Entry
Name
Spliceosome - Nicotiana attenuata (coyote tobacco)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Nicotiana attenuata (coyote tobacco) [GN:
nau ]
Gene
109236102 LOW QUALITY PROTEIN: probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH5 [KO:K12818 ] [EC:5.6.2.6 ]
109241022 probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH4 isoform X1 [KO:K12818 ] [EC:5.6.2.6 ]
109229942 probable pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH2 isoform X1 [KO:K12820 ] [EC:5.6.2.6 ]
109239274 small nuclear ribonucleoprotein-associated protein B'-like [KO:K11086 ]
109214491 transcription initiation factor TFIID subunit 15b-like [KO:K13098 ]
109222445 transcription initiation factor TFIID subunit 15b-like [KO:K13098 ]
109208076 LOW QUALITY PROTEIN: splicing factor 3A subunit 2-like [KO:K12826 ]
109242138 survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839 ]
109208907 DNA-damage-repair/toleration protein DRT111, chloroplastic [KO:K12840 ]
109232437 U4/U6 small nuclear ribonucleoprotein PRP4-like protein [KO:K12662 ]
109210571 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein-like [KO:K12846 ]
109222649 110 kDa U5 small nuclear ribonucleoprotein component CLO [KO:K12852 ]
109213359 stromal 70 kDa heat shock-related protein, chloroplastic [KO:K03283 ]
109207012 stromal 70 kDa heat shock-related protein, chloroplastic-like [KO:K03283 ]
109220112 glycine-rich RNA-binding protein 2, mitochondrial-like [KO:K12741 ]
109241492 glycine-rich RNA-binding protein 4, mitochondrial-like [KO:K12741 ]
109215559 serine/arginine-rich-splicing factor SR34-like isoform X1 [KO:K12890 ]
109215962 serine/arginine-rich splicing factor SR30-like isoform X1 [KO:K12890 ]
109210257 serine/arginine-rich splicing factor RS41-like isoform X1 [KO:K12893 ]
109225360 serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893 ]
109213797 serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893 ]
109241571 serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893 ]
109227799 serine/arginine-rich splicing factor RS31-like isoform X1 [KO:K12893 ]
109235501 serine/arginine-rich splicing factor RSZ21A-like isoform X1 [KO:K12896 ]
109236692 serine/arginine-rich splicing factor RSZ22-like isoform X1 [KO:K12896 ]
109212002 serine/arginine-rich splicing factor RS2Z33-like isoform X1 [KO:K12896 ]
109206648 serine/arginine-rich splicing factor RS2Z33-like isoform X1 [KO:K12896 ]
109235768 serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900 ]
109216003 serine/arginine-rich SC35-like splicing factor SCL33 isoform X1 [KO:K12900 ]
109238628 serine/arginine-rich SC35-like splicing factor SCL30A [KO:K12900 ]
109232307 serine/arginine-rich SC35-like splicing factor SCL28 isoform X1 [KO:K12900 ]
Reference
Authors
Wahl MC, Will CL, Luhrmann R
Title
The spliceosome: design principles of a dynamic RNP machine.
Journal
Reference
Authors
Morris DP, Greenleaf AL
Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal
Reference
Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal
Reference
Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
Title
Spliceosome structure: piece by piece.
Journal
KO pathway
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