KEGG   PATHWAY: gacu05168
Entry
gacu05168                   Pathway                                
Name
Herpes simplex virus 1 infection - Gymnodraco acuticeps
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
gacu05168  Herpes simplex virus 1 infection
gacu05168

Organism
Gymnodraco acuticeps [GN:gacu]
Gene
117543265  tnfb; tumor necrosis factor b (TNF superfamily, member 2) [KO:K05468]
117548661  tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
117561573  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
117541504  tumor necrosis factor receptor superfamily member 14-like isoform X1 [KO:K05152]
117559950  tumor necrosis factor receptor superfamily member 14-like [KO:K05152]
117538173  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
117534956  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
117561444  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
117553440  traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
117560475  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
117536794  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
117547053  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
117541485  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
117539703  nfkbiab; LOW QUALITY PROTEIN: nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
117554163  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
117542722  rela; transcription factor p65 isoform X1 [KO:K04735]
117536004  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117535797  si:ch211-214p13.3; poliovirus receptor homolog [KO:K06081]
117536517  nectin1a; nectin cell adhesion molecule 1a isoform X1 [KO:K06081]
117562013  nectin1b; nectin cell adhesion molecule 1b [KO:K06081]
117549611  nectin-2-like isoform X1 [KO:K06531]
117532831  ptpn11b; tyrosine-protein phosphatase non-receptor type 11b isoform X1 [KO:K07293] [EC:3.1.3.48]
117561487  ptpn11a; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
117557422  integrin alpha-5-like [KO:K06484]
117542227  itga5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
117544911  itgb3b; integrin beta-3b isoform X1 [KO:K06493]
117548627  itgb3a; integrin beta-3a [KO:K06493]
117537386  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117539537  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
117562106  syk; LOW QUALITY PROTEIN: tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
117545135  irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
117552767  tp53; cellular tumor antigen p53 [KO:K04451]
117536248  complement C3-like [KO:K03990]
117561640  complement C3-like [KO:K03990]
117553624  LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
117556193  toll-like receptor 2 [KO:K10159]
117563201  tlr18; toll-like receptor 18 [KO:K10159]
117549862  myeloid differentiation primary response protein MyD88-like [KO:K04729]
117545909  irf7; interferon regulatory factor 7 [KO:K09447]
117556186  tlr3; LOW QUALITY PROTEIN: toll-like receptor 3 [KO:K05401]
117532668  ticam1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
117547837  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
117549320  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
117538648  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
117536277  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
117555242  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
117538684  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
117546446  interleukin-1 beta-like [KO:K04519]
117562823  interleukin-6-like [KO:K05405]
117535957  tumor necrosis factor-like [KO:K03156]
117538330  interleukin-12 subunit alpha-like [KO:K05406]
117554846  il12a; interleukin-12 subunit alpha [KO:K05406]
117545217  il12ba; interleukin 12Ba [KO:K05425]
117540244  il12bb; interleukin-12 subunit beta [KO:K05425]
117560348  si:dkey-88e18.2; interleukin-12 subunit beta [KO:K05425]
117556833  ifih1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
117558876  cell surface glycoprotein 1-like [KO:K12648]
117558877  cell surface glycoprotein 1-like [KO:K12648]
117541281  traf3; TNF receptor-associated factor 3 [KO:K03174]
117547525  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
117556731  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
117547421  interferon a3-like [KO:K05414]
117547422  interferon a3-like [KO:K05414]
117547424  interferon a3-like [KO:K05414]
117536638  LOW QUALITY PROTEIN: cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
117542351  cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
117534702  sting1; stimulator of interferon genes protein isoform X1 [KO:K12654]
117545022  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
117539053  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A isoform X1 [KO:K06269] [EC:3.1.3.16]
117553916  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117548669  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
117548936  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
117542741  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117545130  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
117552924  LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
117553320  LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
117553328  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
117553339  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
