KEGG   PATHWAY: mjv04148
Entry
mjv04148                    Pathway                                
Name
Efferocytosis - Manis javanica (Malayan pangolin)
Class
Cellular Processes; Transport and catabolism
Pathway map
mjv04148  Efferocytosis
mjv04148

Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108389793  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
108384433  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
108388021  PANX1; pannexin-1 isoform X1 [KO:K03443]
108388274  P2RY2; P2Y purinoceptor 2 isoform X1 [KO:K04269]
108388273  P2RY6; P2Y purinoceptor 6 [KO:K04272]
108387338  P2RY12; P2Y purinoceptor 12 isoform X1 [KO:K04298]
108393157  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
108398675  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
108402215  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
108392650  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
108409431  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X1 [KO:K05641]
108405745  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
108398652  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
108406598  LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 17-like [KO:K06059] [EC:3.4.24.86]
108393396  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
108404851  CX3CL1; fractalkine [KO:K05508]
108406917  CX3CR1; CX3C chemokine receptor 1 isoform X2 [KO:K04192]
108391749  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
108385943  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
108402601  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
108410202  nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
118972277  nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
108404522  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
108408262  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
108398989  EPOR; erythropoietin receptor [KO:K05079]
108395333  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108391993  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
108394347  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
108399547  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
108402151  MFGE8; lactadherin isoform X1 [KO:K17253]
108399954  GAS6; growth arrest-specific protein 6 isoform X1 [KO:K05464]
108392264  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
108407748  CD36; platelet glycoprotein 4 [KO:K06259]
108400147  THBS1; thrombospondin-1 [KO:K16857]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108406216  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
108396416  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
108404752  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
108391589  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
108396160  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
108383720  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
108385494  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
108404162  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
108400537  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
108385398  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
108394027  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
108398760  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
108400883  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
108395598  MAPK12; mitogen-activated protein kinase 12 isoform X9 [KO:K04441] [EC:2.7.11.24]
108394635  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
108394636  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108403019  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
108400689  ALOX5; polyunsaturated fatty acid 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
108386766  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
108407827  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108402505  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108405122  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108404435  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108402295  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108396791  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108397336  ANO6; anoctamin-6 isoform X1 [KO:K19500]
108401952  ANO3; anoctamin-3 [KO:K19498]
108409086  ANO4; anoctamin-4 [KO:K19499]
108386747  ANO5; anoctamin-5 isoform X1 [KO:K19480]
108387190  ANO9; anoctamin-9 isoform X1 [KO:K19503]
108391741  BSG; basigin [KO:K06535]
108390352  XKR8; XK-related protein 8 [KO:K26813]
108394168  XKR9; XK-related protein 9 isoform X1 [KO:K26814]
108397283  XKR7; XK-related protein 7 [KO:K26811]
108386993  XKR4; XK-related protein 4 [KO:K26811]
118966865  XKR6; XK-related protein 6 [KO:K26811]
108389522  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
108398088  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
108402747  phospholipid-transporting ATPase IG [KO:K26934] [EC:7.6.2.1]
108400432  ATP11B; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
108409601  ATP11A; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
108392254  TMEM30A; cell cycle control protein 50A [KO:K26935]
108402421  PROS1; vitamin K-dependent protein S isoform X1 [KO:K03908]
108396573  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
108401068  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108410150  ITGB5; integrin beta-5 [KO:K06588]
108383765  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
118971635  tyrosine-protein kinase receptor UFO-like [KO:K05115] [EC:2.7.10.1]
108390078  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
108404685  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 [KO:K26936]
108386688  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
108393802  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
108404432  STAB1; stabilin-1 isoform X1 [KO:K19020]
108395218  STAB2; stabilin-2 [KO:K19013]
108394624  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
108396170  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
108408988  CRKL; crk-like protein [KO:K04438]
108394533  CRK; adapter molecule crk isoform X1 [KO:K04438]
108403664  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
108408449  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108403053  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
108399673  CALR; calreticulin [KO:K08057]
108407308  C1QB; complement C1q subcomponent subunit B [KO:K03987]
108385816  LRP1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
108397815  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
108404541  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
108394542  SCARF1; scavenger receptor class F member 1 isoform X2 [KO:K24318]
108398087  RAB17; ras-related protein Rab-17 [KO:K07909]
108409860  RAB5A; ras-related protein Rab-5A [KO:K07887]
108389601  RAB5B; ras-related protein Rab-5B [KO:K07888]
108388342  ras-related protein Rab-5C [KO:K07889]
118972640  ras-related protein Rab-5C [KO:K07889]
108407194  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 isoform X1 [KO:K20177]
108390909  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
108392501  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
108390385  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
108398369  RAB14; ras-related protein Rab-14 [KO:K07881]
108402501  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
108397772  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
108404246  RAB7A; ras-related protein Rab-7a [KO:K07897]
108390198  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
108383904  SLC66A1; lysosomal amino acid transporter 1 homolog isoform X4 [KO:K23678]
108401161  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
108402088  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
108391560  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
108392866  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
108388644  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
108397926  NR1H2; oxysterols receptor LXR-beta [KO:K08535]
108403489  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
108407876  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X2 [KO:K19523] [EC:2.3.1.21]
118970269  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
108400334  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
108388550  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
118966876  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
108407546  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X2 [KO:K11411] [EC:2.3.1.286]
108391167  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
108403017  IL10; interleukin-10 isoform X1 [KO:K05443]
108392864  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
108402603  PLA2G15; phospholipase A2 group XV [KO:K06129] [EC:3.1.1.5]
108402235  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
108406715  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
108401079  monocarboxylate transporter 1 [KO:K08179]
108401080  monocarboxylate transporter 1-like isoform X1 [KO:K08179]
108394031  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
108404543  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
108390221  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
108409929  sialic acid-binding Ig-like lectin 10 [KO:K06749]
108404321  signal-regulatory protein beta-1-like [KO:K06551]
108389636  SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 [KO:K06551]
108384835  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X3 [KO:K05697] [EC:3.1.3.48]
108405695  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
mjv00010  Glycolysis / Gluconeogenesis
mjv04140  Autophagy - animal
mjv04145  Phagosome
KO pathway
ko04148   
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