KEGG   PATHWAY: cmo03040
Entry
cmo03040                    Pathway                                
Name
Spliceosome - Cucumis melo (muskmelon)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
cmo03040  Spliceosome
cmo03040

Other DBs
GO: 0005681
Organism
Cucumis melo (muskmelon) [GN:cmo]
Gene
127148332  U1 spliceosomal RNA [KO:K14276]
127151643  U1 spliceosomal RNA [KO:K14276]
127144093  U1 spliceosomal RNA [KO:K14276]
127150097  U1 spliceosomal RNA [KO:K14276]
103492239  U1 spliceosomal RNA [KO:K14276]
127144318  U2 spliceosomal RNA [KO:K14277]
127144326  U2 spliceosomal RNA [KO:K14277]
127144323  U2 spliceosomal RNA [KO:K14277]
127149271  U2 spliceosomal RNA [KO:K14277]
127145029  U2 spliceosomal RNA [KO:K14277]
127144327  U4 spliceosomal RNA [KO:K14278]
127148758  U4 spliceosomal RNA [KO:K14278]
127151503  U5 spliceosomal RNA [KO:K14279]
127149134  U6 spliceosomal RNA [KO:K14280]
127144331  U6 spliceosomal RNA [KO:K14280]
127150777  U6 spliceosomal RNA [KO:K14280]
103494190  DEAD-box ATP-dependent RNA helicase 42 [KO:K12811] [EC:5.6.2.7]
103488306  DEAD-box ATP-dependent RNA helicase 15 isoform X2 [KO:K12812] [EC:5.6.2.7]
103494032  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1 [KO:K12813] [EC:5.6.2.6]
103492599  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 isoform X1 [KO:K12815] [EC:5.6.2.6]
103489012  uncharacterized protein LOC103489012 isoform X1 [KO:K12816]
103492665  uncharacterized protein LOC103492665 [KO:K12817]
103501587  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 isoform X1 [KO:K12818] [EC:5.6.2.6]
103495726  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 isoform X1 [KO:K12818] [EC:5.6.2.6]
103487762  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 isoform X1 [KO:K12818] [EC:5.6.2.6]
103495752  ATP-dependent RNA helicase DEAH12, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
103495367  pre-mRNA-splicing factor SLU7 [KO:K12819]
103483592  pre-mRNA-splicing factor SLU7-like [KO:K12819]
103492738  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
103484284  uncharacterized protein LOC103484284 [KO:K11086]
103495011  small nuclear ribonucleoprotein SmD1b [KO:K11087]
103493191  uncharacterized protein LOC103493191 isoform X1 [KO:K11096]
103493808  small nuclear ribonucleoprotein SmD3a [KO:K11088]
103490154  uncharacterized protein LOC103490154 [KO:K11097]
103494302  uncharacterized protein LOC103494302 isoform X2 [KO:K11097]
103495148  small nuclear ribonucleoprotein E-like [KO:K11097]
103501840  probable small nuclear ribonucleoprotein F [KO:K11098]
103500906  probable small nuclear ribonucleoprotein G isoform X1 [KO:K11099]
103485041  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
103494765  U1 small nuclear ribonucleoprotein A [KO:K11091]
103492724  U1 small nuclear ribonucleoprotein C [KO:K11095]
103494828  pre-mRNA-processing protein 40A isoform X1 [KO:K12821]
103493623  pre-mRNA-processing protein 40A [KO:K12821]
103489014  RNA-binding motif protein 25 isoform X1 [KO:K12822]
103502377  DEAD-box ATP-dependent RNA helicase 20 isoform X1 [KO:K12823] [EC:5.6.2.7]
103484188  DEAD-box ATP-dependent RNA helicase 46-like isoform X1 [KO:K12823] [EC:5.6.2.7]
103487108  DEAD-box ATP-dependent RNA helicase 46 [KO:K12823] [EC:5.6.2.7]
103490017  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
103500614  pre-mRNA-processing protein 40C [KO:K12824]
103497038  transcription initiation factor TFIID subunit 15b [KO:K13098]
103498903  U2 small nuclear ribonucleoprotein A' [KO:K11092]
103497024  U2 small nuclear ribonucleoprotein B'' 2-like [KO:K11094]
103485445  probable splicing factor 3A subunit 1 isoform X1 [KO:K12825]
