KEGG   PATHWAY: mjv04010
Entry
mjv04010                    Pathway                                
Name
MAPK signaling pathway - Manis javanica (Malayan pangolin)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
mjv04010  MAPK signaling pathway
mjv04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Manis javanica (Malayan pangolin) [GN:mjv]
Gene
108383338  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
108383439  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
108383459  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
108383482  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
108383501  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
108383696  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
108383720  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
108383914  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
108383974  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
108384016  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X2 [KO:K04416] [EC:2.7.11.25]
108384279  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
108384285  [KO:K04723]
108384296  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
108384371  VEGFD; vascular endothelial growth factor D [KO:K05449]
108384435  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
108384893  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
108385046  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108385086  ARRB1; beta-arrestin-1 isoform X3 [KO:K04439]
108385338  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108385396  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108385397  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
108385404  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
108385409  [KO:K16342] [EC:3.1.1.4]
108385414  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
108385633  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
108385635  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108385648  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
108385666  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
108385741  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
108385943  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
108386081  NGF; beta-nerve growth factor [KO:K02582]
108386668  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
108386709  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
108386817  JUN; transcription factor AP-1 [KO:K04448]
108386996  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
108387236  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
108387253  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
108387321  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
108387427  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
108387612  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
108387768  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
108387830  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
108387895  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
108387965  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
108387997  FLNA; filamin-A isoform X2 [KO:K04437]
108388206  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
108388253  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
108389020  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
108389097  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
108389310  [KO:K03283]
108389506  FGF4; fibroblast growth factor 4 [KO:K04358]
108389793  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
108390012  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
108390054  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
108390154  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
108390300  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
108390345  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
108390480  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
108390484  AKT2; RAC-beta serine/threonine-protein kinase isoform X3 [KO:K04456] [EC:2.7.11.1]
108391002  RELB; transcription factor RelB isoform X1 [KO:K09253]
108391063  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
108391169  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
108391341  FGF23; fibroblast growth factor 23 isoform X2 [KO:K22428]
108391342  [KO:K04358]
108391436  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108391501  VEGFC; vascular endothelial growth factor C [KO:K05449]
108391531  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108391688  LAMTOR3; ragulator complex protein LAMTOR3 isoform X5 [KO:K04370]
108391706  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108391859  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
108391894  SOS2; son of sevenless homolog 2 [KO:K03099]
108391899  KIT; mast/stem cell growth factor receptor Kit isoform X5 [KO:K05091] [EC:2.7.10.1]
108392124  CD14; monocyte differentiation antigen CD14 [KO:K04391]
108392139  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108392181  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
108392300  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X10 [KO:K08018]
108392444  ANGPT1; angiopoietin-1 [KO:K05465]
108392492  CACNG1; voltage-dependent calcium channel gamma-1 subunit isoform X2 [KO:K04866]
108392496  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
108392497  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
108392617  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
108392641  [KO:K07836]
108392664  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
108392844  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
108392845  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
108393027  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
108393034  IL1B; interleukin-1 beta [KO:K04519]
108393043  FGF9; fibroblast growth factor 9 [KO:K04358]
108393196  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108393248  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
108393260  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
108393279  FGF20; fibroblast growth factor 20 [KO:K04358]
108393302  HSPB1; heat shock protein beta-1 [KO:K04455]
108393368  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
108393727  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
108393746  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108393784  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
108393837  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
108393890  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
108394148  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
108394305  [KO:K04365] [EC:2.7.11.1]
108394341  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108394495  RASA1; ras GTPase-activating protein 1 [KO:K04352]
108394533  CRK; adapter molecule crk isoform X1 [KO:K04438]
108394626  FGF3; fibroblast growth factor 3 [KO:K04358]
108394635  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
108394636  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108394776  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
108395068  SRF; serum response factor [KO:K04378]
108395105  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
108395202  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
108395520  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108395540  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X2 [KO:K04424] [EC:2.7.11.25]
108395546  RAP1A; ras-related protein Rap-1A [KO:K04353]
108395598  MAPK12; mitogen-activated protein kinase 12 isoform X9 [KO:K04441] [EC:2.7.11.24]
108395652  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
108395672  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108395732  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
108395733  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108395737  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
108395738  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
108395842  KRAS; GTPase KRas isoform X1 [KO:K07827]
108396001  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
108396152  DAXX; death domain-associated protein 6 [KO:K02308]
108396268  KITLG; kit ligand isoform X1 [KO:K05461]
108396343  FGF5; fibroblast growth factor 5 [KO:K04358]
108396371  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
108396373  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X8 [KO:K04414] [EC:2.7.11.1]
108396401  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
108396432  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
108396677  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
108396791  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108396943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108397005  RELA; transcription factor p65 isoform X1 [KO:K04735]
108397019  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
108397030  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
108397295  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108397360  PDGFB; platelet-derived growth factor subunit B isoform X4 [KO:K17386]
108397364  [KO:K04403]
108397369  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
108397370  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
108397433  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108397589  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X3 [KO:K04430] [EC:2.7.12.2]
108397792  FGF10; fibroblast growth factor 10 [KO:K04358]
108397806  NF1; neurofibromin isoform X1 [KO:K08052]
108397840  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
108397877  TNF; tumor necrosis factor [KO:K03156]
