KEGG   PATHWAY: nsu05415
Entry
nsu05415                    Pathway                                
Name
Diabetic cardiomyopathy - Neomonachus schauinslandi (Hawaiian monk seal)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
nsu05415  Diabetic cardiomyopathy
nsu05415

Organism
Neomonachus schauinslandi (Hawaiian monk seal) [GN:nsu]
Gene
110575252  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
110584441  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
110580279  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
110588745  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
110589302  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
110575536  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
110592665  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
110586778  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
110573755  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
110585996  RYR2; ryanodine receptor 2 [KO:K04962]
110583499  PLN; cardiac phospholamban [KO:K05852]
110588354  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
110589782  ATP2A1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
110593319  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
110577393  SP1; transcription factor Sp1 [KO:K04684]
110586012  AGT; angiotensinogen [KO:K09821]
110577315  REN; renin isoform X1 [KO:K01380] [EC:3.4.23.15]
110585334  chymase [KO:K01329] [EC:3.4.21.39]
110585496  mast cell protease 1-like [KO:K01329] [EC:3.4.21.39]
110577506  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
110586748  AGER; LOW QUALITY PROTEIN: advanced glycosylation end product-specific receptor [KO:K19722]
110573186  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
110589761  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
110591514  cytochrome b-245 light chain isoform X1 [KO:K08009]
110574118  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
110578106  NCF4; neutrophil cytosol factor 4 [KO:K08012]
110572663  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
110571993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110578113  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110576788  AGTR1; type-1 angiotensin II receptor [KO:K04166]
110572155  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110575986  RELA; transcription factor p65 [KO:K04735]
110575614  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
110575674  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578302  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
110578303  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
110591392  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110589690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110580283  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
110593361  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
110579532  MMP9; matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
110579928  COL1A2; collagen alpha-2(I) chain [KO:K06236]
110593078  COL1A1; collagen alpha-1(I) chain [KO:K06236]
110591895  COL3A1; collagen alpha-1(III) chain [KO:K19720]
110590084  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
110588122  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
110571461  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
110579831  CD36; platelet glycoprotein 4 [KO:K06259]
110577966  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
110578311  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
110580110  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
110585952  pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 3, mitochondrial-like [KO:K00898] [EC:2.7.11.2]
110592832  PDK2; pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
110594176  PDK3; pyruvate dehydrogenase kinase, isozyme 3 [KO:K00898] [EC:2.7.11.2]
110570410  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110584785  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
110581560  PTPA; serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
110588340  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110576035  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
110587585  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110582885  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
110574610  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
110575297  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
110576080  INS; insulin [KO:K04526]
110593671  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110574308  IRS1; insulin receptor substrate 1 [KO:K16172]
110575119  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110582352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110570825  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110574558  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110575009  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110591287  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110574156  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110590250  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110571694  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110575132  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
110582720  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110580940  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
110572856  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
110587615  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
110583156  MPC1; mitochondrial pyruvate carrier 1 isoform X1 [KO:K22138]
110573314  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
110574040  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
110582597  mitochondrial pyruvate carrier 2-like [KO:K22139]
110575058  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
110572122  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
110584977  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial isoform X1 [KO:K00162] [EC:1.2.4.1]
110576051  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
110579816  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
110571047  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
110571899  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
110584754  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
110582412  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
110592684  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
110576912  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
110572549  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
110591967  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
110591153  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
110593497  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
110570654  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
110586292  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
110582963  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
110579713  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
110573770  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
110579997  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
110575375  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110582576  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110586505  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110588141  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110589627  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110577241  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110577843  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
110581959  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110581310  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
110588918  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
110583500  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
110591111  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
110578245  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
110593707  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X2 [KO:K03951]
110584080  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8-like [KO:K03952]
110581447  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
110590930  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
110580751  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
110570906  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
110577521  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
110593925  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
110586873  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12-like [KO:K11352]
110578015  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
110574391  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123324034  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
123324583  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
123324840  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
123325710  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
110571749  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
123323387  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
123323596  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
110582840  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
110591923  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
110582519  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
110592724  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
110582472  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
110581859  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
110593783  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
110589289  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
110584316  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9-like [KO:K03965]
110579240  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
110587978  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123323649  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
110571484  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
110591803  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
110573390  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
110576300  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