117553348  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
117553426  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K16195] [EC:2.7.11.1]
117535939  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
117558864  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
117550003  eif2ak4; LOW QUALITY PROTEIN: eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
117562330  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
117561475  eif2b1; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit alpha [KO:K03239]
117533800  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
117558468  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
117533752  eif2b4; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit delta [KO:K03680]
117556594  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
117543725  hcfc1a; host cell factor 1a [KO:K14966]
117560152  hcfc2; LOW QUALITY PROTEIN: host cell factor 2 [KO:K27390]
117536678  POU domain, class 2, transcription factor 1-like isoform X1 [KO:K09364]
117544534  pou2f1b; POU domain, class 2, transcription factor 1b isoform X1 [KO:K09364]
117548937  pou2f3; LOW QUALITY PROTEIN: POU domain, class 2, transcription factor 3 [KO:K09364]
117549613  pou2f2a; POU domain, class 2, transcription factor 2 [KO:K09364]
117549470  interferon alpha/beta receptor 2-like [KO:K05131]
117544360  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
117548316  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
117542661  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
117548849  tyk2; LOW QUALITY PROTEIN: non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
117549497  signal transducer and activator of transcription 1-alpha/beta-like isoform X1 [KO:K11220]
117549793  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
117551086  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
117537659  irf9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
117536899  zinc finger protein 835-like [KO:K09228]
117536900  zinc finger protein 239-like [KO:K09228]
117550346  zinc finger protein 665-like [KO:K09228]
117550347  zinc finger protein 664-like isoform X1 [KO:K09228]
117557231  zinc finger protein 79-like isoform X1 [KO:K09228]
117557234  zinc finger protein 260-like [KO:K09228]
117557236  zinc finger protein 260-like [KO:K09228]
117537735  oocyte zinc finger protein XlCOF8.4-like [KO:K09228]
117551404  zinc finger and SCAN domain-containing protein 12-like [KO:K09228]
117533155  zinc finger protein GLI4-like [KO:K09228]
117533158  zinc finger protein 771-like isoform X1 [KO:K09228]
117533164  zinc finger protein 543-like [KO:K09228]
117551460  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
117545171  zinc finger protein OZF-like [KO:K09228]
117545315  zinc finger protein 391-like [KO:K09228]
117545317  zinc finger protein 771-like [KO:K09228]
117545318  zinc finger protein 454-like [KO:K09228]
117545319  zinc finger protein 771-like [KO:K09228]
117545320  zinc finger protein 771-like [KO:K09228]
117545321  oocyte zinc finger protein XlCOF22-like [KO:K09228]
117545322  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
117545326  zinc finger protein 32-like [KO:K09228]
117545336  oocyte zinc finger protein XlCOF20-like [KO:K09228]
117545687  zinc finger protein OZF-like isoform X1 [KO:K09228]
117545786  zinc finger protein OZF-like isoform X1 [KO:K09228]
117546232  zinc finger protein 79-like [KO:K09228]
117552420  zinc finger protein 14-like [KO:K09228]
117552477  zinc finger protein 585A-like isoform X1 [KO:K09228]
117546302  zinc finger protein 32-like [KO:K09228]
117546304  zinc finger protein 771-like [KO:K09228]
117552646  zinc finger and SCAN domain-containing protein 31-like [KO:K09228]
117553118  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
117553119  zinc finger protein 79-like isoform X1 [KO:K09228]
117553120  zinc finger protein OZF-like [KO:K09228]
117553310  zinc finger protein 883-like isoform X1 [KO:K09228]
117553311  zinc finger protein 583-like [KO:K09228]
117553313  zinc finger and SCAN domain-containing protein 5B-like [KO:K09228]
117553415  zinc finger protein 583-like [KO:K09228]
117553417  zinc finger protein 501-like [KO:K09228]
117553617  zinc finger protein 85-like [KO:K09228]
117534054  zinc finger protein 454-like [KO:K09228]
117534123  zinc finger protein 420-like isoform X1 [KO:K09228]
117540959  zinc finger protein 37-like [KO:K09228]
117540969  zinc finger protein 135-like [KO:K09228]
117554042  im:7147486; zinc finger protein 91 [KO:K09228]
117554067  si:dkeyp-84f3.5; zinc finger protein 91 [KO:K09228]
117534284  zinc finger protein 583-like [KO:K09228]
117534289  zinc finger protein 235-like [KO:K09228]
117534291  zinc finger protein 397-like isoform X1 [KO:K09228]
117534293  zinc finger and SCAN domain-containing protein 22-like isoform X1 [KO:K09228]
117534295  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
117534298  zinc finger and SCAN domain-containing protein 5B-like [KO:K09228]
117534591  zinc finger protein 583-like isoform X1 [KO:K09228]
117534792  zinc finger protein 677-like isoform X1 [KO:K09228]
117534793  zinc finger protein 2 homolog [KO:K09228]
117548583  zinc finger protein 135-like isoform X1 [KO:K09228]
117555250  zinc finger protein 429-like isoform X1 [KO:K09228]
117535270  gastrula zinc finger protein xLCGF3.1-like [KO:K09228]
117542281  zinc finger and SCAN domain-containing protein 12-like isoform X1 [KO:K09228]