108397886  [KO:K03283]
108397962  EGFR; epidermal growth factor receptor isoform X5 [KO:K04361] [EC:2.7.10.1]
108398047  NRAS; GTPase NRas [KO:K07828]
108398133  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
108398275  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X3 [KO:K04465]
108398293  STK4; serine/threonine-protein kinase 4 [KO:K04411]
108398432  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
108398454  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
108398461  TAOK2; serine/threonine-protein kinase TAO2 [KO:K04429] [EC:2.7.11.1]
108398517  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
108398550  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
108398647  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
108398732  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
108398753  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
108398790  STMN1; stathmin [KO:K04381]
108398977  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
108398994  [KO:K04405]
108399089  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
108399127  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108399135  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
108399212  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108399226  PGF; placenta growth factor isoform X1 [KO:K16859]
108399322  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
108399504  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X3 [KO:K04408] [EC:2.7.11.1]
108399643  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
108399649  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
108399795  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108399996  MYC; myc proto-oncogene protein [KO:K04377]
108400295  RRAS; ras-related protein R-Ras [KO:K07829]
108400302  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X3 [KO:K05454]
108400332  FGF21; fibroblast growth factor 21 isoform X2 [KO:K22429]
108400338  NTF4; neurotrophin-4 [KO:K12457]
108400418  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
108400601  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
108400653  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
108400663  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108400781  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
108400819  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
108400895  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
108400921  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
108400987  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
108401029  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
108401059  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
108401094  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
108401280  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
108401438  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
108401589  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
108401834  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
108401845  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
108401853  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
108401876  ELK1; ETS domain-containing protein Elk-1 isoform X2 [KO:K04375]
108402295  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108402355  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
108402439  FGF16; fibroblast growth factor 16 [KO:K04358]
108402505  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108402518  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
108402534  FOS; proto-oncogene c-Fos [KO:K04379]
108402601  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
108402612  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
108402614  INS; insulin [KO:K04526]
108402621  MAP3K11; mitogen-activated protein kinase kinase kinase 11 isoform X1 [KO:K04419] [EC:2.7.11.25]
108402776  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
108402854  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
108402892  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
108403019  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
108403050  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108403112  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
108403151  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
108403280  [KO:K05087] [EC:2.7.10.1]
108403336  ARRB2; beta-arrestin-2 isoform X2 [KO:K04439]
108403720  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
108404049  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
108404175  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
108404213  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
108404266  TP53; cellular tumor antigen p53 [KO:K04451]
108404435  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108404453  ARTN; artemin [KO:K25415]
108404608  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
108404638  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
108404652  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
108404706  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
108404707  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
108404714  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
108404719  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
108404891  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
108404892  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
108404949  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K04372] [EC:2.7.11.1]
108404979  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
108405122  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108405137  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
108405281  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
108405418  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
108405673  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
108405921  FGF8; LOW QUALITY PROTEIN: fibroblast growth factor 8 [KO:K04358]
108406004  JUND; transcription factor jun-D [KO:K04449]
108406085  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
108406200  PSPN; persephin [KO:K25416]
108406382  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
108406519  [KO:K04425] [EC:2.7.11.25]
108406677  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108406797  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
108406827  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
108406934  MAX; protein max isoform X1 [KO:K04453]
108407135  VEGFA; vascular endothelial growth factor A [KO:K05448]
108407285  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
108407356  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
108407421  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
108407453  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
108407564  VEGFB; vascular endothelial growth factor B isoform X3 [KO:K16858]
108407583  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
108407595  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
108407733  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
108407827  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
108407871  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
108408073  EGF; pro-epidermal growth factor [KO:K04357]
108408343  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
108408627  HRAS; GTPase HRas isoform X1 [KO:K02833]
108408755  [KO:K05097] [EC:2.7.10.1]
108408790  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
108408988  CRKL; crk-like protein [KO:K04438]
108409008  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
108409106  AREG; amphiregulin [KO:K09782]
108409115  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
108409214  NRTN; neurturin [KO:K25414]
108409326  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
108409500  CDC25B; M-phase inducer phosphatase 2 isoform X2 [KO:K05866] [EC:3.1.3.48]
108409511  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
108409586  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108409616  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108409974  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
108410138  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
108410188  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
108410200  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
108410204  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
108410340  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118967041  [KO:K04437]
118967667  [KO:K02833]
118969951  [KO:K03283]
118970289  [KO:K04457] [EC:3.1.3.16]
118970652  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118970663  FGF6; fibroblast growth factor 6 [KO:K04358]
118971119  FGF19; fibroblast growth factor 19 [KO:K22603]
118972255  [KO:K05866] [EC:3.1.3.48]
118973114  FGF7; fibroblast growth factor 7 [KO:K04358]
118974052  [KO:K04451]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
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PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
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Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
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Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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Reference
PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
mjv04070  Phosphatidylinositol signaling system
mjv04110  Cell cycle
mjv04115  p53 signaling pathway
mjv04210  Apoptosis
mjv04310  Wnt signaling pathway
mjv04668  TNF signaling pathway
KO pathway
ko04010   

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