KEGG   PATHWAY: omc04510
Entry
omc04510                    Pathway                                
Name
Focal adhesion - Onychostoma macrolepis
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
omc04510  Focal adhesion
omc04510

Other DBs
GO: 0005925
Organism
Onychostoma macrolepis [GN:omc]
Gene
131525893  col1a2; collagen alpha-2(I) chain [KO:K06236]
131551090  col1a1b; collagen, type I, alpha 1b isoform X1 [KO:K06236]
131536845  col1a1a; collagen, type I, alpha 1a isoform X1 [KO:K06236]
131549239  col2a1b; collagen, type II, alpha 1b isoform X1 [KO:K19719]
131545957  col2a1a; collagen, type II, alpha 1a isoform X1 [KO:K19719]
131543551  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
131543552  col4a5; collagen alpha-5(IV) chain [KO:K06237]
131520608  col4a4; LOW QUALITY PROTEIN: collagen alpha-4(IV) chain [KO:K06237]
131520609  col4a3; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
131546662  col4a2; collagen alpha-2(IV) chain isoform X1 [KO:K06237]
131546663  col4a1; collagen alpha-1(IV) chain [KO:K06237]
131549563  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
131549564  col6a1; LOW QUALITY PROTEIN: collagen alpha-1(VI) chain [KO:K06238]
131551936  collagen alpha-6(VI) chain-like [KO:K06238]
131551937  collagen alpha-3(VI) chain-like [KO:K06238]
131521230  col6a4a; LOW QUALITY PROTEIN: collagen alpha-6(VI) chain [KO:K06238]
131546567  collagen alpha-3(VI) chain-like isoform X1 [KO:K06238]
131532041  col9a3; collagen alpha-3(IX) chain [KO:K08131]
131549662  col9a1a; collagen, type IX, alpha 1a [KO:K08131]
131525625  collagen alpha-3(IX) chain isoform X1 [KO:K08131]
131525845  col9a2; collagen alpha-2(IX) chain [KO:K08131]
131552054  col9a1b; collagen, type IX, alpha 1b [KO:K08131]
131533680  lama1; laminin subunit alpha-1 [KO:K05637]
131526766  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
131531796  lama5; laminin subunit alpha-5 isoform X1 [KO:K06240]
131521946  si:ch211-241e1.3; laminin subunit alpha-3 [KO:K06240]
131527493  lama4; laminin subunit alpha-4 [KO:K06241]
131533936  lamb1a; laminin subunit beta-1a [KO:K05636]
131538870  lamb1b; laminin subunit beta-1b isoform X1 [KO:K05636]
131531956  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
131531998  lamb2l; laminin subunit beta-2 isoform X1 [KO:K06243]
131531231  lamb3; laminin subunit beta-3 [KO:K06244]
131533939  lamb4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
131522931  lamc1; LOW QUALITY PROTEIN: laminin subunit gamma-1 [KO:K05635]
131533243  lamc2; laminin subunit gamma-2 [KO:K06246]
131541754  lamc3; laminin subunit gamma-3 isoform X1 [KO:K06247]
131550528  chad; chondroadherin [KO:K06248]
131524245  reln; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
131523347  thbs1a; thrombospondin-1 [KO:K16857]
131527248  thbs1b; thrombospondin-1 [KO:K16857]
131540492  thbs4a; thrombospondin-4a isoform X1 [KO:K04659]
131549197  comp; cartilage oligomeric matrix protein [KO:K04659]
131525542  thbs3b; thrombospondin-3b [KO:K04659]
131551393  thbs2b; thrombospondin-2 isoform X1 [KO:K04659]
131552636  thbs2a; thrombospondin-2 [KO:K04659]
131521246  thbs3a; thrombospondin-3a isoform X1 [KO:K04659]
131528683  thbs4b; thrombospondin-4-B [KO:K04659]
131546899  fn1a; fibronectin 1a isoform X1 [KO:K05717]
131520410  vtna; vitronectin a [KO:K06251]
131528445  vtnb; vitronectin b [KO:K06251]
131540707  tnca; tenascin isoform X1 [KO:K06252]
131521658  tnr; tenascin-R isoform X1 [KO:K06252]
131521675  tnn; tenascin-N isoform X1 [KO:K06252]
131540419  tncb; tenascin isoform X1 [KO:K06252]
131524941  vwf; von Willebrand factor isoform X1 [KO:K03900]
131548439  itga1; integrin alpha-1 [KO:K06480]
131548718  itga2.2; integrin alpha-2 [KO:K06481]
131535970  itga2b; integrin alpha-IIb [KO:K06476]
131551352  itga3b; LOW QUALITY PROTEIN: integrin alpha-3b [KO:K06482]
131536063  itga3a; integrin alpha-3 isoform X1 [KO:K06482]
131547195  itga4; integrin alpha-4 [KO:K06483]
131532331  itga5; integrin alpha-5 [KO:K06484]
131547437  itga6a; integrin alpha-6 isoform X1 [KO:K06485]
131549155  itga6b; integrin alpha-6b [KO:K06485]
131553753  itga6l; integrin alpha-6 isoform X1 [KO:K06485]
131549189  itga7; integrin alpha-7 isoform X1 [KO:K06583]
131521810  itga8; integrin alpha-8 isoform X1 [KO:K06584]
131552007  itga9; integrin alpha-9 isoform X1 [KO:K06585]
131521499  itga10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
131534103  itga11b; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
131544017  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
131546705  itgav; integrin alpha-V isoform X1 [KO:K06487]
131533096  itgb1a; integrin beta-1a [KO:K05719]
131551560  integrin beta-1-like [KO:K05719]
