KEGG   PATHWAY: nau03040
Entry
nau03040                    Pathway                                
Name
Spliceosome - Nicotiana attenuata (coyote tobacco)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
nau03040  Spliceosome
nau03040

Other DBs
GO: 0005681
Organism
Nicotiana attenuata (coyote tobacco) [GN:nau]
Gene
109214172  DEAD-box ATP-dependent RNA helicase 42-like [KO:K12811] [EC:5.6.2.7]
109243637  DEAD-box ATP-dependent RNA helicase 56 isoform X1 [KO:K12812] [EC:5.6.2.7]
109230220  DEAD-box ATP-dependent RNA helicase 56-like isoform X1 [KO:K12812] [EC:5.6.2.7]
109216507  DEAD-box ATP-dependent RNA helicase 56-like isoform X1 [KO:K12812] [EC:5.6.2.7]
109234572  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH1-like isoform X1 [KO:K12813] [EC:5.6.2.6]
109240757  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7 [KO:K12815] [EC:5.6.2.6]
109237304  pre-mRNA-processing factor 17 isoform X1 [KO:K12816]
109242192  pre-mRNA-splicing factor 18 [KO:K12817]
109236102  LOW QUALITY PROTEIN: probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
109235355  ATP-dependent RNA helicase DEAH11, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
109229769  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818] [EC:5.6.2.6]
109234114  pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH10 [KO:K12818] [EC:5.6.2.6]
109241022  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 isoform X1 [KO:K12818] [EC:5.6.2.6]
109215492  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DEAH11, chloroplastic-like [KO:K12818] [EC:5.6.2.6]
109227551  pre-mRNA-splicing factor SLU7-like [KO:K12819]
109229942  probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820] [EC:5.6.2.6]
109239274  small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086]
109210604  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
109234078  small nuclear ribonucleoprotein Sm D1-like [KO:K11087]
109211053  small nuclear ribonucleoprotein Sm D2-like [KO:K11096]
109226472  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
109227130  small nuclear ribonucleoprotein SmD3b-like [KO:K11088]
109234423  small nuclear ribonucleoprotein E-like [KO:K11097]
109227186  small nuclear ribonucleoprotein E-like [KO:K11097]
109234260  probable small nuclear ribonucleoprotein F [KO:K11098]
109211452  probable small nuclear ribonucleoprotein F [KO:K11098]
109217243  probable small nuclear ribonucleoprotein G [KO:K11099]
109208756  probable small nuclear ribonucleoprotein G [KO:K11099]
109210709  U1 small nuclear ribonucleoprotein 70 kDa [KO:K11093]
109205122  U1 small nuclear ribonucleoprotein A [KO:K11091]
109232299  U1 small nuclear ribonucleoprotein C-like isoform X1 [KO:K11095]
109215230  U1 small nuclear ribonucleoprotein C-like [KO:K11095]
109223342  pre-mRNA-processing protein 40A-like isoform X1 [KO:K12821]
109234616  pre-mRNA-processing protein 40A isoform X1 [KO:K12821]
109235419  RNA-binding protein 25 isoform X1 [KO:K12822]
109232225  ATP-dependent RNA helicase-like protein DB10 [KO:K12823] [EC:5.6.2.7]
109223685  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
109209726  ATP-dependent RNA helicase-like protein DB10 [KO:K12823] [EC:5.6.2.7]
109232243  DEAD-box ATP-dependent RNA helicase 40-like [KO:K12823] [EC:5.6.2.7]
109212949  DEAD-box ATP-dependent RNA helicase 20 [KO:K12823] [EC:5.6.2.7]
109230217  ATP-dependent RNA helicase DBP2-like [KO:K12823] [EC:5.6.2.7]
109244201  pre-mRNA-processing protein 40C [KO:K12824]
109214491  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
109222445  transcription initiation factor TFIID subunit 15b-like [KO:K13098]
109208102  transcription initiation factor TFIID subunit 15b [KO:K13098]
109223906  U2 small nuclear ribonucleoprotein A' [KO:K11092]
109226768  U2 small nuclear ribonucleoprotein B'' [KO:K11094]
109215349  probable splicing factor 3A subunit 1 [KO:K12825]
109208076  LOW QUALITY PROTEIN: splicing factor 3A subunit 2-like [KO:K12826]
109229683  splicing factor 3A subunit 2-like [KO:K12826]
109210957  splicing factor SF3a60 homolog [KO:K12827]
109233095  splicing factor 3B subunit 1 [KO:K12828]
109232961  splicing factor 3B subunit 2 [KO:K12829]
109213418  uncharacterized protein LOC109213418 isoform X1 [KO:K12830]
109241505  splicing factor 3B subunit 3-like [KO:K12830]
109215548  splicing factor 3B subunit 4-like [KO:K12831]
109224108  splicing factor 3B subunit 4 [KO:K12831]
109217733  splicing factor 3B subunit 4 isoform X1 [KO:K12831]
109206852  uncharacterized protein At4g14342 [KO:K12832]
109239204  splicing factor 3B subunit 6-like protein [KO:K12833]
