KEGG   PATHWAY: psiu04010
Entry
psiu04010                   Pathway                                
Name
MAPK signaling pathway - Phocoena sinus (vaquita)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
psiu04010  MAPK signaling pathway
psiu04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Phocoena sinus (vaquita) [GN:psiu]
Gene
116738713  EFNA1; ephrin-A1 [KO:K05462]
116738862  CRKL; crk-like protein [KO:K04438]
116738910  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116739025  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
116739067  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
116739088  NRAS; GTPase NRas [KO:K07828]
116739537  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116739538  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
116739544  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
116739565  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116739840  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
116739924  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116739960  [KO:K04381]
116740111  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
116740279  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
116740378  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116740620  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
116740668  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
116740772  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
116740868  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
116740948  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
116741004  HSPB1; heat shock protein beta-1 [KO:K04455]
116741257  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116741444  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116741579  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
116741608  MAP3K21; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
116741676  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
116741677  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
116741753  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
116741789  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
116741806  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116742042  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
116742473  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
116742545  MYC; myc proto-oncogene protein [KO:K04377]
116742624  STK3; serine/threonine-protein kinase 3 [KO:K04412]
116742893  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116742916  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
116743304  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
116743400  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
116743409  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
116743442  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
116743443  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
116743550  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
116743673  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116743695  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
116743696  STMN1; stathmin [KO:K04381]
116743766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
116743843  CACNG6; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
116743848  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
116743895  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
116744047  CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
116744218  RELB; transcription factor RelB isoform X1 [KO:K09253]
116744243  EFNA3; ephrin-A3 [KO:K05462]
116744249  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
116744336  FGF21; fibroblast growth factor 21 [KO:K22429]
116744343  NTF4; neurotrophin-4 [KO:K12457]
116744352  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
116744362  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116744941  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
116745052  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
116745309  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
116745432  CRK; adapter molecule crk isoform X1 [KO:K04438]
116745476  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116745518  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
116745546  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
116745591  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
116745655  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
116745732  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
116745739  TP53; cellular tumor antigen p53 [KO:K04451]
116745757  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
116745771  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
116745822  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116745906  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
116745927  CACNG4; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04869]
116745938  NF1; neurofibromin isoform X1 [KO:K08052]
116745964  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
116746058  CACNB1; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
116746064  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
116746086  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
116746298  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
116746300  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
116746378  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116746660  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116746676  VEGFC; vascular endothelial growth factor C [KO:K05449]
116746707  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
116746732  FGFR1; LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
116746760  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
116746806  FGF20; fibroblast growth factor 20 [KO:K04358]
116746810  DUSP4; dual specificity protein phosphatase 4 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116746947  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
116747062  SOS2; son of sevenless homolog 2 [KO:K03099]
116747370  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
116747382  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
116747398  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
116747442  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
116747589  MAP2K1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116747679  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
116747819  [KO:K16342] [EC:3.1.1.4]
116747835  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
116747847  FGF16; fibroblast growth factor 16 [KO:K04358]
116747906  FLNA; filamin-A isoform X1 [KO:K04437]
116747916  VEGFD; vascular endothelial growth factor D [KO:K05449]
116747944  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
116748015  [KO:K03283]
116748109  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
116748377  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
116748530  [KO:K03283]
116748581  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
116748582  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
116748613  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
116748753  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116748886  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 [KO:K04863]
116748892  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
116748896  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
116748945  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
116748950  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116748962  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
116749058  MAX; protein max isoform X1 [KO:K04453]
116749145  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
116749192  FGF7; fibroblast growth factor 7 [KO:K04358]
116749229  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
116749519  FOS; proto-oncogene c-Fos [KO:K04379]
116749524  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
116749646  PGF; placenta growth factor isoform X1 [KO:K16859]
116749666  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
116749989  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
116750440  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
116750545  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
116750614  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
116750630  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
116750695  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
116750736  [KO:K07830]
116750787  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
116751189  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116751302  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116751331  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
116751332  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
116751451  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
116751460  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
116751461  FGF10; fibroblast growth factor 10 [KO:K04358]
116751555  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
116751566  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
116751570  CD14; monocyte differentiation antigen CD14 [KO:K04391]
116751618  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
116751638  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
116751649  [KO:K02833]
116751676  [KO:K07830]
116751751  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
116751822  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
116751853  JUND; transcription factor jun-D [KO:K04449]
116751903  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
116751966  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
116751991  NRTN; neurturin [KO:K25414]
