KEGG   PATHWAY: bacu04151
Entry
bacu04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Balaenoptera acutorostrata scammoni (minke whale)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
bacu04151  PI3K-Akt signaling pathway
bacu04151

Other DBs
GO: 0043491
Organism
Balaenoptera acutorostrata scammoni (minke whale) [GN:bacu]
Gene
103004366  EGF; epidermal growth factor [KO:K04357]
103010563  TGFA; transforming growth factor alpha [KO:K08774]
103003402  EREG; epiregulin [KO:K09784]
103002922  AREG; amphiregulin [KO:K09782]
103018997  FGF1; fibroblast growth factor 1 [KO:K18496]
103015722  FGF2; fibroblast growth factor 2 [KO:K18497]
103012419  FGF5; fibroblast growth factor 5 [KO:K04358]
103004048  FGF9; fibroblast growth factor 9 [KO:K04358]
103001602  FGF8; fibroblast growth factor 8 [KO:K04358]
103009981  fibroblast growth factor 10-like [KO:K04358]
103002427  FGF6; fibroblast growth factor 6 [KO:K04358]
103013036  FGF20; fibroblast growth factor 20 [KO:K04358]
103020278  FGF7; fibroblast growth factor 7 [KO:K04358]
103018238  FGF17; fibroblast growth factor 17 [KO:K04358]
103012368  fibroblast growth factor 2-like [KO:K04358]
103017891  FGF18; fibroblast growth factor 18 [KO:K04358]
103020625  FGF16; fibroblast growth factor 16 [KO:K04358]
103018926  uncharacterized LOC103018926 [KO:K04358]
103012083  FGF19; fibroblast growth factor 19 [KO:K22603]
103016083  FGF21; fibroblast growth factor 21 [KO:K22429]
103017322  FGF23; fibroblast growth factor 23 [KO:K22428]
103002155  NGF; nerve growth factor [KO:K02582]
103017938  BDNF; brain derived neurotrophic factor [KO:K04355]
102997840  NTF3; neurotrophin 3 [KO:K04356]
103020826  NTF4; neurotrophin 4 [KO:K12457]
103021022  INS; insulin [KO:K04526]
103014780  IGF1; insulin like growth factor 1 [KO:K05459]
102997276  IGF2; insulin like growth factor 2 [KO:K13769]
103005337  PDGFA; platelet derived growth factor subunit A [KO:K04359]
103014878  PDGFB; platelet derived growth factor subunit B [KO:K17386]
103015925  PDGFD; platelet derived growth factor D [KO:K05450]
103019677  PDGFC; platelet derived growth factor C [KO:K05450]
103005966  CSF1; colony stimulating factor 1 [KO:K05453]
103001593  KITLG; KIT ligand [KO:K05461]
103003525  FLT3LG; fms related tyrosine kinase 3 ligand [KO:K05454]
103008131  VEGFA; vascular endothelial growth factor A [KO:K05448]
103008905  VEGFB; vascular endothelial growth factor B [KO:K16858]
103017555  PGF; placental growth factor [KO:K16859]
103014140  VEGFC; vascular endothelial growth factor C [KO:K05449]
103007348  VEGFD; vascular endothelial growth factor D [KO:K05449]
102997605  hepatocyte growth factor-like [KO:K05460]
103009839  ANGPT1; angiopoietin 1 [KO:K05465]
103002510  ANGPT2; angiopoietin 2 [KO:K05466]
103002441  ANGPT4; angiopoietin 4 [KO:K05467]
103011308  EFNA5; ephrin A5 [KO:K05462]
103018674  EFNA3; ephrin A3 [KO:K05462]
103010861  EFNA1; ephrin A1 [KO:K05462]
103011343  EFNA4; ephrin A4 [KO:K05462]
103014464  uncharacterized LOC103014464 [KO:K05462]
103003079  GDNF; glial cell derived neurotrophic factor [KO:K05452]
103005875  NRTN; neurturin [KO:K25414]
103002762  ARTN; artemin [KO:K25415]
103013495  PSPN; persephin [KO:K25416]
103017029  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103002640  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
103015964  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
103004826  ERBB4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
103017733  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103012184  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103002473  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103013305  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103015465  NGFR; nerve growth factor receptor [KO:K02583]
103003654  NTRK1; neurotrophic receptor tyrosine kinase 1 [KO:K03176] [EC:2.7.10.1]
103020777  NTRK2; neurotrophic receptor tyrosine kinase 2 [KO:K04360] [EC:2.7.10.1]
103018249  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
103015537  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102998016  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103019883  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102999126  CSF1R; colony stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
102999027  KIT; KIT proto-oncogene receptor tyrosine kinase [KO:K05091] [EC:2.7.10.1]
103008462  FLT3; fms related tyrosine kinase 3 [KO:K05092] [EC:2.7.10.1]
103015874  FLT1; fms related tyrosine kinase 1 [KO:K05096] [EC:2.7.10.1]