117542284  zinc finger protein 189-like [KO:K09228]
117542285  zinc finger and SCAN domain-containing protein 12-like [KO:K09228]
117542287  zinc finger and SCAN domain-containing protein 12-like [KO:K09228]
117555627  si:dkey-182i3.10; gastrula zinc finger protein XlCGF26.1 isoform X1 [KO:K09228]
117555628  zinc finger protein 431-like [KO:K09228]
117536112  gastrula zinc finger protein XlCGF58.1-like [KO:K09228]
117549581  zinc finger protein 2 homolog [KO:K09228]
117536516  zinc finger protein 239-like isoform X1 [KO:K09228]
117549784  zinc finger protein 708-like [KO:K09228]
117556244  zinc finger protein 271-like [KO:K09228]
117556660  zinc finger protein 11-like [KO:K09228]
117558202  zinc finger protein 235-like [KO:K09228]
117558710  zinc finger and SCAN domain-containing protein 22-like isoform X1 [KO:K09228]
117558711  zinc finger protein 583-like [KO:K09228]
117558712  zinc finger protein 583-like [KO:K09228]
117559514  zinc finger protein 79-like [KO:K09228]
117559515  zinc finger protein 583-like [KO:K09228]
117560039  zinc finger protein 708-like [KO:K09228]
117560037  zinc finger protein 227-like [KO:K09228]
117560045  zinc finger protein 529-like isoform X1 [KO:K09228]
117560068  zinc finger protein 568-like [KO:K09228]
117560089  zinc finger protein 25-like [KO:K09228]
117560266  zinc finger protein 251-like isoform X1 [KO:K09228]
117560267  zinc finger protein 501-like [KO:K09228]
117560268  GDNF-inducible zinc finger protein 1-like [KO:K09228]
117560269  zinc finger protein 70-like [KO:K09228]
117560270  zinc finger protein 184-like [KO:K09228]
117560794  zinc finger protein 33B-like [KO:K09228]
117561007  zinc finger protein 2-like [KO:K09228]
117561006  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
117555255  ifngr1; interferon gamma receptor 1 isoform X1 [KO:K05132]
117560846  ifngr1l; interferon gamma receptor 1-like [KO:K05132]
117552077  jak2b; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
117535901  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
117534667  daxx; death domain-associated protein 6 [KO:K02308]
117543224  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
117547061  tap2t; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
117559109  tap2a; antigen peptide transporter 2a [KO:K05654] [EC:7.4.2.14]
117534665  tapasin-like [KO:K08058]
117557464  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
117550958  LOW QUALITY PROTEIN: calreticulin-like [KO:K08057]
117541486  calreticulin-like [KO:K08057]
117560534  calreticulin-like [KO:K08057]
117552316  major histocompatibility complex class I-related gene protein-like [KO:K06751]
117534791  major histocompatibility complex class I-related gene protein-like [KO:K06751]
117534799  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
117536478  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
117547140  beta-2-microglobulin-like [KO:K08055]
117547148  beta-2-microglobulin-like [KO:K08055]
117553962  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
117553963  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
117556039  cd74a; CD74 molecule, major histocompatibility complex, class II invariant chain a [KO:K06505]
117545508  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117534275  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117541887  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
117542378  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
117532612  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117545568  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
117535004  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
117542274  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
117560597  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
117561441  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117544558  LOW QUALITY PROTEIN: RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117551707  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117550034  akt1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117560397  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
117560747  akt3a; LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117539972  tsc1b; TSC complex subunit 1b [KO:K07206]
117561619  tsc2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
117551161  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
117541129  rheb; GTP-binding protein Rheb [KO:K07208]
117532816  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
117560996  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
117547507  srpk1b; LOW QUALITY PROTEIN: SRSF protein kinase 1b [KO:K15409] [EC:2.7.11.1]
117541965  srpk1a; SRSF protein kinase 1a isoform X1 [KO:K15409] [EC:2.7.11.1]
117540404  srsf1a; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1A [KO:K12890]
117536564  serine/arginine-rich splicing factor 1 [KO:K12890]
117544470  srsf2a; serine and arginine rich splicing factor 2a [KO:K12891]
117539811  srsf2b; serine/arginine-rich splicing factor 2b [KO:K12891]
117551186  srsf3b; serine/arginine-rich splicing factor 3b [KO:K12892]
117548127  srsf3a; serine/arginine-rich splicing factor 3a [KO:K12892]
117533818  srsf5a; serine and arginine rich splicing factor 5a [KO:K12893]
117542010  serine/arginine-rich splicing factor 6-like isoform X1 [KO:K12893]
