KEGG   PATHWAY: esp04148
Entry
esp04148                    Pathway                                
Name
Efferocytosis - Etheostoma spectabile (orangethroat darter)
Class
Cellular Processes; Transport and catabolism
Pathway map
esp04148  Efferocytosis
esp04148

Organism
Etheostoma spectabile (orangethroat darter) [GN:esp]
Gene
116669567  caspase-3-like [KO:K02187] [EC:3.4.22.56]
116697073  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
116670737  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
116672700  caspase-1-like [KO:K01370] [EC:3.4.22.36]
116682072  panx1; pannexin-1 [KO:K03443]
116695405  pannexin-1-like [KO:K03443]
116686744  p2ry2; P2Y purinoceptor 2 [KO:K04269]
116672601  p2ry6; P2Y purinoceptor 6 isoform X1 [KO:K04272]
116685489  P2Y purinoceptor 12-like isoform X1 [KO:K04298]
116691510  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
116705625  sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
116702787  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
116700357  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
116698112  abca1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
116707246  phospholipid-transporting ATPase ABCA1-like isoform X1 [KO:K05641]
116694873  phospholipid-transporting ATPase ABCA1-like isoform X1 [KO:K05641]
116707409  probable G-protein coupled receptor 132 [KO:K08426]
116670032  adam17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
116691941  adam10; LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
116693868  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
116695127  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
116692513  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116687593  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
116691523  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
116701783  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
116692552  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116686525  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
116702364  nuclear factor of activated T-cells, cytoplasmic 3-like isoform X1 [KO:K17333]
116699486  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
116674085  hypoxia-inducible factor 3-alpha-like [KO:K08268]
116669610  hif1a; hypoxia-inducible factor 1-alpha [KO:K08268]
116671748  epas1; endothelial PAS domain-containing protein 1 [KO:K08268]
116691349  aryl hydrocarbon receptor nuclear translocator-like isoform X1 [KO:K09097]
116669392  epo; erythropoietin isoform X1 [KO:K05437]
116686822  erythropoietin receptor-like [KO:K05079]
116689510  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
116703926  tyrosine-protein kinase JAK2-like isoform X1 [KO:K04447] [EC:2.7.10.2]
116690322  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116703753  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
116692082  CCAAT/enhancer-binding protein beta-like [KO:K10048]
116687875  pparg; peroxisome proliferator-activated receptor gamma [KO:K08530]
116691040  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08524]
116704096  rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116693977  lactadherin-like isoform X1 [KO:K17253]
116703948  EGF-like repeat and discoidin I-like domain-containing protein 3 isoform X1 [KO:K17253]
116704914  tyrosine-protein kinase Mer-like [KO:K05117] [EC:2.7.10.1]
116673290  cd36; platelet glycoprotein 4 isoform X1 [KO:K06259]
116706057  thrombospondin-1-like [KO:K16857]
116670144  thbs1; thrombospondin-1 [KO:K16857]
116694773  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116699426  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116699428  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
116695172  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116694962  ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116673836  ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
116704513  ptger4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
116698975  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
116695017  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
116689791  prostaglandin E2 receptor EP4 subtype-like [KO:K04261]
116670342  dnmt3a; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
116697597  cyclic AMP-responsive element-binding protein 1-like isoform X1 [KO:K05870]
116674223  cyclic AMP-responsive element-binding protein 1-like isoform X1 [KO:K05870]
116678953  cyclic AMP-responsive element-binding protein 1-like [KO:K05870]
116682862  transforming growth factor beta-1 proprotein-like [KO:K13375]
116704710  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
116700090  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116686654  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
116694637  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
116671274  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
116689300  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
116703734  sarcoplasmic/endoplasmic reticulum calcium ATPase 1-like [KO:K05853] [EC:7.2.2.10]
116705273  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116686178  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116669783  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
116686615  calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
116671728  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116688857  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
116691890  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
116692206  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
116693198  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
116693572  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
116687835  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
116673128  mitogen-activated protein kinase 11-like isoform X1 [KO:K04441] [EC:2.7.11.24]
116673224  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
116693173  MAP kinase-activated protein kinase 2-like isoform X1 [KO:K04443] [EC:2.7.11.1]
116687726  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
116704939  alox5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
116690100  dual specificity protein phosphatase 2-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116704672  dual specificity protein phosphatase 4-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116676102  dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116698104  dual specificity protein phosphatase 5-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116692201  dual specificity protein phosphatase 7-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116693976  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116687431  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116703532  dual specificity protein phosphatase 8-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116672975  ano6; anoctamin-6 isoform X1 [KO:K19500]
116693861  ano3; anoctamin-3 isoform X1 [KO:K19498]
116673407  ano4; anoctamin-4 isoform X1 [KO:K19499]
116678453  anoctamin-5-like isoform X1 [KO:K19480]
116693863  ano5; anoctamin-5 isoform X1 [KO:K19480]
116692262  ano7; LOW QUALITY PROTEIN: anoctamin-7 [KO:K19501]