103004554  FLT4; fms related tyrosine kinase 4 [KO:K05097] [EC:2.7.10.1]
102999852  KDR; kinase insert domain receptor [KO:K05098] [EC:2.7.10.1]
103002086  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
103016789  TEK; TEK receptor tyrosine kinase [KO:K05121] [EC:2.7.10.1]
103009203  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
103006627  RET; ret proto-oncogene [KO:K05126] [EC:2.7.10.1]
103010512  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102999196  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103019365  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103006545  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103015457  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103004931  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103014337  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103017381  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103018627  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102999619  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103002590  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103011761  IRS1; insulin receptor substrate 1 [KO:K16172]
102998386  TLR2; toll like receptor 2 [KO:K10159]
103015759  TLR4; toll like receptor 4 [KO:K10160]
103007995  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103002153  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856]
103002419  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856]
103003240  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856]
103004077  putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like [KO:K06856]
103013608  SYK; spleen associated tyrosine kinase [KO:K05855] [EC:2.7.10.2]
103020999  CD19; CD19 molecule [KO:K06465]
103009938  PIK3AP1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
103018096  GH1; growth hormone 1 [KO:K05438]
103005353  PRL; prolactin [KO:K05439]
103016655  OSM; oncostatin M [KO:K05418]
103017896  IL2; interleukin 2 [KO:K05429]
103019984  IL3; interleukin 3 [KO:K04736]
103008558  IL6; interleukin 6 [KO:K05405]
103010027  IL4; interleukin 4 [KO:K05430]
103000105  IL7; interleukin 7 [KO:K05431]
103007162  interferon alpha-1-like [KO:K05414]
103008826  interferon alpha-1-like [KO:K05414]
103009695  IFNA7; interferon alpha 7 [KO:K05414]
103010469  interferon alpha-1-like [KO:K05414]
103010766  interferon alpha-1-like [KO:K05414]
103011926  interferon beta-2-like [KO:K05415]
102998833  EPO; erythropoietin [KO:K05437]
103005814  CSF3; colony stimulating factor 3 [KO:K05423]
103002001  GHR; growth hormone receptor [KO:K05080]
103010642  PRLR; prolactin receptor [KO:K05081]
102999596  OSMR; oncostatin M receptor [KO:K05057]
102999308  IL2RA; interleukin 2 receptor subunit alpha [KO:K05068]
103006990  IL2RB; interleukin 2 receptor subunit beta [KO:K05069]
103016442  IL2RG; interleukin 2 receptor subunit gamma [KO:K05070]
103005335  IL3RA; interleukin 3 receptor subunit alpha [KO:K04737]
103019388  IL6R; interleukin 6 receptor [KO:K05055]
103017383  IL4R; interleukin 4 receptor [KO:K05071]
103010049  IL7R; interleukin 7 receptor [KO:K05072]
102998082  IFNAR1; interferon alpha and beta receptor subunit 1 [KO:K05130]
103020704  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103003915  EPOR; erythropoietin receptor [KO:K05079]
103000462  CSF3R; colony stimulating factor 3 receptor [KO:K05061]
103004050  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103016904  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
103012385  JAK3; Janus kinase 3 [KO:K11218] [EC:2.7.10.2]
103019929  collagen alpha-1(I) chain-like [KO:K06236]
103006766  collagen alpha-2(I) chain-like [KO:K06236]
103008168  collagen alpha-1(II) chain-like [KO:K19719]
102999723  collagen alpha-1(II) chain-like [KO:K19719]
103009884  COL4A1; collagen type IV alpha 1 chain [KO:K06237]
103010470  COL4A2; collagen type IV alpha 2 chain [KO:K06237]
103009501  COL4A5; collagen type IV alpha 5 chain [KO:K06237]
103009983  COL4A6; collagen type IV alpha 6 chain [KO:K06237]
103020723  COL4A3; collagen type IV alpha 3 chain [KO:K06237]
103010606  COL4A4; collagen type IV alpha 4 chain [KO:K06237]
103005784  COL6A2; collagen type VI alpha 2 chain [KO:K06238]
103006351  COL6A1; collagen type VI alpha 1 chain [KO:K06238]
103000682  COL6A6; collagen type VI alpha 6 chain [KO:K06238]
103000952  COL6A5; collagen type VI alpha 5 chain [KO:K06238]
103009925  COL6A3; collagen type VI alpha 3 chain [KO:K06238]
103005462  COL9A2; collagen type IX alpha 2 chain [KO:K08131]