117549241  srsf5b; LOW QUALITY PROTEIN: serine and arginine rich splicing factor 5b [KO:K12893]
117559310  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 4-like [KO:K12893]
117540948  serine/arginine-rich splicing factor 7-like [KO:K12896]
117561936  srsf7a; serine and arginine rich splicing factor 7a isoform X1 [KO:K12896]
117541402  srsf9; serine/arginine-rich splicing factor 9 [KO:K21123]
117543534  zgc:153681; LOW QUALITY PROTEIN: nuclear RNA export factor 1 [KO:K14284]
117535391  alyref; THO complex subunit 4 isoform X1 [KO:K12881]
117562549  THO complex subunit 4-like [KO:K12881]
117537588  cd40lg; CD40 ligand [KO:K04389]
117555215  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
117560755  tumor necrosis factor receptor superfamily member 23-like [KO:K04390]
117548000  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117541843  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
117533310  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
117534615  fadd; FAS-associated death domain protein [KO:K02373]
117544401  casp10; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117533360  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117546044  LOW QUALITY PROTEIN: caspase-8-like [KO:K04398] [EC:3.4.22.61]
117556610  casp8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
117556611  caspase-8-like [KO:K04398] [EC:3.4.22.61]
117550799  bida; BH3 interacting domain death agonist [KO:K04726]
117534621  zgc:153993; apoptosis regulator BAX [KO:K02159]
117548746  apoptosis regulator BAX-like [KO:K02159]
117551507  badb; BCL2 associated agonist of cell death b [KO:K02158]
117558349  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
117543686  bcl-2-like protein 1 [KO:K04570]
117547736  bcl2l1; bcl-2-like protein 1 [KO:K04570]
117544313  cytochrome c [KO:K08738]
117551848  cytochrome c [KO:K08738]
117563018  cytochrome c-a [KO:K08738]
117559145  apaf1; apoptotic protease-activating factor 1 [KO:K02084]
117541895  caspase-9-like [KO:K04399] [EC:3.4.22.62]
117542043  caspase-9-like [KO:K04399] [EC:3.4.22.62]
117550380  caspase-3-like [KO:K02187] [EC:3.4.22.56]
117556108  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
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Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
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  Authors
Spear PG
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Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
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Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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Reference
PMID:24262390
  Authors
Ma Y, He B
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Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
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Su C, Zhan G, Zheng C
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Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
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  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
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Reference
PMID:15276609
  Authors
Morrison LA
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The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
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Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
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  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
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J Virol 87:859-71 (2013)
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Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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J Virol 81:3455-64 (2007)
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Reference
PMID:12826401
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Wysocka J, Herr W
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
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J Virol 87:10244-54 (2013)
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Tavalai N, Stamminger T
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Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
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Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
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Liu X, Cohen JI
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
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Vink EI, Smiley JR, Mohr I
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Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
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Sandri-Goldin RM
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Front Biosci 13:5241-56 (2008)
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Reference
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Sandri-Goldin RM
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Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
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Yu X, He S
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
gacu03040  Spliceosome
gacu03050  Proteasome
gacu04115  p53 signaling pathway
gacu04210  Apoptosis
gacu04620  Toll-like receptor signaling pathway
gacu04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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