KEGG   PATHWAY: mjv05224
Entry
mjv05224                    Pathway                                
Name
Breast cancer - Manis javanica (Malayan pangolin)
Description
Breast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gland. The molecular subtypes of breast cancer, which are based on the presence or absence of hormone receptors (estrogen and progesterone subtypes) and human epidermal growth factor receptor-2 (HER2), include: hormone receptor positive and HER2 negative (luminal A subtype), hormone receptor positive and HER2 positive (luminal B subtype), hormone receptor negative and HER2 positive (HER2 positive), and hormone receptor negative and HER2 negative (basal-like or triple-negative breast cancers (TNBCs)). Hormone receptor positive breast cancers are largely driven by the estrogen/ER pathway. In HER2 positive breast tumours, HER2 activates the PI3K/AKT and the RAS/RAF/MAPK pathways, and stimulate cell growth, survival and differentiation. In patients suffering from TNBC, the deregulation of various signalling pathways (Notch and Wnt/beta-catenin), EGFR protein have been confirmed. In the case of breast cancer only 8% of all cancers are hereditary, a phenomenon linked to genetic changes in BRCA1 or BRCA2. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers.
Class
Human Diseases; Cancer: specific types
Pathway map
mjv05224  Breast cancer
mjv05224

Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108405771  ESR1; estrogen receptor [KO:K08550]
108403446  ESR2; estrogen receptor beta [KO:K08551]
108397348  NCOA1; nuclear receptor coactivator 1 isoform X1 [KO:K09101] [EC:2.3.1.48]
108404060  NCOA3; nuclear receptor coactivator 3 [KO:K11256] [EC:2.3.1.48]
108402534  FOS; proto-oncogene c-Fos [KO:K04379]
108386817  JUN; transcription factor AP-1 [KO:K04448]
108394782  SP1; transcription factor Sp1 [KO:K04684]
108388480  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
108399996  MYC; myc proto-oncogene protein [KO:K04377]
108399170  PGR; progesterone receptor isoform X1 [KO:K08556]
108383443  WNT1; proto-oncogene Wnt-1 [KO:K03209]
108391532  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
108407315  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
108390012  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108405921  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
108393279  FGF20; fibroblast growth factor 20 [KO:K04358]
108402439  FGF16; fibroblast growth factor 16 [KO:K04358]
108397295  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108397792  FGF10; fibroblast growth factor 10 [KO:K04358]
108383974  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
108391342  fibroblast growth factor 6 [KO:K04358]
108393043  FGF9; fibroblast growth factor 9 [KO:K04358]
108396343  FGF5; fibroblast growth factor 5 [KO:K04358]
118970663  FGF6; fibroblast growth factor 6 [KO:K04358]
108389506  FGF4; fibroblast growth factor 4 [KO:K04358]
108394626  FGF3; fibroblast growth factor 3 [KO:K04358]
118973114  FGF7; fibroblast growth factor 7 [KO:K04358]
118971119  FGF19; fibroblast growth factor 19 [KO:K22603]
108400332  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
108391341  FGF23; fibroblast growth factor 23 isoform X2 [KO:K22428]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108410340  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
108403280  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
108408073  EGF; pro-epidermal growth factor [KO:K04357]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108391899  KIT; mast/stem cell growth factor receptor Kit isoform X5 [KO:K05091] [EC:2.7.10.1]
108407280  SHC-transforming protein 1 isoform X1 [KO:K06279]
118972101  SHC-transforming protein 1-like isoform X1 [KO:K06279]
108391745  SHC2; SHC-transforming protein 2 isoform X2 [KO:K17447]
108394387  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
108402352  SHC4; SHC-transforming protein 4 [KO:K17449]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108391894  SOS2; son of sevenless homolog 2 [KO:K03099]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
118967667  GTPase HRas-like isoform X1 [KO:K02833]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108398047  NRAS; GTPase NRas [KO:K07828]
108398550  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
108387830  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108394305  LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108406544  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108390365  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108400388  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108383561  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108390475  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
108395975  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108397450  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108390746  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
108393161  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
108401175  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
108402292  JAG1; protein jagged-1 isoform X1 [KO:K06052]