131551400  itgb3b; integrin beta-3b [KO:K06493]
131536226  itgb3a; integrin beta-3a isoform X1 [KO:K06493]
131545944  itgb4; integrin beta-4 isoform X1 [KO:K06525]
131546618  itgb5; integrin beta-5 isoform X1 [KO:K06588]
131549156  itgb6; integrin beta-6 [KO:K06589]
131542224  itgb7; integrin beta-7 [KO:K06590]
131526429  itgb8; integrin beta-8 [KO:K06591]
131537482  emp2; epithelial membrane protein 2 [KO:K26256]
131536183  pdgfbb; uncharacterized protein pdgfbb [KO:K04359]
131538005  pdgfab; platelet-derived growth factor alpha polypeptide b isoform X1 [KO:K04359]
131530560  pdgfaa; platelet-derived growth factor alpha polypeptide a isoform X1 [KO:K04359]
131531329  pdgfba; platelet-derived growth factor beta polypeptide a [KO:K17386]
131520569  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
131553973  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
131552902  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
131539332  igf1; insulin-like growth factor I [KO:K05459]
131538292  vegfab; vascular endothelial growth factor Ab isoform X1 [KO:K05448]
131522141  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
131522970  pgfb; placenta growth factor [KO:K16859]
131526972  pgfa; placenta growth factor [KO:K16859]
131549034  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
131549071  vegfc; vascular endothelial growth factor C isoform X1 [KO:K05449]
131523876  hgfb; hepatocyte growth factor isoform X1 [KO:K05460]
131539107  hgfa; hepatocyte growth factor a [KO:K05460]
131527390  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
131553121  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
131524230  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
131543547  igf1rb; insulin-like growth factor 1b receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
131527360  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
131523087  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
131533491  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
131532892  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
131553494  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
131553902  flt4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
131533942  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
131550671  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
131536573  epithelial membrane protein 1-like [KO:K26255]
131546114  emp1; epithelial membrane protein 1 isoform X1 [KO:K26255]
131531598  src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
131540741  arhgap35b; rho GTPase-activating protein 35 [KO:K05732]
131520746  arhgap35a; rho GTPase-activating protein 35 [KO:K05732]
131522915  arhgap5; rho GTPase-activating protein 5 [KO:K13709]
131531628  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
131542024  rhoca; ras homolog family member Ca [KO:K04513]
131545414  rhocb; rho-related GTP-binding protein RhoA-D isoform X1 [KO:K04513]
131545415  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
131545538  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
131530114  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
131552854  protein diaphanous homolog 1 isoform X1 [KO:K05740]
131525651  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
131526545  rock2b; rho-associated protein kinase 2b isoform X1 [KO:K17388] [EC:2.7.11.1]
131552115  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
131541642  myl2a; myosin regulatory light chain 2a [KO:K10351]
131545696  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
131532385  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
131541959  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
131548413  myl10; myosin regulatory light chain 10 [KO:K12756]
131544155  myl12.1; myosin, light chain 12, genome duplicate 1 [KO:K12757]
131529784  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
131550706  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
131536198  mylpfa; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
131523354  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
131541330  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
131543468  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
131551297  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
131537308  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
131534253  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
131538640  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
131531555  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
131532068  protein phosphatase 1 regulatory subunit 12B-like isoform X1 [KO:K12329]
131542963  ppp1r12c; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
