KEGG   PATHWAY: csem04210
Entry
csem04210                   Pathway                                
Name
Apoptosis - Cynoglossus semilaevis (tongue sole)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
csem04210  Apoptosis
csem04210

Other DBs
GO: 0006915
Organism
Cynoglossus semilaevis (tongue sole) [GN:csem]
Gene
103377512  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
103378994  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
103390031  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
103398930  tumor necrosis factor receptor superfamily member 26-like [KO:K04722]
103376745  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
103390777  uncharacterized protein LOC103390777 [KO:K04389]
103387676  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
103378588  fadd; FAS-associated death domain protein [KO:K02373]
103394480  tumor necrosis factor-like [KO:K03156]
103387943  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
103378721  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103392053  cflar; CASP8 and FADD-like apoptosis regulator [KO:K04724]
103396237  caspase-8-like [KO:K04398] [EC:3.4.22.61]
103396239  caspase-8-like [KO:K04398] [EC:3.4.22.61]
103383854  casp6; caspase-6 [KO:K04396] [EC:3.4.22.59]
103383467  caspase-3-like [KO:K02187] [EC:3.4.22.56]
103391460  casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
103381449  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
103389354  caspase-7-like [KO:K04397] [EC:3.4.22.60]
103393523  apoptosis regulator BAX-like [KO:K02159]
103392613  apoptosis regulator BAX [KO:K02159]
103378040  diablo homolog, mitochondrial-like [KO:K10522]
103378169  diablo homolog, mitochondrial-like isoform X1 [KO:K10522]
103378127  septin-4-like isoform X2 [KO:K16943]
103395062  septin-5-like isoform X1 [KO:K16943]
103376892  serine protease HTRA2, mitochondrial-like [KO:K08669] [EC:3.4.21.108]
103394258  cytochrome c-like [KO:K08738]
103387743  cytochrome c isoform X2 [KO:K08738]
103391581  cytochrome c [KO:K08738]
103382677  apaf1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
103385017  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
103383316  perforin-1-like [KO:K07818]
103383318  perforin-1-like [KO:K07818]
103392686  perforin-1-like [KO:K07818]
103398304  perforin-1-like [KO:K07818]
103392320  granzyme B-like [KO:K01353] [EC:3.4.21.79]
103399906  granzyme G-like [KO:K01353] [EC:3.4.21.79]
103376847  tubulin alpha-1B chain-like [KO:K07374]
103376849  tubulin alpha-1B chain-like [KO:K07374]
103385187  tubulin alpha-1A chain [KO:K07374]
103385219  tubulin alpha-1C chain-like [KO:K07374]
103385300  tubulin alpha chain-like [KO:K07374]
103384708  tubulin alpha-1C chain-like isoform X1 [KO:K07374]
103384726  tubulin alpha-1C chain-like [KO:K07374]
103389754  tubulin alpha-1A chain-like [KO:K07374]
103392215  tubulin alpha chain-like [KO:K07374]
103392216  tubulin alpha chain [KO:K07374]
103391677  tubulin alpha chain-like [KO:K07374]
103389240  tuba4a; tubulin alpha-4A chain [KO:K07374]
103391404  tubulin alpha-1C chain-like [KO:K07374]
103376855  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
103388701  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
103383494  actin, cytoplasmic 2 [KO:K05692]
103393304  actb; actin, beta [KO:K05692]
103389345  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
103388831  lmna; lamin isoform X1 [KO:K12641]
103393959  lamin-A-like isoform X1 [KO:K12641]
103379225  lamin-L(III)-like [KO:K12641]
103396903  lmnb2; lamin-B2 [KO:K07611]
103380840  parp1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070] [EC:2.4.2.30]
103396723  parp2; poly [ADP-ribose] polymerase 2 [KO:K10798] [EC:2.4.2.30]
103391743  parp4; poly [ADP-ribose] polymerase 4 isoform X5 [KO:K10798] [EC:2.4.2.30]
103385907  parp3; poly [ADP-ribose] polymerase 3 [KO:K10798] [EC:2.4.2.30]
103384954  dffa; DNA fragmentation factor subunit alpha isoform X1 [KO:K02310]
103385022  dffb; DNA fragmentation factor subunit beta [KO:K02311] [EC:3.-.-.-]
103397935  endog; endonuclease G, mitochondrial [KO:K01173]
103395291  aifm1; apoptosis-inducing factor 1, mitochondrial [KO:K04727] [EC:1.-.-.-]
103393011  LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103383241  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
103390066  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
103397592  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
103390226  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
103385989  itpr1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
103386616  LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1-like [KO:K04958]
103380150  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
103384462  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
103394997  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103386024  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103387546  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103383277  LOW QUALITY PROTEIN: calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
103383278  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
103383281  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
103387544  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
103387545  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
103383108  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
103381195  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103383414  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
103393286  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
103386391  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
103379409  cathepsin B-like precursor [KO:K01363] [EC:3.4.22.1]
103380823  ctsb; cathepsin B [KO:K01363] [EC:3.4.22.1]
103378542  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
103393287  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