116752001  PSPN; persephin [KO:K25416]
116752024  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
116752074  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
116752233  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
116752252  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
116752262  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
116752293  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
116752435  CDC42; cell division control protein 42 homolog [KO:K04393]
116752784  RASA2; LOW QUALITY PROTEIN: ras GTPase-activating protein 2 [KO:K08053]
116752976  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
116753033  [KO:K04430] [EC:2.7.12.2]
116753175  MRAS; ras-related protein M-Ras [KO:K07831]
116753239  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116753261  [KO:K07836]
116753452  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
116753487  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
116753860  RAPGEF2; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [KO:K08018]
116753887  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116753904  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
116754045  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
116754109  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
116754197  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116754222  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116754298  FGF5; fibroblast growth factor 5 [KO:K04358]
116754393  AREG; amphiregulin [KO:K09782]
116754416  PTPN7; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
116754436  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
116754467  NGF; beta-nerve growth factor [KO:K02582]
116754486  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
116754507  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
116754608  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116754659  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
116754675  EREG; proepiregulin [KO:K09784]
116754735  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116755228  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116755336  NTRK2; LOW QUALITY PROTEIN: BDNF/NT-3 growth factors receptor [KO:K04360] [EC:2.7.10.1]
116755387  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
116755421  CACNA1B; LOW QUALITY PROTEIN: voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
116755488  PPP3R2; LOW QUALITY PROTEIN: calcineurin subunit B type 2 [KO:K06268]
116755617  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
116755801  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
116755848  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
116755898  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
116756129  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
116756311  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
116756540  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
116756610  [KO:K03283]
116756632  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
116756746  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
116756768  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
116756797  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116756875  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
116756965  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
116757004  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
116757345  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
116757391  FGF4; fibroblast growth factor 4 [KO:K04358]
116757392  FGF3; fibroblast growth factor 3 [KO:K04358]
116757444  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
116757499  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
116757626  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
116757663  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
116757726  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
116757757  [KO:K07836]
116757885  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
116757893  HRAS; GTPase HRas isoform X1 [KO:K02833]
116757894  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116757973  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
116758090  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
116758150  RELA; transcription factor p65 isoform X1 [KO:K04735]
116758167  IGF2; LOW QUALITY PROTEIN: insulin-like growth factor II [KO:K13769]
116758168  [KO:K04526]
116758288  [KO:K18497]
116758383  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
116758422  FGF19; fibroblast growth factor 19 [KO:K22603]
116758470  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
116758559  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116758577  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116758674  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116758770  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
116759212  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116759279  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116759402  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
116759669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116759711  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
116759758  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
116760006  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
116760070  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
116760103  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
116760110  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
116760113  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
116760116  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
116760139  ARTN; artemin [KO:K25415]
116760187  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
116760236  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116760244  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
116760326  KRAS; GTPase KRas isoform X1 [KO:K07827]
116760383  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116760487  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
116760562  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
116760605  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116760719  NTF3; neurotrophin-3 [KO:K04356]
116760722  KITLG; kit ligand isoform X1 [KO:K05461]
116760732  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
116760781  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
116760782  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116760842  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
116760902  IGF1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
116760979  FGF6; fibroblast growth factor 6 [KO:K04358]
116761017  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
116761028  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
116761029  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
116761071  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
116761086  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
116761115  JUN; transcription factor AP-1 [KO:K04448]
116761246  FGF23; fibroblast growth factor 23 [KO:K22428]
116761251  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
116761621  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
116761625  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116761737  [KO:K04392]
116761798  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
116761883  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116762009  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
116762072  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
116762073  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
116762074  [KO:K03283]
116762165  VEGFA; vascular endothelial growth factor A [KO:K05448]
116762285  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
116762361  SRF; serum response factor isoform X1 [KO:K04378]
116762489  TNF; tumor necrosis factor [KO:K03156]
116762564  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
116762662  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
116762723  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
116762796  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
116762798  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116762976  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
116763242  MAP3K7; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
116763333  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
116763459  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
116763460  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
116763697  [KO:K04412]
116763745  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
116763886  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
116764094  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
116764139  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
116764281  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
116764289  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
116764546  IL1B; interleukin-1 beta [KO:K04519]
116764634  IL1A; interleukin-1 alpha [KO:K04383]
116764662  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
116764722  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
116764753  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116764767  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
116765180  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
116765202  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
psiu04070  Phosphatidylinositol signaling system
psiu04110  Cell cycle
psiu04115  p53 signaling pathway
psiu04210  Apoptosis
psiu04310  Wnt signaling pathway
psiu04668  TNF signaling pathway
KO pathway
ko04010   

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