KEGG   PATHWAY: rno05146
Entry
rno05146                    Pathway                                
Name
Amoebiasis - Rattus norvegicus (rat)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
rno05146  Amoebiasis
rno05146

Organism
Rattus norvegicus (rat) [GN:rno]
Gene
24494  Il1b; interleukin-1 beta [KO:K04519]
25663  Il1r1; interleukin-1 receptor type 1 precursor [KO:K04386]
117022  Il1r2; interleukin-1 receptor type 2 precursor [KO:K04387]
81736  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580]
309165  Rela; transcription factor p65 [KO:K04735]
24471  Hspb1; heat shock protein beta-1 [KO:K04455]
24572  Muc2; mucin-2 precursor [KO:K10955]
84352  Col1a2; collagen alpha-2(I) chain precursor [KO:K06236]
29393  Col1a1; collagen alpha-1(I) chain precursor [KO:K06236]
290905  Col4a1; collagen alpha-1(IV) chain precursor [KO:K06237]
306628  Col4a2; collagen alpha-2(IV) chain precursor [KO:K06237]
363457  Col4a5; collagen alpha-5(IV) chain precursor [KO:K06237]
363265  Col4a3; collagen alpha-3(IV) chain precursor [KO:K06237]
363458  Col4a6; collagen type IV alpha 6 chain precursor [KO:K06237]
25661  Fn1; fibronectin precursor [KO:K05717]
309368  Lama2; laminin subunit alpha-2 precursor [KO:K05637]
316758  Lama1; laminin subunit alpha-1 precursor [KO:K05637]
140433  Lama5; laminin subunit alpha-5 precursor [KO:K06240]
309816  Lama4; laminin subunit alpha-4 precursor [KO:K06241]
298941  Lamb1; laminin subunit beta-1 precursor [KO:K05636]
25473  Lamb2; laminin subunit beta-2 precursor [KO:K06243]
305078  Lamb3; laminin subunit beta-3 precursor [KO:K06244]
117036  Lamc1; laminin subunit gamma-1 precursor [KO:K05635]
192362  Lamc2; laminin subunit gamma-2 precursor [KO:K06246]
311862  Lamc3; laminin subunit gamma-3 precursor [KO:K06247]
25402  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
81662  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
309242  Gna14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
89788  Gna15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
24680  Prkca; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
25023  Prkcb; protein kinase C beta type isoform 2 [KO:K19662] [EC:2.7.11.13]
24681  Prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
24896  Gnas; SCG6 (secretogranin VI) isoform SCG6 precursor [KO:K04632]
24611  Gnal; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
25636  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  Prkacb; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
64633  Rab5a; ras-related protein Rab-5A [KO:K07887]
100361891  Rab5al1; ras-related protein Rab-5A [KO:K07887]
288779  Rab5b; ras-related protein Rab-5B [KO:K07888]
287709  Rab5c; ras-related protein Rab-5C [KO:K07889]
29448  Rab7a; ras-related protein Rab-7a [KO:K07897]
501854  Rab7b; ras-related protein Rab-7b [KO:K07898]
310553  Tlr2; toll-like receptor 2 precursor [KO:K10159]
29260  Tlr4; toll-like receptor 4 precursor [KO:K10160]
60350  Cd14; monocyte differentiation antigen CD14 precursor [KO:K04391]
24498  Il6; interleukin-6 precursor [KO:K05405]
81503  Cxcl1; growth-regulated alpha protein precursor [KO:K05505]
114105  Cxcl2; C-X-C motif chemokine 2 precursor [KO:K05505]
171551  Cxcl3; C-X-C motif chemokine 3 precursor [KO:K05505]
116630  Csf2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
24835  Tnf; tumor necrosis factor [KO:K03156]
84405  Il12a; interleukin-12 subunit alpha precursor [KO:K05406]
64546  Il12b; interleukin-12 subunit beta precursor [KO:K05425]
25109  Cd1d1; antigen-presenting glycoprotein CD1d precursor [KO:K06448]
25712  Ifng; interferon gamma precursor [KO:K04687]
84032  Col3a1; collagen alpha-1(III) chain precursor [KO:K19720]
25614  Ptk2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
305679  Vcl; vinculin [KO:K05700]
63836  Actn4; alpha-actinin-4 [KO:K05699]
81634  Actn1; alpha-actinin-1 [KO:K05699]
29215  Arg2; arginase-2, mitochondrial precursor [KO:K01476] [EC:3.5.3.1]
29221  Arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
24599  Nos2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
309684  Itgb2; integrin beta-2 precursor [KO:K06464]
25021  Itgam; integrin alpha-M precursor [KO:K06461]
25513  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
60664  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
29741  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
85243  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
170911  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
366508  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
134484121  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
117254  Prdx1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
100363379  Prdx1l1; peroxiredoxin 1-like 1 [KO:K13279] [EC:1.11.1.24]
498209  Serpinb3a; serpin B4-like [KO:K13963]
291085  Serpinb6a; serpin B6 [KO:K13963]
361241  Serpinb9; serpin B9 [KO:K13963]
266775  Serpinb10; serpin B10 [KO:K13963]
304690  Serpinb13; serpin B13 [KO:K13963]
364705  Serpinb6b; serine (or cysteine) peptidase inhibitor, clade B, member 6b [KO:K13963]
304688  Serpinb3; serpin family B member 3 [KO:K13963]
291087  Serpinb6e; serpin B6 [KO:K13963]
306890  Serpinb9d; serine (or cysteine) peptidase inhibitor, clade B, member 9d [KO:K13963]
290257  Ctsg; cathepsin G precursor [KO:K01319] [EC:3.4.21.20]
25325  Il10; interleukin-10 precursor [KO:K05443]
59086  Tgfb1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
81809  Tgfb2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
25717  Tgfb3; transforming growth factor beta-3 proprotein preproprotein [KO:K13377]
298288  C8a; complement component C8 alpha chain precursor [KO:K03997]
313421  C8b; complement component C8 beta chain precursor [KO:K03998]
117512  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
rno00330  Arginine and proline metabolism
rno00590  Arachidonic acid metabolism
rno04144  Endocytosis
rno04210  Apoptosis
rno04510  Focal adhesion
rno04610  Complement and coagulation cascades
rno04612  Antigen processing and presentation
rno04620  Toll-like receptor signaling pathway
rno04672  Intestinal immune network for IgA production
rno04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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