103378862  ctsd; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
103391298  cathepsin L [KO:K01373] [EC:3.4.22.41]
103379443  ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
103388696  cathepsin K [KO:K01371] [EC:3.4.22.38]
103397801  catl; cathepsin L precursor [KO:K01365] [EC:3.4.22.15]
103376680  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
103378601  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
103397133  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
103390648  ctso; cathepsin O [KO:K01374] [EC:3.4.22.42]
103394262  cathepsin L1-like [KO:K01368] [EC:3.4.22.27]
103394264  cathepsin S-like [KO:K01368] [EC:3.4.22.27]
103388697  cathepsin S-like isoform X1 [KO:K01368] [EC:3.4.22.27]
103386030  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
103390711  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
103396679  cathepsin Z-like [KO:K08568] [EC:3.4.18.1]
103395117  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103391373  E3 ubiquitin-protein ligase XIAP-like isoform X1 [KO:K04725] [EC:2.3.2.27]
103385084  survivin; uncharacterized protein LOC103385084 [KO:K08731]
103382361  baculoviral IAP repeat-containing protein 5-like [KO:K08731]
103386857  bcl2l11; bcl-2-like protein 11 [KO:K16341]
103384686  bcl2l1; bcl-2-like protein 1 [KO:K04570]
103386312  bcl-2-like protein 1 [KO:K04570]
103396176  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
103393842  death domain-associated protein 6 [KO:K02308]
103396277  ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
103390067  disabled homolog 2-interacting protein [KO:K19901]
103398046  disabled homolog 2-interacting protein-like [KO:K19901]
103388011  mitogen-activated protein kinase kinase kinase 6-like [KO:K04426] [EC:2.7.11.25]
103381109  map3k5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
103382123  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
103391026  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
103390257  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103387363  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
103384187  bad; bcl2-associated agonist of cell death [KO:K02158]
103398819  transcription factor AP-1-like isoform X2 [KO:K04448]
103376719  jun; transcription factor AP-1 [KO:K04448]
103380804  proto-oncogene c-Fos-like [KO:K04379]
103380805  proto-oncogene c-Fos-like [KO:K04379]
103399847  proto-oncogene c-Fos-like [KO:K04379]
103387239  tp53; cellular tumor antigen p53 [KO:K04451]
103381634  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103392614  mitogen-activated protein kinase kinase kinase 14-like isoform X2 [KO:K04466] [EC:2.7.11.25]
103398848  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
103387400  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
103397763  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103384713  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103380734  NF-kappa-B inhibitor alpha-like [KO:K04734]
103377625  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
103391096  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103385629  putative transcription factor p65 homolog [KO:K04735]
103390256  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
103397674  uncharacterized protein LOC103397674 [KO:K04402]
103396969  uncharacterized protein LOC103396969 [KO:K04402]
103379187  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
103398452  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103396087  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
103389087  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
103389088  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
103377587  atm; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103380278  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
103387931  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
103384424  nerve growth factor-like [KO:K02582]
103386552  nerve growth factor-like [KO:K02582]
103388944  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
103393261  cytokine receptor common subunit beta-like [KO:K04738]
103378227  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103385041  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103396566  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103396148  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
103390039  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103395817  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
103398008  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
103395882  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
103394768  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
103399010  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
103381714  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X2 [KO:K06276] [EC:2.7.11.1]
103377652  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103383890  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103388143  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103387066  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
103395035  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
103380387  hras; GTPase HRas [KO:K02833]
103380146  kras; GTPase KRas isoform X1 [KO:K07827]
103392975  GTPase HRas-like [KO:K07827]
103385533  raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
103380238  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103376625  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103393219  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
103397828  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
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pathway
csem04010  MAPK signaling pathway
csem04020  Calcium signaling pathway
csem04115  p53 signaling pathway
csem04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   
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