Palacios EH, Weiss A.
Title Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.
Journal Reference Authors Kane LP, Lin J, Weiss A.
Title It's all Rel-ative: NF-kappaB and CD28 costimulation of T-cell activation.
Journal Reference Authors Acuto O, Michel F.
Title CD28-mediated co-stimulation: a quantitative support for TCR signalling.
Journal Reference Authors Finkelstein LD, Schwartzberg PL.
Title Tec kinases: shaping T-cell activation through actin.
Journal Reference Authors Duan L, Reddi AL, Ghosh A, Dimri M, Band H.
Title The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.
Journal Reference Authors Schrum AG, Turka LA, Palmer E.
Title Surface T-cell antigen receptor expression and availability for long-term antigenic signaling.
Journal Reference Authors Smith-Garvin JE, Koretzky GA, Jordan MS
Title T cell activation.
Journal Reference Authors Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO
Title Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation.
Journal Reference Authors Blonska M, Lin X
Title CARMA1-mediated NF-kappaB and JNK activation in lymphocytes.
Journal Reference Authors Rebeaud F, Hailfinger S, Thome M
Title Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation.
Journal Reference Authors Ashwell JD
Title The many paths to p38 mitogen-activated protein kinase activation in the immune system.
Journal Reference Authors Round JL, Humphries LA, Tomassian T, Mittelstadt P, Zhang M, Miceli MC
Title Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals toward NFAT but not NF-kappaB transcription factors.
Journal Related KO pathway LinkDB All DBs
