KEGG   PATHWAY: mdo05208
Entry
mdo05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Monodelphis domestica (gray short-tailed opossum)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mdo05208  Chemical carcinogenesis - reactive oxygen species
mdo05208

Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100030124  GSTM1; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
100016032  GSTT2B; glutathione S-transferase theta 2B [KO:K00799] [EC:2.5.1.18]
100011354  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
100022188  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
100014035  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100017050  GSTA3; glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100017091  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
100012866  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
100033072  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
100022164  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
100027420  MGST2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
100016934  glutathione S-transferase alpha I-like [KO:K00799] [EC:2.5.1.18]
100017013  GSTA3; glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
100015886  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
3074661  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
3074668  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
3074658  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
3074656  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
3074657  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
3074665  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
3074664  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100013993  NDUFV1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
100016466  NDUFV2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
103103819  NDUFV3; NADH:ubiquinone oxidoreductase subunit V3 [KO:K03944]
103100668  NDUFA1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
100026394  NDUFA2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
100028584  NDUFA3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
100025610  NDUFA4; NDUFA4, mitochondrial complex associated [KO:K03948]
100013434  NDUFA5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
100018098  NDUFA6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
100017688  NDUFA7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
100016535  NDUFA8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
100019378  NDUFA9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
100619445  NDUFA10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
100015047  NDUFAB1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
100025322  NDUFA11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
100012168  NDUFA12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
100012255  NDUFA13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
100016103  NDUFB1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
100023986  NDUFB2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
100017266  NDUFB4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
100013786  NDUFB5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
100024279  NDUFB6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
100026423  NDUFB7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
100010541  NDUFB8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
100026210  NDUFB9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
100012012  NDUFB10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
100618050  NDUFB11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
100017188  NDUFS1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
100028959  NDUFS2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
100016907  NDUFS3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
100031559  NDUFS4; NADH:ubiquinone oxidoreductase subunit S4 [KO:K03937]
100024981  NDUFS5; NADH:ubiquinone oxidoreductase subunit S5 [KO:K03938]
100015850  NDUFS6; NADH:ubiquinone oxidoreductase subunit S6 [KO:K03939]
100030784  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial-like [KO:K03939]
100020933  NDUFS7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
100618522  NDUFS8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
100019912  NDUFC1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
100027336  NDUFC2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
751085  SDHA; succinate dehydrogenase complex flavoprotein subunit A [KO:K00234] [EC:1.3.5.1]
751078  SDHB; succinate dehydrogenase complex iron sulfur subunit B [KO:K00235] [EC:1.3.5.1]
100032780  SDHC; succinate dehydrogenase complex subunit C [KO:K00236]
100032261  SDHD; succinate dehydrogenase complex subunit D [KO:K00237]
100012527  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
3074659  CYTB; cytochrome b [KO:K00412]
100017630  cytochrome c1, heme protein, mitochondrial [KO:K00413]
100020379  UQCRC1; cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100026672  UQCRC2; cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100023995  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
100030139  cytochrome b-c1 complex subunit 7 [KO:K00417]
100015788  cytochrome b-c1 complex subunit 8 [KO:K00418]
100030790  cytochrome b-c1 complex subunit 9 [KO:K00419]
100013423  UQCR11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
3074662  COX3; cytochrome c oxidase subunit III [KO:K02262]
3074660  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
3074663  COX2; cytochrome c oxidase subunit II [KO:K02261]
100018068  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
103106696  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100030045  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100030336  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
100012494  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
100026117  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100019961  cytochrome c oxidase subunit 6B2-like [KO:K02267]
100013297  cytochrome c oxidase subunit 6B1 [KO:K02267]
100023062  cytochrome c oxidase subunit 6B2-like [KO:K02267]
100010650  cytochrome c oxidase subunit 6B2-like [KO:K02267]
100022184  cytochrome c oxidase subunit 6B2-like [KO:K02267]
103099076  cytochrome c oxidase subunit 6B2-like [KO:K02267]
100020481  cytochrome c oxidase subunit 6B2-like [KO:K02267]
100030489  cytochrome c oxidase subunit 6C-2 [KO:K02268]
100016643  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100032291  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
100618273  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100012618  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
100011523  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100014981  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
103105219  cytochrome c oxidase subunit 8B, mitochondrial-like [KO:K02273]
100014124  ATP5A1; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle [KO:K02132]
103096959  ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
100014350  ATP5B; ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [KO:K02133] [EC:7.1.2.2]