103020918  COL9A1; collagen type IX alpha 1 chain [KO:K08131]
103019864  COL9A3; collagen type IX alpha 3 chain [KO:K08131]
103011922  LAMA1; laminin subunit alpha 1 [KO:K05637]
102998029  LAMA2; laminin subunit alpha 2 [KO:K05637]
103004795  laminin subunit alpha-3-like [KO:K06240]
103010510  LAMA5; laminin subunit alpha 5 [KO:K06240]
103012309  LAMA3; laminin, alpha 3 [KO:K06240]
103014236  LAMA4; laminin subunit alpha 4 [KO:K06241]
102997450  LAMB1; laminin subunit beta 1 [KO:K05636]
102999125  LAMB2; laminin subunit beta 2 [KO:K06243]
103003030  LAMB3; laminin subunit beta 3 [KO:K06244]
103006714  LAMB4; laminin subunit beta 4 [KO:K06245]
102999353  LAMC1; laminin subunit gamma 1 [KO:K05635]
103005240  LAMC2; laminin subunit gamma 2 [KO:K06246]
103006188  LAMC3; laminin subunit gamma 3 [KO:K06247]
102998876  CHAD; chondroadherin [KO:K06248]
102999363  RELN; reelin [KO:K06249] [EC:3.4.21.-]
103019307  THBS1; thrombospondin 1 [KO:K16857]
102999752  THBS2; thrombospondin 2 [KO:K04659]
103007252  COMP; cartilage oligomeric matrix protein [KO:K04659]
103007962  THBS3; thrombospondin 3 [KO:K04659]
102998613  THBS4; thrombospondin 4 [KO:K04659]
103018975  FN1; fibronectin 1 [KO:K05717]
103005187  SPP1; secreted phosphoprotein 1 [KO:K06250]
103000100  VTN; vitronectin [KO:K06251]
103011265  TNN; tenascin N [KO:K06252]
103007093  TNR; tenascin R [KO:K06252]
103014899  TNXB; tenascin XB [KO:K06252]
103017087  TNC; tenascin C [KO:K06252]
103021101  VWF; von Willebrand factor [KO:K03900]
103005935  IBSP; integrin binding sialoprotein [KO:K06253]
103016121  ITGA1; integrin subunit alpha 1 [KO:K06480]
103016586  ITGA2; integrin subunit alpha 2 [KO:K06481]
102999724  ITGA2B; integrin subunit alpha 2b [KO:K06476]
103017998  ITGA3; integrin subunit alpha 3 [KO:K06482]
103010335  ITGA4; integrin subunit alpha 4 [KO:K06483]
103011640  ITGA5; integrin subunit alpha 5 [KO:K06484]
103017654  ITGA6; integrin subunit alpha 6 [KO:K06485]
103006781  ITGA7; integrin subunit alpha 7 [KO:K06583]
103020775  ITGA8; integrin subunit alpha 8 [KO:K06584]
103013408  ITGA9; integrin subunit alpha 9 [KO:K06585]
103004608  ITGA10; integrin subunit alpha 10 [KO:K06586]
103015659  ITGA11; integrin subunit alpha 11 [KO:K06587]
103000411  ITGAV; integrin subunit alpha V [KO:K06487]
103008019  ITGB1; integrin subunit beta 1 [KO:K05719]
103005345  ITGB3; integrin subunit beta 3 [KO:K06493]
103016174  ITGB4; integrin subunit beta 4 [KO:K06525]
103010943  ITGB5; integrin subunit beta 5 [KO:K06588]
103009431  ITGB6; integrin subunit beta 6 [KO:K06589]
103006205  ITGB7; integrin subunit beta 7 [KO:K06590]
103005840  ITGB8; integrin subunit beta 8 [KO:K06591]
103013388  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103012691  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103012931  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103014043  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103008077  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103009307  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103007464  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103006270  F2R; coagulation factor II thrombin receptor [KO:K03914]
103019287  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
103000729  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
103015300  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103016779  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103013128  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
103017315  lysophosphatidic acid receptor 4-like [KO:K04275]
103015627  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103013481  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
103006513  GNB1; G protein subunit beta 1 [KO:K04536]
103000308  GNB2; G protein subunit beta 2 [KO:K04537]
103008105  GNB3; G protein subunit beta 3 [KO:K07825]
103001811  GNB4; G protein subunit beta 4 [KO:K04538]
103000160  GNB5; G protein subunit beta 5 [KO:K04539]
103004854  GNG2; G protein subunit gamma 2 [KO:K07826]
103019275  GNG4; G protein subunit gamma 4 [KO:K04541]
103017244  GNG7; G protein subunit gamma 7 [KO:K04543]
102997635  GNG8; G protein subunit gamma 8 [KO:K04544]
103007358  GNG11; G protein subunit gamma 11 [KO:K04546]
103016707  GNG13; G protein subunit gamma 13 [KO:K04547]
103007657  GNGT1; G protein subunit gamma transducin 1 [KO:K04548]
103004888  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
103014949  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
103015229  PIK3R6; phosphoinositide-3-kinase regulatory subunit 6 [KO:K21290]