109239364  PHD finger-like domain-containing protein 5B [KO:K12834]
109214276  PHD finger-like domain-containing protein 5B [KO:K12834]
109228350  DEAD-box ATP-dependent RNA helicase 24 [KO:K12835] [EC:5.6.2.7]
109216688  splicing factor U2af small subunit B-like [KO:K12836]
109230967  splicing factor U2af small subunit B-like [KO:K12836]
109239482  splicing factor U2af small subunit B-like [KO:K12836]
109226876  splicing factor U2af small subunit B-like [KO:K12836]
109238888  splicing factor U2af large subunit A isoform X1 [KO:K12837]
109245061  uncharacterized protein LOC109245061 [KO:K12837]
109243793  splicing factor U2af large subunit B [KO:K12837]
109223201  splicing factor U2af large subunit A-like isoform X1 [KO:K12837]
109244207  splicing factor U2af large subunit B-like isoform X1 [KO:K12837]
109242138  survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
109208907  DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840]
109209149  protein RRC1-like isoform X1 [KO:K12842]
109237932  protein RRC1-like isoform X1 [KO:K12842]
109208078  sm-like protein LSM2 [KO:K12621]
109223459  sm-like protein LSM2 [KO:K12621]
109244712  sm-like protein LSM3A [KO:K12622]
109225674  sm-like protein LSM3B [KO:K12622]
109209138  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
109240319  probable U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
109220783  sm-like protein LSM5 [KO:K12624]
109233061  sm-like protein LSM36B [KO:K12625]
109215343  sm-like protein LSM7 [KO:K12626]
109217957  sm-like protein LSM8 [KO:K12627]
109206997  U4/U6 small nuclear ribonucleoprotein Prp3 [KO:K12843]
109232437  U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662]
109235375  peptidyl-prolyl cis-trans isomerase CYP22-like [KO:K09567] [EC:5.2.1.8]
109221808  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
109214182  U4/U6 small nuclear ribonucleoprotein Prp31 homolog [KO:K12844]
109207016  NHP2-like protein 1 [KO:K12845]
109208816  NHP2-like protein 1 [KO:K12845]
109210571  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846]
109208334  U4/U6.U5 tri-snRNP-associated protein 2-like [KO:K12847]
109244778  SART-1 family protein DOT2 [KO:K11984]
109233008  zinc finger matrin-type protein 2-like [KO:K12848]
109222870  zinc finger matrin-type protein 2-like [KO:K12848]
109231412  pre-mRNA-splicing factor 38 [KO:K12849]
109242784  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
109222649  110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852]
109208083  DExH-box ATP-dependent RNA helicase DExH12-like [KO:K12854] [EC:5.6.2.6]
109219891  protein STABILIZED1 [KO:K12855]
109214915  pre-mRNA-processing-splicing factor 8A-like [KO:K12856]
109234340  pre-mRNA-processing-splicing factor 8A isoform X1 [KO:K12856]
109234320  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
109242799  DEAD-box ATP-dependent RNA helicase 21 [KO:K12858] [EC:5.6.2.7]
109228450  thioredoxin-like protein YLS8 [KO:K12859]
109244981  thioredoxin-like protein YLS8 [KO:K12859]
109238758  pre-mRNA-processing factor 19 homolog 2-like [KO:K10599] [EC:2.3.2.27]
109238777  pre-mRNA-processing factor 19 homolog 1-like [KO:K10599] [EC:2.3.2.27]
109233146  cell division cycle 5-like protein [KO:K12860]
109213300  cell division cycle 5-like protein [KO:K12860]
109224091  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
109219796  pre-mRNA-splicing factor SPF27 homolog [KO:K12861]
109219773  protein pleiotropic regulatory locus 1-like [KO:K12862]
109230833  protein CWC15 homolog [KO:K12863]
109231243  protein CWC15 homolog [KO:K12863]
109226967  beta-catenin-like protein 1 [KO:K12864]
109208862  heat shock cognate 70 kDa protein 2 [KO:K03283]
109216626  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109212701  heat shock 70 kDa protein [KO:K03283]
109206051  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109212940  heat shock cognate 70 kDa protein [KO:K03283]
109205243  heat shock cognate 70 kDa protein 1-like [KO:K03283]
109208634  heat shock 70 kDa protein-like [KO:K03283]
109222182  heat shock cognate 70 kDa protein 1-like [KO:K03283]
109214331  heat shock cognate 70 kDa protein 2-like [KO:K03283]
109213359  stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283]
109228241  heat shock cognate 70 kDa protein-like [KO:K03283]
109207012  stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283]
109240555  uncharacterized protein LOC109240555 [KO:K12865]
109215629  SNW/SKI-interacting protein-like [KO:K06063]
109229537  SNW/SKI-interacting protein-like [KO:K06063]
109233415  SNW/SKI-interacting protein-like [KO:K06063]