103486522  uncharacterized protein LOC103486522 [KO:K12826]
103504129  splicing factor SF3a60 homolog isoform X1 [KO:K12827]
103501154  LOW QUALITY PROTEIN: uncharacterized protein LOC103501154 [KO:K12828]
103485870  uncharacterized protein LOC103485870 [KO:K12829]
103500181  spliceosome-associated protein 130 A [KO:K12830]
103486735  pre-mRNA-splicing factor RSE1 isoform X1 [KO:K12830]
103483958  uncharacterized protein LOC103483958 [KO:K12831]
103498659  uncharacterized protein LOC103498659 isoform X1 [KO:K12831]
103498657  uncharacterized protein LOC103498657 isoform X1 [KO:K12831]
103483584  uncharacterized protein At4g14342-like isoform X1 [KO:K12832]
103484426  uncharacterized protein At4g14342 [KO:K12832]
103491466  splicing factor 3B subunit 6-like protein [KO:K12833]
103497068  PHD finger-like domain-containing protein 5A [KO:K12834]
103494724  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
103500870  splicing factor U2af small subunit B-like [KO:K12836]
103500459  splicing factor U2af small subunit B-like [KO:K12836]
103493856  splicing factor U2af small subunit B-like [KO:K12836]
103488581  splicing factor U2af large subunit A-like isoform X1 [KO:K12837]
103499435  uncharacterized protein LOC103499435 [KO:K12837]
103499374  uncharacterized protein LOC103499374 isoform X2 [KO:K12839]
103484318  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
103488567  protein RRC1 [KO:K12842]
103499918  sm-like protein LSM2 [KO:K12621]
103497556  sm-like protein LSM2 isoform X1 [KO:K12621]
103485621  sm-like protein LSM3B [KO:K12622]
103500419  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
103494929  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
103494906  sm-like protein LSM5 isoform X2 [KO:K12624]
103499106  sm-like protein LSM36B [KO:K12625]
103504523  sm-like protein LSM7 isoform X1 [KO:K12626]
103482675  sm-like protein LSM8 [KO:K12627]
103500170  protein RDM16 isoform X1 [KO:K12843]
103502534  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
103489527  peptidyl-prolyl cis-trans isomerase CYP22 isoform X2 [KO:K09567] [EC:5.2.1.8]
103489018  U4/U6 small nuclear ribonucleoprotein Prp31 homolog isoform X1 [KO:K12844]
103497328  uncharacterized protein LOC103497328 [KO:K12845]
103487460  uncharacterized protein LOC103487460 [KO:K12845]
103494258  uncharacterized protein LOC103494258 [KO:K12846]
103501728  uncharacterized protein LOC103501728 [KO:K12847]
103498705  SART-1 family protein DOT2 [KO:K11984]
103494358  uncharacterized protein LOC103494358 [KO:K12848]
103494470  pre-mRNA-splicing factor 38 [KO:K12849]
103501359  pre-mRNA splicing factor SR-like 1 isoform X1 [KO:K12850]
103496558  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
103484204  DExH-box ATP-dependent RNA helicase DExH12-like isoform X1 [KO:K12854] [EC:5.6.2.6]
103498810  protein STABILIZED1 [KO:K12855]
103499807  pre-mRNA-processing-splicing factor 8A [KO:K12856]
103488871  uncharacterized protein LOC103488871 [KO:K12857]
103500123  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
103497403  thioredoxin-like protein YLS8 [KO:K12859]
103488767  thioredoxin-like protein YLS8 [KO:K12859]
103483553  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
103499852  cell division cycle 5-like protein [KO:K12860]
103494318  cell division cycle 5-like protein isoform X1 [KO:K12860]
103500959  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
103497843  protein pleiotropic regulatory locus 1 [KO:K12862]
103491040  uncharacterized protein LOC103491040 [KO:K12863]
103501377  uncharacterized protein LOC103501377 [KO:K12864]
