Entry
Name
JAK-STAT signaling pathway - Pteropus vampyrus (large flying fox)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Pteropus vampyrus (large flying fox) [GN:
pvp ]
Gene
105311493 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
105293539 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
105308006 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
105299364 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
105306439 IL11RA; interleukin-11 receptor subunit alpha isoform X4 [KO:K05056 ]
105308496 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
105306433 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
105300827 IL20RB; interleukin-20 receptor subunit beta isoform X5 [KO:K05137 ]
105296672 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
105290707 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
105293045 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
105298078 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
105289309 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
105302576 STAT2; signal transducer and activator of transcription 2 isoform X2 [KO:K11221 ]
105306294 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
105289302 STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222 ]
105306335 signal transducer and activator of transcription 5A-like [KO:K11223 ]
105302552 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
105295182 CISH; LOW QUALITY PROTEIN: cytokine-inducible SH2-containing protein [KO:K04701 ]
105303816 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
105291531 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
105292698 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X2 [KO:K16063 ] [EC:2.3.2.-]
105296186 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
105307040 FHL1; four and a half LIM domains protein 1 isoform X2 [KO:K14365 ]
105293353 GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364 ]
105307215 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
105307575 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105308956 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
105296605 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105297140 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
105299371 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
Reference
Authors
Harrison DA
Title
The Jak/STAT pathway.
Journal
Reference
Authors
Kiu H, Nicholson SE
Title
Biology and significance of the JAK/STAT signalling pathways.
Journal
Reference
Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title
Direct effects of type I interferons on cells of the immune system.
Journal
Reference
Authors
Fish EN, Platanias LC
Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal
Reference
Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal
Reference
Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal
Reference
Authors
Zoranovic T, Grmai L, Bach EA
Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal
Reference
Authors
Ungureanu D, Silvennoinen O
Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal
Reference
Authors
Richard AJ, Stephens JM
Title
The role of JAK-STAT signaling in adipose tissue function.
Journal
Reference
Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal
Reference
Authors
Hirano T, Ishihara K, Hibi M
Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal
Reference
Authors
Rane SG, Reddy EP
Title
Janus kinases: components of multiple signaling pathways.
Journal
Reference
Authors
Heim MH
Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal
Reference
Authors
Morris R, Kershaw NJ, Babon JJ
Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal
Reference
Authors
Tzeng HT, Chyuan IT, Lai JH
Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal
Reference
Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal
Related pathway
pvp04060 Cytokine-cytokine receptor interaction
KO pathway
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