109232402  SNW/SKI-interacting protein-like [KO:K06063]
109227277  pre-mRNA-splicing factor SYF1 [KO:K12867]
109209686  pre-mRNA-splicing factor syf2 [KO:K12868]
109220822  crooked neck-like protein 1 [KO:K12869]
109242593  crooked neck-like protein 1 [KO:K12869]
109225278  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
109241545  peptidyl-prolyl cis-trans isomerase CYP18-2 [KO:K12733] [EC:5.2.1.8]
109212616  coiled-coil domain-containing protein 12 [KO:K12871]
109234568  zinc finger CCCH domain-containing protein 49-like [KO:K12872]
109215596  zinc finger CCCH domain-containing protein 49-like [KO:K12872]
109209407  protein BUD31 homolog 2 [KO:K12873]
109223348  protein BUD31 homolog 1-like [KO:K12873]
109212067  intron-binding protein aquarius [KO:K12874]
109243407  neurofilament heavy polypeptide-like isoform X1 [KO:K12875]
109243408  myosin-9-like isoform X1 [KO:K12875]
109209034  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
109215864  eukaryotic initiation factor 4A-3-like [KO:K13025] [EC:5.6.2.7]
109215020  RNA-binding protein 8A-like [KO:K12876]
109225227  RNA-binding protein 8A-like [KO:K12876]
109219016  protein mago nashi homolog [KO:K12877]
109205132  protein mago nashi homolog [KO:K12877]
109212864  THO complex subunit 1 isoform X1 [KO:K12878]
109206153  THO complex subunit 2 [KO:K12879]
109212797  THO complex subunit 3 [KO:K12880]
109210279  THO complex subunit 4C-like [KO:K12881]
109227206  THO complex subunit 4D-like [KO:K12881]
109217882  THO complex subunit 4B-like isoform X1 [KO:K12881]
109212718  THO complex subunit 4B-like [KO:K12881]
109240800  THO complex subunit 4A-like [KO:K12881]
109208863  THO complex subunit 4A-like [KO:K12881]
109238445  nuclear cap-binding protein subunit 1 [KO:K12882]
109218068  nuclear cap-binding protein subunit 2-like [KO:K12883]
109228470  nuclear cap-binding protein subunit 2-like [KO:K12883]
109220112  glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741]
109212738  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
109231024  UBP1-associated protein 2B-like [KO:K12741]
109235741  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
109228714  UBP1-associated protein 2A-like [KO:K12741]
109241911  UBP1-associated protein 2C-like [KO:K12741]
109241492  glycine-rich RNA-binding protein 4, mitochondrial-like [KO:K12741]
109229513  UBP1-associated protein 2C-like [KO:K12741]
109211438  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
109228638  heterogeneous nuclear ribonucleoprotein 1-like [KO:K12741]
109206250  glycine-rich RNA-binding protein 7-like isoform X1 [KO:K12741]
109227730  UBP1-associated protein 2C-like [KO:K12741]
109225761  RNA-binding protein squid [KO:K12741]
109226666  UBP1-associated protein 2C-like [KO:K12741]
109213225  UBP1-associated proteins 1A-like [KO:K12741]
109215559  serine/arginine-rich-splicing factor SR34-like isoform X1 [KO:K12890]
109243794  serine/arginine-rich splicing factor SR34A-like [KO:K12890]
109215962  serine/arginine-rich splicing factor SR30-like isoform X1 [KO:K12890]
109223453  serine/arginine-rich splicing factor SR34A-like [KO:K12890]
109226828  serine/arginine-rich-splicing factor SR34-like [KO:K12890]
109238534  serine/arginine-rich splicing factor SC35-like [KO:K12891]
109214411  serine/arginine-rich splicing factor SC35-like [KO:K12891]
109214412  serine/arginine-rich splicing factor SC35-like [KO:K12891]
109210257  serine/arginine-rich splicing factor RS41-like isoform X1 [KO:K12893]
109225360  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
109213797  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
109241571  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
109227799  serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893]
109235501  serine/arginine-rich splicing factor RSZ21A-like isoform X1 [KO:K12896]
109236692  serine/arginine-rich splicing factor RSZ22-like isoform X1 [KO:K12896]
109206438  serine/arginine-rich splicing factor RSZ22A [KO:K12896]
109212002  serine/arginine-rich splicing factor RS2Z33-like isoform X1 [KO:K12896]
109206648  serine/arginine-rich splicing factor RS2Z33-like isoform X1 [KO:K12896]
109209260  serine/arginine-rich splicing factor SR45a [KO:K12897]
109235768  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
109216003  serine/arginine-rich SC35-like splicing factor SCL33 isoform X1 [KO:K12900]
109238628  serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900]
109232307  serine/arginine-rich SC35-like splicing factor SCL28 isoform X1 [KO:K12900]
Reference
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

DBGET integrated database retrieval system