103010966  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103015566  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
103018222  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
103019090  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
103009161  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
103010162  TSC1; tuberous sclerosis 1 [KO:K07206]
103008177  TSC2; tuberous sclerosis 2 [KO:K07207]
103000566  RHEB; Ras homolog enriched in brain [KO:K07208]
103018020  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
103004460  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103001225  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
103018352  EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
103000570  eukaryotic translation initiation factor 4E-like [KO:K03259]
103007721  EIF4E1B; eukaryotic translation initiation factor 4E family member 1B [KO:K03259]
103007187  EIF4E2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
103013738  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
103019799  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102998750  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103002380  EIF4B; eukaryotic translation initiation factor 4B [KO:K03258]
103010179  40S ribosomal protein S6-like [KO:K02991]
103003760  RPS6; ribosomal protein S6 [KO:K02991]
103004532  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102998078  PKN1; protein kinase N1 [KO:K06071] [EC:2.7.11.13]
103017096  PKN2; protein kinase N2 [KO:K23691] [EC:2.7.11.13]
103013243  PKN3; protein kinase N3 [KO:K23692] [EC:2.7.11.13]
103016100  SGK1; serum/glucocorticoid regulated kinase 1 [KO:K13302] [EC:2.7.11.1]
103013234  SGK2; SGK2, serine/threonine kinase 2 [KO:K13303] [EC:2.7.11.1]
103003704  SGK3; serum/glucocorticoid regulated kinase family member 3 [KO:K13304] [EC:2.7.11.1]
103002026  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103013147  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103004139  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103013603  MAGI1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
103015233  MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2 [KO:K05629]
102998704  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103002195  THEM4; thioesterase superfamily member 4 [KO:K16339] [EC:3.1.2.2]
103018989  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
103000342  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
103019215  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
103019457  PPP2R1B; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
103017366  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
103003377  PPP2R2B; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
103020854  PPP2R2A; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
103015446  PPP2R2D; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
103001451  PPP2R2C; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
103001016  PPP2R3C; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
102998572  PPP2R3A; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
103010358  uncharacterized LOC103010358 [KO:K11583]
103010924  PPP2R5E; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
103006105  PPP2R5C; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
102998528  PPP2R5D; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
103018733  PPP2R5B; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
103018422  PPP2R5A; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
103011214  HSP90AB1; heat shock protein 90 alpha family class B member 1 [KO:K04079]
103004882  HSP90AA1; heat shock protein 90 alpha family class A member 1 [KO:K04079]
103013472  HSP90B1; heat shock protein 90 beta family member 1 [KO:K09487]
103003990  CDC37; cell division cycle 37 [KO:K09554]
103004880  CRTC2; CREB regulated transcription coactivator 2 [KO:K16333]
103011132  PHLPP1; PH domain and leucine rich repeat protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
103011828  PHLPP2; PH domain and leucine rich repeat protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
103013157  TCL1A; T-cell leukemia/lymphoma 1A [KO:K10167]
103013446  TCL1B; T-cell leukemia/lymphoma 1B [KO:K16836]
103020527  MTCP1; mature T-cell proliferation 1 [KO:K16837]
103017861  NOS3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
103005164  breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
103008156  breast cancer type 1 susceptibility protein homolog [KO:K10605] [EC:2.3.2.27]
