Entry
Name
Axon guidance - Phocoena sinus (vaquita)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Phocoena sinus (vaquita) [GN:
psiu ]
Gene
116740089 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
116744707 PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
116753495 TRPC1; LOW QUALITY PROTEIN: short transient receptor potential channel 1 [KO:K04964 ]
116743095 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
116757835 TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
116753887 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
116755228 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
116741444 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
116755488 PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268 ]
116740306 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
116744362 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
116749495 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
116761737 LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392 ]
116760236 RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
116745822 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
116740323 MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755 ]
116757732 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
116753165 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609 ]
116761812 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
116749946 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630 ]
116759318 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
116760284 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
116762500 SRGAP3; LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 3 [KO:K07526 ]
116743231 SRGAP2; LOW QUALITY PROTEIN: SLIT-ROBO Rho GTPase-activating protein 2 [KO:K07526 ]
116757351 RHOD; rho-related GTP-binding protein RhoD isoform X1 [KO:K07530 ]
116755160 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
116754119 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
116741278 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
116751381 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
116752953 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116752990 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
116751286 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116750604 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
116742613 phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
116751944 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
116744257 LOW QUALITY PROTEIN: partitioning defective 6 homolog beta-like [KO:K06093 ]
116744548 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
Compound
Reference
Authors
Guan KL, Rao Y.
Title
Signalling mechanisms mediating neuronal responses to guidance cues.
Journal
Reference
Authors
Govek EE, Newey SE, Van Aelst L.
Title
The role of the Rho GTPases in neuronal development.
Journal
Reference
Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal
Reference
Authors
Negishi M, Oinuma I, Katoh H.
Title
Plexins: axon guidance and signal transduction.
Journal
Reference
Authors
Huot J.
Title
Ephrin signaling in axon guidance.
Journal
Reference
Authors
Patel BN, Van Vactor DL.
Title
Axon guidance: the cytoplasmic tail.
Journal
Reference
Authors
Yu TW, Bargmann CI.
Title
Dynamic regulation of axon guidance.
Journal
Reference
Authors
Dickson BJ.
Title
Molecular mechanisms of axon guidance.
Journal
Reference
Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal
Reference
Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal
Reference
Authors
Fujita Y, Yamashita T
Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal
Reference
Authors
Yamashita T, Mueller BK, Hata K
Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal
Reference
Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal
Related pathway
psiu04060 Cytokine-cytokine receptor interaction
KO pathway
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