108405743  JAG2; protein jagged-2 isoform X1 [KO:K21635]
108394698  DLL3; delta-like protein 3 [KO:K06051]
108395741  DLL1; delta-like protein 1 isoform X1 [KO:K06051]
108392502  DLL4; delta-like protein 4 [KO:K06051]
118966921  delta-like protein 1 [KO:K06051]
108387650  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
108390794  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
108408749  NOTCH3; neurogenic locus notch homolog protein 3 isoform X2 [KO:K20995]
108393800  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
108399743  HES1; transcription factor HES-1 [KO:K06054]
118968620  HES5; transcription factor HES-5 [KO:K06055]
108397627  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
108393070  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
108401207  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
108408755  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108385913  cyclin-dependent kinase inhibitor 1 [KO:K06625]
118970122  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
108405673  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
108393959  WNT2; protein Wnt-2 [KO:K00182]
108398947  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
108388938  WNT3; proto-oncogene Wnt-3 isoform X1 [KO:K00312]
108398816  WNT3A; protein Wnt-3a [KO:K00312]
108397016  WNT5B; protein Wnt-5b isoform X3 [KO:K00444]
108403168  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
108390505  WNT6; protein Wnt-6 [KO:K00445]
108404182  WNT7A; protein Wnt-7a isoform X2 [KO:K00572]
108410319  WNT8A; protein Wnt-8a [KO:K00714]
108409584  WNT8B; protein Wnt-8b [KO:K00714]
108398815  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
108388856  WNT9B; protein Wnt-9b [KO:K01064]
108390506  WNT10A; protein Wnt-10a isoform X1 [KO:K01357]
108383428  WNT10B; protein Wnt-10b [KO:K01357]
108405770  WNT11; protein Wnt-11 [KO:K01384]
108406833  WNT16; protein Wnt-16 [KO:K01558]
108386027  FZD7; frizzled-7 [KO:K02432]
108384294  frizzled-1 [KO:K02432]
118972654  frizzled-1 [KO:K02432]
108403667  FZD2; frizzled-2 [KO:K02235]
108406043  FZD3; frizzled-3 [KO:K02329]
108395112  FZD4; frizzled-4 [KO:K02354]
108395847  FZD5; frizzled-5 [KO:K02375]
108397709  FZD8; frizzled-8 [KO:K02375]
108386613  FZD6; frizzled-6 isoform X3 [KO:K02376]
108397276  FZD9; frizzled-9 [KO:K02842]
108399714  FZD10; frizzled-10 [KO:K02842]
108392097  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
108403486  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
108395276  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
108401217  segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118973512  segment polarity protein dishevelled homolog DVL-3-like isoform X1 [KO:K02353]
118974014  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
108408942  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
108399888  FRAT1; proto-oncogene FRAT1 [KO:K03069]
118971914  GSK-3-binding protein FRAT2-like [KO:K03096]
118971915  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
108389003  GSK3B; glycogen synthase kinase-3 beta isoform X5 [KO:K03083] [EC:2.7.11.26]
108408106  AXIN1; axin-1 isoform X1 [KO:K02157]
108392410  AXIN2; axin-2 isoform X1 [KO:K04385]
108408639  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
108404758  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
108387548  CTNNB1; catenin beta-1 [KO:K02105]
108398542  LOW QUALITY PROTEIN: casein kinase I-like [KO:K08957] [EC:2.7.11.1]
108394798  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
108406081  TCF7; transcription factor 7 isoform X1 [KO:K02620]
108405898  TCF7L1; transcription factor 7-like 1 [KO:K04490]
108408173  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
108405595  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
108404266  TP53; cellular tumor antigen p53 [KO:K04451]
118974052  cellular tumor antigen p53 [KO:K04451]
108393260  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108404892  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
108393837  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
108400315  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118969429  apoptosis regulator BAX [KO:K02159]
108402940  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
108388647  DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]
108408163  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
108387631  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
108392535  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
108384777  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
108401113  E2F1; transcription factor E2F1 [KO:K17454]
108401353  E2F2; transcription factor E2F2 isoform X1 [KO:K09389]
108401143  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
108394617  BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
108406123  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
Compound
C00410  Progesterone
C00951  Estradiol-17beta
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:27390604
  Authors
Dai X, Xiang L, Li T, Bai Z
  Title
Cancer Hallmarks, Biomarkers and Breast Cancer Molecular Subtypes.