116686789  anoctamin-9-like isoform X1 [KO:K19503]
116693869  anoctamin-9-like isoform X1 [KO:K19503]
116695314  bsg; basigin isoform X1 [KO:K06535]
116702175  XK-related protein 8-like [KO:K26813]
116702177  XK-related protein 8-like [KO:K26813]
116672287  xkr9; XK-related protein 9 isoform X1 [KO:K26814]
116692063  XK-related protein 7-like [KO:K26811]
116692706  XK-related protein 7-like [KO:K26811]
116699640  xkr4; XK-related protein 4 [KO:K26811]
116673958  XK-related protein 6-like [KO:K26811]
116706369  xkr6; XK-related protein 6 [KO:K26811]
116697374  atp8a1; LOW QUALITY PROTEIN: phospholipid-transporting ATPase IA [KO:K14802] [EC:7.6.2.1]
116672534  atp8a2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
116696312  atp11c; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
116697726  probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
116673738  probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
116695170  atp11b; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
116706804  cell cycle control protein 50A-like [KO:K26935]
116670172  cell cycle control protein 50A-like [KO:K26935]
116670728  integrin beta-3-like [KO:K06493]
116702297  integrin beta-3-like [KO:K06493]
116689863  itgb5; integrin beta-5 [KO:K06588]
116680519  axl; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
116669766  LOW QUALITY PROTEIN: tyrosine-protein kinase receptor TYRO3-like [KO:K05116] [EC:2.7.10.1]
116690592  adhesion G protein-coupled receptor B1-like isoform X1 [KO:K04596]
116688700  stab1; stabilin-1 [KO:K19020]
116691433  LOW QUALITY PROTEIN: focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
116701641  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
116694598  bcar1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
116674771  crk; adapter molecule crk [KO:K04438]
116700737  adapter molecule crk-like [KO:K04438]
116703898  crkl; crk-like protein [KO:K04438]
116701312  engulfment and cell motility protein 1 isoform X1 [KO:K12366]
116670996  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116670942  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116702491  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116670753  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
116689401  LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
116698613  calreticulin-like [KO:K08057]
116695809  calreticulin-like [KO:K08057]
116695827  calreticulin-like [KO:K08057]
116692989  low-density lipoprotein receptor-related protein 1-like isoform X1 [KO:K04550]
116688457  low-density lipoprotein receptor-related protein 1-like isoform X1 [KO:K04550]
116704746  multiple epidermal growth factor-like domains protein 10 [KO:K24068]
116677326  LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 10 [KO:K24068]
116685771  LOW QUALITY PROTEIN: multiple epidermal growth factor-like domains protein 11 [KO:K24068]
116694306  megf11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
116687133  scarf1; scavenger receptor class F member 1 [KO:K24318]
116698111  gulp1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
116691900  PTB domain-containing engulfment adapter protein 1-like [KO:K23285]
116698348  rab17; ras-related protein Rab-17 [KO:K07909]
116691143  ras-related protein Rab-5A [KO:K07887]
116702199  ras-related protein Rab-5A [KO:K07887]
116688990  ras-related protein Rab-5B-like [KO:K07888]
116671114  ras-related protein Rab-5C-like [KO:K07889]
116703299  rab5c; ras-related protein Rab-5C [KO:K07889]
116679801  transforming growth factor-beta receptor-associated protein 1-like isoform X1 [KO:K20177]
116669650  transforming growth factor-beta receptor-associated protein 1-like [KO:K20177]
116695424  tgfbrap1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
116696471  vps8; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 8 homolog [KO:K20178]
116700126  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
116706442  vps18; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
116686808  vps33a; LOW QUALITY PROTEIN: vacuolar protein sorting-associated protein 33A [KO:K20182]
116704536  ras-related protein Rab-14 [KO:K07881]
116689983  ras-related protein Rab-14-like [KO:K07881]
116686120  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
116672199  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
116688413  ras-related protein rab7-like [KO:K07897]
116688563  ras-related protein rab7-like [KO:K07897]
116688634  ras-related protein rab7 [KO:K07897]
116693197  slc66a1; lysosomal amino acid transporter 1 homolog [KO:K23678]
116686595  slc66a1l; putative uncharacterized protein SLC66A1L [KO:K23678]
116669597  arg2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
116674236  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
116669919  odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
116704540  ch25h; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
116690062  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
116691766  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
116694557  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
116694687  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
116671246  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
116702582  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
116694821  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
116702647  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
116676151  sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
116699155  pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
116695584  pre-B-cell leukemia transcription factor 1-like isoform X1 [KO:K09355]
116685303  interleukin-10-like [KO:K05443]
116691155  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
116694195  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
116674779  peroxisome proliferator-activated receptor delta-like [KO:K04504]
116692336  peroxisome proliferator-activated receptor delta-like [KO:K04504]
116693030  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
116670313  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
116687907  solute carrier family 2, facilitated glucose transporter member 1-like [KO:K07299]
116692995  monocarboxylate transporter 1-like [KO:K08179]
116688338  monocarboxylate transporter 1-like [KO:K08179]
116674520  LOW QUALITY PROTEIN: serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
116706054  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
116702173  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
116702549  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
116703267  platelet endothelial cell adhesion molecule-like isoform X1 [KO:K06471]
116690432  sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
116690471  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
116691237  ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
116692598  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
116703998  ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
esp00010  Glycolysis / Gluconeogenesis
esp04140  Autophagy - animal
esp04145  Phagosome
KO pathway
ko04148   
LinkDB

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