100011414  ATP5C1; ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 [KO:K02136]
100022173  ATP5D; ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit [KO:K02134]
100021402  ATP5E; ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit [KO:K02135]
3074666  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100033122  ATP5F1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 [KO:K02127]
100018564  ATP5G1; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C1 (subunit 9) [KO:K02128]
100018948  ATP5G3; ATP synthase, H+ transporting, mitochondrial Fo complex subunit C3 (subunit 9) [KO:K02128]
100023278  ATP5H; ATP synthase, H+ transporting, mitochondrial Fo complex subunit D [KO:K02138]
100026076  ATP5O; ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit [KO:K02137]
100030487  ATP synthase subunit O, mitochondrial-like [KO:K02137]
100027682  ATP synthase subunit O, mitochondrial-like [KO:K02137]
100022645  ATP5J; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6 [KO:K02131]
3074667  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100032426  SOD2; superoxide dismutase 2 [KO:K04564] [EC:1.15.1.1]
100014869  VDAC1; voltage dependent anion channel 1 [KO:K05862]
100012461  VDAC2; voltage dependent anion channel 2 [KO:K15040]
100030164  VDAC3; voltage dependent anion channel 3 [KO:K15041]
100011987  SLC25A4; solute carrier family 25 member 4 [KO:K05863]
100010639  SLC25A31; solute carrier family 25 member 31 [KO:K05863]
100010363  SLC25A6; solute carrier family 25 member 6 [KO:K05863]
100010487  ADP/ATP translocase 3 [KO:K05863]
100030680  ADP/ATP translocase 3 [KO:K05863]
100031958  ADP/ATP translocase 3 [KO:K05863]
100018337  ADP/ATP translocase 3-like [KO:K05863]
100014702  PPIF; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
100014993  SOD1; superoxide dismutase 1 [KO:K04565] [EC:1.15.1.1]
100031495  CAT; catalase [KO:K03781] [EC:1.11.1.6]
100025588  SLC26A1; solute carrier family 26 member 1 [KO:K14700]
100028865  SLC26A2; solute carrier family 26 member 2 [KO:K14701]
103102408  SLC26A6; solute carrier family 26 member 6 [KO:K14704]
100014491  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
100029908  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
100015828  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
100018790  CYPIIF2; cytochrome P450, family 2, subfamily f, polypeptide 2 [KO:K07416] [EC:1.14.14.1]
100029871  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
100011610  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
100025778  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
100030580  EPHX2; epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
100012757  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
100026451  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
100024617  AKR1A1; aldo-keto reductase family 1 member A1 [KO:K00002] [EC:1.1.1.2]
100028121  NQO1; NAD(P)H quinone dehydrogenase 1 [KO:K00355] [EC:1.6.5.2]
100015233  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100015103  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100015187  carbonyl reductase [NADPH] 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
100021129  AHR; aryl hydrocarbon receptor [KO:K09093]
103093117  aryl hydrocarbon receptor-like [KO:K09093]
100011653  aryl hydrocarbon receptor-like [KO:K09093]
100012375  LPO; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
100009800  NOX4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
100026086  uncharacterized LOC100026086 [KO:K08009]
100014144  NCF1; neutrophil cytosolic factor 1 [KO:K08011]
100024184  NCF2; neutrophil cytosolic factor 2 [KO:K08010]
100619143  EGF; epidermal growth factor [KO:K04357]
100029625  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
100016122  HGF; hepatocyte growth factor [KO:K05460]
100013788  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
100022894  GRB2; growth factor receptor bound protein 2 [KO:K04364]
100618058  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
100029256  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100022523  GTPase NRas-like [KO:K07828]
100017615  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
100024057  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100031527  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
100019828  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100026752  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100010279  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010891  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100026324  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100018830  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100021705  FOXO3; forkhead box O3 [KO:K09408]
100031246  BAD; BCL2 associated agonist of cell death [KO:K02158]
100028717  PTPN1; protein tyrosine phosphatase, non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
100013036  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100011769  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100030722  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
100619665  PTPRJ; protein tyrosine phosphatase, receptor type J [KO:K05698] [EC:3.1.3.48]
100616835  ACP1; acid phosphatase 1, soluble [KO:K14394] [EC:3.1.3.2 3.1.3.48]
100028991  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100023824  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
100029391  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100619549  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
100016915  ABL2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
100013333  PRKD1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
100011137  PRKD3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
100027188  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
100009769  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
100618309  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100020668  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
100027212  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
100017492  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
100012132  VEGFA; vascular endothelial growth factor A [KO:K05448]
100012710  KEAP1; kelch like ECH associated protein 1 [KO:K10456]
100026605  NFE2L2; nuclear factor, erythroid 2 like 2 [KO:K05638]
100024355  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
100030714  heme oxygenase 1-like [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mdo00190  Oxidative phosphorylation
mdo00980  Metabolism of xenobiotics by cytochrome P450
mdo04010  MAPK signaling pathway
mdo04064  NF-kappa B signaling pathway
mdo04066  HIF-1 signaling pathway
mdo04151  PI3K-Akt signaling pathway
mdo04370  VEGF signaling pathway
mdo05207  Chemical carcinogenesis - receptor activation
mdo05211  Renal cell carcinoma
mdo05215  Prostate cancer
mdo05219  Bladder cancer
mdo05221  Acute myeloid leukemia
mdo05222  Small cell lung cancer
mdo05223  Non-small cell lung cancer
mdo05224  Breast cancer
mdo05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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