  Journal
J Cancer 7:1281-94 (2016)
DOI:10.7150/jca.13141
Reference
PMID:20436504
  Authors
Schnitt SJ
  Title
Classification and prognosis of invasive breast cancer: from morphology to molecular taxonomy.
  Journal
Mod Pathol 23 Suppl 2:S60-4 (2010)
DOI:10.1038/modpathol.2010.33
Reference
PMID:23000897
  Authors
  Title
Comprehensive molecular portraits of human breast tumours.
  Journal
Nature 490:61-70 (2012)
DOI:10.1038/nature11412
Reference
PMID:22178455
  Authors
Eroles P, Bosch A, Perez-Fidalgo JA, Lluch A
  Title
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
  Journal
Cancer Treat Rev 38:698-707 (2012)
DOI:10.1016/j.ctrv.2011.11.005
Reference
  Authors
Karamouzis MV, Papavassiliou KA, Adamopoulos C, Papavassiliou AG.
  Title
Targeting androgen/estrogen receptors crosstalk in cancer
  Journal
Trends Cancer 2:35-48 (2016)
DOI:10.1016/j.trecan.2015.12.001
Reference
  Authors
Sharp A, Harper-Wynne C.
  Title
Treatment of advanced breast cancer (ABC): the expanding landscape of targeted therapies
  Journal
J Cancer Biol Res 2:1036 (2014)
Reference
PMID:24596345
  Authors
Byler S, Goldgar S, Heerboth S, Leary M, Housman G, Moulton K, Sarkar S
  Title
Genetic and epigenetic aspects of breast cancer progression and therapy.
  Journal
Anticancer Res 34:1071-7 (2014)
Reference
PMID:23988612
  Authors
Mohamed A, Krajewski K, Cakar B, Ma CX
  Title
Targeted therapy for breast cancer.
  Journal
Am J Pathol 183:1096-112 (2013)
DOI:10.1016/j.ajpath.2013.07.005
Reference
PMID:22722193
  Authors
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER
  Title
Whole-genome analysis informs breast cancer response to aromatase inhibition.
  Journal
Nature 486:353-60 (2012)
DOI:10.1038/nature11143
Reference
PMID:25907219
  Authors
Ma CX, Reinert T, Chmielewska I, Ellis MJ
  Title
Mechanisms of aromatase inhibitor resistance.
  Journal
Nat Rev Cancer 15:261-75 (2015)
DOI:10.1038/nrc3920
Reference
PMID:16113099
  Authors
Butt AJ, McNeil CM, Musgrove EA, Sutherland RL
  Title
Downstream targets of growth factor and oestrogen signalling and endocrine resistance: the potential roles of c-Myc, cyclin D1 and cyclin E.
  Journal
Endocr Relat Cancer 12 Suppl 1:S47-59 (2005)
DOI:10.1677/erc.1.00993
Reference
PMID:24111892
  Authors
Dasgupta S, Lonard DM, O'Malley BW
  Title
Nuclear receptor coactivators: master regulators of human health and disease.
  Journal
Annu Rev Med 65:279-92 (2014)
DOI:10.1146/annurev-med-051812-145316
Reference
PMID:23702927
  Authors
Brisken C
  Title
Progesterone signalling in breast cancer: a neglected hormone coming into the limelight.
  Journal
Nat Rev Cancer 13:385-96 (2013)
DOI:10.1038/nrc3518
Reference
PMID:20087430
  Authors
Scarpin KM, Graham JD, Mote PA, Clarke CL
  Title
Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression.
  Journal
Nucl Recept Signal 7:e009 (2009)
DOI:10.1621/nrs.07009
Reference
PMID:24291072
  Authors
Knutson TP, Lange CA
  Title
Tracking progesterone receptor-mediated actions in breast cancer.
  Journal
Pharmacol Ther 142:114-25 (2014)
DOI:10.1016/j.pharmthera.2013.11.010
Reference
PMID:25544707
  Authors
Dittrich A, Gautrey H, Browell D, Tyson-Capper A
  Title
The HER2 Signaling Network in Breast Cancer--Like a Spider in its Web.
  Journal
J Mammary Gland Biol Neoplasia 19:253-70 (2014)
DOI:10.1007/s10911-014-9329-5
Reference
PMID:21965336
  Authors
Higgins MJ, Baselga J
  Title
Targeted therapies for breast cancer.