131532666  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
131541945  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
131543617  mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
131527022  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
131546722  mylka; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
131554214  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
131532831  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
131537833  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
131530646  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
131548671  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
131526074  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a [KO:K00889] [EC:2.7.1.68]
131521782  pip5k1ab; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
131546110  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
131522054  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b isoform X1 [KO:K00889] [EC:2.7.1.68]
131549288  actb1; actin, cytoplasmic 1 [KO:K05692]
131537017  actb2; actin, cytoplasmic 2 [KO:K05692]
131524536  rasgrf1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
131530830  capn8; calpain-8 [KO:K03853] [EC:3.4.22.53]
131531102  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
131531156  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
131551993  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
131552022  actn1; alpha-actinin-1 isoform X1 [KO:K05699]
131554103  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
131547739  tln1; talin-1 [KO:K06271]
131534164  tln2b; talin-2 isoform X1 [KO:K06271]
131544065  tln2a; talin-2a isoform X1 [KO:K06271]
131531969  flna; filamin-A [KO:K04437]
131549062  flnbl; filamin-B isoform X1 [KO:K27392]
131531970  flnb; filamin-C isoform X1 [KO:K27392]
131540909  pxna; paxillin a isoform X1 [KO:K05760]
131545798  pxnb; uncharacterized protein pxnb isoform X1 [KO:K05760]
131548819  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
131521894  zyx; zyxin [KO:K06273]
131548208  vaspa; vasodilator stimulated phosphoprotein a [KO:K06274]
131524348  vaspb; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
131550872  vclb; vinculin b [KO:K05700]
131551778  vcla; vinculin a isoform X1 [KO:K05700]
131534840  parvb; beta-parvin isoform X1 [KO:K06275]
131534843  parvg; gamma-parvin isoform X1 [KO:K06275]
131534933  parvaa; parvin, alpha a [KO:K06275]
131545055  parvab; parvin, alpha b [KO:K06275]
131532993  pdpk1b; 3-phosphoinositide dependent protein kinase 1b isoform X1 [KO:K06276] [EC:2.7.11.1]
131536992  pdpk1a; 3-phosphoinositide-dependent protein kinase 1a isoform X1 [KO:K06276] [EC:2.7.11.1]
131523076  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131548207  akt2l; v-akt murine thymoma viral oncogene homolog 2, like [KO:K04456] [EC:2.7.11.1]
131548459  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131524297  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
131527534  RAC-alpha serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
131552423  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
131547336  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
131547844  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b [KO:K03083] [EC:2.7.11.26]
131525681  catenin beta-1-like [KO:K02105]
131521430  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
131542168  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
131535943  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
131536620  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
131539492  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
131521212  prkcg; protein kinase C alpha type isoform X1 [KO:K19663] [EC:2.7.11.13]
131525327  ptk2aa; protein tyrosine kinase 2aa isoform X1 [KO:K05725] [EC:2.7.10.2]
131521265  ptk2ab; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
131532182  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131532482  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
131549562  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
131554420  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
131541975  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
131552189  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
131540458  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
131523186  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131550661  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
131533049  guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
131536490  proto-oncogene vav-like isoform X1 [KO:K05730]
131528302  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