102998893  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103007749  GYS2; glycogen synthase 2 [KO:K00693] [EC:2.4.1.11]
103019791  GYS1; glycogen synthase 1 [KO:K00693] [EC:2.4.1.11]
103019398  PCK2; phosphoenolpyruvate carboxykinase 2, mitochondrial [KO:K01596] [EC:4.1.1.32]
103008859  PCK1; phosphoenolpyruvate carboxykinase 1 [KO:K01596] [EC:4.1.1.32]
103002194  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
103010774  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
103004981  G6PC3; glucose-6-phosphatase catalytic subunit 3 [KO:K01084] [EC:3.1.3.9]
103002931  G6PC2; glucose-6-phosphatase catalytic subunit 2 [KO:K01084] [EC:3.1.3.9]
103016933  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
103013404  CCND1; cyclin D1 [KO:K04503]
103005082  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
103001464  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
103012976  CDK2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103000540  CDK4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103010593  cyclin-dependent kinase 4-like [KO:K02089] [EC:2.7.11.22]
103011327  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103002964  CCND2; cyclin D2 [KO:K10151]
103007761  CCND3; cyclin D3 [KO:K10152]
103008660  CCNE1; cyclin E1 [KO:K06626]
102997538  CCNE2; cyclin E2 [KO:K06626]
102999779  FOXO3; forkhead box O3 [KO:K09408]
103018620  RBL2; RB transcriptional corepressor like 2 [KO:K16332]
102999836  FASLG; Fas ligand [KO:K04389]
103003003  BCL2L11; BCL2 like 11 [KO:K16341]
103010322  14-3-3 protein beta/alpha-like [KO:K16197]
103003945  YWHAQ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta [KO:K16197]
103007341  YWHAB; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [KO:K16197]
103004481  YWHAZ; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta [KO:K16197]
103002120  YWHAE; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon [KO:K06630]
103016364  YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [KO:K16198]
103007429  YWHAH; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta [KO:K16198]
103011078  14-3-3 protein gamma-A-like [KO:K16198]
103005702  BAD; BCL2 associated agonist of cell death [KO:K02158]
103017903  BCL2L1; BCL2 like 1 [KO:K04570]
103015542  BCL2; BCL2, apoptosis regulator [KO:K02161]
103010071  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
103017577  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
102999133  ATF2; activating transcription factor 2 [KO:K04450]
103017770  ATF4; activating transcription factor 4 [KO:K04374]
103007680  CREB3L1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103001736  CREB3; cAMP responsive element binding protein 3 [KO:K09048]
103003868  CREB3L4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
103018056  CREB3L3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
102999898  CREB3L2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
103009193  CREB5; cAMP responsive element binding protein 5 [KO:K09047]
103014625  ATF6B; activating transcription factor 6 beta [KO:K09049]
103006100  MCL1; BCL2 family apoptosis regulator [KO:K02539]
103005517  RXRA; retinoid X receptor alpha [KO:K08524]
103020888  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
103017855  NF-kappa-B essential modulator-like [KO:K07210]
103015414  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103015119  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103019614  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
102999230  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
103010838  MYB; MYB proto-oncogene, transcription factor [KO:K09420]
103017808  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
103003426  TP53; tumor protein p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
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Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
bacu00010  Glycolysis / Gluconeogenesis
bacu04010  MAPK signaling pathway
bacu04012  ErbB signaling pathway
bacu04062  Chemokine signaling pathway
bacu04064  NF-kappa B signaling pathway
bacu04068  FoxO signaling pathway
bacu04110  Cell cycle
bacu04115  p53 signaling pathway
bacu04150  mTOR signaling pathway
bacu04210  Apoptosis
bacu04370  VEGF signaling pathway
bacu04510  Focal adhesion
bacu04620  Toll-like receptor signaling pathway
bacu04630  JAK-STAT signaling pathway
bacu04662  B cell receptor signaling pathway
bacu04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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