  Journal
J Clin Invest 121:3797-803 (2011)
DOI:10.1172/JCI57152
Reference
PMID:26028978
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
Reference
PMID:19088017
  Authors
Schneider BP, Winer EP, Foulkes WD, Garber J, Perou CM, Richardson A, Sledge GW, Carey LA
  Title
Triple-negative breast cancer: risk factors to potential targets.
  Journal
Clin Cancer Res 14:8010-8 (2008)
DOI:10.1158/1078-0432.CCR-08-1208
Reference
PMID:21898546
  Authors
King TD, Suto MJ, Li Y
  Title
The Wnt/beta-catenin signaling pathway: a potential therapeutic target in the treatment of triple negative breast cancer.
  Journal
J Cell Biochem 113:13-8 (2012)
DOI:10.1002/jcb.23350
Reference
PMID:11737884
  Authors
Brown AM
  Title
Wnt signaling in breast cancer: have we come full circle?
  Journal
Breast Cancer Res 3:351-5 (2001)
DOI:10.1186/bcr321
Reference
PMID:21076461
  Authors
Geyer FC, Lacroix-Triki M, Savage K, Arnedos M, Lambros MB, MacKay A, Natrajan R, Reis-Filho JS
  Title
beta-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation.
  Journal
Mod Pathol 24:209-31 (2011)
DOI:10.1038/modpathol.2010.205
Reference
PMID:20971825
  Authors
Al-Hussaini H, Subramanyam D, Reedijk M, Sridhar SS
  Title
Notch signaling pathway as a therapeutic target in breast cancer.
  Journal
Mol Cancer Ther 10:9-15 (2011)
DOI:10.1158/1535-7163.MCT-10-0677
Reference
PMID:26968398
  Authors
Rangel MC, Bertolette D, Castro NP, Klauzinska M, Cuttitta F, Salomon DS
  Title
Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.
  Journal
Breast Cancer Res Treat 156:211-26 (2016)
DOI:10.1007/s10549-016-3746-7
Reference
PMID:26040571
  Authors
Jamdade VS, Sethi N, Mundhe NA, Kumar P, Lahkar M, Sinha N
  Title
Therapeutic targets of triple-negative breast cancer: a review.
  Journal
Br J Pharmacol 172:4228-37 (2015)
DOI:10.1111/bph.13211
Reference
PMID:23196196
  Authors
Karamboulas C, Ailles L
  Title
Developmental signaling pathways in cancer stem cells of solid tumors.
  Journal
Biochim Biophys Acta 1830:2481-95 (2013)
DOI:10.1016/j.bbagen.2012.11.008
Reference
PMID:23881035
  Authors
Ignatiadis M, Sotiriou C
  Title
Luminal breast cancer: from biology to treatment.
  Journal
Nat Rev Clin Oncol 10:494-506 (2013)
DOI:10.1038/nrclinonc.2013.124
Reference
PMID:25013431
  Authors
Shin SJ, Gong G, Lee HJ, Kang J, Bae YK, Lee A, Cho EY, Lee JS, Suh KS, Lee DW, Jung WH
  Title
Positive expression of insulin-like growth factor-1 receptor is associated with a positive hormone receptor status and a favorable prognosis in breast cancer.
  Journal
J Breast Cancer 17:113-20 (2014)
DOI:10.4048/jbc.2014.17.2.113
Reference
PMID:11879567
  Authors
Gasco M, Shami S, Crook T
  Title
The p53 pathway in breast cancer.
  Journal
Breast Cancer Res 4:70-6 (2002)
DOI:10.1186/bcr426
Reference
PMID:15343273
  Authors
Narod SA, Foulkes WD
  Title
BRCA1 and BRCA2: 1994 and beyond.
  Journal
Nat Rev Cancer 4:665-76 (2004)
DOI:10.1038/nrc1431
Related
pathway
mjv03440  Homologous recombination
mjv04010  MAPK signaling pathway
mjv04110  Cell cycle
mjv04115  p53 signaling pathway
mjv04151  PI3K-Akt signaling pathway
mjv04310  Wnt signaling pathway
mjv04330  Notch signaling pathway
mjv04915  Estrogen signaling pathway
KO pathway
ko05224   
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