131529433  vav3b; guanine nucleotide exchange factor VAV3b isoform X1 [KO:K05730]
131551015  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
131536680  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
131520971  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
131536939  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
131551082  rac3b; ras-related C3 botulinum toxin substrate 3b [KO:K07861]
131537430  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
131524117  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
131530842  pak2b; serine/threonine-protein kinase PAK 2b isoform X1 [KO:K04410] [EC:2.7.11.1]
131553262  pak2a; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2a [KO:K04410] [EC:2.7.11.1]
131540594  serine/threonine-protein kinase PAK 3-like isoform X1 [KO:K05733] [EC:2.7.11.1]
131520730  serine/threonine-protein kinase PAK 4-like isoform X1 [KO:K05734] [EC:2.7.11.1]
131526695  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
131522894  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
131527719  pak6b; serine/threonine-protein kinase PAK 6b [KO:K05735] [EC:2.7.11.1]
131531530  cdc42l2; cell division cycle 42 like 2 [KO:K04393]
131549282  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
131521510  cdc42l; cell division cycle 42, like [KO:K04393]
131524147  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
131529150  crkl; crk-like protein [KO:K04438]
131554391  crk; adapter molecule crk [KO:K04438]
131550812  dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
131545683  rapgef1a; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
131528880  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
131549384  rap1ab; ras-related protein rap1ab [KO:K04353]
131545529  rap1aa; RAP1A, member of RAS oncogene family a [KO:K04353]
131539666  rap1b; ras-related protein Rap-1b isoform X1 [KO:K07836]
131550853  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131552218  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
131528511  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
131528658  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
131527636  jun; transcription factor AP-1 [KO:K04448]
131540839  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
131539604  braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
131533944  cav1; caveolin-1 [KO:K06278]
131531819  cav4b; caveolin-2 [KO:K12958]
131549800  cav4a; caveolin-2 [KO:K12958]
131533945  cav2; caveolin-2 [KO:K12958]
131543064  caveolin-2-like [KO:K12958]
131542601  cav3; caveolin-3 [KO:K12959]
131523357  fyna; tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
131526727  fynb; tyrosine-protein kinase fynb isoform X1 [KO:K05703] [EC:2.7.10.2]
131522592  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
131530701  shc2; SHC-transforming protein 2 isoform X1 [KO:K17447]
131528767  shc3; SHC-transforming protein 3 [KO:K17448]
131542705  grb2a; growth factor receptor-bound protein 2a [KO:K04364]
131537364  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
131548892  sos1; son of sevenless homolog 1 [KO:K03099]
131552620  sos2; son of sevenless homolog 2 [KO:K03099]
131534047  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
131543828  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
131531944  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
131549244  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
131524475  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
131540661  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
131536056  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
131546156  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
131544494  ccnd1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
131534119  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
131539081  ccnd2b; LOW QUALITY PROTEIN: G1/S-specific cyclin-D2b [KO:K10151]
131529954  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
131528262  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
131553879  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
131543359  badb; BCL2 associated agonist of cell death b [KO:K02158]
131528556  bada; bcl2-associated agonist of cell death [KO:K02158]
131533091  bcl2a; apoptosis regulator Bcl-2a [KO:K02161]
131521209  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
omc04010  MAPK signaling pathway
omc04060  Cytokine-cytokine receptor interaction
omc04070  Phosphatidylinositol signaling system
omc04110  Cell cycle
omc04310  Wnt signaling pathway
omc04512  ECM-receptor interaction
omc04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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