110570042  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
110580048  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial-like [KO:K03937]
110586598  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
110574926  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
110586743  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
110591634  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
110577698  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
110593830  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
110576057  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
110570505  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
110589489  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
110572508  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial-like [KO:K03967]
110571228  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
110593480  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
110577684  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
110575148  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
110582689  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
110573521  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
110586328  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
110590331  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
110578997  cytochrome c1, heme protein, mitochondrial [KO:K00413]
110577574  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
110577487  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
110575016  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
110585923  cytochrome b-c1 complex subunit 7-like [KO:K00417]
110579043  cytochrome b-c1 complex subunit 7-like [KO:K00417]
110593661  cytochrome b-c1 complex subunit 7-like [KO:K00417]
110576985  cytochrome b-c1 complex subunit 7-like [KO:K00417]
110578709  cytochrome b-c1 complex subunit 7 [KO:K00417]
110574791  cytochrome b-c1 complex subunit 8-like [KO:K00418]
110591028  cytochrome b-c1 complex subunit 8 [KO:K00418]
110592411  cytochrome b-c1 complex subunit 9 [KO:K00419]
110593793  cytochrome b-c1 complex subunit 10 [KO:K00420]
110589382  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
110575607  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like isoform X1 [KO:K02263]
110586371  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like isoform X1 [KO:K02263]
110594193  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
110579539  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
110583791  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
110590484  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
110574024  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
110580218  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
110589771  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
110585947  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
110585318  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
110585549  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
110592483  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
110578665  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
110590161  cytochrome c oxidase subunit 6B1 [KO:K02267]
110583483  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110591870  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110573684  cytochrome c oxidase subunit 6B2 [KO:K02267]
110585078  cytochrome c oxidase subunit 6C-like [KO:K02268]
110593289  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C [KO:K02268]
110590162  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
110583520  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
110592553  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
110587283  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
110590872  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
110578761  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
110584241  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
110589106  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
110578029  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
110589450  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
110590815  cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
110575931  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
110576915  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 8A, mitochondrial-like [KO:K02273]
110577084  ATP5F1A; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
110577765  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
110578633  ATP synthase subunit gamma, mitochondrial-like [KO:K02136]
110586565  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
110593995  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
110569835  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
110573405  LOW QUALITY PROTEIN: ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
110580551  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
110592221  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
110581177  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
110583089  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
110591855  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
110582960  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
110592852  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
110577448  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X2 [KO:K02128]
110589959  ATP synthase subunit d, mitochondrial-like [KO:K02138]
110572326  ATP synthase subunit d, mitochondrial-like [KO:K02138]
110572615  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
110570015  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
110580212  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
110587937  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
110589287  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
110589650  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
110570123  ATP5PF; ATP synthase-coupling factor 6, mitochondrial isoform X2 [KO:K02131]
110577120  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
110572629  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
110579854  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
110587929  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
110591289  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
110594300  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
110577984  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
110589660  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
110573114  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
110584101  LOW QUALITY PROTEIN: ADP/ATP translocase 2-like [KO:K05863]
110592115  ADP/ATP translocase 2-like [KO:K05863]
110584198  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
110573020  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
110576274  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
110570194  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
110589180  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
110573626  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110582947  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110581083  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
110575364  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
110590663  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
110569916  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
110576815  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
110571646  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
123323281  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
110571398  PARP1; poly [ADP-ribose] polymerase 1 isoform X1 [KO:K24070] [EC:2.4.2.30]
110574205  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
110584057  GSR; glutathione reductase, mitochondrial isoform X1 [KO:K00383] [EC:1.8.1.7]
110581718  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
110570864  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
110583310  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
110577095  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
110583782  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
110575943  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
110585213  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
110579316  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
110579349  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
110570363  angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
110570385  ACE; angiotensin-converting enzyme isoform X3 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
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Of mice and men: models and mechanisms of diabetic cardiomyopathy.
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Basic Res Cardiol 114:2 (2018)
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Reference
PMID:24462787
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Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
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Pharmacol Ther 142:375-415 (2014)
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Nat Rev Cardiol 17:585-607 (2020)
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Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
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Front Endocrinol (Lausanne) 8:72 (2017)
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Nature 414:813-20 (2001)
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Related
pathway
nsu00010  Glycolysis / Gluconeogenesis
nsu00020  Citrate cycle (TCA cycle)
nsu00190  Oxidative phosphorylation
nsu00520  Amino sugar and nucleotide sugar metabolism
nsu03320  PPAR signaling pathway
nsu04071  Sphingolipid signaling pathway
nsu04150  mTOR signaling pathway
nsu04210  Apoptosis
nsu04260  Cardiac muscle contraction
nsu04350  TGF-beta signaling pathway
nsu04614  Renin-angiotensin system
nsu04910  Insulin signaling pathway
nsu04930  Type II diabetes mellitus
nsu04931  Insulin resistance
nsu04933  AGE-RAGE signaling pathway in diabetic complications
nsu04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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