103496889  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
103490108  heat shock cognate 70 kDa protein 2 [KO:K03283]
103492106  heat shock 70 kDa protein [KO:K03283]
103498170  heat shock cognate 70 kDa protein 2-like [KO:K03283]
103498164  heat shock cognate 70 kDa protein [KO:K03283]
103500413  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
103486911  uncharacterized protein LOC103486911 isoform X1 [KO:K12865]
103492552  SNW/SKI-interacting protein-like [KO:K06063]
103498019  SNW/SKI-interacting protein-like [KO:K06063]
103484548  uncharacterized protein LOC103484548 [KO:K12867]
103497339  uncharacterized protein LOC103497339 [KO:K12868]
103500640  uncharacterized protein LOC103500640 [KO:K12869]
103499848  uncharacterized protein LOC103499848 [KO:K12870]
103486634  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
103482658  uncharacterized protein LOC103482658 [KO:K12871]
103493581  zinc finger CCCH domain-containing protein 40-like [KO:K12872]
103500879  protein BUD31 homolog 2 [KO:K12873]
103500278  protein BUD31 homolog 1-like [KO:K12873]
103489488  uncharacterized protein LOC103489488 [KO:K12874]
103494402  uncharacterized protein LOC103494402 [KO:K12875]
103500360  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
103492008  RNA-binding protein Y14 [KO:K12876]
103483105  protein mago nashi homolog [KO:K12877]
103499294  THO complex subunit 1 [KO:K12878]
103504529  THO complex subunit 2 [KO:K12879]
103491048  THO complex subunit 3 [KO:K12880]
103490589  THO complex subunit 4A-like isoform X2 [KO:K12881]
103496802  THO complex subunit 4D [KO:K12881]
103497214  THO complex subunit 4A [KO:K12881]
103492007  nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
103502423  nuclear cap-binding protein subunit 2 [KO:K12883]
103501266  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
103491813  glycine-rich RNA-binding protein 3, mitochondrial-like [KO:K12741]
103494399  RNA-binding protein P-like isoform X2 [KO:K12741]
103497476  UBP1-associated protein 2A-like [KO:K12741]
103486777  UBP1-associated protein 2C-like isoform X1 [KO:K12741]
103494047  glycine-rich RNA-binding protein 2, mitochondrial [KO:K12741]
103492928  UBP1-associated protein 2C [KO:K12741]
107992116  heterogeneous nuclear ribonucleoprotein 1 [KO:K12741]
103500720  heterogeneous nuclear ribonucleoprotein 1 isoform X1 [KO:K12741]
103483084  serine/arginine-rich splicing factor SR34A [KO:K12890]
103492811  serine/arginine-rich-splicing factor SR34-like isoform X1 [KO:K12890]
103492152  serine/arginine-rich splicing factor SR30 isoform X1 [KO:K12890]
103495427  serine/arginine-rich splicing factor SC35 isoform X1 [KO:K12891]
103488401  serine/arginine-rich splicing factor SC35-like [KO:K12891]
103483164  serine/arginine-rich splicing factor RS31 isoform X1 [KO:K12893]
103491067  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
103491066  serine/arginine-rich splicing factor RS40-like isoform X1 [KO:K12893]
103503748  serine/arginine-rich splicing factor RSZ22A [KO:K12896]
103489020  serine/arginine-rich splicing factor RSZ21 [KO:K12896]
103488725  serine/arginine-rich splicing factor RS2Z32-like isoform X1 [KO:K12896]
103485170  serine/arginine-rich splicing factor SR45a [KO:K12897]
103500205  serine/arginine-rich SC35-like splicing factor SCL30 [KO:K12900]
103483786  serine/arginine-rich SC35-like splicing factor SCL28 [KO:K12900]
103491955  serine/arginine-rich SC35-like splicing factor SCL30A isoform X1 [KO:K12900]
103486733  serine/arginine-rich SC35-like splicing factor SCL33 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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